Article
Oncology
Mi Shen, Yuhan Chen, Wei Tang, Mengru Ming, Yingchao Tian, Fei Ding, Han Wu, Yuhua Ji
Summary: Schwann cells (SCs) are crucial for peripheral nerve (PN) regeneration. This study reveals that Sema3E promotes the proliferation and migration of SCs, involving the receptors PlexinD1, Neuropilin 1 (Nrp1), and Vascular Endothelial Growth Factor Receptor 2 (VEGFR2).
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Optics
Rui Li, Xinran Wei, Yuzhang Liang, Huixuan Gao, Svetlana Kurilkina, Wei Peng
Summary: The electrical regulation of plasmonic Au nanodisk (AuND) arrays integrated with conductive polymers (PPy, PANI, and PEDOT) is systematically investigated in this work. By altering the complex dielectric function of the polymer coatings based on electrically controlled redox reaction, the reflection spectrum and structural color of the hybrid AuND arrays are dynamically modulated. Different polymers exhibit distinct refractive index responses to external voltage, resulting in different spectral variations, response time, and cycle stability for the polymer-coated AuND arrays.
Article
Biochemistry & Molecular Biology
Stefanie Gaertner, Angelina Graf, Carla Triunfo, Davide Laurenzi, Stefan M. Schupp, Gabriele Maoloni, Giuseppe Falini, Helmut Coelfen
Summary: This study successfully synthesized a polypyrrole/CaCO3 composite material using waste seashell powder as a template, improving the electrical conductivity of polymers. The transformation of waste seashells into sustainable, electronically conductive materials and their potential application as an antistatic agent in polymers is demonstrated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Cong Yao, Zhennan Qiu, Xiao Li, Hui Zhu, Dichen Li, Jiankang He
Summary: Electrohydrodynamic (EHD) printing is used to fabricate microfibrous architectures for cellular orientation, but orderly deposition of microfibers with cell-scale spacing is challenging. A finite element method is established to analyze the electrostatic forces induced on the EHD-printed microfibers, and it is found that uniform fiber arrangement can be achieved when the fiber spacing is five times larger than the fiber diameter. Decreasing the fiber spacing improves neurite outgrowth length and Schwann cell migration.
Article
Biochemistry & Molecular Biology
Hua Xu, Ai-Ling Yu, Da-Peng Zhao, Guang-Yuan Meng, Ling Wang, Min Shan, Nai-Xia Hu, Yun-Lin Liu
Summary: Ursolic acid can inhibit the differentiation of Th17 cells by suppressing the STAT3/ROR gamma t pathway and inhibit Th17 cell migration by down-regulating CXCL9/10 expression in SCs.
Article
Engineering, Chemical
Xian-ying Shi, Meng-hang Gao, Wen-wen Hu, Dan Luo, Shao-zhong Hu, Ting Huang, Nan Zhang, Yong Wang
Summary: In this study, MXene/PPy composite particles were prepared, and it was found that the introduction of PPy nanoparticles can enhance the adsorption capacity and stability of MXene, showing promising potential applications in wastewater treatment.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sina Ibne Noor, Marcus Hoffmann, Natalie Rinis, Markus F. Bartels, Patrick R. Winterhalter, Christina Hoelscher, Rene Hennig, Nastassja Himmelreich, Christian Thiel, Thomas Ruppert, Erdmann Rapp, Sabine Strahl
Summary: This study highlights the molecular changes in cell-cell adhesion caused by POMGNT1 deficiency, revealing an increased abundance of N-cadherin and site-specific changes in N-glycan structures. Furthermore, POMGNT1-deficient cells activate ERK1/2 and p38 signaling pathways and trigger transcriptional changes comparable to epithelial-mesenchymal transition (EMT), suggesting a potential molecular mechanism underlying the observed phenotype. The impact of changes in O-mannosylation on N-glycosylation may contribute to the complex clinical symptoms of MEB or alpha-dystroglycanopathy.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Neurosciences
Venkat Krishnan Sundaram, Tatiana El Jalkh, Rasha Barakat, Camille Julie Isabelle Fernandez, Charbel Massaad, Julien Grenier
Summary: Embryonic Dissociated Dorsal Root Ganglia (DRG) cultures are commonly used to study the role of novel molecular pathways or drugs in Schwann cell development and myelination. This study found that the transition from SCP to iSC occurs between the 5th and 7th day in culture, and immature Schwann cells can differentiate into myelinating Schwann cells as early as 4 days post the induction of myelination in cocultures. Furthermore, coculture-derived Schwann cell monocultures exhibit similar myelinating potential to cultures established from neonatal sciatic nerves, providing valuable insight for future studies on Schwann cell development and myelination.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jordan L. Kohlmeyer, Courtney A. Kaemmer, Shaikamjad Umesalma, Francoise A. Gourronc, Aloysius J. Klingelhutz, Dawn E. Quelle
Summary: Schwann cells' abnormal proliferation and transformation can lead to benign neurofibromas and deadly malignant peripheral nerve sheath tumors, with RABL6A potentially promoting this process by inhibiting RB1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Koji Nagahama, Seika Aoyama, Natsumi Ueda, Yuka Kimura, Tokitaka Katayama, Kimika Ono
Summary: This study introduces an approach inspired by biological tissues, where azide-modified living cells are covalently cross-linked with alkyne-modified alginate polymers via bioorthogonal reactions to create self-healing hydrogels. The unique self-healing capabilities of these hydrogels come from cadherin-mediated adhesion between cells within the gel. This research showcases the incorporation of living components into synthetic materials to enhance self-healing properties.
