Article
Marine & Freshwater Biology
Kaden K. Fujita, Jon A. Doering, Eric Stock, Zhe Lu, Tony Montina, Steve Wiseman
Summary: This study assessed the effects of benzotriazole ultraviolet stabilizers (BZT-UVs) on the reproductive success of Japanese medaka. The results showed that dietary exposure to BZT-UVs at concentrations as low as 634 ng/g food did not significantly impact the reproductive performance of Japanese medaka, but it could potentially affect steroidogenesis.
AQUATIC TOXICOLOGY
(2022)
Article
Environmental Sciences
Yamin Raza, Emily Mertens, Lauren Zink, Zhe Lu, Jon A. Doering, Steve Wiseman
Summary: This study investigated the effects of benzotriazole ultraviolet stabilizers (BUVSs) on the reproductive success of zebrafish. The results showed that although there was no significant effect on fecundity, UV-P exposure had a significant impact on fertilization success. In addition, exposed male fish exhibited decreased synthesis of sex steroids, decreased transcript abundances of genes involved in spermatogenesis, and decreased sperm quantity, suggesting that embryonic exposure to UV-P may impair the reproductive function of male fish.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Engineering, Environmental
Junyan Wei, Shengnan Zhang, Ruixue Guo, Ahmed A. Allam, Jamaan S. Ajarem, Naif G. Altoom, Afzal Ahmed Dar, Ruijuan Qu, Zongli Huo, Feng Zhu
Summary: The transformation behavior of UV328 in polyethylene (PE) plastic by NaClO was investigated. The reaction rate was found to depend on the concentration of free active chlorine and the decrease of UV328 concentration. The main transformation pathways were speculated to be chlorination, hydroxylation, coupling, and bond cleavage.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Toxicology
Heike Denghel, Julia Hiller, Edgar Leibold, Thomas Goeen
Summary: UV 328 is a UV absorber added to plastics and polymers for stability. The study found that UV 328 is primarily metabolized through oxidation pathways in the body, with a higher presence of metabolites in urine.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Olga G. Shakirova, Irina A. Os'kina, Evgeniy V. Korotaev, Sergey A. Petrov, Natalia V. Kuratieva, Alexsei Ya. Tikhonov, Lyudmila G. Lavrenova
Summary: New iron(II) complexes with 2,6-bis(1H-imidazol-2-yl)-4-methoxypyridine (L) as the ligand have been synthesized and studied. The coordination ability of the ligand was determined through analysis of a copper(II) complex by X-ray technique. The compounds I-III exhibit a (1)A(1) & LRARR; T-5(2) spin crossover, accompanied by thermochromism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Inorganic & Nuclear
Caroline Marie Gallati, Sina Katharina Goetzfried, Anna Ortmeier, Jessica Sagasser, Klaus Wurst, Martin Hermann, Daniel Baecker, Brigitte Kircher, Ronald Gust
Summary: A series of novel gold complexes were synthesized and evaluated for their anti-cancer properties in various cell lines, showing that the bis-NHC gold(i) complexes exhibited higher activity and selectivity compared to their mono-NHC analogues, with greater potency against tumor cells and minimal effects on non-cancerous cells.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Organic
Dinesh Singla, Vijay Luxami, Kamaldeep Paul
Summary: A palladium-catalyzed [4+2] oxidative annulation of coumarin-benzimidazoles with olefins has been successfully achieved for the synthesis of polycyclic aromatic hydrocarbons. This synthetic method provides access to structurally distinct imidazo[1,2-a]chromeno[3,4-c]pyridines in moderate to good yields with high functional group tolerance. Additionally, the photophysical properties of the annulated scaffolds have been examined, revealing interesting solvatochromic emission behaviors.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Jianhang Huang, Xinren Wang, Ruinan Dong, Xiaoyue Liu, Hongmei Li, Tianyi Zhang, Junyu Xu, Chenhe Liu, Yanmin Zhang, Shaohua Hou, Weifang Tang, Tao Lu, Yadong Chen
Summary: The research focused on the discovery of a novel series of quinazoline derivatives as CDK inhibitors for the treatment of hematologic malignancies. Compound 37d was identified as the most active inhibitors of CDKs 1, 2, 4, 8, and 9, showing promising antitumor efficacy in multiple HM mouse xenograft models with no obvious toxicity. These results indicate the potential use of CDK inhibitors for certain hematologic malignancies.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ida Ziccarelli, Lucia Veltri, Tommaso Prestia, Roberta Amuso, Maria A. Chiacchio, Raffaella Mancuso, Bartolo Gabriele
Summary: Unreported 2-(4-acylfuran-2-yl)acetamides were selectively synthesized in fair to good yields (54-81%) over 19 examples through a mild catalytic process involving Csp-H activation, 5-exo-dig O-cyclization, and aromative isomerization.
