期刊
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE
卷 66, 期 -, 页码 M1248-U750出版社
INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S1600536810035543
关键词
-
资金
- BRHE [RUX0-008-NO-06]
- Presidium of Russian Academy of Sciences
- Innovation Project of Rosobrazovanie [456]
A new polymorph (beta) was obtained for an active pharmaceutical ingredient, bismuth tribenzoate, [Bi(C6H5CO2)(3)]. The new beta-polymorph is 1.05 times denser than the previously known polymorph [Rae et al. (1998). Acta Cryst. B54, 438-442]. In the beta-polymorph, the Bi atom is linked with three benzoate anions, each of them acting as a bidentate ligand, and these assemblies with C-3 point symmetry can be considered as 'molecules'. The structure of the beta-polymorph has no polymeric chains, in contrast to the previously known polymorph. The 'molecules' in the beta-polymorph are stacked along [001], so that the phenyl rings of the neighbouring molecules are parallel to each other. Based on the pronounced difference in the crystal structures, one can suppose that two polymorphs should differ in the dissolution kinetics and bioavailability.
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