Article
Endocrinology & Metabolism
J. J. Drinkwater, F. K. Chen, A. M. Brooks, B. T. Davis, A. W. Turner, T. M. E. Davis, W. A. Davis
Summary: This study found an independent association between macrovascular disease and arterial stiffness with diabetic retinopathy in patients with type 2 diabetes. The occurrence of diabetic retinopathy is closely related to patients' age at diagnosis, blood glucose control level, treatment method, and cardiovascular health.
Article
Medicine, General & Internal
Mervat Naguib, Aya Tarabay, Nashwa ElSaraf, Lila Rashed, Amr ElMeligy
Summary: Research found a negative correlation between Beclin1 levels and atherosclerosis in patients with T2DM. Beclin1 levels were correlated with various variables, with a level greater than 2.2 ng/dL accurately predicting CIMT >0.05 cm.
Article
Biochemistry & Molecular Biology
Jolanta Neubauer-Geryk, Melanie Wielicka, Grzegorz M. Kozera, Leszek Bieniaszewski
Summary: The levels of angiogenin and carotid intima-media thickness (cIMT) were analyzed in patients with type 1 diabetes (DM1) with and without metabolic syndrome (MS). The study found that angiogenin levels were lower in DM1 patients compared to controls, but not significantly affected by MS. cIMT measurements showed no significant difference between the study subgroups, except when smokers were excluded.
Article
Biology
Guang-Quan Zhou, Hao Wei, Xiaoyi Wang, Kai-Ni Wang, Yuzhao Chen, Fei Xiong, Guanqing Ren, Chunying Liu, Le Li, Qinghua Huang
Summary: In this work, we propose an end-to-end boundary-salience multi-branch network, BSMNet, to identify the carotid intima-media from ultrasound images. Our method exploits prior shape knowledge and anatomical dependence to improve the accuracy of boundary identification and incorporates a strip attention model for segmenting thin strip regions. Experimental results demonstrate the promising performance of our method, achieving about 0.02 improvement in Dice and HD95 compared to other state-of-the-art methods. Our method is expected to advance the analysis of systemic arterial disease with ultrasound imaging.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Mingyue Zhou, Jia Zhang, Jiaokun Jia, Yanfang Liu, Mengyi Guo, Xiaoyu Lv, Xingquan Zhao, Shengyun Chen
Summary: In the Chinese middle-aged and elderly population without diabetes, higher levels of hemoglobin A1c are associated with an increased risk of carotid intima-media thickness, particularly in younger individuals.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Akito Sakanaka, Naoto Katakami, Masahiro Furuno, Hitoshi Nishizawa, Kazuo Omori, Naohiro Taya, Asuka Ishikawa, Shota Mayumi, Moe Inoue, Emiko Tanaka Isomura, Atsuo Amano, Iichiro Shimomura, Eiichiro Fukusaki, Masae Kuboniwa
Summary: This study identified saliva metabolites, including allantoin and 1,5-anhydroglucitol, as important predictors of atherosclerosis in patients with T2D, and demonstrated their diagnostic potential in non-invasive identification of high IMT group.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Endocrinology & Metabolism
Xiu Li Guo, Jian Wen Wang, Mei Tu, Wei Wang
Summary: This study found that perirenal fat thickness is associated with subclinical carotid atherosclerosis in patients with type 2 diabetes mellitus, suggesting that perirenal adipose tissue may play a role in regulating the cardiovascular system in this population. Perirenal fat thickness is also identified as a superior marker for subclinical carotid atherosclerosis in individuals with type 2 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Christopher Morrissey, Marie-Josephe Amiot, Aurelie Goncalves, Cecile Raverdy, Delphine Masson, Catherine Tardivel, Sandrine Gayrard, Myriam Carrere, Jean-Francois Landrier, Agnes Vinet, Antonia Perez-Martin
Summary: This study assessed the effects of vitamin D supplementation on arterial stiffness in obese adolescents. The researchers found that a high proportion of obese adolescents had vitamin D deficiency and supplementation improved carotid intima-media thickness (IMT) and reduced the risk of arterial stiffness.
