Review
Biotechnology & Applied Microbiology
Fei Fan, Sanjoy Saha, Donny Hanjaya-Putra
Summary: Hydrogels play a crucial role in wound healing by supporting a hydrated environment and promoting better healing outcomes through the incorporation of biomolecules and supporting cells. Various types of hydrogels have been developed and modified to match different stages of wound healing, with challenges related to adoption and future perspectives discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Jueying Chen, Jiahui He, Yutong Yang, Lipeng Qiao, Juan Hu, Jie Zhang, Baolin Guo
Summary: The development of compressible, stretchable and self-healing hydrogel dressings with good adhesive, antibacterial and angiogenesis properties is needed to promote the regeneration of diabetic wounds in clinical applications.
ACTA BIOMATERIALIA
(2022)
Article
Biotechnology & Applied Microbiology
Anu K. Solanki, Helene Autefage, Antonio R. Rodriguez, Shweta Agarwal, Joaquin Penide, Muzamir Mahat, Thomas Whittaker, Amy Nommeots-Nomm, Elena Littmann, David J. Payne, Anthony D. Metcalfe, Felix Quintero, Juan Pou, Molly M. Stevens, Julian R. Jones
Summary: In this study, novel glass fibers were developed to improve chronic wound healing by activating the HIF pathway. The results showed that the glass fibers released therapeutic ions, including cobalt, which greatly promoted the expression of angiogenic genes. This suggests the potential use of these fibers in chronic wound dressings.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rong-Fu Chen, Keng-Fan Liu, Su-Shin Lee, Shu-Hung Huang, Yi-Chia Wu, Yun-Nan Lin, Chun-Ting Wang, Yur-Ren Kuo
Summary: The study revealed that FIR therapy could significantly accelerate diabetic wound healing, associated with suppressed inflammatory response, increased neovascularization, and tissue regeneration.
Article
Chemistry, Multidisciplinary
Wenfeng Li, Rui Qing, Haojie Zhang, Ziwei Wang, Yuhan Yuan, Lili Wang, Jia Deng, Bochu Wang, Shilei Hao
Summary: The study demonstrates the significant promise of trichocyte keratins in promoting wound healing, with distinct behaviors and advantages observed among different types. Transcriptomic analysis reveals the regulatory mechanisms of keratins in cell proliferation, migration, and blood vessel generation. These findings can contribute to the development and precision application of keratins.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Hamed Nosrati, Reza Aramideh Khouy, Ali Nosrati, Mohammad Khodaei, Mehdi Banitalebi-Dehkordi, Korosh Ashrafi-Dehkordi, Samira Sanami, Zohreh Alizadeh
Summary: The skin serves as the body's primary barrier against external pathogens and maintaining homeostasis. Damage to the skin can have significant impacts on health and quality of life. Tissue engineering aims to enhance tissue regeneration, with improving angiogenesis being one of the most effective treatments for skin tissue regeneration.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Endocrinology & Metabolism
Tangtang He, Pengfei Sun, Bo Liu, Shiwei Wan, Penghua Fang, Jun Chen, Guicheng Huang, Wen Min
Summary: The study found that puffball spores can accelerate diabetic wound healing by activating the Akt/Nrf2 signaling pathway, promoting the expression of antioxidant genes, and enhancing angiogenesis and collagen deposition. This provides a theoretical basis for the treatment of diabetic and refractory wounds.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Engineering, Biomedical
Que Bai, Caiyun Zheng, Na Sun, Wenting Chen, Qian Gao, Jinxi Liu, Fangfang Hu, Tong Zhou, Yanni Zhang, Tingli Lu
Summary: This study presents an oxygen-releasing hydrogel that promotes cell survival, migration, and tube formation under hypoxic conditions, and facilitates tissue repair by reducing inflammation, increasing angiogenesis, and collagen deposition.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Yongxin Guo, Guodong Chu, Weijia Cai, Yaying Li, Xinxin Lan, Jing Li, Linna Du, Jing Yang
