Article
Cell Biology
Xiukun Hou, Xianle Shi, Wei Zhang, Dapeng Li, Linfei Hu, Jihong Yang, Jingzhu Zhao, Songfeng Wei, Xi Wei, Xianhui Ruan, Xiangqian Zheng, Ming Gao
Summary: High expression levels of LDHA in papillary thyroid carcinoma are associated with aggressive clinicopathological features and poor prognosis. LDHA promotes cancer cell migration, invasion, and proliferation, making it a potential therapeutic target.
CELL DEATH & DISEASE
(2021)
Article
Biology
Peng Ding, Chuan Gao, Youshui Gao, Delin Liu, Hao Li, Jun Xu, Xiaoyi Chen, Yigang Huang, Changqing Zhang, Minghao Zheng, Junjie Gao
Summary: This study demonstrates that osteocytes play a critical role in regulating lineage cell specifications in bone and bone marrow through mediating senescence. Loss of osteocytes affects mesenchymal and hematopoietic lineage commitment, leading to osteoporosis, sarcopenia, and degenerative changes in the spine in mice.
Article
Medicine, General & Internal
Murat Yilmaz, Beliz Oztok Tekten
Summary: This study aimed to determine the potential role of postictal serum LDH activities in differentiating epileptic seizures from non-epileptic seizures. The results showed significantly higher LDH activities in patients with epileptic seizures compared to those with non-epileptic seizures, suggesting the potential use of LDH activities as a diagnostic tool in distinguishing between seizure types.
Article
Biochemistry & Molecular Biology
Anastasya Boyarski, Noam Shlush, Shiraz Paz, Jerry Eichler, Lital Alfonta
Summary: In this study, four different enzymatic constructs of L-lactate dehydrogenase were compared and the fusion enzyme containing two cytochromes showed superior catalytic and electrochemical properties. This fusion enzyme exhibited higher activity, lower redox potential, wider dynamic range, and higher product inhibition concentration than the native enzyme. Additionally, it displayed measurable lactate-dependent oxygen reduction.
BIOELECTROCHEMISTRY
(2023)
Article
Agriculture, Dairy & Animal Science
Katrina N. Klobucher, Rachel Badger, Thomas Foxall, Peter S. Erickson
Summary: This study evaluated the viability of sporozoites from Eimeria bovis when exposed to different substances and compared the effects of sodium butyrate and monensin on the invasion of bovine epithelial cells. The results showed that sodium butyrate reduced the number of live sporozoites and decreased cellular damage, suggesting it may be a potential alternative to monensin.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Cell Biology
Changhao Wu, Chenglong Zheng, Shiyu Chen, Zhiwei He, Hao Hua, Chengyi Sun, Chao Yu
Summary: Pancreatic cancer (PC) is a gastrointestinal tract malignant tumor with a poor prognosis. FOXQ1 has been found to be overexpressed in PC tissues and associated with poor prognosis. FOXQ1 overexpression promotes PC cell proliferation, tumor stemness, invasion, and metastasis, while FOXQ1 silencing shows the reverse effect. Mechanistic studies reveal that FOXQ1 promotes LDHA transcription to enhance aerobic glycolysis, contributing to the progression of PC.
CELL DEATH & DISEASE
(2023)
Article
Chemistry, Multidisciplinary
Panasa Mahesh, Parameswari Akshinthala, Naresh Kumar Katari, Lavleen Kumar Gupta, Dikshita Panwar, Manoj Kumar Sharma, Sreekantha Babu Jonnalagadda, Rambabu Gundla
Summary: In this study, two new series of 3,5-dimethyl-1H-pyrazole-4-sulfonamide and 1,3,5-trimethyl-1H-pyrazole-4-sulfonamide derivatives were designed and synthesized. These derivatives were characterized by various analytical techniques and their biological evaluation data were presented, paving the way for the development of new pyrazole-4-sulfonamide derivatives.
Review
Cell Biology
Jiarui Cui, Yo Shibata, Tianmin Zhu, Jun Zhou, Jiaming Zhang
Summary: Osteocytes play a critical role in maintaining bone homeostasis and are involved in age-related bone deterioration. Studies have identified specific characteristics and molecular mechanisms of aging osteocytes, such as impaired mechanosensitivity and cellular senescence. RNA sequencing has provided insights into bone aging-related genes and signaling pathways in osteocytes.