Article
Cardiac & Cardiovascular Systems
Joseph F. Polak, Jye-Yu C. Backlund, Matt Budoff, Philip Raskin, Ionut Bebu, John M. Lachin
Summary: In individuals with type 1 diabetes, common carotid artery IMT is weakly associated with subsequent coronary artery events, but this association disappears after adjusting for traditional cardiovascular risk factors. There is no significant association between internal carotid artery IMT and coronary artery disease events.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medicine, General & Internal
Chung-Ze Wu, Li-Ying Huang, Fang-Yu Chen, Chun-Heng Kuo, Dong-Feng Yeih
Summary: The study compares the effectiveness of different machine learning methods and traditional multiple logistic regression in predicting carotid intima-media thickness (c-IMT) in type 2 diabetes (T2D) patients. It identifies age, sex, creatinine, body mass index, diastolic blood pressure, and duration of diabetes as the most significant risk factors for c-IMT. The results show that machine learning methods improve the prediction of c-IMT compared to conventional logistic regression models, which could have important implications for early identification and management of cardiovascular disease in T2D patients.
Article
Cardiac & Cardiovascular Systems
Wendy Wang, Faye L. Norby, Kristen M. George, Alvaro Alonso, Thomas H. Mosley, Rebecca F. Gottesman, Michelle L. Meyer, Pamela L. Lutsey
Summary: The study found that higher levels of carotid intima-media thickness and interadventitial diameter in midlife are associated with an increased risk of dementia, while the presence of carotid plaque did not show a significant association. Higher distensibility was associated with a lower risk of dementia.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Daniela Efremova, Natalia Ciobanu, Danu Glavan, Pavel Leahu, Renata Racila, Tatiana Balanua, Alexandru Matei, Maria Vasilieva, Cristina Cheptea, Paula Bitca, Cristina Damian, Ana Bondarciuc, Irina Bejenari, Adelina Cojocaru, Diana Manea, Mihail Ciocanu, Eremei Zota, Dumitru Ciolac, Stanislav A. Groppa
Summary: This study aims to evaluate the interrelations between serum urate (SU) levels and carotid atherosclerosis in subjects with different obesity phenotypes. The results showed that subjects with central obesity and mixed obesity had higher SU levels and markers of carotid atherosclerosis compared to subjects with general obesity and non-obese individuals.
Article
Endocrinology & Metabolism
Wei Li, Yan Wang, Shengrong Ouyang, Mengdi Li, Rui Liu, Yuqi Zhang, Xiaojun Liu, Tianfang Li, Shengyun Liu
Summary: In patients with type 2 diabetes mellitus, elevated serum uric acid levels are closely associated with metabolic syndrome and its components, but not with carotid atherosclerosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Atsushi Tanaka, Masataka Sata, Yosuke Okada, Hiroki Teragawa, Kazuo Eguchi, Michio Shimabukuro, Isao Taguchi, Kazuo Matsunaga, Yumiko Kanzaki, Hisako Yoshida, Tomoko Ishizu, Shinichiro Ueda, Masafumi Kitakaze, Toyoaki Murohara, Koichi Node
Summary: This study aimed to examine the effects of ipragliflozin on carotid intima-media thickness (IMT) in type 2 diabetes patients. After a 24-month treatment, it was found that ipragliflozin did not affect carotid IMT status compared to standard care for type 2 diabetes.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Xue Bao, Biao Xu, Lars Lind, Gunnar Engstrom
Summary: Subclinical carotid atherosclerosis is an important factor in cardiovascular risk estimation by SCORE2. Carotid ultrasound improves the predictive performance of SCORE2 for cardiovascular risk assessment. SCORE2 may over-predict the risk in individuals without carotid plaque and under-predict the risk in those with carotid plaque.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Surgery
