Article
Materials Science, Multidisciplinary
Tao Gao, Junwei Zhang, Nihui Zhang, Yao Wang, Jing He, Fang Wu
Summary: The study focused on incorporating Sr ions into porous titanium alloy with the assistance of dopamine to improve stability and stimulating effects. Results showed that dopamine-assisted incorporation of Sr ions could promote early apatite formation, enhance cell adhesion and mineralization, potentially significantly improving osseointegration of implants.
Article
Metallurgy & Metallurgical Engineering
Lara Moreno, Marta Mohedano, Raul Arrabal, Endzhe Matykina
Summary: PEO coatings were developed on MgZnxCay alloys for biomedical applications using different treatment times and a novel transparent electrolyte containing Ca, P, Si and F. The study found that Zn-rich intermetallics favor the formation of large voids in the coatings, and Ca, P, F, and Si are successfully incorporated into the coatings. The coatings consist of crystalline phases and amorphous material. Corrosion of the bare substrates can be accelerated by amino acids and organic components in the α-MEM solution, but they have no significant influence on the corrosion resistance of coated specimens. Furthermore, Zn-rich intermetallic particles in the undercoating crevice induce a more aggressive corrosive environment and enhanced micro-galvanic couple effect, leading to faster degradation of the coated alloys.
JOURNAL OF MAGNESIUM AND ALLOYS
(2022)
Article
Polymer Science
Qiuye Zhang, Jingjing Wang, Luen Xu, Shi-Yu Lu, Huawei Yang, Yifan Duan, Qiang Yang, Mengfan Qiu, Chunmei Chen, Sheng Zhao, Xiaohong Liu, Hui Liu
Summary: A polydopamine-based nanoplatform was developed for photothermal-enhanced chemodynamic therapy, where the nanoparticles could react with GSH to generate Cu+ and produce hydroxyl radicals through a Fenton-like reaction, showing potential for tumor treatment.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Materials Science, Coatings & Films
J. Alipal, T. C. Lee, P. Koshy, H. Z. Abdullah, M. I. Idris
Summary: Anodic oxidation of titanium in a Ca-P base electrolytic solution with different alteration agents resulted in coatings with varying characteristics, such as different morphology and bioactivity. The presence of functional ions like hydronium groups from sulphuric acid led to superior coating performance compared to carboxyl ions from acetic acid, with coatings altered by sulphuric acid showing super hydrophilicity and rough topographies ideal for cell attachment and proliferation in implant applications.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Taesik Eom, Junghyun Lee, Seunghyeon Lee, Busra Ozlu, Sunwoo Kim, David C. Martin, Bong Sup Shim
Summary: The article presents an electrochemical synthesis method for highly conductive PDA composites and demonstrates their advantages in terms of electrochemical performance and structural modulation. This unique PDA composite can be used to develop edible/implantable/biodegradable electrodes, biosensors, and neuromorphic electrochemical devices for future bioelectronic applications.
ACS APPLIED POLYMER MATERIALS
(2022)
Review
Orthopedics
Victor V. Rerikh, Vladimir D. Sinyavin
Summary: The study aims to determine the properties of modern bioactive composite materials most suitable for use in traumatology and orthopedics, particularly in spine surgery. A comprehensive literature search was conducted to evaluate the properties through a combination of materials and 3D bioprinting techniques.