Article
Chemistry, Physical
Kolade Adebowale, Ze Gong, Jay C. Hou, Katrina M. Wisdom, Damien Garbett, Hong-pyo Lee, Sungmin Nam, Tobias Meyer, David J. Odde, Vivek B. Shenoy, Ovijit Chaudhuri
Summary: The study highlights the significance of substrate stress relaxation in cell migration on soft substrates. Cells migrate robustly on 2kPa substrates with fast stress relaxation, exhibiting a rounded morphology, filopodia protrusions, and weak adhesions.
Article
Biochemistry & Molecular Biology
Yaxian Wang, Fuchao Zhang, Yunsong Zhang, Qi Shan, Wei Liu, Fengyuan Zhang, Feiyu Zhang, Sheng Yi
Summary: Research findings indicate that Btc plays essential roles in regulating Schwann cell migration and axon elongation, suggesting the potential application of Btc as a regenerative strategy for treating peripheral nerve injury.
MOLECULAR MEDICINE
(2021)
Article
Materials Science, Paper & Wood
Nattinee Krathumkhet, Toyoko Imae, Nophawan Paradee
Summary: This study focused on electrically controlled transdermal drug delivery using pectin/bacteria cellulose hydrogel composites. The research showed that drug release was optimized at 30 wt% bacteria cellulose content, and could be increased to 78% under applied electrical potential. The hydrogel composites also exhibited remarkable antibacterial activity, making them valuable alternative materials for transdermal drug delivery.
Article
Neurosciences
Min You, Haizhu Xing, Ming Yan, Jie Zhang, Jiayi Chen, Yang Chen, Xiaoli Liu, Jing Zhu
Summary: Paclitaxel-induced peripheral neuropathy (PIPN) is a neurological disorder caused by paclitaxel (PTX) treatment in cancer patients. Schwann cell-derived exosomes (SC-EXOs) have been found to effectively improve PIPN both in vitro and in vivo. SC-EXOs alleviate PTX-induced mechanical nociceptive sensitization, ameliorate nerve fiber loss and DRG injury, and protect damaged neurons by upregulating miR-21 to repress the PTEN signaling pathway. These findings provide a novel strategy for the treatment of PIPN.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hongxu Liang, Xinkun Zhao, Ning Li, Hongwei Zhang, Zengchao Geng, Diao She
Summary: This study transformed industrial lignin into a lignin-based polyporous carbon@polypyrrole (LPC@PPy) using a hydrothermal-activation-in situ polymerization strategy for removal of reactive blue 19. The adsorption capacity of LPC@PPy for reactive blue 19 is significantly higher compared to LPC and LC, due to the even distribution of oxygen and nitrogen groups in the 3D pore structure. LPC@PPy maintained a high adsorption capacity even after 8 cycles and N and O groups, such as pyridinic-N, C-OH, -COOR, -C-O-, and C--C, played important roles in the adsorption process.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Nikunj K. Agrawal, Peter Allen, Young Hye Song, Rebecca A. Wachs, Yan Du, Andrew D. Ellington, Christine E. Schmidt
ACTA BIOMATERIALIA
(2020)
Article
Engineering, Biomedical
Benjamin S. Spearman, Nikunj K. Agrawal, Andres Rubiano, Chelsey S. Simmons, Sahba Mobini, Christine E. Schmidt
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2020)
Article
Engineering, Biomedical
Sahba Mobini, Cary A. Kuliasha, Zachary A. Siders, Nicole A. Bohmann, Syed-Mustafa Jamal, Jack W. Judy, Christine E. Schmidt, Anthony B. Brennan
Summary: The chronic reliability of bioelectronic neural interfaces has been challenged by foreign body reactions, but engineered microtopographies, such as Sharklet (TM), have shown potential in manipulating cellular responses to the implanted device. While surface patterning is a strong physical tool for modulating cell behavior, responses to micropatterns are highly dependent on the cell type, with Schwann cells found to be more metabolically active and aligned than fibroblasts when compared between the same pattern.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Polymer Science
Mark D. Ashton, Isabel C. Appen, Melike Firlak, Naomi E. Stanhope, Christine E. Schmidt, William R. Eisenstadt, Byul Hur, John G. Hardy
Summary: The development of stimuli-responsive drug delivery systems provides significant opportunities for industrial innovation, enabling spatiotemporal control of drug release. The wireless controller device has the potential to revolutionize the field of biomaterial design and application.