Article
Chemistry, Inorganic & Nuclear
Melek Tercan, Osman Dayan, Namik Ozdemir
Summary: In this study, a ligand (L) and its Pd(II) complex (Pd(L)Cl2) were synthesized and characterized. The crystal structure of L was determined by X-ray diffraction and the properties were obtained using density functional theory (DFT). The Pd(II) complex was immobilized onto TiO2 support material to prepare a catalyst (15% Pd(L)Cl2-TiO2) used for the reduction of organic pollutants. The catalyst demonstrated high conversion values due to the synergistic effect of the catalytic properties of Pd and the photocatalytic properties of TiO2.
Article
Chemistry, Organic
Yulia Krivolapova, Olesya A. Tomashenko, Liya D. Funt, Dar'ya Spiridonova, Mikhail S. Novikov, Alexander F. Khlebnikov
Summary: Azirine-triazole hybrids were selectively synthesized under different reaction conditions and the reaction mechanism and selectivity were discussed based on DFT calculations.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Akif Evren Parlak, Rebaz Anwar Omar, Pelin Koparir, Musher Ismael Salih
Summary: In this study, a new compound was synthesized using a chemical method and characterized through experimental and theoretical calculations. The results showed the validity of the used molecular structure and the correlation between the electronic structural parameters of the compound and its corrosion inhibition efficacy.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Valentina Ferraro, Leonardo Genesin, Jesus Castro, Luca Pietrobon, Andrea Vavasori, Marco Bortoluzzi
Summary: Palladium(II) chloro- and methyl-complexes with N -((pyridin-2-yl)methylene)-4-amino-2,1,3-benzothiadiazole in the coordination sphere were synthesized and found to be catalytically active towards the methoxycarbonylation of iodobenzene to methyl benzoate. The ligand interacts with the metal centre through the pyridine and imine nitrogen atoms, while the benzothiadiazole heterocycle remains as a free pendant. The structure of the acyl-complex was determined by X-ray diffraction.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Irinela Chilibon, Adina-Maria Paun, Cristina Vasiliu, Elena Diacu, Raluca Isopescu, Eleonora-Mihaela Ungureanu
Summary: Sensitive electrodes based on complexing azulene polymer films were prepared using electrochemical deposition. The films were characterized using various methods and it was found that the complexing units were preserved in the films.
Article
Chemistry, Inorganic & Nuclear
Daniel Lueert, Anne-Kathrin Kreyenschmidt, Christina M. Legendre, Regine Herbst-Irmer, Dietmar Stalke
Summary: Three isostructural dinuclear lanthanide complexes based on the N,N'-chelating monoanionic bis(4-methylbenzoxazol-2-yl)methanide ligand were synthesized and characterized, with the DyIII complex displaying slow relaxation of magnetization at zero field and a weak antiferromagnetic coupling estimated from the GdIII equivalent.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Sivasankar Kulandaivel, Chia-Her Lin, Yi-Chun Yeh
Summary: The study reported a bi-metal organic framework, MOF-919 (Fe-Cu), capable of bifunctional-enzyme mimicking activity with oxidase- and peroxidase-like activities. A simple epinephrine colorimetric biosensor was developed based on this MOF, with a broad linear range and low detection limit, demonstrating its potential application as new nanosensors.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Ling- Hung, Dai-Yi Hsieh, Tsung-Hsiu Hsieh, Pei-Lin Chen, Chia-Her Lin, Sue-Lein Wang
Summary: In this study, three new trivalent titanium phosphorus oxides were synthesized using a simple strategy, each showing proton-coupled electron transfer (PCET) reactivity in a solid state. These compounds exhibit different structures and behaviors, providing new insights into the pathways of solid-state PCET reactions.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Chen-Yen Tsai, Yi-Hsuan Chen, Szetsen Lee, Chia-Her Lin, Chu-Han Chang, Wan-Ting Dai, Wan-Ling Liu
Summary: A SiO2@MOF core-shell microsphere was synthesized for environmentally friendly applications, showing high catalytic activity in the cycloaddition reaction of epoxides. Specifically, SiO2@ZIF-67 achieved a maximum conversion of 97% and could be used for multiple reaction cycles.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Pei-Fang Hsieh, Zhi Xuan Law, Chia-Her Lin, De-Hao Tsai
Summary: This study demonstrated the synthesis of metal-organic framework (MOF) colloids via a solvothermal growth process using electrospray-differential mobility analysis (ES-DMA). The results showed the effects of synthetic parameters on the properties of Cu-MOF, and confirmed the correlation between mobility size increase and crystallinity. The experiment also showed the good CO2 adsorption ability of synthesized Cu-MOF.
