Review
Urology & Nephrology
Micaela Gentile, Luis Sanchez-Russo, Leonardo Riella, Alberto Verlato, Joaquin Manrique, Simona Granata, Enrico Fiaccadori, Francesco Pesce, Gianluigi Zaza, Paolo Cravedi
Summary: Immunoglobulin A (IgA) nephropathy (IgAN) is a common kidney disease characterized by the deposition of IgA antibodies in the glomerulus. This leads to kidney damage and can progress to end-stage kidney disease. The disease involves a complex immune process and is influenced by genetic and environmental factors.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Toshiki Kano, Hitoshi Suzuki, Yuko Makita, Yoshihito Nihei, Yusuke Fukao, Maiko Nakayama, Mingfeng Lee, Rina Kato, Ryosuke Aoki, Koshi Yamada, Masahiro Muto, Yusuke Suzuki
Summary: The dysregulation of the mucosal immune response is closely associated with the pathogenesis of immunoglobulin A nephropathy (IgAN), but it remains unclear how exogenous antigens interact with the mucosal immune system to induce or exacerbate IgAN.
Article
Urology & Nephrology
Katerina Zachova, Jana Jemelkova, Petr Kosztyu, Yukako Ohyama, Kazuo Takahashi, Josef Zadrazil, Jiri Orsag, Karel Matousovic, Dana Galuszkova, Nadezda Petejova, Jiri Mestecky, Milan Raska
Summary: This study found an increased number of migratory Gd-IgA1-?(+) cells in the peripheral blood of IgAN patients, which have the potential to home to mucosal sites in the upper respiratory and digestive tracts where Gd-IgA1 could be produced during local infections.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Immunology
Loreto Gesualdo, Vincenzo Di Leo, Rosanna Coppo
Summary: The pathogenesis of IgA nephropathy may be associated with mucosal immunity, microbiota, genetic factors, food antigens, infections, and mucosal immune response. Potential therapies targeting microbes and mucosal hyperresponsiveness in IgAN patients are currently being evaluated.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Review
Immunology
Yoshihito Nihei, Hitoshi Suzuki, Yusuke Suzuki
Summary: Immunoglobulin A (IgA) is the most abundant isotype of antibodies that plays a key role in defending against pathogens at mucosal surfaces. Although considered non-inflammatory, IgA can also cause diseases such as IgA nephropathy and IgA vasculitis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ji Eun Oh, Eric Song, Miyu Moriyama, Patrick Wong, Sophia Zhang, Ruoyi Jiang, Shirin Strohmeier, Steven H. Kleinstein, Florian Krammer, Akiko Iwasaki
Summary: Research shows that intranasal immunization induces local IgA secretion in the bronchoalveolar space, providing effective protection against respiratory virus infections; single-cell RNA sequencing reveals a heterogeneous population of IgA-expressing cells within the respiratory mucosa, including tissue-resident memory B cells, plasmablasts, and plasma cells.
SCIENCE IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Caiqiong Liu, Xiaoyan Li, Lanjun Shuai, Xiqiang Dang, Fangrong Peng, Mingyi Zhao, Shiqiu Xiong, Ying Liu, Qingnan He
Summary: The study revealed that AS-IV could inhibit Gd-IgA1 secretion via miR-98-5p, and increased levels of miR-98-5p in pediatric IgAN patients might affect the glycosylation of IgA1 by targeting C1GALT1. Additionally, the pathogenesis of IgAN may differ from that of IgAV-N, providing significant insight into potential therapeutic targets.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Yoshihito Nihei, Kei Haniuda, Mizuki Higashiyama, Shohei Asami, Hiroyuki Iwasaki, Yusuke Fukao, Maiko Nakayama, Hitoshi Suzuki, Mika Kikkawa, Saiko Kazuno, Yoshiki Miura, Yusuke Suzuki, Daisuke Kitamura
Summary: This study demonstrates that IgA nephropathy is the most common form of primary glomerulonephritis, characterized by the deposition of IgA in the glomerular mesangium. The researchers found that patients with IgA nephropathy and a spontaneous mouse model produce IgA antibodies against mesangial antigens, specifically beta II-spectrin. These antibodies have substantial V-region mutations and can bind to the surface of mesangial cells, indicating the presence of a tissue-specific autoimmune response in IgA nephropathy.
