Article
Chemistry, Multidisciplinary
Xuan Gao, Jing Feng, Shuyan Song, Kai Liu, Kaimin Du, Yifei Zhou, Kehong Lv, Hongjie Zhang
Summary: This study presents a multi-layered porous biocatalyst (USCGP) that enables cascade reactions-enhanced synergistic cancer therapy. By loading glucose oxidase (GOD) for glucose decomposition and tumor microenvironment regulation, as well as cascade reactions and photodynamic therapy, USCGP demonstrates effective tumor suppression and imaging capabilities for tumor diagnosis.
Article
Materials Science, Biomaterials
Lu Fu, Rupeng Li, John M. Whitelock, Megan S. Lord
Summary: This study reveals that functionalized cerium oxide nanoparticles with heparin corona can promote angiogenesis, with the surface grafting density positively correlated with angiogenesis. Heparin-nanoceria supports FGF2 signaling in vitro and promotes FGF2-mediated angiogenesis in vivo.
REGENERATIVE BIOMATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Naseer Ahmad, Sufian Rasheed, Muhammad Ikram Nabeel, Waqas Ahmad, Abrar Mohyuddin, Syed Ghulam Musharraf, Muhammad Najam-ul-Haq, Zafar Khan Ghouri, Dilshad Hussain
Summary: In this study, a fluorine-free, durable superhydrophobic cotton fabric with CeO2 nanoparticles and stearic acid was developed to mimic the lotus effect. The modified fabric exhibited high superhydrophobicity, self-cleaning, antiwater absorption, UV-blocking, and antibacterial properties. The proposed strategy is simple, green, economical, and has potential for commercial applications in functional fabric preparation.
Article
Nanoscience & Nanotechnology
Johoon Kim, Gwanui Hong, Luda Mazaleuskaya, Jessica C. Hsu, Derick N. Rosario-Berrios, Tilo Grosser, Park F. Cho-Park, David P. Cormode
Summary: The ultrasmall CeONP demonstrated potent antioxidant and anti-inflammatory properties, reducing acute inflammation and being effectively excreted from the body within a short period, minimizing long-term toxicity concerns.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Ophthalmology
Thomas Stax Jakobsen, Jakob Appel ostergaard, Mads Kjolby, Elisa Lund Birch, Toke Bek, Anders Nykjaer, Thomas J. Corydon, Anne Louise Askou
Summary: The level and localization of the multifunctional receptor sortilin in the diabetic retina were investigated, and the effect of sortilin inhibition on retinal neurodegeneration in experimental diabetes was studied. Increased levels of sortilin were observed in human and murine diabetic retinas, and sortilin was highly localized to retinal Muller cells. Sortilin inhibition effectively protected against neuronal loss in diabetic mice by reducing inner retinal thickness and the count of retinal ganglion cells.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Adrian Boey, Shu Qing Leong, Sayali Bhave, Han Kiat Ho
Summary: Exposure to metallic nanoparticles can lead to unintended accumulation in body tissues, with cerium oxide nanoparticles showing potential beneficial effects by reducing oxidative stress levels and TGF-beta-mediated signaling in liver cells. These findings suggest a therapeutic pathway for hepatic fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Yuemei Li, Yongmei Li, Haoming Wang, Riyue Liu
Summary: Yb/Er/CeO2-x upconversion nanoparticles have shown promising antioxidative activities in the treatment of Parkinson's disease, with increased enzyme-like catalytic activities and reductions in ROS production in the brain, indicating their potential as a therapeutic option for PD.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Muling Zeng, Xu Zhang, Jie Tang, Xingfei Liu, Yichao Lin, Dongdong Guo, Yuping Zhang, Shijie Ju, Guillermo Fernandez-Varo, Ya-Chao Wang, Xiangyu Zhou, Gregori Casals, Eudald Casals
Summary: This study investigates the evolution behavior of two commonly used cerium oxide nanozymes (CeO(2)NZs) in different fluids. The results show that the biocompatibility and antioxidant activity of CeO(2)NZs are retained in all cases, despite the different behaviors observed in different fluids. This provides experimental evidence supporting the therapeutic effectiveness of CeO(2)NZs for the treatment of chronic inflammation and cancer.
