Article
Computer Science, Interdisciplinary Applications
Benyamin Grosman, Di Wu, Neha Parikh, Anirban Roy, Gayane Voskanyan, Natalie Kurtz, Jeppe Sturis, Ohad Cohen, Magnus Ekelund, Robert Vigersky
Summary: This study utilized a virtual patient simulator to model and predict insulin therapy outcomes using NovoLog (R) and Fiasp (R) with the MiniMed (TM) 670G system, demonstrating that Fiasp (R) improves glycemic control and reduces the occurrence of hypoglycemia.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Developmental Biology
Miyuki Suzawa, Michelle L. Bland
Summary: Nutrients alone are not enough for animal growth and development, as insulin and related hormones are also necessary for normal growth. These hormones communicate nutrient status between organs, allowing animals to coordinate growth and metabolism. Insulin signaling plays important roles in development and metabolism, and defects in insulin production and signaling can lead to diabetes.
Article
Medicine, Research & Experimental
Anne-Laure Castell, Clara Goubault, Melanie Ethier, Grace Fergusson, Caroline Tremblay, Marie Baltz, Dorothee Dal Soglio, Julien Ghislain, Vincent Poitout
Summary: Puberty is associated with transient insulin resistance, and beta cell proliferation is related to the rise in growth hormone levels. Changes in gene expression of the 5-hydroxytryptamine pathway are consistent with the proliferative effect. Inhibition of 5-HT receptor blocks the increase in beta cell proliferation during puberty.
Review
Biochemistry & Molecular Biology
Mariam Ahmed Galal, Samhar Samer Alouch, Buthainah Saad Alsultan, Huda Dahman, Nouf Abdullah Alyabis, Sarah Ammar Alammar, Ahmad Aljada
Summary: This comprehensive review thoroughly explores the intricate involvement of insulin receptor isoforms and insulin-like growth factor receptors in the insulin and insulin-like growth factor signaling pathway, emphasizing their crucial roles in cancer development and resistance to anti-cancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Julian Bailes, Mikhail Soloviev
Summary: IGF-1, the principal mediator of GH, plays a crucial role in cell growth, differentiation, and apoptosis, with its bioavailability affected by IGFBPs. The varying expression levels of IGF-1 in clinical conditions and its misuse in sports have raised significant concerns.
Article
Biochemistry & Molecular Biology
Karina Piatek, Andrzej Kutner, Dan Cacsire Castillo-Tong, Teresa Manhardt, Nadja Kupper, Urszula Nowak, Michal Chodynski, Ewa Marcinkowska, Enikoe Kallay, Martin Schepelmann
Summary: This study found that newly developed low calcemic vitamin D analogs (an1,25Ds) can be used as anticancer agents in ovarian cancer cells, with PRI-5202 showing the best efficacy. The potency of these analogs and their ability to increase CYP24A1 expression in HGSOC cell lines were dependent on the cell line and chemical structure, suggesting that further optimization of the analogs' structure may lead to new treatment options for ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Pernilla Lang, Christina Patlaka, Goran Andersson
Summary: TRAP 5a increases proliferation of preadipocytes by promoting entry into S-phase, likely through increased IGF-1 signaling and Akt pathway activation.
Article
Multidisciplinary Sciences
Katrin Strassburger, Marilena Lutz, Sandra Mueller, Aurelio A. Teleman
Summary: The size of Drosophila wing discs is determined by the hormone ecdysone through a TORC1-dependent mechanism, with most cells stopping proliferation when the organ reaches the correct size. Reactivation of TORC1 can bypass the termination of proliferation, indicating its role as a main effector in regulating growth arrest at the maximal ecdysone-dependent size. Manipulation of Dpp or Yki signaling can affect proliferation termination in different regions of the wing disc.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Bruno Oliveira Silva Duran, Daniel Garcia de la Serrana, Bruna Tereza Thomazini Zanella, Erika Stefani Perez, Edson Assuncao Mareco, Vander Bruno Santos, Robson Francisco Carvalho, Maeli Dal-Pai-Silva
Summary: Fish muscle growth is regulated by complex molecular mechanisms, with duplicated genes playing a significant role in controlling gene expression related to myogenesis and protein balance. The majority of duplicated genes show similar expression profiles in response to fasting and refeeding, suggesting conservation of their functions post whole genome duplication (WGD). Redundancy appears to be more important in retaining duplicated genes of regulatory pathways than initially thought.