Article
Immunology
Matt D. T. Hitchings, Brooke A. Borgert, Adam Shir, Bingyi Yang, Kyra H. Grantz, Jacob Ball, Carlos A. Moreno, Kenneth Rand, Parker A. Small Jr, Keith R. Fowke, Derek A. T. Cummings
Summary: By conducting surveillance on a retirement community in Gainesville, Florida, we found that mucosal IgA is a correlate of influenza infection. Individuals with PCR-confirmed influenza A had lower preseason IgA levels. There was evidence for cross-reactivity in mucosal IgA across influenza A subtypes.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Chemistry, Multidisciplinary
Aatman S. Doshi, Susan Cantin, Laura B. Prickett, Deanna A. Mele, Mansoor Amiji
Summary: In this study, a systemically administered CD103+ dendritic cell (DCs) targeted liposomal formulation was developed, which enhanced anti-tumor immune response and reduced off-target toxicities by targeted delivery of CDNs. The results showed significant anti-tumor efficacy of the liposomal formulation at low dose.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Immunology
Jessica Denis, Annabelle Garnier, Laurence Cheutin, Audrey Ferrier, Hawa Timera, Fanny Jarjaval, Carine Hejl, Emmanuelle Billon-Denis, Damien Ricard, Jean-Nicolas Tournier, Aurelie Trignol, Marie Mura
Summary: Currently approved COVID-19 vaccines cannot fully protect against infection and transmission of various SARS-CoV-2 variants. The mucosal immunity at the upper respiratory tract is critical for developing a vaccine to block human-to-human transmission.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Yating Du, Tingzhu Cheng, Chenxuan Liu, Tingting Zhu, Chuan Guo, Shen Li, Xiangrong Rao, Jinpu Li
Summary: Immunoglobulin A nephropathy (IgAN) is a common kidney disease with different features among individuals, particularly across races. It is caused by increased levels of galactose-deficient IgA1 and deposition of IgA-containing immune complexes in the kidneys. Recent evidence suggests the involvement of genes, environment, mucosal immunity, and the complement system. This review summarizes current knowledge and new findings in the prognosis, clinical trials, and translational research of IgAN.
Article
Medicine, General & Internal
Yusuke Fukao, Hitoshi Suzuki, Jin Sug Kim, Kyung Hwan Jeong, Yuko Makita, Toshiki Kano, Yoshihito Nihei, Maiko Nakayama, Mingfeng Lee, Rina Kato, Jer-Ming Chang, Sang Ho Lee, Yusuke Suzuki
Summary: In patients with IgA nephropathy (IgAN), urinary Gd-IgA1 levels are higher and correlated with disease severity. Urinary Gd-IgA1 can also be detected in early stages of the disease. Therefore, urinary Gd-IgA1 may serve as a useful disease-specific biomarker.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Shyamala Ganesan, Hugo Acosta, Chris Brigolin, Kallista Orange, Kevin Trabbic, Charles Chen, Chia-En Lien, Yi-Jiun Lin, Meei-Yun Lin, Ya-Shan Chuang, Ali Fattom, Vira Bitko
Summary: This study demonstrates the efficacy of an intranasal vaccine that utilizes a nanoemulsion adjuvant to deliver spike protein, resulting in robust immune responses and protection against SARS-CoV-2 infection in animal models. The vaccine also induces significant mucosal immune responses, suggesting its potential in addressing specific public health issues and medical needs.
