Article
Medicine, General & Internal
Xinyuan Zhang, Samantha A. Molsberry, Michael A. Schwarzschild, Alberto Ascherio, Xiang Gao
Summary: Better diet quality and physical activity are associated with a lower risk of developing Parkinson's disease (PD) and lower all-cause mortality among individuals with PD.
Article
Allergy
Paola Facheris, Joel Correa Da Rosa, Angel D. D. Pagan, Michael Angelov, Ester Del Duca, Grace Rabinowitz, Pedro Jesus Gomez Arias, Camille Rothenberg Lausell, Yeriel D. D. Estrada, Swaroop Bose, Mashkura Chowdhury, Avner Shemer, Ana B. B. Pavel, Emma Guttman-Yassky
Summary: The unique characteristics of adult-onset atopic dermatitis (AOAD) compared to pediatric-onset AD persisting into adulthood (POAD) have not been well-studied, hindering the development of targeted therapeutics. This study analyzed skin and blood samples from AOAD, POAD, and healthy controls and found that both AOAD and POAD showed immune and barrier dysregulations with shared Th2/Th22 hyperactivation. POAD had greater inflammation and compromised epidermal barrier compared to AOAD. AOAD also had more dysregulated proteins in serum, including pro-inflammatory and cardiovascular-risk markers.
Article
Medicine, General & Internal
Kristian Reich, Jacob P. Thyssen, Andrew Blauvelt, Kilian Eyerich, Weily Soong, Zakiya P. Rice, H. Chih-ho Hong, Norito Katoh, Fernando Valenzuela, Marco DiBonaventura, Tamara A. Bratt, Fan Zhang, Claire Clibborn, Ricardo Rojo, Hernan Valdez, Urs Kerkmann
Summary: This study compared the efficacy and safety of abrocitinib versus dupilumab in adults with moderate-to-severe atopic dermatitis. Results showed that abrocitinib was more effective in inducing early reductions of itch and atopic dermatitis disease signs under background topical therapy.
Article
Medicine, General & Internal
Thomas Bieber, Eric L. Simpson, Jonathan I. Silverberg, Diamant Thaci, Carle Paul, Andrew E. Pink, Yoko Kataoka, Chia-Yu Chu, Marco DiBonaventura, Ricardo Rojo, Jeremias Antinew, Ileana Ionita, Rodney Sinclair, Seth Forman, Jacek Zdybski, Pinaki Biswas, Bimal Malhotra, Fan Zhang, Hernan Valdez
Summary: The study demonstrated that both 200 mg and 100 mg doses of abrocitinib showed significant efficacy in treating moderate-to-severe atopic dermatitis compared to placebo, with the 200 mg dose being superior to dupilumab in improving itch response. Neither dose of abrocitinib showed significant differences from dupilumab in most other key secondary endpoints at week 16.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Health Care Sciences & Services
Heping Fang, Lin Chen, Juan Li, Luo Ren, Yu Yin, Danleng Chen, Huaying Yin, Enmei Liu, Yan Hu, Xiaoyan Luo
Summary: This study developed and validated a web-based instrument for infantile AD identification and confirmed that infantile AD can be identified through web-based questionnaires without the attendance of doctors. This method can be easily applied to community-based epidemiological studies and provide acceptable identification reliability.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Health Care Sciences & Services
Shaan Khurshid, Lu-Chen Weng, Victor Nauffal, James P. Pirruccello, Rachael A. Venn, Mostafa A. Al-Alusi, Emelia J. Benjamin, Patrick T. Ellinor, Steven A. Lubitz
Summary: This study analyzed data from the UK Biobank using wearable accelerometers and found a strong association between physical activity and lower disease risk. The association was particularly strong for cardiac, digestive, endocrine/metabolic, and respiratory conditions. In contrast, self-reported physical activity showed weaker associations with disease risk.
NPJ DIGITAL MEDICINE
(2022)
Article
Biology
Regina Foelster-Holst, Rahel Reimer, Claudia Neumann, Erhardt Proksch, Elke Rodriguez, Stephan Weidinger, Mohamad Goldust, Eckhard Hanisch, Stephan Daehnhardt-Pfeiffer, Sandra Freitag-Wolf
Summary: Atopic dermatitis and prurigo nodularis are two chronic skin diseases characterized by impaired skin barrier and disturbed water balance. Basic barrier repair is crucial for the treatment of both conditions.