TRAVMATOLOGIYA I ORTOPEDIYA ROSSII
(2021)
Review
Materials Science, Biomaterials
Mohsen Khodadadi Yazdi, Mehrak Zare, Ali Khodadadi, Farzad Seidi, S. Mohammad Sajadi, Payam Zarrintaj, Ahmad Arefi, Mohammad Reza Saeb, Masoud Mozafari
Summary: Designing biomaterials that mimic wound healing and skin regeneration has gained attention recently. Some biopolymers behave similarly to the extracellular matrix (ECM), supporting adhesion and cellular interactions. Polydopamine (PDA) is a natural bioadhesive and bioactive polymer with high chemical versatility, making it an exciting candidate for various biomedical applications. PDA-based biomaterials have near-infrared (NIR) absorption, excellent cell affinity, and can regulate cell behavior through signal transduction pathways.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Materials Science, Biomaterials
Vidushi Sharma, Sheetal Chowdhury, Suryasarathi Bose, Bikramjit Basu
Summary: In this study, a PVDF-based nanocomposite coating with beta fraction of up to 96% was deposited on a Ti6Al4V substrate through modification with pDOPA and reinforcement with BaTiO3 nanoparticles, enhancing cellular viability and bioactivity. The coating facilitated faster nucleation and growth of the biomineralized apatite layer in simulated body fluid, showing promise for musculoskeletal reconstruction and regeneration applications.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Acoustics
Hanxiao Mei, Zhiliang Gao, Qian Wang, Haifeng Sun, Kaijie Zhao, Peiyu Zhang, Jingcheng Hao, Muthupandian Ashokkumar, Jiwei Cui
Summary: This study introduces a simple and green sonochemical process for PDA coatings, which can be obtained independent of solution pH and gas nature. The rate of film deposition by high frequency ultrasound is found to be faster than traditional methods, enabling the creation of PDA coatings in neutral or acidic aqueous solutions.
ULTRASONICS SONOCHEMISTRY
(2021)
Review
Polymer Science
Hannah Feinberg, Timothy W. Hanks
Summary: Polydopamine is a simple and versatile biopolymer that is being extensively studied as a surface modifying agent due to its ease of preparation and biocompatibility. Its resemblance to key components of mussel adhesive proteins has led to its incorporation into composite materials. This review focuses on the emerging investigations into the mechanism, structures, and potential applications of polydopamine, with a particular emphasis on its use in biomedicine.
POLYMER INTERNATIONAL
(2022)
Article
Physics, Multidisciplinary
Sumeyye Durmaz, Ekrem Yildiz, Bengu Ozugur Uysal, Onder Pekcan
Summary: Polyacrylamide (PAAm) has diverse applications, including as hydrogel and in the medical field, with added molybdenum disulfide providing new functionalities. During copolymerization, microgel trees are formed, and fractal geometry is used to measure randomness. With its highly desired 3D self-assemble feature, these materials may find great potential in wearable and implantable electronics.
TURKISH JOURNAL OF PHYSICS
(2022)
Article
Engineering, Biomedical
Zhaoyuan Guo, Zhuangzhuang Zhang, Nan Zhang, Wenxia Gao, Jing Li, Yuji Pu, Bin He, Jing Xie
Summary: In this study, a composite antibacterial hydrogel PDA-PAM/Mg2+ was developed for accelerated wound healing. This hydrogel showed excellent self-healing and tissue adhesive properties, as well as photothermal antibacterial functions. It demonstrated efficient bacteria inhibition and enhanced wound healing in a rat model.
BIOACTIVE MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Farnaz Ghorbani, Behafarid Ghalandari, Chaozong Liu
Summary: The study developed pomegranate-like PDAMS microspheres using self-oxidative polymerization technique, which resulted in uniform micron-sized particles with interactions with bone formation proteins and demonstrated in-vitro degradation capability, highlighting their potential for hard tissue repair applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zi-Hao Zhou, Jian-Guo Zhang, Qing Chen, Yan-Ling Luo, Feng Xu, Ya-Shao Chen
Summary: A novel temperature responsive lateral chain photosensitive block copolymer was synthesized, showing apparent light and temperature dual responsiveness, making it a potential drug controlled release carrier for cancer therapy.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Baiyan Sui, Zhiyan Xu, Zhiyu Xue, Yong Xiang, Tian Zhou, Ana M. Beltraïn, Kai Zheng, Xin Liu, Aldo R. Boccaccini
Summary: A postgrafting strategy mediated by polydopamine (PDA) coating is proposed to incorporate different metal elements into mesoporous silicate bioactive glass nanoparticles (MBG NPs) while maintaining their stability. However, the PDA coating reduces the ion-binding free energy of MBG NPs for calcium and phosphate ions, resulting in minimal deposition of calcium phosphate clusters on the PDA@MBG NP surface after immersion in simulated body fluid for 7 days, indicating a lack of hydroxyapatite mineralization.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Andrew Liaw, Chun Liu, Mark Bartold, Saso Ivanovski, Pingping Han
Summary: This study aimed to investigate the expression levels of HDACs in human saliva in different periodontal conditions. The results suggest that HDAC4, 8, and 9 could have potential as biomarkers for periodontal diagnosis.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Orthopedics
X. Wu, C. Liyanage, M. Plan, T. Stark, T. McCubbin, R. A. Barrero, J. Batra, R. Crawford, Y. Xiao, I. Prasadam
Summary: This study aims to identify the changes in energy metabolism in osteoarthritis (OA) cartilage. Metabolomics, proteomics, and transcriptomics analyses were conducted to investigate the global alterations in OA metabolism. The results showed increased lactate production and decreased mitochondrial respiratory rates in OA chondrocytes. This study provides a basis for targeting metabolism as a therapeutic approach for OA.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Biochemistry & Molecular Biology
Sheng Yao, Zhibin Du, Lan Xiao, Fuhua Yan, Saso Ivanovski, Yin Xiao
Summary: Osteocytes play a crucial role in bone metabolism and their interactions with the microenvironment can affect cellular and lacunar morphology. This study developed a novel method to analyze osteocytes/lacunae and used it to evaluate morphological changes in diabetic pig mandibular bone. Using backscattered electron scanning microscopy, the size of osteocyte lacunae was found to be significantly decreased in the diabetic group.
