Article
Engineering, Biomedical
Yafeng Wen, Qingshan Liu, Jingfeng Wang, Qiming Yang, Weikang Zhao, Bo Qiao, Yuling Li, Dianming Jiang
Summary: A novel Mg-1Zn-1Sn-0.2Sr alloy was developed in this study, which demonstrated enhanced corrosion resistance and mechanical properties with the addition of a small amount of strontium. Additionally, the release of hydrogen was significantly reduced in this alloy.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Physical
Jung-Eun Park, Yong-Seok Jang, Ji-Bong Choi, Tae-Sung Bae, Il-Song Park, Min-Ho Lee
Summary: The study explored the biocompatibility of Sr-CaP coatings on pure magnesium surfaces for bone applications. The research found that Sr-CaP coatings improved corrosion resistance of magnesium and enhanced its biocompatibility. This Ca-SrP coating shows promise for magnesium-based orthopedic implant applications.
Article
Materials Science, Multidisciplinary
Jung-Eun Park, Yong-Seok Jang, Seo -Young Kim, Ji-Bong Choi, Tae-Sung Bae, Il -Song Park, Min -Ho Lee
Summary: This study demonstrated that coating biodegradable magnesium with calcium phosphate doped strontium can improve its bioactivity and corrosion resistance, preventing damage and corrosion of the magnesium surface while promoting cell proliferation. The in vivo implantation experiment also confirmed the positive effect of modified magnesium on bone regeneration.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Materials Science, Coatings & Films
R. Vignesh, G. Sakthinathan, Raja Velusamy, Seeram Ramakrishna
Summary: The research focused on surface modification of pure magnesium with coatings of pure iron and hydroxyapatite, which improved mechanical strength and decreased corrosion rate. The study showed that all three substrates - pure magnesium, pure iron, and hydroxyapatite - exhibited non-hemolytic properties, and coating did not affect biological characteristics.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Materials Science, Coatings & Films
Ekaterina S. Marchenko, Arina A. Shishelova, Pavel I. Butyagin, Ivan I. Gordienko, Anton P. Khrustalev, Svetlana S. Arbuzova, Ilya A. Zhukov, Gulsharat A. Baigonakova, Alex A. Volinsky
Summary: This study investigates the effects of electrolyte exposure time on phase composition, biodegradation, and biocompatibility during micro-arc oxidation of the Mg-Ca-Zn alloy. The results show that micro-arc oxidation can form a dense coating with a gradient structure, and the amorphous component of the coating increases with exposure time. The coated Mg-Ca-Zn samples exhibit reduced weight loss in vitro and high biocompatibility in animal experiments.
SURFACE & COATINGS TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Yafei Li, Yan Wang, Zhenquan Shen, Fulong Miao, Jianfeng Wang, Yufeng Sun, Shijie Zhu, Yufeng Zheng, Shaokang Guan
Summary: In this study, a new structurally designed magnesium alloy stent was proposed and optimized to improve its plastic deformation, expansion, and compression resistance performance. Experimental results verified the simulation results, demonstrating that the optimized stent has higher radial strength and reduced stress concentration compared to the traditional sinusoidal stent.
ACTA BIOMATERIALIA
(2022)
Article
Materials Science, Multidisciplinary
Rinmayee Praharaj, Snigdha Mishra, R. D. K. Misra, Tapash R. Rautray
Summary: In this study, an electrochemical cathodic deposition method was used to modify the surface of Ti implants with a bilayer coating. The research found that this coating has high bioactivity and adhesion strength, which contribute to osseointegration and bone healing.