Article
Medicine, General & Internal
Youping Zhou, Youlin Deng, Jing Wang, Zhengjian Yan, Qiang Wei, Jixing Ye, Junhui Zhang, Tong-Chuan He, Min Qiao
Summary: In this study, it was found that monensin effectively inhibits cell proliferation, migration, and cell cycle progression, while inducing apoptosis and G1 arrest in human colorectal cancer cells. Monensin targets multiple cancer-related signaling pathways, including the IGF1R signaling pathway, by increasing IGF1 expression and suppressing IGF1R expression. These findings suggest that monensin has the potential to be repurposed as an anti-colorectal cancer agent. Further investigation is needed to understand the detailed mechanisms underlying its anti-cancer effects.
ANNALS OF MEDICINE
(2023)
Review
Oncology
Elena Tirro, Michele Massimino, Chiara Romano, Federica Martorana, Maria Stella Pennisi, Stefania Stella, Giuliana Pavone, Sandra Di Gregorio, Adriana Puma, Cristina Tomarchio, Silvia Rita Vitale, Livia Manzella, Paolo Vigneri
Summary: The IGF signaling pathway plays a key role in the pathogenesis of GBM, contributing to clinical significance and resistance development to standard and experimental treatments.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Ming Xiu, Xia Huan, Yang Ou, Sha Ying, Jianmeng Wang
Summary: The study investigated the cellular behavior and characteristics of IGF-1/IGF-1R in intestinal cells, revealing that IGF-1 can internalize into the cytoplasm and transport into the cell nuclei. It was found that IGF-1R undergoes clathrin-mediated endocytosis and enters into Rab-5-positive endosomes before being transported to the cell nuclei along microtubules, promoting cell proliferation.
CELL PROLIFERATION
(2021)
Article
Endocrinology & Metabolism
Marc Tatar
Summary: Mutations of the insulin-like receptor in Drosophila can extend lifespan through two modes of operation, one slowing reproduction and growth, and the other prolonging lifespan without impairing growth and reproduction. The structure of the insulin receptor can modulate aging by influencing the balance between reproduction and survival in fruit flies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Michele Massimino, Laura Sciacca, Nunziatina Laura Parrinello, Nunzio Massimo Scalisi, Antonino Belfiore, Riccardo Vigneri, Paolo Vigneri
Summary: IR isoforms exhibit different effects on cell proliferation and survival. While both IR-A and IR-B can inhibit cell proliferation when unbound to insulin, IR-B is more effective in reducing resistance to DNA damage. In the presence of insulin, IR-A provides a selective growth advantage over IR-B, particularly at high concentrations. Insulin-bound IR-A, but not IR-B, can protect cells from cytotoxicity induced by DNA damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zhiwen Zhu, Dongdong Li, Zeran Jia, Wenhao Zhang, Yuling Chen, Ruixue Zhao, Yan-Ping Zhang, Wen-Hong Zhang, Haiteng Deng, Yinqing Li, Wei Li, Shouhong Guang, Guangshuo Ou
Summary: Eukaryotic organisms adapt to environmental fluctuations by altering their epigenomic landscapes and transcriptional programs. Histone H2Bs are globally degraded in Caenorhabditis elegans during starvation, and the mechanisms underlying this degradation involve ubiquitin and ubiquitin-related enzymes. The retention of aberrant nucleosomal H2Bs leads to abnormal gene expression and impacts animal viability. Furthermore, the ubiquitin-proteasome system regulates chromosomal histone turnover in human cells.