Review
Engineering, Biomedical
Yuqing Mu, Zhibin Du, Lan Xiao, Wendong Gao, Ross Crawford, Yin Xiao
Summary: Bone is capable of remodeling its size, shape, and quality to maintain its strength and meet the body's needs. This remodeling process is regulated by interactions among different types of cells, extracellular matrix, surrounding environments, and cell metabolisms. Inorganic ions released during bone matrix degradation not only form apatite crystals or enter the bloodstream, but also modulate cellular activities. The understanding of the naturally balanced ionic microenvironment during bone remodeling can guide the design of biomaterials for bone tissue engineering.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yan-Pei Zou, Hai-Feng Liang, Ben Wang, Qi-Chen Zhang, Di-Han Su, Shun-Yi Lu, Qian-Yi Zhang, Tao Wu, Lan Xiao, Yin Xiao, Jian Dong, Li-Bo Jiang, Xi-Lei Li
Summary: A simple strategy of precipitation is developed to prepare a fast gelling, shape-adaptive, and highly adhesive regenerated silk fibroin/TA/Fe3O4 hydrogel system that can respond to a static magnetic field. This biomaterial shows sufficient adhesion and osteogenic effect, and has potential clinical application in the treatment of critical-sized bone defects.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yamin Li, Lan Xiao, Daixu Wei, Shengyang Liu, Zeren Zhang, Ruixian Lian, Liren Wang, Yunsu Chen, Jia Jiang, Yin Xiao, Changsheng Liu, Yulin Li, Jinzhong Zhao
Summary: This study aims to develop an injectable biomaterial with bone regeneration-adapted degradability to facilitate functional bone regeneration. A hybrid hydrogel (LP-CPC@gelatin, LC) is synthesized by incorporating laponite and CPC into gelatin hydrogel, with the LC gel degradation rate controlled to match the bone regeneration rate. The LC hydrogel shows good osteoinduction, osteoconduction, and angiogenesis effects, providing a strategy for functional bone regeneration and skeletal muscle repair.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Cell Biology
Jing Wang, Yi Zhang, Jin Cao, Yi Wang, Nadia Anwar, Zihan Zhang, Dingmei Zhang, Yaping Ma, Yin Xiao, Lan Xiao, Xin Wang
Summary: The skeletal system is crucial for muscle attachment, organ protection, mineral storage, hematopoiesis, and participation in the endocrine and immune system. Autophagy plays a vital role in bone regeneration by controlling molecular degradation and organelle renewal. Autophagy is involved in various bone diseases and can be modulated through autophagy regulators and the use of biomaterials. Understanding autophagy in bone diseases has significant clinical implications.
