Article
Radiology, Nuclear Medicine & Medical Imaging
Noam Barda, Noa Dagan, Amos Stemmer, Janni Yuval, Eitan Bachmat, Eldad Elnekave, Ran Balicer
Summary: This study demonstrates that using machine learning algorithms to extract coronary artery calcium scores from existing CT images can improve the performance of cardiovascular disease (CVD) prediction models, providing assistance in CVD risk assessment while avoiding additional radiation exposure.
JOURNAL OF DIGITAL IMAGING
(2022)
Review
Cardiac & Cardiovascular Systems
Keishi Ichikawa, Shriraj Susarla, Matthew J. Budoff
Summary: Although the overall incidence of atherosclerotic cardiovascular disease (ASCVD) is declining in the United States, the incidence of ASCVD events in young adults is increasing. The use of coronary artery calcium (CAC) scores can improve ASCVD risk assessment, but is not recommended for universal screening in young adults.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Omar Dzaye, Alexander C. Razavi, Zeina A. Dardari, Daniel S. Berman, Matthew J. Budoff, Michael D. Miedema, Olufunmilayo H. Obisesan, Ellen Boakye, Khurram Nasir, Alan Rozanski, John A. Rumberger, Leslee J. Shaw, Martin Bodtker Mortensen, Seamus P. Whelton, Michael J. Blaha
Summary: This study found that mean and peak calcium density may describe plaque composition differently in the early stages of atherosclerosis, and mean calcium density performs better than peak calcium density factor for predicting ASCVD mortality among individuals with Agatston CAC 1-99.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Daan Ties, Yldau M. van der Ende, Gabija Pundziute, Yvonne T. van der Schouw, Michiel L. Bots, Congying Xia, Peter M. A. van Ooijen, Gert Jan Pelgrim, Rozemarijn Vliegenthart, Pim van der Harst
Summary: Evaluated the ability of different pre-screening methods to identify individuals with high coronary artery calcium score in the general population. Found that pre-screening based on at least one coronary artery disease risk factor can better identify individuals with high coronary artery calcium score and may improve coronary artery disease prevention.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Simon Winther, Samuel E. Schmidt, Borek Foldyna, Thomas Mayrhofer, Laust D. Rasmussen, Jonathan N. Dahl, Udo Hoffmann, Pamela S. Douglas, Juhani Knuuti, Morten Bottcher
Summary: The risk factor-weighted clinical likelihood (RF-CL) model and the coronary artery calcium score-weighted clinical likelihood (CACS-CL) model improve the identification of obstructive coronary artery disease (CAD) compared with basic pretest probability (PTP) models. These new models provide improved risk stratification for myocardial infarction and death.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Anurag Mehta, Nestor Vasquez, Colby R. Ayers, Jaideep Patel, Ananya Hooda, Amit Khera, Roger S. Blumenthal, Michael D. Shapiro, Carlos J. Rodriguez, Michael Y. Tsai, Laurence S. Sperling, Salim S. Virani, Michael J. Blaha, Parag H. Joshi
Summary: Elevated lipoprotein(a) and coronary artery calcium are independently associated with ASCVD risk, and may be concurrently useful in guiding primary prevention therapy decisions, as demonstrated in the MESA and DHS cohorts.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Health Care Sciences & Services
David Eng, Christopher Chute, Nishith Khandwala, Pranav Rajpurkar, Jin Long, Sam Shleifer, Mohamed H. Khalaf, Alexander T. Sandhu, Fatima Rodriguez, David J. Maron, Saeed Seyyedi, Daniele Marin, Ilana Golub, Matthew Budoff, Felipe Kitamura, Marcelo Straus Takahashi, Ross W. Filice, Rajesh Shah, John Mongan, Kimberly Kallianos, Curtis P. Langlotz, Matthew P. Lungren, Andrew Y. Ng, Bhavik N. Patel
Summary: Coronary artery disease (CAD) is the most common cause of mortality in the United States, and coronary artery calcium (CAC) scoring is an important non-invasive tool for assessing heart disease risk. Despite limitations in current clinical practice implementation for CAC scoring, the introduction of automated CAC scoring models may allow for more patients to undergo screening, potentially enabling early preventive interventions.
