期刊
APPETITE
卷 59, 期 1, 页码 27-33出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.appet.2012.03.007
关键词
D-3 receptor; Dopamine; Obesity; Food images; Reward circuitry; Obesity
资金
- Wellcome Trust [095692, 093270] Funding Source: Medline
The dopamine D-3 receptor is thought to be a potential target for treating compulsive disorders such as drug addiction and obesity. Here, we used functional Magnetic Resonance Imaging (fMRI) to investigate the effects the selective dopamine D-3 receptor antagonist GSK598809 on brain activation to food images in a sample of overweight and obese binge-eating subjects. Consistent with previous studies, processing of food images was associated with activation of a network of reward areas including the amygdala, striatum and insula. However, brain activation to food images was not modulated by GSK598809. The results demonstrate that D-3 receptor manipulation does not modulate brain responses to food images in overweight and obese subjects. (C) 2012 Elsevier Ltd. All rights reserved.
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