Article
Engineering, Biomedical
Long Bai, Yanpeng Liu, Xiaohui Zhang, Peiru Chen, Ruiqiang Hang, Yin Xiao, Jing Wang, Changsheng Liu
Summary: The pace of bone formation slows down with aging, leading to osteoporosis. Senescent macrophages in the bone marrow produce inflammatory cytokines, contributing to inflammaging and the development of osteoporosis. Activation of autophagy by bioactive components, such as icariin (ICA) from traditional Chinese herbal medicine, exerts an anti-inflammaging effect on macrophages and rejuvenates old bone marrow stem cells, alleviating bone loss in osteoporotic mice. This suggests that targeting autophagy could be an innovative treatment strategy for osteoporosis and age-related comorbidities.
Article
Biotechnology & Applied Microbiology
Shengfang Wang, Peiyu Wang, Rik Thompson, Kostya Ostrikov (Ken), Yin Xiao, Yinghong Zhou
Summary: PAM can reduce the inflammatory response of macrophages by activating autophagy and promote the regeneration of periodontal tissues, making it an ideal choice for periodontitis treatment.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Engineering, Biomedical
Qing Zhang, Mengyu Xin, Shuang Yang, Qiuyu Wu, Xi Xiang, Tianqi Wang, Wen Zhong, Marco N. Helder, Richard T. Jaspers, Janak Lal Pathak, Yin Xiao
Summary: Targeting macrophages to regulate the immune microenvironment is a new strategy for bone regeneration with nano-drugs. Nano-drugs have achieved surprising anti-inflammatory and bone-regenerative effects, however, their underlying mechanisms in macrophages remain to be clarified.
MATERIALS TODAY BIO
(2023)
Article
Cell Biology
Tianyu Qin, Jiansen Yan, Shuangxing Li, Xiaolin Lin, Jiajun Wu, Zhengqi Huang, Chao Zhang, Yangyang Zhang, Zhihuai Deng, Dong Xiao, Song Jin, Yin Xiao, Kang Xu, Wei Ye
Summary: This study demonstrated that miR-155 could protect against cholesterol-induced intervertebral disc degeneration (IDD) by targeting RORa to inhibit matrix degradation, apoptosis, and pyroptosis in the nucleus pulposus (NP).
CELLULAR SIGNALLING
(2023)
Article
Dentistry, Oral Surgery & Medicine
Pingping Han, Nigel Johnson, Abdalla Abdal-hay, Corey S. S. Moran, Carlos Salomon, Saso Ivanovski
Summary: This study aimed to enrich and compare three types of extracellular vesicles (apoptotic bodies, microvesicles, and small EV) from three periodontal cells (PDLCs, OBs, and GFs), and evaluate their uptake and effects on BFP-MSCs. The results showed that the EVs from the periodontal cells promoted proliferation, migration, and expression of osteogenic genes in the BFP-MSCs.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Srinivas Sulugodu Ramachandra, Fekade Bruck Sime, Saiyuri Naicker, Pingping Han, Ryan S. B. Lee, Steven Wallis, Jason A. Roberts, Saso Ivanovski
Summary: This study investigated the antimicrobial effect of amoxicillin on polymicrobial microcosm biofilms derived from subgingival plaque using an in vitro dynamic bioreactor model. The results showed that amoxicillin had a significant antimicrobial effect on the biofilms and could reduce/eliminate certain bacteria.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Cell & Tissue Engineering
Pingping Han, Kexin Jiao, Corey S. Moran, Andrew Liaw, Yinghong Zhou, Carlos Salomon, Saso Ivanovski
Summary: This pilot study investigated the gene expression of markers for bone turnover and pro-inflammatory cytokines in extracellular vesicles (EVs) derived from saliva in periodontal disease. The study found that the mRNA levels of the bone turnover marker osterix and the pro-inflammatory cytokine marker tumor necrosis factor-alpha were significantly altered in periodontitis patients compared to healthy controls. These findings suggest that salivary EVs may serve as a potential noninvasive biomarker source for diagnosing periodontal disease.
TISSUE ENGINEERING PART C-METHODS
(2023)
Article
Biochemistry & Molecular Biology
Guohou Miao, Liyu Liang, Wenzhi Li, Chaoyang Ma, Yuqian Pan, Hongling Zhao, Qing Zhang, Yin Xiao, Xuechao Yang
Summary: In this study, a multi-component hydrogel was developed for the fabrication of tissue engineering scaffolds via bioprinting, showing good biological activity and regenerative capabilities for periodontal tissue.