MATERIALS TECHNOLOGY
(2022)
Review
Geriatrics & Gerontology
Elizabeth M. Curtis, Cyrus Cooper, Nicholas C. Harvey
Summary: Calcium supplementation in combination with vitamin D is recommended for bone health in those deficient in these nutrients, with no convincing evidence of cardiovascular risks associated. Magnesium supplementation does not have clear benefits for musculoskeletal outcomes, while higher dietary intake and serum concentrations are protective against cardiovascular events. Strontium ranelate, available as a generic medication, has anti-fracture efficacy but an increased risk of thromboembolic disease, while hypotheses of increased myocardial infarction risk have not been widely supported.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Instruments & Instrumentation
Thomas Tice
Summary: Long-acting injectables have had a significant impact on clinical medicine, with contributions from various fields and pioneers who envisioned and implemented new drug delivery concepts over 50 years ago.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Applied
Jie Chen, Xuhui Liu, Qingxiang Hong, Lingjie Meng, Yan Ji, Lingtao Wang, Qiuyang Zhang, Jiafeng Lin, Changjiang Pan
Summary: By modifying the surface of magnesium-based alloys with a novel polymer coating that releases nitric oxide (NO), this study successfully improved the anticorrosion performance, hydrophilicity, and biocompatibility of the magnesium alloy coating, promoting the growth of endothelial cells and enhancing hemocompatibility. This research opens up a new avenue for the development of multifunctional coatings for magnesium-based alloys that can release NO, simultaneously reducing corrosion, improving hemocompatibility, and accelerating endothelial regeneration.
PROGRESS IN ORGANIC COATINGS
(2024)
Article
Chemistry, Physical
Karel Klima, Dan Ulmann, Martin Bartos, Michal Spanko, Jaroslava Duskova, Radka Vrbova, Jan Pinc, Jiri Kubasek, Tereza Ulmannova, Rene Foltan, Eitan Brizman, Milan Drahos, Michal Beno, Jaroslav Capek
Summary: The pilot study demonstrated that the Zn-0.8Mg-0.2Sr alloy had good biocompatibility, low degradation rate, and showed no inflammatory reaction or bone resorption after implantation in a rabbit model.
Article
Materials Science, Ceramics
Tingting Ma, Jianguo Liao, Yanru Zhang, Jinlun Feng, Yue Yang, Hang Li, Wenjie Guo, Junying Chen
Summary: N-acetyl-L-cysteine modified nano-hydroxyapatite/magnesium phosphate cement has improved strength, degradation, and biological activity. The addition of 0.5% N-acetyl-L-cysteine increased the compressive strength by 6.3% compared to the control group, and exhibited higher softening coefficient after soaking in simulated body fluid for 28 days. Cell experiments showed that N-acetyl-L-cysteine promoted cell proliferation and enhanced osteogenic gene and protein expression. In vivo experiments in rats demonstrated that the N-acetyl-L-cysteine bone cement promoted bone formation. Therefore, the composite bone cement has potential application prospects in clinical bone repair.
CERAMICS INTERNATIONAL
(2023)
Article
Engineering, Biomedical
Lu Jin, Lei Yao, Feng Yuan, Guangcheng Dai, Boxin Xue
Summary: A new type of biodegradable ureteral stents made from degradable polyurethane and magnesium alloys was developed and tested for its biocompatibility and degradation properties. The study confirmed the good biocompatibility of the biodegradable stents and their ability to completely degrade within 4 weeks, providing better drainage than conventional stents and potentially reducing the need for secondary procedures and stent-related infections.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Tengda Shang, Kebing Wang, Lu Zhang, Lei Zhou, Luying Liu, Changqi Liu, Hao Zhang, Xin Li, Yuancong Zhao, Jin Wang
Summary: The corrosion and degradation behavior of magnesium-based materials in simulated in vivo environment was studied using a microfluidic system. The system provided near physiological conditions and applied flow-induced shear stress close to the wall shear stress of the human coronary artery. The results demonstrated the feasibility of the microfluidic system for evaluating the corrosion resistance of magnesium-based materials.
JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES
(2023)
Article
Crystallography
Natalia S. Martynenko, Natalia Yu Anisimova, Olga Rybalchenko, Mikhail Kiselevskiy, Georgy Rybalchenko, Boris Straumal, Diana Temralieva, Almagul T. Mansharipova, Aigul O. Kabiyeva, Maratbek T. Gabdullin, Sergey Dobatkin, Yuri Estrin
Summary: The Mg-1%Zn-0.3%Ca alloy modified by equal-channel angular pressing demonstrates good biocompatibility and osteogenic stimulation, making it a promising candidate for the manufacture of biodegradable orthopedic implants.