Article
Chemistry, Multidisciplinary
Abhishek Bhattacharjee, Emma Goodall, Bruno Leandro Pereira, Paulo Soares, Ketul C. Popat
Summary: Titanium (Ti) is a popular biomaterial for orthopedic implants due to its superior properties. However, around 10% of these implants fail annually due to infection and poor osseointegration. Nanoscale surface modification and doping of trace elements can improve cell adhesion and reduce bacterial infection.
Article
Chemistry, Physical
Christie Y. K. Lung, Mohamed M. Abdalla, Chun Hung Chu, Iris Yin, Sofiya-Roksolana Got, Jukka P. Matinlinna
Summary: A novel multi-element-doped porous bioactive glass coating for titanium implants was developed and showed promising biocompatibility and antibacterial activity, suggesting potential clinical applications.
Article
Orthopedics
Toshiharu Shirai, Hiroyuki Tsuchiya, Ryu Terauchi, Shinji Tsuchida, Seiji Shimomura, Yoshitomo Kajino, Kenji Takahashi
Summary: This study developed an iodine coating for titanium implants to reduce surgical site infections, and conducted a prospective clinical study to evaluate its efficacy and potential drawbacks.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Jia-Jun Qiu, Ting-Ting Yang, Yi-Fan Li, Wen-Hao Qian, Xuan-Yong Liu
Summary: Au@Ag@Pt core-shell nanorods with noble metal combination were fabricated and assembled on medical titanium surface to investigate their antibacterial activity and biocompatibility. The Pt shell layer on Ti-Au@Ag@Pt was found to slow down the Ag ion release rate, which endowed the medical titanium surface with both antibacterial activity and good biocompatibility without obvious cell toxicity. The antibacterial rates of Ti-Au@Ag@Pt against S. epidermidis and P. aeruginosa were 89.7% and 92.7%, respectively.
Article
Engineering, Biomedical
Yifu Zhuang, Ling Ren, Shuyuan Zhang, Xiang Wei, Ke Yang, Kerong Dai
Summary: A copper-containing titanium alloy was fabricated for the prevention and treatment of MRSA-induced implant-associated infection, showing stable and continuous release of Cu2+ and effective antibacterial performance. In vivo studies demonstrated the alloy's ability to prevent severe infection in a rat model and its favorable biocompatibility.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Michal Bartmanski, Lukasz Pawlowski, Anna Belcarz, Agata Przekora, Grazyna Ginalska, Gabriel Strugala, Bartlomiej Michal Cieslik, Anna Palubicka, Andrzej Zielinski
Summary: Nanosilver and nanocopper dispersed in nanohydroxyapatite coatings deposited on titanium alloy can enhance corrosion resistance and hydrophilicity, effectively kill bacteria and inhibit biofilm growth, but show toxicity towards osteoblasts. These coatings may be valuable for antibacterial purposes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Nikhil Anand, Neha Mehrotra, Kaushik Pal
Summary: In this study, a biodegradable Zn-1Mg-1Cu-1HA (ZHA) and Zn-1Mg-1Cu-1ZrO2 (ZZR) composite was created using the stir-casting process and enhanced with a ceramic composite coating by electrodeposition technique. Microstructural analysis revealed uniform distribution of fine MgZn2 and CuZn2 phases in an α-Zn matrix. The mechanical test confirmed high tensile and compressive properties of the ZZR composite, along with low corrosion rate and degradation rate, and good cell viability. Overall, the coated ZZR composite shows promise as a material for implant applications.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Fengyuan Gao, Adeel Ahmed, Hailin Cong, Bing Yu, Youqing Shen
Summary: Traumatic multidrug resistant bacterial infections are the most lethal threat to wound healing. Antimicrobial peptides are effective in shielding both Gram-positive and Gram-negative bacteria. In this study, bacterial membrane chromatography was used to quickly screen for peptides with antibacterial effects. An antimicrobial peptide was successfully screened and used to develop an antimicrobial hydrogel, which showed a powerful therapeutic effect in a wound infection model.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biotechnology & Applied Microbiology