Review
Biochemistry & Molecular Biology
Somu Yadav, Shivangi Chamoli, Piyush Kumar, Pawan Kumar Maurya
Summary: Cerium oxide nanoparticles have wide applications in biomedical fields, but their safety and biocompatibility pose challenges. Polysaccharides can be used as coatings for cerium oxide nanoparticles, affecting their properties. This review explores the impact of biopolymer coatings on size, stability, aggregation, and biocompatibility of cerium oxide nanoparticles, as well as their applications in bone tissue regeneration, liver inflammation, wound healing, and antibacterial and anticancer activities. Biocompatible cerium oxide nanoparticles will enhance their biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Valentina A. Petrova, Natallia V. Dubashynskaya, Iosif V. Gofman, Alexey S. Golovkin, Alexander I. Mishanin, Arthur D. Aquino, Daria V. Mukhametdinova, Alexandra L. Nikolaeva, Elena M. Ivan'kova, Alexander E. Baranchikov, Alexander V. Yakimansky, Vladimir K. Ivanov, Yury A. Skorik
Summary: Polymeric nanocomposite materials have the potential to enhance tissue-engineered scaffolds by influencing the structure and properties of polymeric materials and regulating cell behavior. In this study, cerium oxide nanoparticles were incorporated into a chitosan film to promote the proliferation of mesenchymal stem cells. The resulting CS-CeONP films exhibited good biocompatibility and regenerative potential in both in vitro and in vivo experiments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Biomaterials
Baofu Ma, Jianyu Han, Kun Zhang, Qike Jiang, Zhigang Sui, Zhixin Zhang, Baofeng Zhao, Zhen Liang, Lihua Zhang, Yukui Zhang
Summary: Nanoceria-rod exhibits high enzymatic activity and cytotoxicity towards tumor cells due to its high concentration of oxygen vacancies on the surface, allowing selective entry into tumor cells.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Biotechnology & Applied Microbiology
George P. Lee, Alexander Willis, Sebastian Pernal, Abhijit Phakatkar, Tolou Shokuhfar, Vincent Blot, Herbert H. Engelhard
Summary: The study demonstrated the use of titanium dioxide (TiO2) nanoparticles conjugated to anti-EGFR antibody for sonodynamic therapy (SDT) against glioblastoma cells. The antibody-nanoparticle conjugates (ANCs) reduced cell viabilities and induced reactive oxygen species production, showing potential in killing glioblastoma cells through SDT.
Article
Engineering, Biomedical
Akhil Patel, Jessica Kosanovich, Sameera Sansare, Sricharani Balmuri, Vinayak Sant, Kerry M. Empey, Shilpa Sant
Summary: This study investigates the potential of cube and sphere-shaped cerium oxide nanoparticles (CNP) to modulate reactive oxygen (ROS) and nitrogen (RNS) species and immune cell phenotypes in the presence of RSV infection. The results show that cube CNP significantly reduces RSV-induced ROS levels and drives an M1 phenotype in RSV-infected macrophages. Sphere CNP increases RSV-induced RNS levels with minimal effect on ROS levels and decreases M2 marker CD206 expression. Cube CNP preferentially accumulates in murine alveolar macrophages and induces their activation, avoiding enhanced uptake and activation of other inflammatory cells.
BIOACTIVE MATERIALS
(2023)
Article
Polymer Science
Vasily V. Spiridonov, Andrey V. Sybachin, Vladislava A. Pigareva, Mikhail I. Afanasov, Sharifjon A. Musoev, Alexander V. Knotko, Sergey B. Zezin
Summary: An elegant method for synthesizing nanocomposites consisting of cerium-containing nanoparticles stabilized by carboxymethyl cellulose (CMC) macromolecules at room temperature was introduced in this study. The nanocomposites were characterized using microscopy, XRD, and IR spectroscopy analysis. The crystal structure of the inorganic nanoparticles, corresponding to CeO2, was determined and a mechanism for nanoparticle formation was proposed. The study demonstrated that the size and shape of the nanoparticles in the resulting nanocomposites were independent of the ratio of the initial reagents. Spherical particles with a mean diameter of 2-3 nm were obtained in different reaction mixtures with a cerium mass fraction ranging from 6.4% to 14.1%. The study also proposed a dual stabilization scheme for CeO2 nanoparticles involving carboxylate and hydroxyl groups of CMC. These findings suggest that the easily reproducible technique has promise for the large-scale development of nanoceria-containing materials.
Article
Chemistry, Multidisciplinary
Hongbing Liu, Muse Ji, Yuti Bi, Peifu Xiao, Jiansong Zhao, Jingxin Gou, Tian Yin, Haibing He, Huaiwei Ding, Xing Tang, Yu Zhang
Summary: This study presents a novel mesoporous cerium oxide nanozymes (MCN) loaded with Myeloid differentiation factor-88 (MyD88) inhibitor for synergistic treatment of ulcerative colitis. The MCN exhibits excellent ROS scavenging abilities and can carry the MyD88 inhibitor, achieving a dual therapeutic effect. Coating the MCN with dextran sulfate sodium (DSS) and enteric material Eudragit S100 enhances their anti-inflammatory abilities and colon targeting. The combination of MCN-mediated ROS scavenging and MyD88 inhibition effectively reduces inflammation in colitis mice.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Genetics & Heredity
Vanessa Castelli, Cosimo Andrea Stamerra, Michele d'Angelo, Annamaria Cimini, Claudio Ferri
Summary: Fabry disease is a rare pan-ethnic disease affecting both males and females. It is caused by mutations of the GLA gene, leading to complications such as renal failure, cardiovascular problems, and neuropathy. Current in vivo and in vitro models help in understanding the pathogenesis of the disease and can aid in optimizing existing therapies and developing new treatment options.