Chrysostomos V. Aravanis, Alkistis Kapelouzou, Stylianos Vagios, Diamantis I. Tsilimigras, Michalis Katsimpoulas, Demetrios Moris, Theano D. Demesticha, Dimitrios Schizas, Alkiviadis Kostakis, Anastasios Machairas, Theodore Liakakos
JOURNAL OF INVESTIGATIVE SURGERY
(2020)
Letter
Cardiac & Cardiovascular Systems
Kalliopi Keramida, Christos Maniotis, George Makavos, Constantinos H. Papadopoulos, Alexandros Stefanidis, Anastasios Theodossis Georgilas, Demetrios J. Beldekos, Nikolaos Kouris
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Nikolaos P. E. Kadoglou, Marianna Stasinopoulou, Triantafyllos Giannakopoulos, Anastasios Papapetrou, Constantinos Dimitriou, Anthi Travlou, Efrosyni Merkouri, Nikolaos Kostomitsopoulos, Christos D. Liapis
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
(2020)
Article
Biochemistry & Molecular Biology
Nikolaos P. E. Kadoglou, George Kassimis, Nikolaos Patsourakos, Ioannis Kanonidis, Georgia Valsami
Summary: The study found that low levels of omentin-1 and vaspin in serum are associated with preclinical carotid atherosclerosis, and atorvastatin treatment significantly increases the levels of these adipokines. Further investigation is needed to understand the underlying mechanisms and clinical impact of these changes.
Article
Chemistry, Medicinal
Ignatios Ikonomidis, George Pavlidis, Nikolaos Kadoglou, George Makavos, Konstantinos Katogiannis, Aikaterini Kountouri, John Thymis, Gavriella Kostelli, Irini Kapniari, Konstantinos Theodoropoulos, John Parissis, Pelagia Katsimbri, Evangelia Papadavid, Vaia Lambadiari
Summary: The phosphodiesterase 4 inhibitor apremilast has significant effects on endothelial glycocalyx, vascular, and myocardial function in the treatment of psoriasis. It restores glycocalyx integrity and confers greater improvement in vascular and myocardial function compared to anti-tumor necrosis factor-alpha or cyclosporine.
Article
Medicine, General & Internal
Emmanouil Korakas, Theodoros Argyropoulos, Georgia-Angeliki Koliou, Aristofanis Gikas, Aikaterini Kountouri, Stavroula Kostaridou Nikolopoulou, Panagiotis Plotas, Konstantinos Kontoangelos, Ignatios Ikonomidis, Nikolaos P. E. Kadoglou, Athanasios Raptis, Vaia Lambadiari
Summary: This is the first report on the prevalence of stress hyperglycemia in pediatric patients in Greece. Asthma, corticosteroids, and beta 2-agonists significantly increase the risk of stress hyperglycemia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Chemistry, Medicinal
Nikolaos P. E. Kadoglou, Chrystalla Panayiotou, Michail Vardas, Nikolaos Balaskas, Nikolaos G. Kostomitsopoulos, Alexandra K. Tsaroucha, Georgia Valsami
Summary: Silibinin/silymarin has various pharmacological properties including antioxidant, hypolipidemic, hypoglycemic, anti-hypertensive, and cardioprotective effects. Clinical trials have shown significant improvements in glycemic and lipid profiles in patients with diabetes mellitus and hyperlipidemia, but the anti-hypertensive effects are modest. However, the current clinical trial data are insufficient to draw conclusive results.
Review
Chemistry, Medicinal
Anastasia Stella Perpinia, Nikolaos Kadoglou, Maria Vardaka, Georgios Gkortzolidis, Apostolos Karavidas, Theodoros Marinakis, Chrysostomi Papachrysostomou, Panagiotis Makaronis, Charikleia Vlachou, Marina Mantzourani, Dimitrios Farmakis, Konstantinos Konstantopoulos
Summary: Modern treatment modalities in hematology have improved clinical outcomes of patients with hematological malignancies, but some anticancer drugs may have adverse effects on the cardiovascular system, leading to various cardiac disorders. Therefore, it is crucial to understand all aspects of cardiotoxicity and provide appropriate care promptly to patients.
