期刊
ACTA BIOMATERIALIA
卷 9, 期 9, 页码 8318-8327出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2013.06.003
关键词
Drug delivery; Surgical suture; Pain relief; Mechanical strength; Biocompatibility
资金
- Advanced medical new material (fiber) development program through the Ministry of Knowledge Economy (MKE)
- Korea Institute for Advancement of Technology (KIAT) [A0043-00017]
- National Research Foundation of Korea (NRF)
- Korean Government [2012-0002526]
- SNUH Research Fund [04-2010-0630]
- SNUBH Research Fund [02-2010-032]
Surgical suture is a strand of biocompatible material designed for wound closure, and therefore can be a medical device potentially suitable for local drug delivery to treat pain at the surgical site. However, the preparation methods previously introduced for drug-delivery sutures adversely influenced the mechanical strength of the suture itself - strength that is essential for successful wound closure. Thus, it is not easy to control drug delivery with sutures, and the drug-delivery surgical sutures available for clinical use are now limited to anti-infection roles. Here, we demonstrate a surgical suture enabled to provide controlled delivery of a pain-relief drug and, more importantly, we demonstrate how it can be fabricated to maintain the mechanical strength of the suture itself. For this purpose, we separately prepare a drug-delivery sheet composed of a biocompatible polymer and a pain-relief drug, which is then physically assembled with a type of surgical suture that is already in clinical use. In this way, the drug release profiles can be tailored for the period of therapeutic need by modifying only the drug-loaded polymer sheet without adversely influencing the mechanical strength of the suture. The drug-delivery sutures in this work can effectively relieve the pain at the surgical site in a sustained manner during the period of wound healing, while showing biocompatibility and mechanical properties comparable to those of the original surgical suture in clinical use. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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