Article
Genetics & Heredity
Iwona Goracy, Anna Goracy, Mariusz Kaczmarczyk, Jakub Rosik, Klaudyna Lewandowska, Andrzej Ciechanowicz
Summary: This study aimed to investigate the association of RAS key genetic variants with HF risk in the Polish population. The results suggested that the A(-6)G AGT polymorphism may be associated with HF risk, and the A1166C AGTR1 polymorphism may modulate HF risk.
Review
Pharmacology & Pharmacy
Annamaria Mascolo, Gabriella Di Mauro, Donato Cappetta, Antonella De Angelis, Daniele Torella, Konrad Urbanek, Liberato Berrino, Giovanni Francesco Nicoletti, Annalisa Capuano, Francesco Rossi
Summary: The incidence of heart failure is stabilizing or declining, except for heart failure with preserved ejection fraction (HFpEF), which may be increasing due to the lack of effective treatment. Patients with mildly reduced ejection fraction (HFmrEF) also lack specific pharmacological treatment. The cornerstone therapy for heart failure with reduced ejection fraction (HFrEF) includes ACE inhibitors/ARNI, beta-blockers, and mineralocorticoid receptor antagonists, but there is still a significant treatment gap for HFpEF/HFmrEF. Alternative treatments, such as stimulating the non-classic RAAS (ACE2 and A1-7) and newer drug classes like SGLT2 inhibitors, may hold promise.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Noemi Pavo, Suriya Prausmueller, Georg Spinka, Georg Goliasch, Philipp E. Bartko, Raphael Wurm, Henrike Arfsten, Guido Strunk, Marko Poglitsch, Oliver Domenig, Julia Mascherbauer, Keziban Uyanik-Unal, Christian Hengstenberg, Andreas Zuckermann, Martin Huelsmann
Summary: In patients with heart failure, AngII and AngIII are the predominant peptides in the heart, especially in those receiving ARB treatment. Myocardial RAS enzyme regulation is independent of the type of RAS inhibitor used, and tissue chymase is the main enzyme for cardiac AngII generation.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Health Care Sciences & Services
Christina Binder, Marko Poglitsch, Franz Duca, Rene Rettl, Theresa Marie Dachs, Daniel Dalos, Lore Schrutka, Benjamin Seirer, Luciana Camuz Ligios, Christophe Capelle, Roza Badr Eslam, Hong Qin, Christian Hengstenberg, Diana Bonderman
Summary: The study found that high plasma renin activity (PRA-S) is associated with poor prognosis in patients with heart failure with preserved ejection fraction (HFpEF), regardless of treatment with drugs that interact with the renin angiotensin aldosterone system (RAAS). Even with RAASi therapy, PRA-S levels remained predictive of all-cause death, possibly due to the hyperactivated RAAS leading to negative effects on the cardiovascular and renal system in HFpEF patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Peripheral Vascular Disease
Vanessa Oliveira, Anne E. Kwitek, Curt D. Sigmund, Lisa L. Morselli, Justin L. Grobe
Summary: Obesity is the major obstacle to improving cardiovascular health, involving changes in energy balance control that may lead to hypertension. Drug development targeting metabolism often leads to hypertension, but new research suggests different subtypes of AGRP neurons may have varying effects on feeding, metabolism, or blood pressure control.
Review
Pharmacology & Pharmacy
Persoulla A. Nicolaou
Summary: Sex-related differences in clinical manifestations, risk factors, and treatment drug use in patients with heart failure are significant, particularly in the regulation of the renin-angiotensin-aldosterone system (RAAS). While current evidence suggests potential differences in the efficacy of RAAS drugs between men and women, further research is needed to determine the optimal treatment strategies for both genders.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Joo-Hee Kim, Jeong Yee, Byung-Chul Chang, Hye-Sun Gwak
Summary: This study revealed that carriers of the H2 haplotype of the ACE gene, the G allele of AGT rs5050, and the A allele of AGTR1 rs2640543 are at increased risk of bleeding complications during warfarin treatment. Machine learning methods can be utilized for bleeding prediction, with patients in the highest quartile group of weighted risk score showing a significantly elevated risk of bleeding.