NPJ DIGITAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Michael J. Blaha, Seamus P. Whelton, Mahmoud Al Rifai, Zeina Dardari, Leslee J. Shaw, Mouaz H. Al-Mallah, Kunihiro Matsushita, Alan Rozanski, John A. Rumberger, Daniel S. Berman, Matthew J. Budoff, Michael D. Miedema, Khurram Nasir, Miguel Cainzos-Achirica
Summary: This study compared the risk discrimination for predicting CHD and CVD deaths between the Pooled Cohort Equations (PCE), the MESA Risk Score (with and without CAC), and the addition of CAC to the PCE. The results showed that adding CAC to the PCE improved risk discrimination, and the MESA Risk Score with CAC, as well as the PCE plus CAC, performed best among patients with 5% to 20% estimated risk. Additionally, CAC also modestly improved discrimination in low- and high-risk groups.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Hematology
Jing-Wei Gao, Si You, Zhao-Yu Liu, Qing-Yun Hao, Jing-Feng Wang, Dominique A. Vuitton, Shao-Ling Zhang, Pin-Ming Liu
Summary: The study found that metabolically healthy obesity (MHO) is associated with an increased risk of coronary artery calcium (CAC) progression and subsequent cardiovascular disease events. However, MHO individuals have a lower risk of cardiovascular disease compared to metabolically healthy individuals with normal weight.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Abdul Rahman Ihdayhid, Nick S. R. Lan, Michelle Williams, David Newby, Julien Flack, Simon Kwok, Jack Joyner, Sahil Gera, Lawrence Dembo, Brendan Adler, Brian Ko, Benjamin J. W. Chow, Girish Dwivedi
Summary: This study developed and evaluated a fully automated model for identifying and quantifying coronary artery calcium (CAC). The model showed high accuracy and low analysis times, indicating its potential to optimize clinical workflow efficiency and improve patient outcomes.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ashlee Jeffries, Benedict Costello, Wendy Corkill, Seeba Varghese, Hussam Tayeb, Celine Gallagher, Nicholas Clarke, Samuel J. Tu, Bradley M. Pitman, Nicole Hanna-Rivero, Donald D. Chang, Nimisha Manek, Nadarajah Kangaharan, Christopher X. Wong
Summary: The study included patients undergoing CTCA in Central Australia from 2013 to 2017, revealing higher MACE incidence rates in patients with coronary calcification and obstructive CAD. These factors were associated with increased risk of MACE.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Paul T. Jurgens, John J. Carr, James G. Terry, Jamal S. Rana, David R. Jacobs, Daniel A. Duprez
Summary: This study investigated the predictive value of abdominal aorta calcium (AAC) relative to coronary artery calcium (CAC) for cardiovascular disease (CVD) and coronary heart disease (CHD) events in Black and White early middle-aged participants. The results showed that AAC and CAC had similar predictive effects on CVD, with only CAC being able to predict CHD. Additionally, AAC was able to predict incident CVD when CAC was 0.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Endocrinology & Metabolism
Teodor Duro, Molly McClain, Kelsea Gallegos Aragon, Christina Casson, Eun Ho Eunice Choi, Matthew Bouchonville, Patricia Kapsner
Summary: The study evaluates cardiovascular risk factors and prevalent coronary artery disease (CAD) using Coronary Artery Calcium (CAC) scoring in transgender and gender-diverse (TGD) individuals receiving gender-affirming hormone therapy (GAHT) and compares the CAC scores of TGD individuals with those of the general population. The presence of CAC in TGD individuals on GAHT is similar to that in the cisgender age-matched population. CAC scoring is a means to assess the prevalence of CAD in TGD individuals and identify those in whom aggressive risk reduction is indicated.
ENDOCRINE PRACTICE
(2023)
Review
Medicine, General & Internal
David S. Schade, Martin Hickey, Philip Eaton
Summary: Coronary artery calcium scanning is a test used to assess the risk of cardiovascular disease by measuring the calcium deposition in the coronary arteries. The score obtained from the test helps determine the likelihood of future cardiovascular events. Higher scores indicate higher risks and warrant aggressive treatment.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marta Marcos-Mangas, Ana Revilla-Orodea, Teresa Sevilla, Esther Gonzalez-Bartol, Israel Sanchez-Lite, Noelia Uruena-Martinez, Roman Arnold, Itziar Gomez, J. Alberto San Roman
Summary: Coronary artery calcification is associated with cardiovascular events in patients with chest pain, while aortic valve calcification is not.
EUROPEAN RADIOLOGY
(2023)
Meeting Abstract
Peripheral Vascular Disease
T. Bayrak, A. Deniz, L. Tokgozoglu, B. Yavuz, E. Demirpence, A. Bayrak, K. Kilinc, B. Salanci, M. Alikasifoglu, E. Tuncbilek
ATHEROSCLEROSIS SUPPLEMENTS
(2008)
Article
Peripheral Vascular Disease
Ahmet Bayrak, Tulin Bayrak, S. Lale Tokgozoglu, Bilge Volkan-Salanci, Ali Deniz, Bunyamin Yavuz, Mehmet Alikasifoglu, Ediz Demirpence
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2012)
Article
Biochemical Research Methods
Tuelin Bayrak, Ahmet Bayrak, Ediz Demirpence, Kamer Kilinc
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2010)
Article
Biochemical Research Methods
Ahmet Bayrak, Tulin Bayrak, Ediz Demirpence, Kamer Kilinc
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2011)
Article
Biochemistry & Molecular Biology
Tulin Bayrak, Ahmet Bayrak, Bilge Volkan-Salanci, Ali Deniz, S. Lale Tokgozoglu, Bunyamin Yavuz, Mehmet Alikasifoglu, Ediz Demirpence
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2012)
Meeting Abstract
Biochemistry & Molecular Biology
A. Bayrak, T. Bayrak, E. Demirpence, K. Kilinc
Meeting Abstract
Biochemistry & Molecular Biology
T. Bayrak, A. Bayrak, E. Demirpence, K. Kilinc
Meeting Abstract
Biochemistry & Molecular Biology
F. Akbiyik, T. Bayrak, S. Cevik, A. L. Dogan, E. Demirpence
Article
Surgery
Cuneyt Koksoy, Erpulat Ozis, Atil Cakmak, Ugur Yazgan, Aylin Okcu-Heper, Aslihan Koksoy, Ediz Demirpence, U. Deniz Dincer
JOURNAL OF VASCULAR SURGERY
(2007)
Article
Biochemistry & Molecular Biology
Hani Alotaibi, Ellf Cankaya Yaman, Ediz Demirpence, Uygar H. Tazebay
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2006)
Meeting Abstract
Biochemistry & Molecular Biology
F Akbiyik, DM Ray, E Demirpence, H Bozkaya, RP Phipps
PROSTAGLANDINS & OTHER LIPID MEDIATORS
(2006)
Article
Biochemistry & Molecular Biology
Filiz Akbiyik, Sevgi Cevik, Tuelin Bayrak, A. Lale Dogan, Ahmet Bayrak, Ediz Demirpence
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2010)
Meeting Abstract
Biochemistry & Molecular Biology
E. Yaman Cankaya, H. Alotaibi, E. Demirpence, U. H. Tazebay
Meeting Abstract
Biochemistry & Molecular Biology
O. Duzguncmar, E. Demirpence