Review
Biology
Elina Khattab, Nikolaos Velidakis, Evaggelia Gkougkoudi, Nikolaos P. E. Kadoglou
Summary: Exercise-induced pulmonary hypertension (EIPH) is characterized by an increase in pulmonary arterial pressure during exercise in otherwise healthy individuals. It may precede the development of manifest pulmonary hypertension and is associated with decreased life expectancy in patients with heart failure or left ventricle valvular diseases. The gold standard for EIPH assessment is right heart catheterization, but non-invasive methods like exercise stress echocardiography and cardiopulmonary exercise testing are also used. However, further research is needed to determine the role of EIPH diagnosis in clinical practice.
Review
Biochemistry & Molecular Biology
Konstantinos Parperis, Nikolaos Velidakis, Elina Khattab, Evangelia Gkougkoudi, Nikolaos P. E. Kadoglou
Summary: Pulmonary hypertension is commonly seen in patients with systemic lupus erythematosus, presenting with non-specific symptoms and negatively affecting survival. It can result from immune system dysregulation, as well as various other conditions. Early diagnosis and identification of underlying pathogenetic mechanisms are crucial for introducing targeted therapy and preventing irreversible pulmonary vascular damage. The management of pulmonary hypertension in SLE patients is similar to that of idiopathic PAH, but specific diagnostic tools for early diagnosis seem to be unavailable yet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ekaterina-Michaela Tomou, Paraskevi Papakyriakopoulou, Helen Skaltsa, Georgia Valsami, Nikolaos P. E. Kadoglou
Summary: Cardiovascular diseases are the leading cause of morbidity and mortality worldwide, making it a top priority for scientific research to find interventions that modify risk factors. Herbal supplements, such as apigenin, quercetin, and silibinin, have shown potential as beneficial supplements for preventing CVDs. This comprehensive review focuses on the cardioprotective effects and mechanisms of these compounds, as well as their extraction and identification methods. However, uncertainties remain due to limited clinical studies, inconsistent doses, diverse constituents, and the lack of pharmacodynamic/pharmacokinetic analyses.
Article
Biology
Alkistis Kapelouzou, Styliani Geronikolou, Irene Lidoriki, Christos Kontogiannis, Loukas Kaklamanis, Loukas Tsourelis, Dennis V. V. Cokkinos
Summary: Higher levels of six biomarkers associated with cardiovascular pathology were found in the serum and tissue of patients with Degenerative Aortic Stenosis (DAS). These biomarkers were also present in the aortic valve cusps of DAS patients but not in transplantation valves. The study aims to investigate novel biomarkers to understand the biological processes involved in DAS.
Article
Chemistry, Medicinal
Nikolaos P. E. Kadoglou, Marianna Stasinopoulou, Evangelia Gkougkoudi, Eirini Christodoulou, Nikolaos Kostomitsopoulos, Georgia Valsami
Summary: Dabigatran etexilate and exercise training have complementary effects on the development and stability of atherosclerotic lesions in diabetic mice, mediated by anti-inflammatory modulation.
Review
Chemistry, Medicinal
Kyriakos Goulas, Dimitrios Farmakis, Anastasia Constantinidou, Nikolaos P. E. Kadoglou
Summary: This systematic review and meta-analysis found that the use of beta-blockers, angiotensin receptor blockers, or angiotensin converting enzyme inhibitors did not significantly reduce the occurrence of cardiotoxicity in breast cancer patients receiving trastuzumab therapy.
Review
Biology
Nikolaos Velidakis, Elina Khattab, Evangelia Gkougkoudi, Nikolaos P. E. Kadoglou
Summary: Left ventricular valvular diseases are common causes of pulmonary hypertension. The pathophysiology involves increased left ventricular filling pressure and left atrial pressure, leading to elevated pulmonary artery pressure and increased pulmonary vascular resistance. Early intervention in patients with severe LV valvular diseases can improve prognosis, but post-operative cardiac and all-cause mortality rates remain relatively high.
