期刊
ACTA BIOMATERIALIA
卷 10, 期 1, 页码 40-46出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2013.09.012
关键词
Polycation; Heparin; Lysine; Coacervate; Controlled release
资金
- National Science Foundation [DMR 1005766]
- American Heart Association [12EIA9020016]
- National Institutes of Health [2T32HL076124]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL076124] Funding Source: NIH RePORTER
Polycations have good potential as carriers of proteins and genetic material. However, poor control over the release rate and safety issues currently limit their use as delivery vehicles. Here we introduce a new lysine-based polycation, poly(ethylene lysinylaspartate diglyceride) (PELD), which exhibits high cytocompatibility. PELD self-assembles with the biological polyanion heparin into a coacervate that incorporates proteins with high loading efficiency. Coacervates of varying surface charge were obtained by simple alteration of the PELD:heparin ratio and resulted in diverse release profiles of the model protein bovine serum albumin. Therefore, coacervate charge represents a direct means of control over release rate and duration. The PELD coacervate also rapidly adsorbed onto a porous polymeric scaffold, demonstrating potential use in tissue engineering applications. This coacervate represents a safe and tunable protein delivery system for biomedical applications. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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