Article
Environmental Sciences
Giulia Caioni, Carmine Merola, Monia Perugini, Michele d'Angelo, Anna Maria Cimini, Michele Amorena, Elisabetta Benedetti
Summary: The extensive use of pesticides is driven by the need to sustain population growth and promote agricultural production. Research shows that pesticide mixtures may lead to unpredictable effects, diverging from those observed after single exposure.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Pharmacology & Pharmacy
Luana di Leandro, Francesco Giansanti, Sabrina Mei, Sara Ponziani, Martina Colasante, Matteo Ardini, Francesco Angelucci, Giuseppina Pitari, Michele d'Angelo, Annamaria Cimini, Maria Serena Fabbrini, Rodolfo Ippoliti
Summary: A novel suicide gene therapy approach was tested in U87 MG glioblastoma multiforme cells, utilizing a G-rich double-stranded DNA aptamer and glioma-specific aptamer to effectively kill target cells. The main findings support the proof-of-concept for local delivery in rat glioblastoma models.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Maria Grazia Tupone, Michele d'Angelo, Vanessa Castelli, Mariano Catanesi, Elisabetta Benedetti, Annamaria Cimini
Summary: Exploring and developing multifunctional intelligent biomaterials is crucial for improving next-generation therapies in tissue engineering and regenerative medicine. These biomaterials can mimic the in situ microenvironment and provide specialized bioactive signals to regulate the surrounding biological habitat, contributing to wound healing and biomaterial integration. The connection between stem cells and biomaterials can stimulate specific modifications in cell properties and fate, influencing processes such as self-renewal, adhesion, and differentiation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mariarosaria Cuozzo, Vanessa Castelli, Carmen Avagliano, Annamaria Cimini, Michele d'Angelo, Claudia Cristiano, Roberto Russo
Summary: Research has shown the efficacy of probiotic formulations in preventing chemotherapy-induced peripheral neuropathy, reducing inflammation, modulating pain receptor expression, preserving gut functionality, and preventing increased pain sensitivity. These probiotic treatments may be a useful and non-toxic adjuvant agent to improve long-term therapies for patients undergoing chemotherapy.
Article
Cell Biology
Laura Brandolini, Michele d'Angelo, Rubina Novelli, Vanessa Castelli, Cristina Giorgio, Anna Sirico, Pasquale Cocchiaro, Francesco D'Egidio, Elisabetta Benedetti, Claudia Cristiano, Antonella Bugatti, Anna Ruocco, Pier Giorgio Amendola, Carmine Talarico, Candida Manelfi, Daniela Iaconis, Andrea Beccari, Andreza U. Quadros, Thiago M. Cunha, Arnaldo Caruso, Roberto Russo, Annamaria Cimini, Andrea Aramini, Marcello Allegretti
Summary: This study discovered that paclitaxel can bind and activate C5a receptor 1 (C5aR1), which is crucial in the development of chemotherapy-induced peripheral neuropathy (CIPN) and hypersensitivity reactions (HSRs). In vitro studies and animal experiments confirmed the effectiveness of C5aR1 inhibition in protecting against neuropathological effects and reducing CIPN symptoms. Additionally, C5aR1 inhibition can counteract paclitaxel-induced hypersensitivity reactions. Thus, C5aR1 is identified as a potential pharmacological target for the prevention and treatment of CIPN and HSRs induced by paclitaxel.
CELL DEATH & DISEASE
(2022)
Review
Nutrition & Dietetics
Giulia Caioni, Annamaria Cimini, Elisabetta Benedetti
Summary: Maintaining a healthy lifestyle is crucial for the well-being and health of the population, especially in terms of balanced nutrition. The choice of food and dietary habits can impact disease management, including Parkinson's disease. However, in today's western lifestyle, it has become challenging to maintain a balanced diet, and the importance of a healthy diet tends to be neglected. This issue should not only be addressed in terms of food choice, but also from an environmental perspective.