Summary: In this study, human fibroblast growth factor 1 was successfully fused with oleosomes, and the beneficial effects of the fusion product on wound healing were explored. The results showed improvements in angiogenesis, vascular integrity, collagen, and inflammation in rat models with skin defects. In vivo and in vitro experiments clarified the positive role of the fusion product in promoting angiogenesis and provided insights into its potential mechanisms. These findings suggest that the fusion product has promising prospects for developing drugs for wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Li Li, Zhiyu Wang, Kepeng Wang, Siyuan Fu, Dan Li, Mao Wang, Yi Cao, Houjuan Zhu, Ziyan Li, Lixing Weng, Zhiyang Li, Xianguang Ding, Lianhui Wang
Summary: An efficient extracellular vesicle (EV) ink was developed to regulate the inflammatory microenvironment and promote vascular regeneration for wound healing. This bioactive EV ink, called PAINT, utilizes bioactive EVs derived from M2 macrophages and sodium alginate precursor to form a biocompatible EV-Gel for application on wounds. The PAINT technology reprograms macrophage polarization and enhances angiogenesis, significantly accelerating cutaneous wound healing. It demonstrates the high potential of bioactive EV ink as a portable biomedical platform for healthcare when integrated with a 3D printing pen.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Yun-Lung Chung, Pei-Yu Chou, Ming-Jyh Sheu
Summary: This study evaluated the wound-healing activity of PEDOT: PSS and found that it significantly improved wound healing in SD rats. The treatment increased angiogenic behavior and VEGF expression, indicating its angiogenic effects. The results suggest that PEDOT: PSS can be potentially used as a dressing for medical use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Guiting Liu, Yuan Zhou, Zejun Xu, Ziting Bao, Li Zheng, Jun Wu
Summary: In this study, a novel sodium alginate/chitosan (SA/CS) Janus hydrogel dressing was fabricated to combine the functions of anti-infection and neovascularization at the wound site. The inner CS-ArgMS hydrogel released L-arginine and promoted vascular regeneration, while the outer SA-AgNP hydrogel prevented infection. The SA-AgNP/CS-ArgMS hydrogel showed excellent biocompatibility and demonstrated antibacterial and angiogenesis characteristics, leading to enhanced diabetic wound healing in vivo.
CHINESE CHEMICAL LETTERS
(2023)
Article
Engineering, Environmental
Zhixin Ling, Zhikun Chen, Jin Deng, Yifu Wang, Bo Yuan, Xiao Yang, Hai Lin, Jun Cao, Xiangdong Zhu, Xingdong Zhang
Summary: A self-healing hydrogel with angiogenic and antibacterial properties was developed for skin wound repair in this study. The hydrogel exhibited good mechanical properties and biocompatibility, accelerating wound healing and reducing scar formation.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Chi Yuan, Jian Liao, Liying Zheng, Lingzhi Ding, Xiao Teng, Xuesong Lin, Le Wang
Summary: This review examines the association between leptin and wound healing, speculating on the molecular mechanisms and the need for further research to understand its specific role in different phases of wound repair.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Fanxing Xu, Jingxian Wu, Yumei Hu, Chun Chu, Wenjun Liu, Xiang Li, Wen Zheng, Weishuo Yang, Boyan Zhao, Jiangxue Guo, Zhenzhong Wang, Ying Jia, Wei Xiao
Summary: This study aimed to evaluate the pro-healing effect of Tongsaimai (TSM) and its underlying mechanisms using experimental validation and network pharmacology analysis. The results showed that TSM enhanced wound contraction, epithelial cell proliferation, collagen deposition, and had antioxidant and anti-inflammatory effects. The network pharmacology analysis revealed the involvement of multiple pathways in TSM's pharmacological actions on wound healing, including VEGF, PI3K/Akt, and MAPK pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lauren A. Biwer, Henry R. Askew-Page, Kwangseok Hong, Jenna Milstein, Scott R. Johnstone, Edgar Macal, Miranda E. Good, Pooneh Bagher, Swapnil K. Sonkusare, Brant E. Isakson
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Abigail Wolpe, Matteo Ottolini, Mabruka Alfaidi, Scott Johnstone, Henry Askew-Page, Kevin Barr, Frank Beier, A. Orr, Stephanie Redemann, Silvia Penuela, Swapnil Sonkusare, Brant Isakson
Meeting Abstract
Biochemistry & Molecular Biology
Matteo Ottolini, Kwangseok Hong, Eric Cope, Zdravka Daneva, Scott Johnstone, Brant Isakson, Swapnil Sonkusare