Review
Biochemistry & Molecular Biology
Texali C. Garcia-Garduno, Jorge R. Padilla-Gutierrez, Diego Cambron-Mora, Yeminia Valle
Summary: The global prevalence of heart failure is increasing, especially in medium-low sociodemographic areas, where risk factors are rising. Heart failure is associated with various comorbidities, including cancer, presenting challenges in treatment and quality of life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Agnes Bosch, Marko Poglitsch, Dennis Kannenkeril, Julie Kolwelter, Kristina Striepe, Christian Ott, Manfred Rauh, Mario Schiffer, Stephan Achenbach, Roland E. Schmieder
Summary: Empagliflozin activates the Ang I-ACE-Ang II receptor pathway and the Mas receptor pathway in patients with chronic heart failure. The activation is only observed in patients with co-medication of angiotensin receptor blockers (ARB), and not in patients with co-medication of angiotensin-converting enzyme inhibitors (ACEI).
Letter
Medicine, General & Internal
Robert C. Speth
Summary: The article does not differentiate between ACE inhibitor therapy and ARB therapy in advanced CKD. The mechanisms of action of ACE inhibitors and ARBs differ substantially, with varying effects on renal function.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Abdallah S. Attia, Mohammad Hussein, Mohamed A. Aboueisha, Mahmoud Omar, Mohanad R. Youssef, Nicholas Mankowski, Michael Miller, Ruhul Munshi, Aubrey Swinford, Adam Kline, Therese Nguyen, Eman Toraih, Juan Duchesne, Emad Kandil, Tai-Heng Chen, Tai-Heng Chen, Tai-Heng Chen, Tai-Heng Chen, Tai-Heng Chen
Summary: The study shows that neurological manifestations in COVID-19 patients upon admission are associated with increased odds of adverse outcomes, including higher rates of ICU admission, mechanical ventilation, kidney injury, and mortality.
Article
Multidisciplinary Sciences
Yoichiro Otaki, Tetsu Watanabe, Tsuneo Konta, Masafumi Watanabe, Koichi Asahi, Kunihiro Yamagata, Shouichi Fujimoto, Kazuhiko Tsuruya, Ichiei Narita, Masato Kasahara, Yugo Shibagaki, Kunitoshi Iseki, Toshiki Moriyama, Masahide Kondo, Tsuyoshi Watanabe
Summary: This study found that a 1-year change in plasma volume could serve as an additional risk factor for all-cause, cardiovascular, and non-cardiovascular (mainly cancer) mortality in the general population. Adding this change to cardiovascular risk factors significantly improved risk assessment accuracy.
Review
Pharmacology & Pharmacy
Annamaria Mascolo, Cristina Scavone, Concetta Rafaniello, Antonella De Angelis, Konrad Urbanek, Gabriella di Mauro, Donato Cappetta, Liberato Berrino, Francesco Rossi, Annalisa Capuano
Summary: The renin-angiotensin-aldosterone system (RAAS) is now recognized as a local tissue system that affects organ function and can contribute to the onset of diseases. It operates in both the heart and lungs, with classic and non-classic pathways having different effects on cardiovascular and pulmonary health.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
D. Marshall Brinkley, Li Wang, Chang Yu, E. Wilson Grandin, Michael S. Kiernan
Summary: In LVAD patients, treatment with ACEI/ARB but not MRA was independently associated with lower mortality. ACEI/ARB therapy was also associated with decreased risk of cardiovascular death, gastrointestinal bleeding, and creatinine level, while MRA therapy was associated with lower risk of gastrointestinal bleeding but higher risk of hemolysis.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Shota Shirotani, Kentaro Jujo, Takuma Takada, Takuro Abe, Makoto Kishihara, Shonosuke Watanabe, Nana Endo, Hiroko Fujita, Satoshi Murasaki, Junichi Yamaguchi
Summary: Serum chloride levels are associated with the prognosis of patients with heart failure and preserved ejection fraction (HFpEF). This study found that the prognostic benefit of renin-angiotensin system inhibitors (RASi) in HFpEF patients depends on baseline serum chloride levels. RASi administration improves prognosis only in HFpEF patients with low baseline serum chloride levels.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Nanoscience & Nanotechnology
Maximilian George Dindelegan, Cristina Blebea, Maria Perde-Schrepler, Anca Dana Buzoianu, Alma Aurelia Maniu
Summary: Sensorineural hearing loss is a global health issue caused by inner ear cell destruction, resulting in permanent hearing loss. Nanoparticles offer a potential treatment approach by enabling direct and targeted drug delivery through the round and oval window membranes.