POLYMER INTERNATIONAL
(2021)
Review
Engineering, Biomedical
Mary Kasper, Curt Deister, Florence Beck, Christine E. Schmidt
ADVANCED HEALTHCARE MATERIALS
(2020)
Article
Cardiac & Cardiovascular Systems
Deanna Bousalis, Christopher S. Lacko, Nora Hlavac, Fariz Alkassis, Rebecca A. Wachs, Sahba Mobini, Christine E. Schmidt, Hideko Kasahara
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2020)
Article
Materials Science, Biomaterials
Tran B. Ngo, Benjamin S. Spearman, Nora Hlavac, Christine E. Schmidt
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Review
Engineering, Biomedical
Eleana Manousiouthakis, Junggeon Park, John G. Hardy, Jae Young Lee, Christine E. Schmidt
Summary: This review explores the applications of conductive and electroactive materials in neural tissue regeneration, which is of significant interest to a broad readership and particularly relevant to scientists, engineers, and clinicians in academia and industry who develop innovative medical devices for tissue engineering and regenerative medicine.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Nora Hlavac, Dillon T. Seroski, Nikunj K. Agrawal, Leilani Astrab, Renjie Liu, Gregory A. Hudalla, Christine E. Schmidt
Summary: The study explored the functional and in vitro application of engineered ChABC fused to galectin-3, demonstrating extended release time and enhanced enzymatic activity compared to wild type ChABC when incorporated in hydrogels. These stabilized ChABC-Gal3 oligomers combined with HA-based scaffolds show promising potential for neural regeneration applications.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Nora Hlavac, Deanna Bousalis, Raffae N. Ahmad, Emily Pallack, Angelique Vela, Yuan Li, Sahba Mobini, Erin Patrick, Christine E. Schmidt
Summary: This study investigated the impact of low-level electrical stimulation on the regenerative potential of adipose-derived stem cells, revealing that frequency and duration significantly affect the expression of growth factors. Continuous exposure to 1 Hz pulses for 24 hours was found to optimally promote the expression of neural growth factors and induce significant increase in neurite extension.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Mary Kasper, Bret Ellenbogen, Ryan Hardy, Madison Cydis, Jorge Mojica-Santiago, Abdullah Afridi, Benjamin S. Spearman, Ishita Singh, Cary A. Kuliasha, Eric Atkinson, Kevin J. Otto, Jack W. Judy, Carlos Rinaldi-Ramos, Christine E. Schmidt
Summary: The magnetically aligned regenerative tissue-engineered electronic nerve interface (MARTEENI) combines polyimide threads encapsulated within a magnetically aligned hydrogel scaffold to address concerns over traditional peripheral nerve interfaces. The technology promotes nerve regeneration and increased axon densities, while also attenuating foreign-body responses. Experimental results demonstrate the potential of MARTEENI devices in promoting nerve regeneration and improving nerve interface selectivity.
Article
Engineering, Biomedical
Deanna Bousalis, Michaela W. McCrary, Natalie Vaughn, Nora Hlavac, Ashley Evering, Shruti Kolli, Young Hye Song, Cameron Morley, Thomas Angelini, Christine E. Schmidt
Summary: Damage to the nervous system can lead to severe consequences, but utilizing biomaterial strategies can promote neural regeneration and functional recovery. Injectable hydrogels offer flexibility and growth-permissive properties for neural cells, making them a promising approach for neural tissue engineering.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Cell Biology
Shelby Giza, Jorge A. Mojica-Santiago, Maddalena Parafati, Legrand K. Malany, Don Platt, Christine E. Schmidt, Paul M. Coen, Siobhan Malany
Summary: Microphysiological systems (MPS) incorporating 3D skeletal myobundles are used to study new medical treatments for sarcopenia. In this study, myobundles derived from young, active individuals showed better response to electrical stimulation and increased hypertrophic potential compared to myobundles derived from older sedentary individuals. This research provides a disease model and experimental platform for studying the effects of electrical stimulation on muscle aging and evaluating the efficacy and toxicity of new drugs for sarcopenia.
Article
Materials Science, Biomaterials
Young Hye Song, Mark A. Maynes, Nora Hlavac, Daniel Visosevic, Kaitlyn O. Daramola, Stacy L. Porvasnik, Christine E. Schmidt
Summary: The article introduces a method for decellularizing lung tissue using apoptosis, which can be widely utilized in both regenerative medicine and disease modeling.
BIOMATERIALS SCIENCE
(2021)
Review
Materials Science, Multidisciplinary
N. Hlavac, M. Kasper, C. E. Schmidt
MATERIALS TODAY ADVANCES
(2020)
