期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 45, 页码 25077-25083出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b08907
关键词
cellular imaging; core-shell nanoparticles; fluorescence; fluorescence enhancement; polymer
资金
- National Natural Science Foundation of China [51403018, 51373022]
- Fundamental Research Funds for the Central Universities [FRF-TP-15-002A2]
In this work, we report the facile synthesis of functional core-shell structured nanoparticles with fluorescence enhancement, which show specific targeting of cancer cells. Biopolymer poly-l-lysine was used to coat the silver core with various shell thicknesses. Then, the nanoparticles were functionalized with folic acid as a targeting agent for folic acid receptor. The metal-enhanced fluorescence effect was observed when the fluorophore (5-(and-6)-carboxyfluorescein-succinimidyl ester) was conjugated to the modified nanoparticle surface. Cellular imaging assay of the nanoparticles in folic acid receptor-positive cancer cells showed their excellent biocompatibility and selectivity. The as-prepared functional nanoparticles demonstrate the efficiency of the metal-enhanced fluorescence effect and provide an alternative approach for the cellular imaging and targeting of cancer cells.
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