Article
Nanoscience & Nanotechnology
Yu-An Hsueh, Yi Ching Chuah, Chia-Her Lin, De-Hao Tsai
Summary: This study demonstrates a continuous aerosol route for the gas-phase synthesis of Cu-MOF supported on CeO2 nanoparticle clusters. The resulting hybrid nanomaterials show enhanced metal surface area and dispersion when the Cu/Ce atomic ratio is decreased. Incorporation of CeO2 nanoparticle clusters improves the activity and stability of the MOF-derived nanostructured catalysts. This research opens up opportunities for the design of nanostructured catalysts useful for CO2 capture and utilization applications.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Vijayanath Elakkat, Eskedar Tessema, Chia-Her Lin, Xiaoping Wang, Huan-Cheng Chang, You-Ning Zheng, Yu-Cheng Huang, Zhong-Yun Gurumallappa, Zhong-Yun Zhang, Ka Long A. Chan, Hening A. S. Rahayu, Joseph S. Francisco, Norman Lu
Summary: To understand the effect of non-covalent weak interactions on molecules, we investigated different types of weak interactions in fluorinated chiral zinc complexes, including improper H-bonding, tetrel bonds, and halogen bonds. High resolution neutron diffraction studies revealed elongation and shortening of the methylene carbon-hydrogen bond due to tetrel bonds and improper H-bond interactions, respectively. We demonstrated how multiple weak interactions can cumulatively affect the C-H bond and offset its elongation through formation of an improper H-bond. Non-covalent interaction and electrostatic potential analysis investigations confirmed the nature of these interactions using density functional theory (DFT) and related calculations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Po-Hsiang Tang, Pamela Berilyn So, Zi-Jing Lin, Chia-Chun Hsieh, Lee-Jene Lai, Chia-Her Lin
Summary: This paper mainly discusses the applicability of using soft x-ray tomography technology to examine the multidimensional structure of metal-organic frameworks, such as their core-shell and hollow framework. By visually observing their corresponding images in different energy bands by different excitation energies for different elements, the researchers can effectively observe the distribution of metals in the structure and the type of hollow pores the metal-organic framework possesses. This pioneering evaluation of MOFs via SXT shows excellent performance in the structure identification of multidimensional metal-organic frameworks.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Manivannan Govindaraj, Shih-Ying Zhong, Chia-Her Lin, Jhy-Der Chen
Summary: Eight coordination polymers constructed from divalent metal salts, N,N-'-bis(pyridin-3-ylmethyl)terephthalamide (L), and various dicarboxylic acids were reported. The structural types of these compounds are subject to the metal and ligand identities, showing different 2D and 3D structures. The investigation on the photodegradation of methylene blue by using complexes 1-3 reveals that the degradation efficiency may increase with increasing surface areas.
