Review
Chemistry, Multidisciplinary
Yuvaraj Arun, Radhakanta Ghosh, Abraham J. Domb
Summary: Biodegradable, hydrophobic, and injectable liquid polymers are able to achieve sustained, local drug release, with potential applications in regenerative medicine.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Engineering, Biomedical
Min Wang, Peng Xu, Bo Lei
Summary: Developing bioactive biomaterials with highly controlled functions is crucial to enhancing their applications in regenerative medicine. Citrate-based polymers are widely used in biomedicine due to their facile synthesis, controllable structure, biocompatibility, biomimetic mechanical behavior, and functional groups available for modification. They have been extensively studied and applied in various biomedical fields, showing great potential for clinical applications.
BIOACTIVE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Malgorzata Oleksy, Klaudia Dynarowicz, David Aebisher
Summary: The introduction of new biomaterials has greatly improved the quality of human life in terms of health by enabling the development of fields such as medicine, tissue, and regenerative engineering. These materials, with their specific features like biocompatibility and ease of sterilization, have led to the availability of various implants, prostheses, tools, and surgical equipment. The use of biomaterials in tissue engineering and regenerative medicine strategies aims to restore damaged tissues by providing an ideal rate of regenerated tissue development.
Review
Pharmacology & Pharmacy
Suzana Goncalves Carvalho, Aline Martins dos Santos, Amanda Leticia Polli Silvestre, Alberto Gomes Tavares, Marlus Chorilli, Maria Palmira Daflon Gremiao
Summary: This review discusses the progress and applications of nano-in-microparticle systems in drug targeting. It also emphasizes the use of biomaterials in these systems and the challenges they face. The article proposes future perspectives for advances in clinical and field translation of multifunctional systems based on nano-in-microparticles.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Review
Chemistry, Multidisciplinary
Junya Uchida, Bartolome Soberats, Monika Gupta, Takashi Kato
Summary: Liquid crystals have been studied intensively as functional materials, and recent integration of various disciplines has opened up new possibilities for the design and functionality of liquid-crystalline materials in fields such as energy, water, photonics, actuation, sensing, and biotechnology. This review focuses on recent advances in functional liquid crystals based on polymers, supramolecular complexes, gels, colloids, and inorganic-based hybrids, discussing design strategies, functionalization, and the insights provided by advanced measurements and computational simulations.
ADVANCED MATERIALS
(2022)
Review
Engineering, Chemical
Mariana Chelu, Adina Magdalena Musuc
Summary: Biomaterials are natural and synthetic materials compatible with the human body. They are widely used in the medical field for various purposes. This review provides an overview of the classification, applications, and challenges in the field of biomaterials.
Article
Engineering, Multidisciplinary
Payam Zarrintaj, Farzad Seidi, Mohamadreza Youssefi Azarfam, Mohsen Khodadadi Yazdi, Amir Erfani, Mahmood Barani, Narendra Pal Singh Chauhan, Navid Rabiee, Tairong Kuang, Justyna Kucinska-Lipka, Mohammad Reza Saeb, Masoud Mozafari
Summary: Biomimetic scaffolds play an important role in tissue regeneration and have multifunctional characteristics. Biopolymers, with their unique biocompatibility and biodegradability, are ideal candidates for tissue engineering and regenerative medicine. This article reviews different types of biopolymers and their composites, as well as their interactions with specific cells and tissues. Cellular mechanisms in tissue regeneration are also considered, along with the challenges and improvements required for using biopolymer-based composites in tissue engineering.
COMPOSITES PART B-ENGINEERING
(2023)
Review
Chemistry, Multidisciplinary
Mingqiu Hu, Thomas P. Russell
Summary: This review highlights the developments in the past decade that used polymers with advanced architectures as multifunctional emulsifiers in various industries such as food, cosmetics, and pharmaceuticals. These emulsifiers have been utilized for encapsulation, delivery, and as templates for polymerization reactions.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Review
Biochemistry & Molecular Biology
Sandra Laner-Plamberger, Michaela Oeller, Eva Rohde, Katharina Schallmoser, Dirk Strunk
Summary: Heparin and its derivatives play a crucial role in preventing and treating thromboembolic events, but further research is needed to fully understand their influence on cell behavior and the risks associated. New applications in regenerative medicine are emerging, supporting the production of cell-based therapeutics and the creation of functionalized matrices in biotechnology. The resurgence of interest in heparins is driven by the potential combined anti-inflammatory, anti-thrombotic, and anti-viral action against COVID-19, highlighting the importance of discriminating between different types of heparins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Yasmeen Shamiya, Shruthi Polla Ravi, Ali Coyle, Subrata Chakrabarti, Arghya Paul
Summary: This article reviews emerging therapeutic nanoparticles for treating diabetic wounds and discusses their discrete delivery mechanisms and sites of action. The current challenges of these nanoengineered materials for successful clinical translation are critically assessed, along with their potential for growth in the clinical marketplace.