JOURNAL OF NANOMATERIALS
(2022)
Article
Nutrition & Dietetics
Ioana Adriana Muntean, Ioana Corina Bocsan, Lena Katharina Wiest, Irena Pintea, Carmen Teodora Dobrican, Emanuela Duca, Corina Ureche, Anca Dana Buzoianu, Diana Deleanu
Summary: This study analyzed clinical and biological factors that might predict tolerance in patients with IgE-mediated cow milk allergy. The results suggest that basal levels of sIgE to milk and casein may help identify patients who could become tolerant to milk.
Review
Biochemistry & Molecular Biology
Ioana Corina Bocsan, Dan Claudiu Magureanu, Raluca Maria Pop, Antonia Mihaela Levai, Stefan Octavian Macovei, Ioana Maria Patrasca, Veronica Sanda Chedea, Anca Dana Buzoianu
Summary: Grape pomace, a byproduct of the wine industry, is a reliable source of polyphenols with antioxidant and anti-inflammatory activities. Differences in antioxidant and anti-inflammatory activities exist between red and white grape pomace, with more focus on red grape pomace and the need for further research on white grape pomace.
Article
Biochemistry & Molecular Biology
Maria-Adriana Neag, Carmen-Stanca Melincovici, Adrian Catinean, Dana-Maria Muntean, Raluca-Maria Pop, Ioana-Corina Bocsan, Andrei-Otto Mitre, Mihai-Bogdan Cardos, Andreea-Ioana Inceu, Anca-Dana Buzoianu
Summary: The study suggests that modulation of gut microbiota through administration of probiotics, immunoglobulins, and amino acids could be an effective therapy for preventing NSAID-induced enteropathy.
Article
Biochemistry & Molecular Biology
Damiana-Maria Vulturar, Maria Adriana Neag, Stefan Cristian Vesa, Anca-Diana Maierean, Diana Gherman, Anca Dana Buzoianu, Olga Hilda Orasan, Doina-Adina Todea
Summary: This retrospective cohort study investigated the clinical outcomes of severe COVID-19 pneumonia patients treated with remdesivir alone or a combination of remdesivir and tocilizumab. The combination therapy showed improved inflammatory markers and decreased oxygen requirement, although it had a higher rate of superinfection compared to remdesivir alone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Maria-Adriana Neag, Anca-Elena Craciun, Andreea-Ioana Inceu, Diana-Elena Burlacu, Cristian-Ioan Craciun, Anca-Dana Buzoianu
Summary: Diabetes mellitus is a multifactorial disease with gastrointestinal symptoms caused by the enteric nervous system, which functions independently of the central nervous system. Short-chain fatty acids (SCFAs), bacterial metabolites of gut microbiota, modulate the enteric nervous system and have beneficial effects on diabetes. However, the specific nutraceuticals to increase SCFAs and achieve these effects are uncertain. Further studies are needed to understand the modulation of gut dysbiosis with SCFAs in diabetes, as well as the interplay between gut microbiota and the enteric nervous system.
Article
Pediatrics
Claudia Felicia Pop, Petronela Coblisan, Ligia Capalna, Paraschiva Chereches Panta, Anca Dana Buzoianu, Ioana Corina Bocsan
Summary: This study analyzed the immediate adverse reactions induced by vaccines included in the national program of immunization for the first year of life. The results showed that the rate of adverse events was lower than 30% of the total number of doses, and most of them were mild. The incidence and severity of vaccine-induced adverse effects were correlated with prematurity. The vaccine hesitancy rate was lower than the national one, possibly due to a high level of education and good information provided by doctors that might have led to parents' concerns regarding vaccination being answered.
Review
Oncology
Diana Gulei, Rares Drula, Gabriel Ghiaur, Anca Dana Buzoianu, Yelena Kravtsova-Ivantsiv, Ciprian Tomuleasa, Aaron Ciechanover
Summary: The ubiquitin-proteasome system (UPS) is crucial for protein degradation, and its dysregulation is closely related to malignant pathologies. KPC1, an E3 ubiquitin ligase component, plays a key role in cancer by regulating p27 signaling and the NF-xB pathway. KPC1 maintains the ubiquitination of cytoplasmic p27, influencing cell-cycle progression, and also induces the ubiquitination of p105 to control NF-xB signaling. Therapeutic reinforcement of the KPC1-p50 axis shows promising tumor suppressor activity in multiple malignancies.
