Article
Biochemistry & Molecular Biology
Eva Tvrda, Jan Kovac, Kristina Ferenczyova, Barbora Kalocayova, Michal Duracka, Filip Benko, Viera Almasiova, Monika Bartekova
Summary: The aim of this study is to investigate the effects of quercetin on testicular architecture and markers of oxidative, inflammatory, and apoptotic profile in Zucker diabetic fatty rats with Type 2 diabetes mellitus. The results showed that quercetin improved testicular appearance, stabilized antioxidant capacity, decreased lipid peroxidation, and reduced inflammation levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Tian Zhao, Libin Zhan, Wen Zhou, Wanxin Chen, Jintong Luo, Lijing Zhang, Zebin Weng, Chunyan Zhao, Shenlin Liu
Summary: The study found that Erchen Decoction (ECD) can reduce body weight, improve insulin resistance (IR) and lipid metabolism by interfering with specific signaling pathways in Zucker diabetic fatty (ZDF) rats. Additionally, ECD was shown to adjust the structure of gut microbiota and change its function in ZDF rats, demonstrating a potentially close relationship between specific biomarkers, metabolites, and host phenotypes. The results suggest that ECD's beneficial effects on obesity, particularly lipid metabolism disorders, are linked to regulation of gut microbiota in ZDF rats, providing a foundation for further research on its mechanisms and clinical applications.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Guanrong Wu, Baoyi Liu, Qiaowei Wu, Changting Tang, Zijing Du, Ying Fang, Yijun Hu, Honghua Yu
Summary: The study found that the expression of various angiogenesis and inflammation mediators in the vitreous fluid of eyes with proliferative diabetic retinopathy (PDR) was significantly increased, and there were correlations between these mediators. The levels of these mediators were also correlated with kidney damage, indicating potential common pathways in diabetic retinopathy and nephropathy.
FRONTIERS IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Krzysztof Gomulka, Michal Ruta
Summary: Diabetic retinopathy (DR), the most common complication in diabetes mellitus (DM) patients, is the leading cause of blindness among adults. The development of DR is related to chronic hyperglycemia, hypoinsulinemia, dyslipidemia, and hypertension, which induce oxidative stress, formation of advanced glycation end-products, microvascular changes, inflammation, and retinal neurodegeneration as key factors in diabetes-associated retinal perturbations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Alana Aragon-Herrera, Manuel Otero-Santiago, Laura Anido-Varela, Sandra Morana-Fernandez, Manuel Campos-Toimil, Tomas Garcia-Caballero, Luis Barral, Estefania Tarazon, Esther Rosello-Lleti, Manuel Portoles, Oreste Gualillo, Isabel Moscoso, Ricardo Lage, Jose Ramon Gonzalez-Juanatey, Sandra Feijoo-Bandin, Francisca Lago
Summary: This study found that empagliflozin can alter the hepatic lipid metabolism profile, showing a protective profile. Additionally, empagliflozin also decreases the levels of inflammatory markers in the liver. These results provide new evidence regarding the molecular pathways through which empagliflozin could exert hepatoprotective effects in patients with type 2 diabetes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Sachin Suryavanshi, Kalyani Barve, Sachin Utpat, Yogesh A. Kulkarni
Summary: Triphala churna has antioxidant and anti-diabetic properties, and can significantly improve blood glucose levels, reduce damaging enzymes and oxidative stress, and protect the structure and function of the retina in diabetic retinopathy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Tiannan Wang, Xia Tang, Xinge Hu, Jing Wang, Guoxun Chen
Summary: The study found that reducing dietary vitamin A status can prevent the development of type 2 diabetes and obesity in ZDF rats, especially in high-fat diets.
Article
Integrative & Complementary Medicine
Yajing Li, Jiaojiao Chen, Haiye Tu, Quanxin Ma, Mulan Wang, Jie Chen, Minli Chen
Summary: In this study, it was found that GuanXinNing Tablet (GXNT) has a highly satisfactory protective effect on diabetic encephalopathy (DE) in ZDF rats. Its mechanism of action may be based on the regulation of glucolipid metabolism and its protective effect on the vascular endothelium.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Biochemistry & Molecular Biology
Barbora Bot'anska, Monika Bartekova, Kristina Ferenczyova, Maria Fogarassyova, Lucia Kindernay, Miroslav Barancik
Summary: This study revealed that obesity worsened heart function with changes in MMP-2, MMP-28, and SODs, which were not modulated by QCT treatment. However, QCT activated Akt kinase and prevented diabetes-induced negative effects on SODs, suggesting its potential in mediating adaptive responses against oxidative stress in diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rocio Bautista-Perez, Agustina Cano-Martinez, Elisa Gutierrez-Velazquez, Martin Martinez-Rosas, Rosa M. Perez-Gutierrez, Francisco Jimenez-Gomez, Javier Flores-Estrada
Summary: The study demonstrated that SME could attenuate retinal degeneration in diabetic rats by reducing oxidative stress, inflammation, and apoptosis through inhibition of the CML-RAGE interaction.