DRUG DISCOVERY TODAY
(2022)
Review
Biochemistry & Molecular Biology
Courtney R. Lynch, Pierre P. D. Kondiah, Yahya E. Choonara
Summary: Tissue engineering involves various aspects of science, medicine, and engineering, focusing on promoting the growth of new cells and tissue components for severe tissue injury and damage treatment. Different biofabrication strategies, including hydrogels, 3D bioprinted scaffolds, and nanotechnology, are vital for this purpose. Biopolymers, specifically those with natural origins, have become increasingly popular due to their biocompatibility, biodegradability, and lack of immune response in the body.
Review
Chemistry, Multidisciplinary
Mehdi Derradji, Oussama Mehelli, Wenbin Liu, Nicholas Fantuzzi
Summary: High performance thermosetting resins are widely used in aerospace and marine fields, and sustainable and ecofriendly thermosetting polymers have shown similar or even better performances. Exploring alternative renewable feedstock is crucial for meeting industry demands.
FRONTIERS IN CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Chen Zhang, Yihong Li, Xinyong Ma, Wenxin He, Chenxi Liu, Zhe Liu
Summary: Chemically functionalized gas-filled bubbles at micro/nano scale have shown great potential in disease diagnosis and treatment, with applications in biomedical imaging, drug delivery, gene transfection, and disease-oriented therapy. The use of ultrasound in conjunction with functional micro/nanobubbles has led to significant advancements in disease precision therapy and holds promise for future healthcare advancements.
SCIENCE CHINA-CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Gan Luo, Yaqi Sun, Jue Zhang, Zhipeng Xu, Wuyuan Lu, Hanbin Wang, Yan Zhang, Hui Li, Zhengwei Mao, Shixin Ye, Baoli Cheng, Xiangming Fang
Summary: NDEFgel, a nanoengineered human alpha-defensin 5 encased hydrogel, was developed and shown to promote wound healing by modulating fibroblast behavior and upregulating genes related to collagen deposition. Pluronic F127 (Plu) hydrogel was identified as the optimal carrier for ND delivery, exhibiting controlled release and good compatibility. These findings suggest that NDEFgel may offer a promising dual-action therapeutic option for advanced wound management in the future.
Review
Polymer Science
Partha Sikdar, Tanvir Mahady Dip, Avik K. Dhar, Maitry Bhattacharjee, Md. Saiful Hoque, Solaiman Bin Ali
Summary: This review paper outlines the recent advances of polyurethanes (PUs) in functional textiles, intelligent functionality, and medical applications. It provides a comprehensive discussion of the diverse structure and responsiveness of PUs under various conditions, as well as future challenges and research opportunities.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Muhammad Farhan, Deeptangshu Chaudhary, Ulrich Noechel, Marc Behl, Karl Kratz, Andreas Lendlein
Summary: In this study, electrically triggerable poly[ethylene-co-(vinyl acetate)] (PEVA)-based fiber actuators were developed and showed higher conductivity in coated fibers, with a higher switching temperature and reversible length change. These electro-conductive polymeric actuators are suitable for scaling up and exploring their application potential as artificial muscles in future studies.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2021)
Article
Materials Science, Biomaterials
Anne Krueger-Genge, Sandra Hauser, Axel T. Neffe, Yue Liu, Andreas Lendlein, Jens Pietzsch, Friedrich Jung
Summary: The study revealed that different material properties of gelatin-based hydrogels have an impact on the interaction with venous endothelial cells (HUVEC) and the formation of a monolayer. Hydrogels with higher moduli were more effective in promoting the formation of a functionally confluent endothelial cell monolayer, suggesting their potential as biomaterials for implants in the venous system.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Hematology
Xun Xu, Yan Nie, Weiwei Wang, Imran Ullah, Wing Tai Tung, Nan Ma, Andreas Lendlein
Summary: By adjusting cell distribution and seeding methods, successful lung bud organoids were established, with single-cell seeding at moderate density and homogenous distribution showing better results, while clump seeding was suitable for high density. The use of 2.5D culture enabled direct monitoring of internal structure, providing a simple, efficient, and valuable tool for drug screening, disease modeling, and personalized medicine.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2021)
Article
Hematology
Janita A. Maring, Matthias Becker, Wing Tai Tung, Christof Stamm, Nan Ma, Andreas Lendlein
Summary: Polymeric materials used as artificial grafts in cardiovascular applications can induce immune responses from peripheral blood, but coating with ECM components may slightly improve the response of immune cells. In this study, comparing the response of blood-born immune cells to uncoated and coated fiber meshes from polyesteretherurethane (PEEUm), it was found that the coating with ECM may not justify the additional effort.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2021)
Article
Materials Science, Multidisciplinary
Rainhard Machatschek, Matthias Heuchel, Andreas Lendlein
Summary: Polyimides and polyetherimides (PEI) exhibit the capability to react with nucleophiles under mild conditions, allowing for surface properties adjustment through post-functionalization targeting phthalimide groups. Investigating surface functionalization using ultra-thin PEI films on a Langmuir trough, it was found that hydrolysis enhances film stability and activates ester formation. The direct amidation of PEI with Lewis acid catalyst resulted in free amine groups, showing a greater impact of hydrolysis on material properties when compared to amidation.