Article
Endocrinology & Metabolism
David N. Huynh, Hanan Elimam, Valerie L. Bessi, Liliane Menard, Yan Burelle, Riccarda Granata, Andre C. Carpentier, Huy Ong, Sylvie Marleau
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Loredana Bergandi, Umberto Lucia, Giulia Grisolia, Riccarda Granata, Iacopo Gesmundo, Antonio Ponzetto, Emilio Paolucci, Romano Borchiellini, Ezio Ghigo, Francesca Silvagno
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2019)
Article
Endocrinology & Metabolism
Mari C. Vazquez-Borrego, Antonio C. Fuentes-Fayos, Aura D. Herrera-Martinez, Eva Venegas-Moreno, Fernando L-Lopez, Alessandro Fanciulli, Paloma Moreno-Moreno, Maria R. Alhambra-Exposito, Ana Barrera-Martin, Elena Dios, Cristobal Blanco-Acevedo, Juan Solivera, Riccarda Granata, Rhonda D. Kineman, Manuel D. Gahete, Alfonso Soto-Moreno, Maria A. Galvez-Moreno, Justo P. Castano, Raul M. Luque
NEUROENDOCRINOLOGY
(2020)
Article
Multidisciplinary Sciences
Lucia Recinella, Annalisa Chiavaroli, Giustino Orlando, Claudio Ferrante, Guya Diletta Marconi, Iacopo Gesmundo, Riccarda Granata, Renzhi Cai, Wei Sha, Andrew Schally, Luigi Brunetti, Sheila Leone
SCIENTIFIC REPORTS
(2020)
Correction
Multidisciplinary Sciences
Lucia Recinella, Annalisa Chiavaroli, Giustino Orlando, Claudio Ferrante, Guya Diletta Marconi, Iacopo Gesmundo, Riccarda Granata, Renzhi Cai, Wei Sha, Andrew V. Schally, Luigi Brunetti, Sheila Leone
SCIENTIFIC REPORTS
(2020)
Article
Endocrinology & Metabolism
Iacopo Gesmundo, Francesca Silvagno, Dana Banfi, Valentina Monica, Alessandro Fanciulli, Giacomo Gamba, Noemi Congiusta, Roberta Libener, Chiara Riganti, Ezio Ghigo, Riccarda Granata
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Multidisciplinary Sciences
Lucia Recinella, Annalisa Chiavaroli, Valentina Di Valerio, Serena Veschi, Giustino Orlando, Claudio Ferrante, Iacopo Gesmundo, Riccarda Granata, Renzhi Cai, Wei Sha, Andrew Schally, Rossano Lattanzio, Luigi Brunetti, Sheila Leone
Summary: The newly synthesized GHRH antagonists MIA-690 and MR-409 have shown potent pharmacological effects in colon inflammation models, reducing sensitivity to nociceptive stimuli and decreasing the impact of acute and persistent inflammatory stimuli in mice.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Iacopo Gesmundo, Barbara Pardini, Eleonora Gargantini, Giacomo Gamba, Giovanni Birolo, Alessandro Fanciulli, Dana Banfi, Noemi Congiusta, Enrica Favaro, Maria Chiara Deregibus, Gabriele Togliatto, Gaia Zocaro, Maria Felice Brizzi, Raul M. Luque, Justo P. Castano, Maria Alessandra Bocchiotti, Simone Arolfo, Stefania Bruno, Rita Nano, Mario Morino, Lorenzo Piemonti, Huy Ong, Giuseppe Matullo, Juan M. Falcon-Perez, Ezio Ghigo, Giovanni Camussi, Riccarda Granata
Summary: Healthy adipocyte-derived EVs are beneficial for beta cell survival and function, while EVs from inflamed adipocytes cause beta cell death and dysfunction. Lean adipocyte-derived EVs have similar beneficial effects, whereas EVs from obese adipose tissue are harmful for beta cells. Differential expression of miRNAs and alterations in signaling pathways and gene expression in recipient beta cells were observed, suggesting that adipocyte-derived EVs may influence beta cell fate and function depending on the physiological and pathological state of adipose tissue.