Article
Chemistry, Multidisciplinary
Vipul K. Singh, Eric Chau, Abhishek Mishra, Alexandro DeAnda, Venkatesh L. Hegde, Jagannadha K. Sastry, David Haviland, Chinnaswamy Jagannath, Biana Godin, Arshad Khan
Summary: This study describes the role of CD44-mediated signaling in host-defense against tuberculosis (TB). CD44-targeting liposomes were designed and tested as a new vaccine to enhance host immunity in TB. The results showed that CD44TA-LIP enhanced the killing of Mtb in human macrophages and increased the production of pro-inflammatory cytokines. It also activated antigen presentation to CD4 T-cells and exhibited antimicrobial effects. In Mtb-infected mice, CD44TA-LIP led to reduced colony forming units of Mtb and increased IFN-gamma + CD4 T cells. Biodistribution studies showed that CD44TA-LIP accumulated in the lungs and were associated with CD11b+ cells.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Yu-Pu Juang, You-Yu Lin, She-Hung Chan, Chun-Kai Chang, Jiun-Jie Shie, Yves S. Y. Hsieh, Jih-Hwa Guh, Pi-Hui Liang
BIOORGANIC CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Wei-Chieh Cheng, Ting-Yun You, Zhen-Zhuo Teo, Ashik A. Sayyad, Jitendra Maharana, Chih-Wei Guo, Pi-Hui Liang, Chung-Shun Lin, Fan-Chun Meng
CHEMISTRY-AN ASIAN JOURNAL
(2020)
Article
Dermatology
Musin Kelel, Ruey-Bing Yang, Tsen-Fang Tsai, Pi-Hui Liang, Fu-Yu Wu, Yu-Tien Huang, Ming-Fong Yang, Yu-Ping Hsiao, Li-Fang Wang, Chen-Fen Tu, Fu-Tong Liu, Yungling L. Lee
Summary: The study reveals that FUT8 remodeling of EGFR plays a critical role in the development of psoriasis phenotypes and is associated with disease severity. FUT8 gain of function promotes cell proliferation, while short hairpin FUT8 reduces proliferation and alters the cell cycle.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Jia-Tsrong Jan, Ting-Jen Rachel Cheng, Yu-Pu Juang, Hsiu-Hua Ma, Ying-Ta Wu, Wen-Bin Yang, Cheng-Wei Cheng, Xiaorui Chen, Ting-Hung Chou, Jiun-Jie Shie, Wei-Chieh Cheng, Rong-Jie Chein, Shi-Shan Mao, Pi-Hui Liang, Che Ma, Shang-Cheng Hung, Chi-Huey Wong
Summary: The COVID-19 pandemic has resulted in over 50 million confirmed cases and more than 1 million deaths globally as of November 2020. Currently, there are no effective antivirals approved by the FDA, posing a major challenge in vaccine development. Alternative treatments are urgently needed.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Agriculture, Multidisciplinary
Jing Li, Damao Wang, Shu-Chieh Chang, Pi-Hui Liang, Vaibhav Srivastava, Shih-Yun Guu, Jiun-Jie Shie, Kay-Hooi Khoo, Vincent Bulone, Yves S. Y. Hsieh
Summary: Partially acetylated chito-oligosaccharides (paCOSs) are bioactive compounds with potential medical applications, and their biological activities are largely dependent on their structural properties, especially the degree of polymerization (DP) and the position of acetyl groups. A newly discovered chitinase from Paenibacillus pabuli (PpChi) has been shown to produce structurally defined paCOSs with specific compositions, demonstrating stability and activity over a wide temperature range, making it a promising biocatalyst for industrial processes. When used in combination with a recently discovered fungal oxidase, PpChi significantly increases the release of oligosaccharides, contributing to the green production of valuable paCOSs with a well-defined structure.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Cell Biology
Shu-Chieh Chang, Rebecka Karmakar Saldivar, Pi-Hui Liang, Yves S. Y. Hsieh
Summary: (1,3;1,4)-beta-D-Glucans, a type of polysaccharides with unique linkages, are found in various taxonomic groups. Their synthesis, evolutionary patterns, and functions remain to be fully understood and require further investigation.
Article
Chemistry, Medicinal
Chun-Kai Chang, Pei-Fang Chiu, Hui-Yi Yang, Yu-Pu Juang, Yen-Hsun Lai, Tzung-Sheng Lin, Lih-Ching Hsu, Linda Chia-Hui Yu, Pi-Hui Liang
Summary: The study demonstrates that a novel GLUTs-targeting drug conjugate shows better antitumor efficacy than 5-FU in an orthotopic colorectal cancer mice model, with lower exposure of 5-FU during treatment and no significant side effects. This suggests that GLUT-targeting theranostics with a disulfide linker may be a promising approach for antitumor therapy.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Yu-Pu Juang, Yu-Ting Chou, Ru-Xian Lin, Hsiu-Hua Ma, Tai-Ling Chao, Jia-Tsrong Jan, Sui-Yuan Chang, Pi-Hui Liang
Summary: 22 niclosamide analogues were synthesized and compound 5 exhibited the best anti-SARS-CoV-2 efficacy. Compounds 5, 6, and 11 showed higher stability and improved oral bioavailability compared to niclosamide.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Damao Wang, Mu-Rong Kao, Jing Li, Peicheng Sun, Qijun Meng, Anisha Vyas, Pi-Hui Liang, Yane-Shih Wang, Yves S. Y. Hsieh
Summary: In this study, a composite enzymatic photocatalysis-Fenton reaction system based on nano-alpha-Fe2O3 was designed to enhance cellulose degradation and liquefaction yield. The results showed that this method could increase the liquefaction yield of cellulose to 93%.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jing Li, Shih-Yi Hsiung, Mu-Rong Kao, Xiaohui Xing, Shu-Chieh Chang, Damao Wang, Pei-Yun Hsieh, Pi -Hui Liang, Zaibiao Zhu, Ting -Jen Rachel Cheng, Jiun-Jie Shie, Jing-Ping Liou, D. Wade Abbott, Sung Won Kwon, Yves S. Y. Hsieh
Summary: This study investigated the cell wall structures of Polygonatum odoratum in different plant parts. It was found that the rhizome contains a higher proportion of heteromannans compared to the leaf and stem. The pectic polysaccharides in the rhizome were also structurally more diverse. The 2-linked Araf was specific to the rhizome, indicating a more complex cell wall structure. Additionally, a high proportion of HMs was found in the rhizome cell walls, which induced a specific immune response in mice macrophage cells.