Hao Zhang, Xiaolong Shen, Zhikui Fei, Xingping Fan, Lan Ma, Haibo Wang, Congxue Tian, Bo Zhang, Rifang Luo, Yunbing Wang, Shengtian Huang
Summary: In this study, an Ag-incorporated polydopamine/tannic acid coating was prepared and successfully applied to the surface of titanium implants. The coating exhibited improved hydrophilicity, good cytocompatibility, and antibacterial effectiveness, providing a potential solution for surface modification of titanium implants.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biophysics
Ming Ma, Mengli Zhao, Haiyan Deng, Zuoda Liu, Liping Wang, Linhu Ge
Summary: To overcome the low bactericidal activity and poor osteogenic activity of titanium in dental implants, researchers surface-modify biomedical titanium through the plasma immersion coimplantation of magnesium and copper ions. The best-performing Mg/Cu(8/10)-Ti sample promotes cell proliferation and initial cell adhesion, exhibits high hydrophilicity, outstanding activity against periimplantitis-causing bacteria, and shows good bio-/hemocompatibility. This study concludes that Mg/Cu coimplantation endows the titanium surface with high bacteriostatic activity and biocompatibility, which could pave the way for widespread use of titanium-based dental implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Polymer Science
Dmitriy E. Burmistrov, Dmitriy A. Serov, Aleksander Simakin, Ilya Baimler, Oleg Uvarov, Sergey Gudkov
Summary: Nanoparticle coatings are effective in inhibiting bacterial contamination and can provide long-term antibacterial effects. In this study, a coating containing aluminum oxide nanoparticles was successfully produced using polytetrafluoroethylene as a polymer matrix. These coatings exhibited good biocompatibility and mechanical properties, preventing bacterial growth and eliminating micro damages in the food production process.
Article
Materials Science, Ceramics
Mostafizur Rahman, Mohammad Asaduzzaman Chowdhury, Md Shahin Mia, Md Ramjan Ali, Atiqur Rahman, Md Osman Ali, Saifullah Mahmud
Summary: This study reported a novel interfacial engineering approach for the fabrication of polymer/ceramic hybrid coating on magnesium alloy, which significantly improved mechanical properties, enhanced biointerface property, and slowed down degradation in simulated body fluid. The hybrid coating also improved corrosion resistance and enhanced biocompatibility and bioactivity.
CERAMICS INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Jon Andrade del Olmo, Leyre Perez-Alvarez, Miguel Angel Pacha-Olivenza, Leire Ruiz-Rubio, Oihane Gartziandia, Jose Luis Vilas-Vilela, Jose Maria Alonso
Summary: Different polymeric antibacterial coatings were developed and analyzed for Ti6Al4V surface covering in this study, showing good cytocompatibility and antibacterial properties, which confirms their effectiveness against bacterial infections for future applications in protecting biomedical implants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Integrative & Complementary Medicine
Reza Eftekhar Ashtiani, Mostafa Alam, Sara Tavakolizadeh, Kamyar Abbasi
Summary: Dental implants represent a combination of technology and science, involving physics, biomechanics, and surface chemistry. They promote bone response and biomechanical ability, and it is crucial for biomaterials to be biodegradable without harmful effects on tissues and cells. Biomaterials play important roles in dental prosthetic conditions and offer promising candidates for coatings of dental implants.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Seiji Yamaguchi, Phuc Thi Minh Le, Seine A. Shintani, Hiroaki Takadama, Morihiro Ito, Sara Ferraris, Silvia Spriano
Summary: The study developed a new method to incorporate iodine into titanium and its alloys, enhancing their antibacterial properties and demonstrating strong antibacterial activity against various bacteria. The treated metals showed long-term stability in antibacterial activity and cytocompatibility, making them potentially useful for orthopedic and dental implants.