Article
Endocrinology & Metabolism
Hongyan Yao, Zijing Li
Summary: This study analyzed retinal vessel density and thickness characteristics in patients with diabetic nephropathy (DN) and preclinical diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA). The findings suggest that DN individuals have more severe microvascular and microstructural impairment compared to individuals without DN. Additionally, estimated glomerular filtration rate (eGFR) may serve as an indicator for retinal microvascular impairment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nguyen Ngoc Trang, Ting-Wei Lee, Yu-Hsun Kao, Tze-Fan Chao, Ting- Lee, Yi-Jen Chen
Summary: The ketogenic diet may improve the condition of diabetic cardiomyopathy by suppressing fatty acid metabolism, increasing ketone utilization, and reducing endoplasmic reticulum stress and inflammation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Neurosciences
Shuxing Wang, Shaoyuan Li, Xu Zhai, Peijing Rong, Jietao He, Lina Liu, Xinxin He, Wenguo Liu
Summary: Type 2 diabetes (T2D) and COVID-19 are both associated with decreased levels of melatonin, and chronic pain is a common symptom in patients with both conditions. This study found that transcutaneous auricular vagal nerve stimulation (taVNS) can increase melatonin concentration, upregulate melatonin receptors (MTRs), and relieve peripheral neuropathic pain. The therapeutic effect of taVNS is mediated by the release of extrapineal melatonin and the positive regulation of central MTR expression. Therefore, taVNS may be beneficial for managing chronic pain in individuals with diabetes during COVID-19 rehabilitation.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Annalisa Canta, Valentina A. A. Carozzi, Alessia Chiorazzi, Cristina Meregalli, Norberto Oggioni, Virginia Rodriguez-Menendez, Barbara Sala, Roberto Cosimo Melcangi, Silvia Giatti, Raffaella Lombardi, Roberto Bianchi, Paola Marmiroli, Guido Cavaletti
Summary: The development and progression of diabetic polyneuropathy (DPN) involve multiple mechanisms. Reliable animal models of DPN are still challenging. Most of the current knowledge on DPN pathogenesis is based on results from rodent models, despite their differences from humans.
Review
Multidisciplinary Sciences
Qinkang Lu, Juntao Zhang, Sheng C. Chen, Hongbo Lin, Xiao M. Lai, Weikun Gong, Yufei Wu, Xinxin Hu
Summary: Preclinical studies on circRNA, particularly focusing on diabetic retinophathy (DR), have shown promising results in regulating various cellular functions to impact disease progression. The functional exploration of circRNAs in DR offers new insights and potential therapeutic targets for the prevention and control of DR.
Article
Pharmacology & Pharmacy
Tamara R. Castaneda, Maria Mendez, Ian Davison, Ralf Elvert, Uwe Schwahn, Galina Boldina, Corinne Rocher, Petra Scherer, Kuldeep Singh, Dinesh S. Bangari, Mechthilde Falkenhahn, Aimo Kannt, Anish Konkar, Philip J. Larsen, Cynthia Arbeeny, Pradeep K. Dhal, Thomas Huebschle
Summary: The novel nonabsorbed polymeric sequestrant SAR442357, possessing optimized phosphate and bile salt sequestration characteristics, demonstrated pharmacological benefits including improved glycemic control, lowered serum cholesterol, and attenuation of diabetic kidney disease progression.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Aimo Kannt, Paulus Wohlfart, Andreas Nygaard Madsen, Sanne Skovgard Veidal, Michael Feigh, Dieter Schmoll
Summary: The study demonstrated that treatment with resmetirom in DIO-NASH mice significantly improved hepatic metabolism and fibrosis levels, reflecting the benefits of THR-beta activation.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Food Science & Technology
Charalampia Amerikanou, Stavroula Kanoni, Andriana C. Kaliora, Angela Barone, Mladen Bjelan, Giuseppe D'Auria, Aristea Gioxari, Maria Jose Gosalbes, Sofia Mouchti, Maria G. Stathopoulou, Beatriz Soriano, Stefan Stojanoski, Rajarshi Banerjee, Maria Halabalaki, Eleni V. Mikropoulou, Aimo Kannt, John Lamont, Carlos Llorens, Fernando Marascio, Miriam Marascio, Francisco J. Roig, Ilias Smyrnioudis, Iraklis Varlamis, Sophie Visvikis-Siest, Milan Vukic, Natasa Milic, Milica Medic-Stojanoska, Lucia Cesarini, Jonica Campolo, Amalia Gastaldelli, Panos Deloukas, Maria Giovanna Trivella, M. Pilar Francino, George V. Dedoussis