AGEING RESEARCH REVIEWS
(2022)
Article
Medicine, General & Internal
Yauhen Statsenko, Fatmah Al Zahmi, Tetiana Habuza, Klaus Neidl-Van Gorkom, Nazar Zaki
Summary: The study aimed to identify predictive biomarkers of COVID-19 severity and determine threshold values for risk stratification, particularly in determining the need for transfer to the ICU. The study used a supervised machine learning algorithm to customize threshold values for predicting worsening, and found that setting specific cut-off levels improved model performance. Additionally, the study provided threshold values for various laboratory tests to help in the prediction of disease severity.
Article
Pharmacology & Pharmacy
Maitham A. Khajah, Sarah Khushaish, Yunus A. Luqmani
Summary: This study revealed that the expression, activity, and lactate production of LDH-A and B were significantly enhanced in endocrine-resistant breast cancer cells. Targeting LDH might be an effective strategy to inhibit cancer cell motility.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
John M. Macharia, Zsolt Kaposztas, Timea Varjas, Ferenc Budan, Afshin Zand, Imre Bodnar, Raposa L. Bence
Summary: Although the pathophysiology of colorectal cancer (CRC) is complex and not well understood, interactions between risk factors play a crucial role in the development and progression of the disease. The use of lactic acid bacteria (LAB) prebiotics and probiotics to modulate the tumor microenvironment (TME) has become increasingly popular in CRC management. This study aims to investigate the negative effects of LAB-derived lactic acid in the colonic mucosa in colorectal cancer management. More research is needed to ensure that LAB and their lactic acid by-products do not have unintended adverse effects in CRC management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Cristina Sanchez-de-Diego, Leonardo Pedrazza, Carolina Pimenta-Lopes, Arturo Martinez-Martinez, Norma Dahdah, Jose Antonio Valer, Pablo Garcia-Roves, Jose Luis Rosa, Francesc Ventura
Summary: The study unveils that increased NRF2 activity during osteocytogenesis leads to elevated ROS levels, promoting the expression of osteocyte-specific genes. Ablation of Nfe2l2 can result in osteopenia and mitigate bone loss induced by ovariectomy.
Article
Environmental Sciences
Ruilong Song, Shuangjiang He, Ying Cao, Yicheng Lu, Yunwen Peng, Hui Zou, Xishuai Tong, Di Ran, Yonggang Ma, Zongping Liu
Summary: Cadmium can damage bone cells and cause osteoporosis. Autophagy plays an important role in the progression of osteoporosis. This study found that cadmium induces autophagy in osteocytes and inhibits the PI3K/AKT/mTOR signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Cell Biology
Jun Li, Qian Zhang, Yupeng Guan, Dingzhun Liao, Donggen Jiang, Haiyun Xiong, Hengji Zhan, Jun Pang
Summary: The study reveals a novel molecular mechanism by which circVAMP3 promotes glycolysis and proliferation in RCC by regulating the enzymatic activity of LDHA, suggesting circVAMP3 as a biomarker and treatment target for RCC.