Article
Immunology
Yang Yang, Leon J. Delalio, Angela K. Best, Edgar Macal, Jenna Milstein, Iona Donnelly, Ashley M. Miller, Martin McBride, Xiaohong Shu, Michael Koval, Brant E. Isakson, Scott R. Johnstone
JOURNAL OF IMMUNOLOGY
(2020)
Article
Urology & Nephrology
Leon J. DeLalio, Ester Masati, Suresh Mendu, Claire A. Ruddiman, Yang Yang, Scott R. Johnstone, Jenna A. Milstein, Tc Stevenson Keller, Rachel B. Weaver, Nick A. Guagliardo, Angela K. Best, Kodi S. Ravichandran, Douglas A. Bayliss, Maria Luisa S. Sequeira-Lopez, Swapnil N. Sonkusare, Xiaohong H. Shu, Bimal Desai, Paula Q. Barrett, Thu H. Le, R. Ariel Gomez, Brant E. Isakson
KIDNEY INTERNATIONAL
(2020)
Article
Physiology
Leigh Anne Swayne, Scott R. Johnstone, Chen Seng Ng, Juan C. Sanchez-Arias, Miranda E. Good, Silvia Penuela, Alexander W. Lohman, Abigail G. Wolpe, Victor E. Laubach, Michael Koval, Brant E. Isakson
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2020)
Letter
Cardiac & Cardiovascular Systems
Miranda E. Good, Alexander P. Young, Abigail G. Wolpe, Manxiu Ma, Philip J. Hall, Colleen K. Duffy, Mark J. Aronovitz, Gregory L. Martin, Robert M. Blanton, Norbert Leitinger, Scott R. Johnstone, Matthew J. Wolf, Brant E. Isakson
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Daniela Maier-Begandt, Heather Skye Comstra, Samuel A. Molina, Nenja Krueger, Claire A. Ruddiman, Yen-Lin Chen, Xiaobin Chen, Lauren A. Biwer, Scott R. Johnstone, Alexander W. Lohman, Miranda E. Good, Leon J. DeLalio, Kwangseok Hong, Hannah M. Bacon, Zhen Yan, Swapnil K. Sonkusare, Michael Koval, Brant E. Isakson
Summary: The study found that the proinflammatory cytokine TNF alpha specifically decreased barrier function in venous endothelium but not arterial endothelium, which was attributed to the differential expression of CLDN11. TNF alpha also increased the permselectivity of Cl- over Na+ in venous endothelium but not in arterial endothelium, indicating vein-specific effects.
Review
Biochemistry & Molecular Biology
D. Ryan King, Meghan W. Sedovy, Xinyan Leng, Jianxiang Xue, Samy Lamouille, Michael Koval, Brant E. Isakson, Scott R. Johnstone
Summary: Gap junctions (GJ) and connexins are crucial in cellular physiology and have been investigated for their potential therapeutic applications in various diseases. Modulating GJ signaling pathways and designing peptides have shown promise as attractive targets for therapeutic intervention. However, the overall mechanisms of action of connexin targeting peptides are still not fully understood despite years of research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Abigail G. Wolpe, Melissa A. Luse, Scott R. Johnstone, Jianxiang Xue, Vikram Sabapathy, Brent Wakefield, Rahul Sharma, Kevin Barr, Frank Beier, Dale Laird, Stefanie Redemann, Linda Columbus, Silvia Penuela, Brant E. Isakson
Review
Physiology
Meghan W. Sedovy, Xinyan Leng, Melissa R. Leaf, Farwah Iqbal, Laura Beth Payne, John C. Chappell, Scott R. Johnstone
Summary: Connexin 43 (Cx43) plays a vital role in vascular function by enabling communication between vascular cells and influencing cell signaling and vasomotor activity. It is expressed in various vascular cell types and its expression and function differ depending on vessel size and location. Alterations in Cx43 expression, localization, and post-translational modification have been observed in vascular diseases such as atherosclerosis, hypertension, and diabetes.
JOURNAL OF VASCULAR RESEARCH
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Xiaobo Wu, David King, Gregory Hoeker, Scott R. Johnstone, Robert G. Gourdie, Seth Weinberg, Steven Poelzing
CIRCULATION RESEARCH
(2022)
Meeting Abstract
Hematology
Louisa Mezache, Andrew Soltisz, Scott R. Johnstone, Brant Isakson, Rengasayee Veeraraghavan
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Meeting Abstract
Dermatology
Harry Scott, Li Dong, Sharmila Srinivasan, Andrew Stevenson, Alasdair MacDonald, Paola Massimi, Lawrence Banks, Malcolm Hodgins, Patricia Martin, Scott Johnstone, Sheila Graham
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Meeting Abstract
Biophysics
Louisa Mezache, Andrew M. Soltisz, Scott R. Johnstone, Brant Isakson, Rengasayee Veeraraghavan
BIOPHYSICAL JOURNAL
(2022)