Summary: Mastiha supplementation improves microbiota dysbiosis and lipid metabolite levels in patients with NAFLD, particularly reducing liver inflammation/fibrosis parameters in severely obese patients.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Aimo Kannt, Sridharan Rajagopal, Mahanandeesha S. Hallur, Indu Swamy, Rajendra Kristam, Saravanakumar Dhakshinamoorthy, Joerg Czech, Gernot Zech, Herman Schreuder, Sven Ruf
Summary: Nicotinamide-N-methyltransferase (NNMT) is a cytosolic enzyme that catalyzes the transfer of a methyl group from S-adenosyl-methionine (SAM) to nicotinamide (Nam). Its expression in various tissues has been linked to metabolic diseases, and potent small molecule inhibitors with different binding modes have been identified through X-ray crystallographic studies.
Article
Physiology
Sarah Riemann, Matthias Kolibabka, Stephanie Busch, Jihong Lin, Sigrid Hoffmann, Norbert Gretz, Yuxi Feng, Paulus Wohlfart, Hans-Peter Hammes
Summary: Vascular dysfunction and vasoregression are characteristics of various inflammatory central nervous system disorders and inflammation-related retinal diseases. Activation of microglia and the humoral innate immune system play contributing roles. In this study, clodronate treatment led to an increase in activated CD74(+) microglia and prevented acellular capillaries and pericyte loss, indicating a shift towards induction of pleiotropic protective pathways supporting vasoprotection in neurovascular retinal diseases.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Lucas M. Wiggenhauser, Lena Metzger, Katrin Bennewitz, Silas Soleymani, Mike Boger, Christoph T. Tabler, Ingrid Hausser, Carsten Sticht, Paulus Wohlfart, Nadine Volk, Elena Heidenreich, Michael Buettner, Hans-Peter Hammes, Jens Kroll
Summary: This study identified the pdx1 mutant as a novel model for the study of DKD, showing signs of the early disease progression already in the larval stage and several selective features of later DKD in adult mutants.
Article
Biochemistry & Molecular Biology
Natasja de Bruin, Ann-Kathrin Schneider, Philipp Reus, Sonja Talmon, Sandra Ciesek, Denisa Bojkova, Jindrich Cinatl, Imran Lodhi, Bruce Charlesworth, Simon Sinclair, Graham Pennick, William F. Laughey, Philip Gribbon, Aimo Kannt, Susanne Schiffmann
Summary: The study found that ibuprofen, flurbiprofen, etoricoxib, and paracetamol have no effect on ACE2 expression and activity in vitro or in vivo. However, high concentrations of ibuprofen and flurbiprofen can reduce the replication of SARS-CoV-2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biophysics
Esben Sovso Szocska Hansen, Lotte Bonde Bertelsen, Nikolaj Bogh, Jack Miller, Paulus Wohlfart, Steffen Ringgaard, Christoffer Laustsen
Summary: Personalized medicine or individualized therapy has great significance in complex diseases like diabetes. This study demonstrates the potential of using hyperpolarized [1-C-13]-pyruvate magnetic resonance imaging to differentiate treatment effects, enabling personalized therapy.
NMR IN BIOMEDICINE
(2022)
Article
Cell & Tissue Engineering
Susanne Krasemann, Undine Haferkamp, Susanne Pfefferle, Marcel S. Woo, Fabian Heinrich, Michaela Schweizer, Antje Appelt-Menzel, Alevtina Cubukova, Janica Barenberg, Jennifer Leu, Kristin Hartmann, Edda Thies, Jessica Lisa Littau, Diego Sepulveda-Falla, Liang Zhang, Kathy Ton, Yan Liang, Jakob Matschke, Franz Ricklefs, Thomas Sauvigny, Jan Sperhake, Antonia Fitzek, Anna Gerhartl, Andreas Brachner, Nina Geiger, Eva-Maria Koenig, Jochen Bodem, Soren Franzenburg, Andre Franke, Stefan Moese, Franz-Josef Mueller, Gerd Geisslinger, Carsten Claussen, Aimo Kannt, Andrea Zaliani, Philip Gribbon, Benjamin Ondruschka, Winfried Neuhaus, Manuel A. Friese, Markus Glatzel, Ole Pless
Summary: Neurological complications are common in COVID-19. This study reveals that SARS-CoV-2 can enter the brain through the blood-brain barrier and cause increased interferon signaling. In vitro experiments show that SARS-CoV-2 can infect BCECs and replicate, with the virus being transported across the barrier. This process can be inhibited by specific antibodies or inhibitors.