Article
Chemistry, Analytical
Sivasankar Kulandaivel, Chia-Her Lin, Yi-Chun Yeh
Summary: In this study, copper-based coordination polymer (Cu-CP) nanozymes were successfully synthesized to accelerate the oxidation of epinephrine (Epi) with high specificity. The Cu-CP nanozymes showed a wide linear range for Epi detection and excellent stability and recyclability. Moreover, colorimetric and fluorescence signals were used for sequential detection of the coexistence of Epi and norepinephrine (NE), making it possible to track the treatment outcomes of patients with pheochromocytoma. Experiments using artificial urine confirmed the efficacy of the proposed system.
Article
Biochemical Research Methods
Tarik Abdelkareem Mostafa Amer, Sathyadevi Palanisamy, Pamela Berilyn So, Priya Vijayaraghavan, Shey-Cherng Tzou, Tsai-Te Lu, Chia-Her Lin, Yun-Ming Wang
Summary: The use of MOF-based nanomaterials in bioapplications has increased due to their biocompatibility, drug degradation, tunable porosity, and intrinsic biodegradability. Bimetallic MOFs embedded with and without folic acid were synthesized and used for tissue sealing and repairing incisional wound sites in mice models. These materials displayed antibacterial properties and enhanced wound healing rates, and also showed potential for cell migration and angiogenesis.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Chen-Yen Tsai, Chin-Hung Liao, Mei-Ling Lin, Chia-Her Lin
Summary: The objective of this research is to create monolithic heterogeneous catalysts (cordierite@MOFs) through the application of metal-organic framework (MOF) materials onto honeycomb cordierite for CO2 cycloaddition. By employing monolithic catalysts instead of powdered catalysts, the recycling and reusability of catalysts during post-reaction treatment can be significantly improved. The cordierite@ZIF-67 catalyst, known for its high activity, stability, and easy recyclability, offers significant advantages in terms of practicality and efficiency. It not only improves the overall efficiency of the catalytic process but also contributes to the sustainability and environmental friendliness of the production process by minimizing waste and resource consumption.
INORGANIC CHEMISTRY
(2023)
Article
Materials Science, Biomaterials
Sivasankar Kulandaivel, Hsin-Tsung Chen, Chia-Her Lin, Yi-Chun Yeh
Summary: Finding materials that balance enzyme-like reactivity, stability, and affordability is crucial for future biosensing. Iron-based metal-organic frameworks (MOFs) with peroxidase properties offer potential solutions due to their variable pore size, surface area, and Lewis acid active sites. This study demonstrates the enhanced peroxidase catalytic activity of MIL-88B(Fe) (1,4-NDC) MOF and explores the sequential application of Fe-MOF and enzyme-encapsulating ZIF-90 PVP MOF for glucose detection. It highlights the potential of nanozymes as alternatives to natural enzymes in biosensing.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Venkatesan Lakshmanan, Chia-Yi Lee, Yu-Wen Tseng, Yu-Hsiang Liu, Chia-Her Lin, Jhy-Der Chen
Summary: In this study, six coordination polymers with different topological structures and adsorption properties were synthesized through hydro(solvo)thermal reactions. Two of the polymers exhibited high selectivity for the detection of pesticides and good recyclability. Moreover, the effect of surface modification on the wettability of the materials was investigated.
Article
Biochemistry & Molecular Biology
Manivannan Govindaraj, Wei-Chun Huang, Chia-Yi Lee, Venkatesan Lakshmanan, Yu-Hsiang Liu, Pamela Berilyn So, Chia-Her Lin, Jhy-Der Chen
Summary: This study reports the synthesis and structural characterization of various Hg(II) halide complexes using single-crystal X-ray diffraction analyses. The ligand type and halide anion were found to play important roles in determining the structural diversity of the complexes. The luminescent properties and stability of selected complexes were also evaluated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Pamela Berilyn So, Chen-Yu Liu, Yu-Lun Lai, Cheng-Shiuan Lee, Chia-Her Lin
Summary: This work explores the capacity of metal-organic framework-polyvinyl alcohol composites in adsorbing volatile organic compounds. The experiment shows that these composites have higher adsorption capacity than commercially available adsorbents. Among them, MIL-68@PVA beads exhibit the best static adsorption capacity, while HKUST-1@PVA beads show the best adsorption capacity for low concentration toluene.
MATERIALS ADVANCES
(2022)