JOURNAL OF MATERIALS RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Yue Liu, Oliver E. C. Gould, Karl Kratz, Andreas Lendlein
Summary: Polymeric devices capable of controlled release of submicron particles on demand have been demonstrated using a temperature-memory polymer sheet as a matrix to embed and release polystyrene subMP based on particle size and temperature. The technology allows for sequential release of subMPs based on their size and temperature-memory effect, showing potential applications in assembly, particle sorting, and release technologies in microtechnology, catalysis, and controlled release.
Article
Materials Science, Multidisciplinary
Hanieh Moradian, Manfred Gossen, Andreas Lendlein
Summary: This study investigates the effects of different payload designs on gene co-expression, and finds that co-delivery of individual monocistronic nucleic acids is more effective than a bicistronic design.
MRS COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Lucile Tartivel, Anna M. Blocki, Steffen Braune, Friedrich Jung, Marc Behl, Andreas Lendlein
Summary: This study presents microporous hydrogels with an inverse shape-memory effect, which can change their shape through heating and cooling. These hydrogels can gently load bioactive components without causing activation, making them potential candidates for tissue regeneration.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Shuo Zhou, Xun Xu, Nan Ma, Friedrich Jung, Andreas Lendlein
Summary: Glycerol-based epoxy networks have great potential for surface functionalization, but the production process may lead to the presence of organochlorides, affecting cytotoxicity.
Article
Materials Science, Multidisciplinary
Shanshan Zhang, Yue Liu, Rainhard Machatschek, Andreas Lendlein
Summary: We report the successful production of cohesive and well-organized type I collagen ultrathin films of about 10 nm thickness using the Langmuir-Blodgett technique. Investigation of molecular behavior at the air-water interface reveals the existence and disappearance of a network structure in the protein nanosheet. Highly aligned and fibrillar structures are observed by atomic force microscopy and optical microscopy.
Article
Energy & Fuels
Natalia A. Tarazona, Rainhard Machatschek, Jennifer Balcucho, Andreas Lendlein, Jinneth Lorena Castro-Mayorga, Juan F. Saldarriaga
Summary: The production and consumption of commodity polymers are crucial for the development of modern society. Polymer-based materials play important roles in various fields such as healthcare, transport, food preservation, construction, electronics, and water management. However, considering the environmental crisis caused by plastic consumption, advanced polymers should incorporate functions that meet application demands and minimize environmental harm. This article discusses strategies to enhance the sustainability of plastics, including measuring and reducing negative impacts, using renewable sources for synthesis, designing biodegradable and recyclable materials, and enzymatic recycling for a circular bioeconomy. International cooperation is also emphasized for achieving the Sustainable Development Goals (SDGs) through leading-edge polymer-based materials.
MRS ENERGY & SUSTAINABILITY
(2022)
Article
Materials Science, Multidisciplinary
Falk Hoffmann, Rainhard Machatschek, Andreas Lendlein
Summary: This study investigates the degradation of polymers using mathematical models, comparing different chain cut mechanisms and analyzing the influence of internal molecular parameters. The results show that the shape of the degradation curve is similar for both chain cut mechanisms, and a characteristic time and maximum length of soluble fragments can be extracted to enhance the description and design of polymers.
JOURNAL OF MATERIALS RESEARCH
(2022)
Article
Medicine, Research & Experimental
Hanieh Moradian, Toralf Roch, Larissa Anthofer, Andreas Lendlein, Manfred Gossen
Summary: In vitro transcribed (IVT)-mRNA is a promising therapeutic modality that can be tailored to modulate innate immune responses of human cells. Uridine modifications were found to be particularly important for IVT-mRNA performance, while 5'-end modifications had modest effects on mRNA expression and immune responses.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Materials Science, Multidisciplinary
Magdalena Mazurek-Budzynska, Marc Behl, Richard Neumann, Andreas Lendlein
Summary: This study presents multifunctional 4D actuators processed by 3D-printing, with actuator functionality integrated into the shaped body. The materials are based on crosslinked poly(carbonate-urea-urethane) networks (PCUU) synthesized in an integrated process, showing reversible deformation when thermomechanically programmed.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Wing Tai Tung, Xianlei Sun, Weiwei Wang, Xun Xu, Nan Ma, Andreas Lendlein
Summary: The degradation behavior of a degradable implant made of polyesteretherurethane (PEEU70) was studied, showing that the sustained mechanical stability of PEEU70-based meshes depends on the fiber diameter and molecular weight. Crack or wrinkle formation was observed in all samples as degradation progressed, with maximum mass loss reached by week 6.