Article
Chemistry, Organic
Denis Dardic, Nils Bohringer, Alberto Plaza, Florian Zubeil, Juliane Pohl, Svenja Sommer, Leo Padva, Jonathan Becker, Maria A. Patras, Mona-Katharina Bill, Michael Kurz, Luigi Toti, Sven W. Gorgens, Soren M. M. Schuler, Andre Billion, Oliver Schwengers, Paulus Wohlfart, Alexander Goesmann, Norbert Tennagels, Andreas Vilcinskas, Peter E. Hammann, Till F. Schaberle, Armin Bauer
Summary: Seven new polyketides, called veramycins, were isolated from a Streptomyces sp. and shown to increase glucose uptake and insulin sensitivity in rat skeletal muscle cells. The syntheses of these compounds were successfully achieved, enabling further exploration of their potential as anti-diabetic lead structures. The biosynthetic pathway for veramycin A was also proposed based on feeding experiments and gene inactivation.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Pharmacology & Pharmacy
Jiedong Qiu, Benito A. Yard, Bernhard K. Kraemer, Harry van Goor, Peter van Dijk, Aimo Kannt
Summary: CN1 concentration and activity are associated with the prediction and diagnosis of diabetic kidney disease, but further research is needed for validation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Physiology
Zeynep E. Yesilyurt, Jan Matthes, Edith Hintermann, Tamara R. Castaneda, Ralf Elvert, Jesus H. Beltran-Ornelas, Diana L. Silva-Velasco, Ning Xia, Aimo Kannt, Urs Christen, David Centurion, Huige Li, Andrea Pautz, Ebru Arioglu-Inan, Martin C. Michel
Summary: This study explores the relationship between bladder enlargement and diabetes in rodent models, finding significant variations in bladder enlargement across different models, particularly in type 2 diabetes models. The study concludes that bladder enlargement is not primarily driven by glucose levels.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Sven Ruf, Sridharan Rajagopal, Sanjay Venkatachalapathi Kadnur, Mahanandeesha S. Hallur, Shilpa Rani, Rajendra Kristam, Srinivasan Swaminathan, Bharat Ravindra Zope, Pavan Kumar Gondrala, Indu Swamy, V. P. Rama Kishore Putta, Saravanan Kandan, Gernot Zech, Herman Schreuder, Christine Rudolph, Ralf Elvert, Joerg Czech, Swarnakumari Birudukota, M. Amir Siddiqui, Niranjan Naranapura Anand, Vishal Subhash Mane, Sreekanth Dittakavi, Juluri Suresh, Ramachandraiah Gosu, Mullangi Ramesh, Takeshi Yura, Saravanakumar Dhakshinamoorthy, Aimo Kannt
Summary: NNMT is a metabolic regulator associated with various diseases. A potential NNMT small molecule inhibitor, JBSNF-000028, was identified and shown to reduce MNA levels and improve insulin sensitization and weight reduction in mouse models. The findings suggest that JBSNF-000028 could be a potential therapeutic option for metabolic disorders.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Athina Amanatidou, Andriana C. Kaliora, Charalampia Amerikanou, Stefan Stojanoski, Natasa Milosevic, Chara Vezou, Mirjana Beribaka, Rajarshi Banerjee, Ioanna-Panagiota Kalafati, Ilias Smyrnioudis, Mary Jo Kurth, Aimo Kannt, M. Pilar Francino, Sophie Visvikis-Siest, Panos Deloukas, Carlos Llorens, Fernando Marascio, Natasa Milic, Milica Medic-Stojanoska, Amalia Gastaldelli, Maria Giovanna Trivella, George Dedoussis
Summary: This study investigated the association between dietary patterns and MRI parameters in European NAFLD patients. The results showed a positive correlation between the Western dietary pattern and the severity of liver disease, while the Low-Fat Dairy and Poultry dietary pattern was associated with lower liver disease values. These findings emphasize the importance of diet in NAFLD.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)