CYP2J2 attenuates metabolic dysfunction in diabetic mice by reducing hepatic inflammation via the PPARγ

CYP2J2 Targeting to Endothelial Cells Attenuates Adiposity and Vascular Dysfunction in Mice Fed a High-Fat Diet by Reprogramming Adipocyte Phenotype

(2014) Nader G. Abraham et al.   HYPERTENSION

Cytochrome P450–dependent metabolism of ω-6 and ω-3 long-chain polyunsaturated fatty acids

(2014) Cosima Arnold et al.   Pharmacological Reports

AT1-receptor-deficiency induced atheroprotection in diabetic mice is partially mediated via PPARγ

(2013) Vedat Tiyerili et al.   Cardiovascular Diabetology

PPARγ activation blocks development and reduces established neuropathic pain in rats

(2013) J. Morgenweck et al.   NEUROPHARMACOLOGY

Differential Use of TLR2 and TLR9 in the Regulation of Immune Responses during the Infection with Trypanosoma cruzi

(2013) Humberto D. Gravina et al.   PLoS One

The Impact of Bdnf Gene Deficiency to the Memory Impairment and Brain Pathology of APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease

(2013) Tomi Rantamäki et al.   PLoS One

CD11c+ Alveolar Macrophages are a Source of IL-23 During Lipopolysaccharide-Induced Acute Lung Injury

(2013) Markus Bosmann et al.   SHOCK

Functional endothelial progenitor cells selectively recruit neurovascular protective monocyte-derived F4/80+/Ly6c+macrophages in a mouse model of retinal degeneration

(2013) Shinichi Fukuda et al.   STEM CELLS

Differential immune modulation by deoxynivalenol (vomitoxin) in mice

(2013) Mohammad Rafiqul Islam et al.   TOXICOLOGY LETTERS

Spatio-temporal analysis of type 2 diabetes mellitus based on differential expression networks

(2013) Shao-Yan Sun et al.   Scientific Reports

Inhibition of Hypothalamic Inflammation Reverses Diet-Induced Insulin Resistance in the Liver

(2012) M. Milanski et al.   DIABETES

Delivery of AAV2-CYP2J2 Protects Remnant Kidney in the 5/6-Nephrectomized Rat via Inhibition of Apoptosis and Fibrosis

(2012) Gang Zhao et al.   HUMAN GENE THERAPY

Insulin Resistance and Metabolic Derangements in Obese Mice Are Ameliorated by a Novel Peroxisome Proliferator-activated Receptor γ-sparing Thiazolidinedione

(2012) Zhouji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammasomes in liver diseases

(2012) Gyongyi Szabo et al.   JOURNAL OF HEPATOLOGY

Citrus unshiu peel extract ameliorates hyperglycemia and hepatic steatosis by altering inflammation and hepatic glucose- and lipid-regulating enzymes in db/db mice

(2012) Hae-Jin Park et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Deletion of CaMKK2 from the Liver Lowers Blood Glucose and Improves Whole-Body Glucose Tolerance in the Mouse

(2012) Kristin A. Anderson et al.   MOLECULAR ENDOCRINOLOGY

Antibodies to MHC Class II Molecules Induce Autoimmunity: Critical Role for Macrophages in the Immunopathogenesis of Obliterative Airway Disease

(2012) Masashi Takenaka et al.   PLoS One

Direct Angiotensin II Type 2 Receptor Stimulation Ameliorates Insulin Resistance in Type 2 Diabetes Mice with PPARγ Activation

(2012) Kousei Ohshima et al.   PLoS One

PPARs at the crossroads of lipid signaling and inflammation

(2012) Walter Wahli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin-induced type 1 diabetes

(2011) Ahmed A. Elmarakby et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Evaluation of Morroniside, Iridoid Glycoside from Corni Fructus, on Diabetes-Induced Alterations such as Oxidative Stress, Inflammation, and Apoptosis in the Liver of Type 2 Diabetic db/db Mice

(2011) Chan Hum Park et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Selective Inactivation of c-Jun NH2-Terminal Kinase in Adipose Tissue Protects Against Diet-Induced Obesity and Improves Insulin Sensitivity in Both Liver and Skeletal Muscle in Mice

(2011) X. Zhang et al.   DIABETES

Elevated NF-κB Activation Is Conserved in Human Myocytes Cultured From Obese Type 2 Diabetic Patients and Attenuated by AMP-Activated Protein Kinase

(2011) Charlotte J. Green et al.   DIABETES

Endogenous Epoxygenases Are Modulators of Monocyte/Macrophage Activity

(2011) Jonas Bystrom et al.   PLoS One

Nuclear Receptors and Inflammation Control: Molecular Mechanisms and Pathophysiological Relevance

(2010) Wendy Huang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling

(2010) Stacey B. Dula et al.   CELL CALCIUM

Modulation of PPAR-γ by telmisartan protects the heart against myocardial infarction in experimental diabetes

(2010) Sameer Goyal et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Increased CYP2J3 Expression Reduces Insulin Resistance in Fructose-Treated Rats and db/db Mice

(2010) X. Xu et al.   DIABETES

Cytochrome P450 2J2 Is Highly Expressed in Hematologic Malignant Diseases and Promotes Tumor Cell Growth

(2010) C. Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Insulin Resistance, Inflammation, and Obesity: Role of Monocyte Chemoattractant Protein-1 (orCCL2) in the Regulation of Metabolism

(2010) Anna Rull et al.   MEDIATORS OF INFLAMMATION

A Nonthiazolidinedione Peroxisome Proliferator-Activated Receptor  /  Dual Agonist CG301360 Alleviates Insulin Resistance and Lipid Dysregulation in db/db Mice

(2010) H. W. Jeong et al.   MOLECULAR PHARMACOLOGY

Eicosapentaenoic acid increases cytochrome P-450 2J2 gene expression and epoxyeicosatrienoic acid production via peroxisome proliferator-activated receptor γ in endothelial cells

(2009) Dahai Wang et al.   Journal of Cardiology

Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases

(2009) John D. Imig et al.   NATURE REVIEWS DRUG DISCOVERY

Expression and Regulation of Soluble Epoxide Hydrolase in Adipose Tissue

(2009) Bart M. De Taeye et al.   Obesity

Eicosapentaenoic acid inhibits interleukin-6 production in interleukin-1β-stimulated C6 glioma cells through peroxisome proliferator-activated receptor-gamma

(2008) Akiko Kawashima et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance

(2008) G. Sabio et al.   SCIENCE