Article
Cardiac & Cardiovascular Systems
Niekbachsh Mohammadnia, Jan Los, Tjerk S. J. Opstal, Aernoud T. L. Fiolet, John W. Eikelboom, Arend Mosterd, Stefan M. Nidorf, Charley A. Budgeon, Jan G. P. Tijssen, Peter L. Thompson, Cees J. Tack, Suat Simsek, Willem A. Bax, Jan H. Cornel, Saloua El Messaoudi
Summary: Despite optimal treatment, patients with chronic coronary artery disease and diabetes mellitus are at high risk of cardiovascular events. The Low-Dose Colchicine 2 trial showed that colchicine reduces cardiovascular risk in patients with chronic coronary artery disease. The efficacy of colchicine in patients with chronic coronary artery disease and diabetes mellitus, as well as its effect on the development of new-onset type 2 diabetes mellitus, were evaluated.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Javier Donate-Correa, Ernesto Martin-Nunez, Carmen Mora-Fernandez, Ainhoa Gonzalez-Luis, Alberto Martin-Olivera, Juan F. Navarro-Gonzalez
Summary: In this study, the association between inflammation, hemoglobin, and coronary artery disease (CAD) in subjects with type 2 diabetes mellitus (T2DM) and preserved kidney function was evaluated. The findings suggest that inflammation markers may not be related to the severity of stenosis in subjects with diabetes, while reductions in hemoglobin levels may be a more important risk factor for CAD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
T. Alnima, R. I. Meijer, H. M. H. Spronk, M. Warle, H. Ten Cate
Summary: Peripheral artery disease (PAD) is a significant health problem linked to diabetes mellitus (DM) and smoking. Current medical treatment fails to distinguish between diabetes-related PAD and non-diabetic patients, potentially leading to worse outcomes. This review discusses the pathophysiologic mechanisms of PAD and focuses on the treatment of diabetes-related PAD.
CARDIOVASCULAR DIABETOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Joanna Szydelko, Beata Matyjaszek-Matuszek
Summary: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease with a growing incidence worldwide and a higher risk of developing coronary artery disease (CAD). Current diagnostic methods are inadequate for early detection of CAD, necessitating extensive research on non-invasive blood-based biomarkers. MicroRNAs (miRNAs) show promise as stable and easily detectable biomarkers. Aberrant expression of miRNAs has been implicated in the pathophysiology of atherosclerosis, linking T2DM with CAD. This review discusses the role of miRNAs in diabetic CAD development and highlights their potential as non-invasive biomarkers and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Tianyu Li, Deshan Yuan, Peizhi Wang, Guyu Zeng, Sida Jia, Ce Zhang, Pei Zhu, Ying Song, Xiaofang Tang, Runlin Gao, Bo Xu, Jinqing Yuan
Summary: This study investigated the impact of nutritional-immunological status and diabetes on the prognosis of coronary artery disease (CAD). It was found that CAD patients with diabetes and low nutritional-immunological status had the worst prognosis. Diabetes amplified the negative effect of low nutritional-immunological status on all-cause death, and in CAD patients, poor nutritional-immunological status outweighed diabetes in increasing the risk of all-cause death.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Endocrinology & Metabolism
Xinmei Huang, Bingbing Zha, Manna Zhang, Yue Li, Yueyue Wu, Rui Zhang, Li Sheng, Jiong Xu, Zhiyan Yu, Cuijun Gao, Zaoping Chen, Heyuan Ding, Ling Ma, Yanquan Zhang, Shufei Zang, Tie-Ning Zhang, Jun Liu
Summary: The study found that decreased monocyte count throughout pregnancy was closely associated with the development of gestational diabetes mellitus (GDM), macrosomia, and the chronic inflammatory state of GDM. First-trimester monocyte count performed better as a risk factor and diagnostic predictor of GDM and macrosomia compared to second and third trimester counts.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Yasemin Dogan, Yucel Yilmaz, Saban Kelesoglu, Bekir Calapkorur, Salim Neselioglu, Ozcan Erel, Nihat Kalay
Summary: The aim of this study was to investigate the relationship between thiol, the main component of the antioxidant system, and coronary collateral circulation (CCC). The results showed that patients with stable coronary artery disease (sCAD) who developed poor CCC had lower levels of native thiol, total thiol, and disulfide compared to those with good CCC. Additionally, DM, total thiol, and disulfide were identified as independent predictors of poor CCC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Efstratios Karagiannidis, Dimitrios Moysidis, Andreas S. Papazoglou, Eleftherios Panteris, Olga Deda, Nikolaos Stalikas, Georgios Sofidis, Anastasios Kartas, Alexandra Bekiaridou, George Giannakoulas, Helen Gika, George Theodoridis, Georgios Sianos