Article
Dermatology
L. Jacob, G. F. Lopez-Sanchez, A. Koyanagi, N. Veronese, J. Vioque-Lopez, H. Oh, J. I. Shin, A. Schnitzler, C. P. Ilie, S. Stefanescu, C. Gillvray, M. O. Machado, V. Piguet, A. Carvalho, L. Smith
Summary: The prevalence of chronic skin disease was low in Spanish adults, with lower levels of physical activity observed in men with chronic skin conditions than in men without, while no significant difference was found in women.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2021)
Article
Dermatology
Maria C. Schneeweiss, Lourdes Perez-Chada, Joseph F. Merola
Summary: In this population-based study on adult AD patients, cyclosporine and methotrexate had the lowest 6-month risks of serious infections, while increased risks were observed for prednisone, azathioprine, and mycophenolate relative to methotrexate.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ling Li, Jiajun Yu, Baoqing Chen, Ying Guo, Yufeng Yang
Summary: This study aimed to investigate the safety and efficacy of abrocitinib in treating moderate-to-severe AD in adolescents and adults. The meta-analysis of 7 studies found that 100 mg or 200 mg of abrocitinib significantly improved IGA and EASI-75 responses, and it was still superior to placebo in both the adolescent and adult groups. Abrocitinib showed higher efficacy and safety in the treatment of moderate-to-severe AD.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Dermatology
Z. Ali, A. Egeberg, J. P. Thyssen, C. S. Ulrik, S. F. Thomsen
Summary: Adults with concomitant AD and asthma have different patterns of healthcare utilization compared to those with AD or asthma alone, suggesting that improvements in management and monitoring may reduce unscheduled healthcare visits and lower healthcare costs.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Medicine, General & Internal
Federica Gelato, Luca Mastorino, Ekaterina Stepkina, Giovanni Cavaliere, Simone Ribero, Pietro Quaglino, Michela Ortoncelli
Summary: This retrospective study compares the efficacy of dupilumab therapy in patients with intrinsic and extrinsic atopic dermatitis (AD) and finds no significant differences in treatment outcome between the two groups, suggesting that dupilumab is equally effective regardless of IgE levels.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Francesca Felisatti, Julie Gonneaud, Cassandre Palix, Antoine Garnier-Crussard, Florence Mezenge, Brigitte Landeau, Anne Chocat, Anne Quillard, Eglantine Ferrand-Devouge, Vincent de La Sayette, Denis Vivien, Gael Chetelat, Geraldine Poisnel
Summary: The objective of this study was to assess whether cardiovascular risk factors mediate the association between physical activity and brain integrity markers in older adults. The results showed that higher physical activity was associated with higher gray matter volume and cerebral glucose metabolism. Lower insulin level and BMI were related to higher gray matter volume. Mediation analyses confirmed that insulin level and BMI mediated the association between physical activity and gray matter volume.
Article
Allergy
Ioana Agache, Cezmi Akdis, Mubeccel Akdis, Knut Brockow, Tomas Chivato, Stefano del Giacco, Thomas Eiwegger, Kilian Eyerich, Ana Gimenez-Arnau, Jan Gutermuth, Emma Guttman-Yassky, Marcus Maurer, Graham Ogg, Peck Y. Ong, Liam O'Mahony, Juergen Schwarze, Amena Warner, Thomas Werfel, Oscar Palomares, Marek Jutel
Summary: Atopic dermatitis imposes a significant burden on patients, families and healthcare systems. Management is difficult and there are still many issues that require further clarification.
Letter
Medicine, General & Internal
Brandon I. Smith, Priya Engel, Jashin Wu
Summary: The authors conclude that lebrikizumab therapy is safe and effective for moderate-to-severe atopic dermatitis in adolescents and adults based on two phase 3 trials. However, they note the lack of racial diversity in the trials, with majority of the patients being White.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