CARBOHYDRATE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Chiao-Nien Chang, I-Chun Lin, Tzung-Sheng Lin, Pei -Fang Chiu, Yeh-Lin Lu, Manmath Narwane, I-Chen Liu, Yue Hng, Keng-Chang Tsai, Mei-Hsiang Lin, Yves S. Y. Hsieh, Mei-Jou Chen, Pi-Hui Liang
Summary: The study focuses on the synthesis and evaluation of compound inhibitors for steroid sulfatase, which showed that the introduction of chlorine substitution enhanced the inhibition of STS. The kinetic analysis revealed the high efficiency of irreversible inhibition for chloride-bearing compounds. The selected compounds also demonstrated safety and anticancer activity.
BIOORGANIC CHEMISTRY
(2022)
Article
Plant Sciences
Shih-Yi Hsiung, Jing Li, Balazs Imre, Mu-Rong Kao, Hsien-Chun Liao, Damao Wang, Chih-Hui Chen, Pi-Hui Liang, Philip J. Harris, Yves S. Y. Hsieh
Summary: The xyloglucans of aquatic Araceae species have unique structures compared to other non-commelinid monocotyledon families. Lemna minor, a species of aquatic Araceae, was found to have xyloglucans with a different structure from other non-commelinid monocotyledons. A study of 26 Araceae species, including L. minor, revealed that all seven aquatic species examined had xyloglucans with one or two of three distinct features: a < 77% XXXG core motif, no fucosylation, and > 14% oligosaccharide units with S or D side chains. Two terrestrial species also lacked fucose in their xyloglucans, indicating this feature is not unique to aquatic species.
Article
Plant Sciences
Osbert Chou, Yu-Pu Juang, Tai-Ling Chao, Sheng-Fa Tsai, Pei-Fang Chiu, Chun-Tang Chiou, Keng-Chang Tsai, Sui-Yuan Chang, Pi-Hui Liang, Chi-Huey Wong
Summary: Traditional herbal medicine was explored for potential therapeutics against SARS-CoV-2 mutation. Mint (Mentha canadensis L.) was selected for bioactivity-guided extraction, resulting in the isolation and characterization of seven constituents. Syringic acid and methyl rosmarinate showed promising results in drug combination treatment. Synthetic derivatives of methyl rosmarinate demonstrated significantly improved antiviral activity against Omicron BA.1 compared to methyl rosmarinate alone.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Medicinal
Pei-Fang Chiu, Chun-Kai Chang, Pin-Shuo Huang, You-Yu Lin, Chung-Shun Lin, Hui-Yi Yang, Lih-Ching Hsu, Linda Chia-Hui Yu, Pi-Hui Liang
Summary: To enhance the selectivity and therapeutic efficacy of SN38, researchers developed conjugates of SN38 and glucose transporter inhibitors. These conjugates released SN38 in the tumor microenvironment and displayed improved antitumor efficacy with lower systemic exposure.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Yen-Hsun Lai, Yu-Ting Chou, You-Yu Lin, Yi-Chi Wang, Jing-Xiu Cao, Pi-Hui Liang
Summary: Chemical triterpene 3-O-glucuronidation was conducted to meet the increasing demand for natural source compounds. Reactive donors with higher reactivity values were found to improve the production of 3-O-glucuronide triterpenes. The use of a bulky pivaloyl group provided β-selectivity and prevented side reactions. These findings provide insights into the synthesis of 3-O-β-glucuronide triterpenes and are valuable for accessing desired saponins in the future.
JOURNAL OF ORGANIC CHEMISTRY
(2023)