Summary: Diabetes mellitus (DM) and coronary artery disease (CAD) are interrelated clinical entities. There is a need for novel biomarkers and metabolomics-based prediction models to predict clinical outcomes and assess CAD complexity in the comorbid population of DM and CAD.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Immunology
Ebin Johny, Pathoori Bhaskar, Md Jahangir Alam, Indra Kuladhipati, Rupam Das, Ramu Adela
Summary: The study revealed increased platelet activation and platelet-immune cell aggregate formation in T2DM and T2DM_CAD groups compared to the control and CAD groups. Immunome profiling showed altered monocyte subpopulations and dendritic cell populations in T2DM, CAD, and T2DM_CAD groups. Additionally, significantly elevated levels of inflammatory cytokines/chemokines and decreased levels of certain immune factors were observed in the T2DM_CAD group compared to the control group.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Immunology
Sverre Grover Aukrust, Kristine Bech Holte, Trine B. Opstad, Ingebjorg Seljeflot, Tore Julsrud Berg, Ragnhild Helseth
Summary: In patients with long-term T1DM, the levels of circulating NETs are not consistently associated with the presence of T1DM or the development of CAD. This suggests altered neutrophil function and reduced NETosis in T1DM.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Francesca Romana Prandi, Dalgisio Lecis, Federica Illuminato, Marialucia Milite, Roberto Celotto, Stamatios Lerakis, Francesco Romeo, Francesco Barilla
Summary: Diabetes mellitus is a glucose metabolism disorder that affects more than 1 in 10 adults and is associated with an increased risk of cardiovascular disease. The main cause of death in diabetic patients is cardiovascular disease, with coronary artery disease and ischemic cardiomyopathy as major contributors. Damage to vascular endothelial cells caused by high blood sugar levels leading to endothelial dysfunction is the main initiating factor in the development of diabetic vascular complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Aybike Sena Ozuynuk, Aycan Fahri Erkan, Berkay Ekici, Nihan Erginel-Unaltuna, Neslihan Coban
Summary: Coronary artery disease (CAD) is a complex cardiovascular disease and the leading cause of global mortality. This study aimed to assess the contribution of selected cholesterol metabolism-related gene polymorphisms to CAD presence. It was found that LDLR rs5930 polymorphism was associated with T2DM presence in male CAD patients.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Cardiac & Cardiovascular Systems
Ying Shen, Xiao Qun Wang, Yang Dai, Yi Xuan Wang, Rui Yan Zhang, Lin Lu, Feng Hua Ding, Wei Feng Shen
Summary: Coronary collateralization is impaired in patients with type 2 diabetes and occlusive coronary artery disease, leading to worse prognosis. Dyslipidemia and glycoxidative modification of lipoprotein particles contribute to endothelial dysfunction and impaired collateral vessel growth. The effect of lipid-lowering treatments on collateral formation is also discussed in this review.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Yi Zhong, Guoyong Du, Jie Liu, Shaohua Li, Junhua Lin, Guoxiong Deng, Jinru Wei, Jun Huang
Summary: This study used weighted gene correlation network analysis (WGCNA) to identify CCL3 as a key regulator and RUNX1 as a key transcription factor in diabetes mellitus-associated coronary artery disease (DMCAD).
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Lei Wu, Yan Zhang, Hong Zhao, Guodong Rong, Peijun Huang, Fang Wang, Ting Xu
Summary: This study found that APOE gene polymorphisms are associated with CAD with or without T2DM and have an influence on lipid profiles in both T2DM and CAD patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Peripheral Vascular Disease
Cagri Yayla, Ugur Canpolat, Ahmet Akyel, Kadriye Gayretli Yayla, Samet Yilmaz, Sadik Kadri Acikgoz, Firat Ozcan, Osman Turak, Mehmet Dogan, Ekrem Yeter, Sinan Aydogdu
Editorial Material
Cardiac & Cardiovascular Systems
Tolga Cimen, Hasan Ali Durmaz, Ahmet Akyel, Ekrem Yeter, Kasim Karapinar, Mehmet Ali Felekoglu
ANATOLIAN JOURNAL OF CARDIOLOGY
(2015)
Article
Cardiac & Cardiovascular Systems
Mehmet Erat, Mehmet Dogan, Hamza Sunman, Lale Dinc Asarcikli, Tolga Han Efe, Murat Bilgin, Tolga Cimen, Ahmet Akyel, Ekrem Yeter
ANATOLIAN JOURNAL OF CARDIOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Tolga Cimen, Hamza Sunman, Mehmet Erat, Tolga Han Efe, Ahmet Akyel, Murat Bilgin, Sadik Acikel, Mehmet Dogan, Ekrem Yeter
ANATOLIAN JOURNAL OF CARDIOLOGY
(2017)