Article
Biochemistry & Molecular Biology
Lucia Recinella, Annalisa Chiavaroli, Giustino Orlando, Claudio Ferrante, Serena Veschi, Alessandro Cama, Guya Diletta Marconi, Francesca Diomede, Iacopo Gesmundo, Riccarda Granata, Renzhi Cai, Wei Sha, Andrew V. Schally, Luigi Brunetti, Sheila Leone
Summary: Anxiety and depression are suggested to increase the risk for PTSD, while GHRH analogs may have therapeutic effects on mood disorders including PTSD by modulating inflammatory and oxidative status and affecting neural pathways.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Lucia Recinella, Annalisa Chiavaroli, Giustino Orlando, Claudio Ferrante, Iacopo Gesmundo, Riccarda Granata, Renzhi Cai, Wei Sha, Andrew Schally, Luigi Brunetti, Sheila Leone
Summary: The study found that MIA-690 increased food intake and body weight, while also elevating hypothalamic hormone and neurotransmitter levels and reducing serotonin levels. MR-409 had no significant effects on these markers.
Article
Oncology
Iacopo Gesmundo, Giuseppina Granato, Antonio C. Fuentes-Fayos, Clara Alvarez, Carlos Dieguez, Maria Chiara Zatelli, Noemi Congiusta, Dana Banfi, Nunzia Prencipe, Sheila Leone, Luigi Brunetti, Justo P. Castano, Raul M. Luque, Renzhi Cai, Wei Sha, Ezio Ghigo, Andrew Schally, Riccarda Granata
Summary: Various studies have shown that GHRH antagonists have inhibitory activities in experimental cancers, and this study found that MIA-602 and MIA-690 have anti-tumor effects in PAs by reducing cell growth and promoting cell death, suggesting they may be considered as new therapeutic options for the treatment of PAs.
Article
Medicine, Research & Experimental
Lucia Recinella, Annalisa Chiavaroli, Serena Veschi, Valentina Di Valerio, Rossano Lattanzio, Giustino Orlando, Claudio Ferrante, Iacopo Gesmundo, Riccarda Granata, Renzhi Cai, Wei Sha, Andrew V. Schally, Luigi Brunetti, Sheila Leone
Summary: The MIAMI class GHRH antagonist MIA-690 was shown to suppress the progression and growth of colorectal cancer (CRC) by reducing inflammatory and oxidative markers, modulating apoptotic and oncogenic pathways, and improving survival rates in mice. Further research is needed to explore the translation of these findings into clinical applications.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Loredana Bergandi, Umberto Lucia, Giulia Grisolia, Iris Chiara Salaroglio, Iacopo Gesmundo, Riccarda Granata, Romano Borchiellini, Antonio Ponzetto, Francesca Silvagno
Summary: The study developed a thermodynamic biochemical model to select the resonant frequency affecting different types of cancer, and demonstrated its effects in vitro. It investigated the cellular response to ELF electromagnetic wave in 3D cell culture models, finding that ELF-EMF can hinder cancer cell growth and alter metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Iacopo Gesmundo, Francesca Pedrolli, Nicoletta Vitale, Alessia Bertoldo, Giulia Orlando, Dana Banfi, Giuseppina Granato, Ramesh Kasarla, Federico Balzola, Silvia Deaglio, Renzhi Cai, Wei Sha, Mauro Papotti, Ezio Ghigo, Andrew Schally, Riccarda Granata
Summary: This study found that GHRH antagonist MIA-690 enhances the antitumor effect of cisplatin and pemetrexed in pleural mesothelioma by inhibiting proliferative and oncogenic pathways, as well as reducing inflammatory pathways and expression of oxidative, angiogenic, tumorigenic markers, and growth factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Marina Boido, Iacopo Gesmundo, Anna Caretto, Francesca Pedrolli, Roberta Schellino, Sheila Leone, Renzhi Cai, Wei Sha, Ezio Ghigo, Andrew V. Schally, Alessandro Vercelli, Riccarda Granata
Summary: The study shows that MR-409 has protective effects on SMN Delta 7 mice, indicating its potential as a promising drug for the treatment of SMA.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