Article
Pharmacology & Pharmacy
Laura Brandolini, Andrea Aramini, Gianluca Bianchini, Anna Ruocco, Riccardo Bertini, Rubina Novelli, Patrizia Angelico, Anna Elisa Valsecchi, Roberto Russo, Vanessa Castelli, Annamaria Cimini, Marcello Allegretti
Summary: DF2755A, a selective inhibitor of chemokine receptors CXCR1/2, can prevent and reverse peripheral neuropathy in non-ulcerative interstitial cystitis (IC)/bladder pain syndrome (BPS) by inhibiting chemokine-induced excitation of sensory neurons. It shows anti-hyperalgesic effects by inhibiting the expression of CXCR2 agonists CXCL1/KC, CXCL5, and TRPV1.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Reyes Benot-Dominguez, Annamaria Cimini, Daniela Barone, Antonio Giordano, Francesca Pentimalli
Summary: This review provides an overview of the potential use of plant-based foods, nutraceuticals, and derived micronutrients as anticancer agents, with a focus on their mechanism of action as cyclin-dependent kinase inhibitors. It also discusses the importance of CDKs as a target in breast and ovarian cancer treatment, as well as ongoing research on the management of obesity-related cancers through nutritional strategies and phytochemicals.
Review
Biology
Francesco D'Egidio, Giorgia Lombardozzi, Housem E. Kacem Ben Haj M'Barek, Giada Mastroiacovo, Margherita Alfonsetti, Annamaria Cimini
Summary: Neuropathic pain, caused by lesions or diseases of the somatosensory nervous system, affects 7-10% of the global population. Dietary interventions, such as the use of nutraceuticals or probiotics, may be beneficial in alleviating neuropathic pain and associated symptoms.
Article
Multidisciplinary Sciences
Oscar Solis, Andrea R. Beccari, Daniela Iaconis, Carmine Talarico, Camilo A. Ruiz-Bedoya, Jerome C. Nwachukwu, Annamaria Cimini, Vanessa Castelli, Riccardo Bertini, Monica Montopoli, Veronica Cocetta, Stefano Borocci, Ingrid G. Prandi, Kelly Flavahan, Melissa Bahr, Anna Napiorkowski, Giovanni Chillemi, Masato Ooka, Xiaoping Yang, Shiliang Zhang, Menghang Xia, Wei Zheng, Jordi Bonaventura, Martin G. Pomper, Jody E. Hooper, Marisela Morales, Avi Z. Rosenberg, Kendall W. Nettles, Sanjay K. Jain, Marcello Allegretti, Michael Michaelides
Summary: This study discovered an interaction between the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human estrogen receptor alpha (ER alpha), and identified a highly conserved and functional nuclear receptor coregulator (NRC) LXD-like motif on the S2 sub-unit.
Article
Cell Biology
Michele d'Angelo, Laura Brandolini, Mariano Catanesi, Vanessa Castelli, Cristina Giorgio, Margherita Alfonsetti, Mara Tomassetti, Mara Zippoli, Elisabetta Benedetti, Maria Candida Cesta, Sandro Colagioia, Pasquale Cocchiaro, Annamaria Cimini, Marcello Allegretti
Summary: Intestinal barrier disruption can lead to leaky gut, characterized by loss of epithelial integrity. Non-steroidal anti-inflammatory drugs (NSAIDs) are known to have harmful effects on intestinal and gastric epithelial integrity. This study compared the effects of different classes of NSAIDs in an in vitro model of leaky gut. The results showed that ketoprofen and ketoprofen lysine salt counteracted oxidative stress and morphological changes in the intestinal barrier, while ibuprofen and its salts had similar effects.
Article
Developmental Biology
Carmine Merola, Giulia Caioni, Annamaria Cimini, Monia Perugini, Elisabetta Benedetti
Summary: This study evaluated the impact of sodium valproate (SV) on zebrafish early-life stages and found that SV has teratogenic potential, causing morphological abnormalities in the head and body of zebrafish, as well as significant malformations in the brain. Additionally, the study suggests a potential protective role of pparg in SV dose-dependent toxicity, which is reported for the first time.
BIRTH DEFECTS RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Francesco D'Egidio, Vanessa Castelli, Annamaria Cimini, Michele d'Angelo
Summary: Huntington's Disease (HD) is a hereditary neurodegenerative disorder caused by the expansion of a CAG triplet repeat in the HTT gene, resulting in the production of an aberrant huntingtin (Htt) protein. The accumulation of mutant protein leads to neuronal dysfunction and cell death, primarily through oxidative damage, excitotoxicity, inflammation, and mitochondrial impairment. This review aims to provide an overview of the cell's response to stress in HD, with a focus on the role of oxidative stress and its interaction with the antioxidant system.
Article
Biochemistry & Molecular Biology
Chiara Compagnoni, Veronica Zelli, Andrea Bianchi, Antinisca Di Marco, Roberta Capelli, Davide Vecchiotti, Laura Brandolini, Anna Maria Cimini, Francesca Zazzeroni, Marcello Allegretti, Edoardo Alesse, Alessandra Tessitore
Summary: This study analyzed the regulation of microRNA levels in corneal cells in response to recombinant human NGF (rhNGF) treatment, and identified key genes and pathways involved in neurotrophin signaling and cell proliferation and apoptosis control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