Review
Biochemistry & Molecular Biology
Andreea-Ioana Inceu, Maria-Adriana Neag, Anca-Elena Craciun, Anca-Dana Buzoianu
Summary: Atherosclerotic cardiovascular disease is a leading cause of illness and death worldwide. Diabetes mellitus increases the risk of cardiovascular issues. Heart failure and atrial fibrillation are related comorbidities that have similar cardiovascular risk factors. The use of incretin-based therapies has shown potential in reducing atherosclerosis and heart failure risk through alternative signaling pathways. Gut-derived molecules, gut hormones, and gut microbiota metabolites have both positive and negative effects on cardiometabolic disorders. Inflammation plays a crucial role, but other intracellular signaling pathways may also contribute to the observed effects. Understanding the molecular mechanisms involved could lead to new therapeutic strategies and improved knowledge of the gut-metabolic syndrome-cardiovascular disease relationship.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Stefan Strilciuc, Constantin Radu, Diana-Alecsandra Grad, Adina Dora Stan, Cristian Vladescu, Anca Dana Buzoianu, Dafin Muresanu
Summary: This study aims to examine the cost-effectiveness of Cerebrolysin as an add-on therapy for moderate-severe acute ischemic stroke. The findings suggest that Cerebrolysin is cost-effective within a certain threshold.
Review
Nutrition & Dietetics
Alexandru Constantin Sirbu, Octavia Sabin, Ioana Corina Bocsan, Stefan Cristian Vesa, Anca Dana Buzoianu
Summary: The COVID-19 pandemic has become a global health crisis, and researchers have been exploring treatments to improve patient outcomes. Vitamin D, known for its role in the immune system, has been suggested as a potential treatment for COVID-19. A systematic review and meta-analysis of 13 randomized controlled trials were conducted, indicating that high-dose vitamin D supplementation may reduce hospital stay and ICU admission rates for COVID-19 patients. However, the overall effect on mortality was not statistically significant. Further large-scale trials are needed to provide more robust evidence.
Article
Medicine, General & Internal
Carina Mihu, Codrua Alina Popescu, Maria Adriana Neag, Ioana Corina Bocsan, Carmen Stanca Melincovici, Adrian Lucian Baican, Bogdana Adriana Nasui, Anca-Dana Buzoianu
Summary: This study examined the effects of pruritus intensity on quality of life and depression in psoriasis patients, as well as the relationships between anger, self-esteem, and depression. The study also compared the differences between early and late onset psoriasis patients. The results showed that psoriasis patients had lower self-esteem and higher levels of anger and depression. Patients with early onset had higher depression scores and lower quality of life. Self-esteem was negatively correlated with depression, anger, disability severity, and disease duration.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Andrada Larisa Deac, Raluca Maria Pop, Cristina Florina Crisan, Claudia Cristina Burz, Anca Dana Buzoianu
Summary: This article describes a case of recurrent fluoropyrimidine toxicity in a patient without a mutation and discusses how this case was managed by the oncologist and cardiologist while considering the need for fluoropyrimidine treatment.
ARCHIVE OF CLINICAL CASES
(2023)
Article
Polymer Science
Maximilian George Dindelegan, Violeta Pascalau, Maria Suciu, Bogdan Neamtu, Maria Perde-Schrepler, Cristina Maria Blebea, Alma Aurelia Maniu, Violeta Necula, Anca Dana Buzoianu, Miuta Filip, Alexandra Csapai, Catalin Popa
Summary: This study investigates a biopolymer-lipid hybrid microcarrier for the treatment of sensorineural hearing loss. Dexamethasone-loaded microparticles were prepared using a combination of biopolymers and lipid components, exhibiting physical and chemical stability. The results demonstrate sustained release of dexamethasone and protective effects on inner ear sensory cells.
Article
Biochemistry & Molecular Biology
Paul-Mihai Boarescu, Ioana Boarescu, Raluca Maria Pop, Stefan Horia Rosian, Ioana Corina Bocsan, Vasile Rus, Razvan Olimpiu Mada, Iulia Diana Popa, Nicholas Neagu, Adriana Elena Bulboaca, Anca Dana Buzoianu, Sorana D. Bolboaca
Summary: This study aimed to compare the oxidative stress biomarkers, pro-inflammatory cytokines, and histological changes induced by three cardiovascular risk factors. The results showed that hypertension, dyslipidemia, and type 1 diabetes mellitus all increased oxidative stress and inflammation, with type 1 diabetes mellitus having the most significant irreversible changes on the arterial wall.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
