期刊
ACTA BIOMATERIALIA
卷 10, 期 7, 页码 2996-3006出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2014.01.006
关键词
Cardiac tissue engineering; In vivo functional evaluation; Electrospinning; Plasma polymerization; Echocardiography: cell therapy
资金
- SNF [122334]
- Inselspital, Bern
Cardiac tissue engineering approaches can deliver large numbers of cells to the damaged myocardium and have thus increasingly been considered as a possible curative treatment to counteract the high prevalence of progressive heart failure after myocardial infarction (MI). Optimal scaffold architecture and mechanical and chemical properties, as well as immune- and bio-compatibility, need to be addressed. We demonstrated that radio-frequency plasma surface functionalized electrospun poly (epsilon-caprolactone) (PCL) fibres provide a suitable matrix for bone-marrow-derived mesenchymal stem cell (MSC) cardiac implantation. Using a rat model of chronic MI, we showed that MSC-seeded plasma-coated PCL grafts stabilized cardiac function and attenuated dilatation. Significant relative decreases of 13% of the ejection fraction (EF) and 15% of the fractional shortening (FS) were observed in sham treated animals; respective decreases of 20% and 25% were measured 4 weeks after acellular patch implantation, whereas a steadied function was observed 4 weeks after MSC-patch implantation (relative decreases of 6% for both EF and FS). (C) 2014 Published by Elsevier Ltd. on behalf of Acts Materialia Inc.
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