CELL DEATH & DISEASE
(2022)
Article
Immunology
Hang Xu, Tianhai Lin, Jianzhong Ai, Jiapeng Zhang, Shiyu Zhang, Yifan Li, Xiaonan Zheng, Peng Zhang, Qiang Wei, Ping Tan, Lu Yang
Summary: This study aimed to determine the prognostic value of the preoperative lactate dehydrogenase-to-albumin ratio (LAR) in patients with urothelial carcinoma of the bladder (UCB) after radical cystectomy (RC). The results showed that preoperative low LAR was associated with decreased overall survival (OS) and recurrence-free survival (RFS), and LAR was an independent prognostic factor. Incorporating LAR into the nomograms improved the predictive performance.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
K. Subramani, S. N. Pandruvada, D. A. Puleo, J. K. Hartsfield, S. S. Huja
PROGRESS IN ORTHODONTICS
(2016)
Article
Engineering, Biomedical
Matt E. Brown, Yuan Zou, Rebecca Peyyala, Sarandeep S. Huja, Larry L. Cunningham, Todd A. Milbrandt, Thomas D. Dziubla, David A. Puleo
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2018)
Article
Dentistry, Oral Surgery & Medicine
Yu-Jen Chang, Antonio C. O. Ruellas, Marilia S. Yatabe, Philip M. Westgate, Lucia H. S. Cevidanes, Sarandeep S. Huja
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2017)
Editorial Material
Dentistry, Oral Surgery & Medicine
J. C. Nickel, D. A. Covell, S. A. Frazier-Bowers, S. Kapila, S. S. Huja, L. R. Iwasaki
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2017)
Article
Dentistry, Oral Surgery & Medicine
A. Y. Ibrahim, S. Gudhimella, S. N. Pandruvada, S. S. Huja
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2017)
Article
Dentistry, Oral Surgery & Medicine
C. R. Exposto, U. Oz, J. S. Callard, M. J. Allen, H. Khurana, A. D' Atri, X. Mo, S. A. Fernandez, D. N. Tatakis, K. Edmonds, P. M. Westgate, S. S. Huja
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2017)
Article
Dentistry, Oral Surgery & Medicine
McKenzie E. Woods, Cynthia S. Beeman, Philip M. Westgate, Lucas Cardinal, Sarandeep S. Huja
CLEFT PALATE-CRANIOFACIAL JOURNAL
(2018)
Article
Dentistry, Oral Surgery & Medicine
McKenzie E. Woods, Cynthia S. Beeman, Philip M. Westgate, Lucas Cardinal, Sarandeep S. Huja
CLEFT PALATE-CRANIOFACIAL JOURNAL
(2018)
Article
Dentistry, Oral Surgery & Medicine
Sudha Gudhimella, Abdelhamed Y. Ibrahim, Divakar Karanth, Alex M. Kluemper, Philip M. Westgate, David A. Puleo, Sarandeep S. Huja
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2019)
Editorial Material
Dentistry, Oral Surgery & Medicine
Laura R. Iwasaki, David A. Covell, Sylvia A. Frazier-Bowers, Sarandeep S. Huja, Sunil Kapila, Jeff C. Nickel
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2019)
Article
Dentistry, Oral Surgery & Medicine
Cristina R. Exposto, Ulas Oz, Philip M. Westgate, Sarandeep S. Huja
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2019)
Article
Dentistry, Oral Surgery & Medicine
Ulas Oz, Antonio Carlos Ruellas, Philip M. Westgate, Lucia H. Cevidanes, Sarandeep S. Huja
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2019)
Article
Dentistry, Oral Surgery & Medicine
Samer A. Faraj, Ahmad Kutkut, Robert C. Taylor, Alejandro Villasante-Tezanos, Sarandeep S. Huja, Dolphus R. Dawson, Nehal Almehmadi, Mohanad Al-Sabbagh
Summary: The study compared the use of human amnion-chorion membrane with collagen membrane in exposed-barrier ridge preservation technique for implant placement. Intentional membrane exposure did not compromise ridge dimensions or bone vitality, and there was no significant difference in bone formation between the two membrane types.
JOURNAL OF ORAL IMPLANTOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Subramanya N. Pandruvada, Jeffrey L. Ebersole, Sarandeep S. Huja
Article
Dentistry, Oral Surgery & Medicine
Jonathan Christian Francis, Ulas Oz, Larry L. Cunningham, Pinar Emecen Huja, Richard J. Kryscio, Sarandeep S. Huja
ANGLE ORTHODONTIST
(2017)
Article
Cell Biology
Abril Alondra Barrientos-Bonilla, Paola Belem Pensado-Guevara, Abraham Puga-Olguin, Rasajna Nadella, Aurora del Carmen Sanchez-Garcia, Laura Mireya Zavala-Flores, Arnulfo Villanueva-Olivo, Iliana Tamara Cibrian-Llanderal, Maria de Jesus Rovirosa-Hernandez, Daniel Hernandez-Baltazar
Summary: This study evaluated the impact of BrdU on liver function and found that multiple injections of BrdU did not induce hepatocellular damage.
Article
Cell Biology
Pan Zhang, Qun Feng, Wenxiao Chen, Xizhuang Bai
Summary: It was found that catalpol antagonizes LPS-mediated inflammation and suppressive osteoblast differentiation by inhibiting inflammation and promoting osteoblast differentiation. This finding contributes to a better understanding of the pathogenesis of osteoporosis.