Article
Chemistry, Multidisciplinary
Hongqiu Wei, Bo Zhang, Ming Lei, Zhe Lu, Jupen Liu, Baolin Guo, You Yu
Summary: A straightforward and low-cost visible-lightmediated nano-biomineralization strategy was developed for rapid preparation of Biomineralized tough hydrogels (BTHs). This strategy allows for the improvement of mechanical and biological properties of BTHs, making them suitable for applications such as skin repair and bone regeneration.
Article
Engineering, Biomedical
Zhuo Li, Haixing Wang, Kunyu Zhang, Boguang Yang, Xian Xie, Zhengmeng Yang, Lingchi Kong, Peng Shi, Yuan Zhang, Yi-Ping Ho, Zhi-Yong Zhang, Gang Li, Liming Bian
Summary: The research assembled a biomimetic hyaluronic acid nanocomposite hydrogel with bisphosphonates (BPs), and demonstrated its expedited release of BPs in an acidic environment. The in vitro studies showed that the hydrogel inhibits mature osteoclastic differentiation, while promoting the initial differentiation of primary macrophages to preosteoclasts. In vivo evaluation confirmed the hydrogel's ability to enhance in situ bone regeneration.
BIOACTIVE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Yiwen Xi, Prashant Kumar Sharma, Hans Jan Kaper, Chang-Hwan Choi
Summary: The study investigated the tribological properties of micropored pHEMA under physiologically relevant conditions, finding that it significantly reduced frictional energy dissipation at relatively high loads and sliding speeds. This was attributed to the greater amount and retentivity of the interfacial fluid supported by the free water squeezed out of micropores with smaller dimensions under higher load and sliding speed.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Biochemistry & Molecular Biology
Elena Merotto, Piero G. Pavan, Martina Piccoli
Summary: Three-dimensional bioprinting uses cell-loaded bioinks to create living structures and has brought significant innovation to biomedicine, specifically tissue engineering. Naturally derived hydrogels, especially those obtained through decellularization of biological tissues, show promise as bioinks due to their excellent biocompatibility. However, many natural hydrogels lack the necessary mechanical properties for 3D printing. This review focuses on the bioactive and mechanical characteristics of natural hydrogels to enable efficient production of organs and tissues, with an emphasis on reinforcement techniques to improve their biomechanical properties.
Article
Materials Science, Multidisciplinary
Bahar Aslanbay Guler, Zeliha Demirel, Esra Imamoglu
Summary: From a bioengineering perspective, incorporating microalgae into chemobrionic structures can lead to functional materials with potential in various applications. In this study, the incorporation of Arthrospira platensis microalgae was successfully achieved, resulting in the development of a bioactive and biomimetic material called biochemobrionic. Various characterization analyses confirmed the presence of microalgal biomass and extract, and it was demonstrated that the incorporation of A. platensis extract improved the mechanical strength of the chemobrionics. Cytotoxicity, biodegradability, and antioxidant activity assays further revealed the bioactive potential of the extract-incorporated biochemobrionics.
APPLIED MATERIALS TODAY
(2023)
Article
Nanoscience & Nanotechnology
Letian Feng, Ruixing Liu, Xiacong Zhang, Jingguo Li, Lei Zhu, Zhanrong Li, Wen Li, Afang Zhang
Summary: DC hydrogels possess excellent biocompatibility and properties to promote corneal cell proliferation and migration, showing promising applications in corneal tissue engineering.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Biomedical
Siming Zhang, Gaoran Ge, Yi Qin, Wenhao Li, Jiale Dong, Jiawei Mei, Ruixiang Ma, Xianzuo Zhang, Jiaxiang Bai, Chen Zhu, Weiwei Zhang, Dechun Geng
Summary: Poor wound healing after diabetes mellitus is characterized by persistent bleeding, inflammation dysregulation, blocked cell proliferation, infection susceptibility, and impaired tissue remodeling. Conventional wound dressings have limited functionality and fail to meet the requirements of diabetic wound healing. Stimuli-responsive hydrogels, which can change their properties in response to various stimuli, have shown promise in improving therapeutic efficacy and reducing toxicity for diabetic wound healing.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Applied
Zhixiao Yao, Yun Qian, Yi Jin, Shikun Wang, Juehong Li, Wei-En Yuan, Cunyi Fan
Summary: The use of MLT-loaded PCL/ALG composite scaffold can effectively promote tendon injury repair by controlled release of MLT, possibly relying on an antioxidant stress pathway, both in vivo and in vitro.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Fatemeh Hakimi, Hamed Jafari, Samaneh Hashemikia, Siamak Shabani, Ali Ramazani
Summary: This study aimed to prepare a novel organic-mineral nanofiber/hydrogel of chitosan-polyethylene oxide (CS-PEO)/nanoclay-alginate (NC-ALG) and investigate its effects on mineralization and biocompatibility. The scaffolds composed of CS-PEO and NC-ALG were evaluated for their properties and characteristics. The results showed that the incorporation of NC particles in the scaffold enhanced bone-like apatite formation and demonstrated compatibility and safety for osteoblastic cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Pharmacology & Pharmacy
Yanbing Gao, Xiaobo Zhang, Haiyu Zhou
Summary: Biomimetic hydrogels have great potential in tissue engineering and regenerative medicine for tissue repair and regeneration. They can tune mechanical and biological properties, provide three-dimensional network structures, and imitate normal tissue microenvironments to integrate cells, scaffolds, and bioactive substances. However, further research is needed for the biomedical and clinical trial applications of biomimetic hydrogels.
Review
Biotechnology & Applied Microbiology
Saba Salehi, Seyed Morteza Naghib, Hamid Reza Garshasbi, Sadegh Ghorbanzadeh, Wei Zhang
Summary: Hydrogels are widely used biomaterials for therapeutic agent delivery and tissue engineering due to their biocompatibility and similarity to natural body tissues. Some substances have injectable properties, allowing for minimally invasive administration. Gelation can be induced by stimuli, making the material stimuli-responsive. This article introduces various stimuli for gelation and investigates the mechanisms of solution-to-gel transformation, while also studying special structures such as nano gels or nanocomposite gels.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Xing Li, Shaoquan Bian, Mingda Zhao, Xiaowen Han, Jie Liang, Kefeng Wang, Qing Jiang, Yong Sun, Yujiang Fan, Xingdong Zhang
Summary: The supramolecular hydrogels composed of aromatic short peptide gelators exhibited promising application prospects due to their convenient synthesis, nano-fibrillar microstructure, and responsive nature to external stimuli. The study showed that the amino acid arrangement significantly influenced the gelation behavior, with specific combinations able to form nanostructured supramolecular hydrogels. The biphenyl-tripeptide hydrogels demonstrated potential for cartilage tissue engineering applications, promoting cell adhesion, proliferation, ECM secretion, and maintenance of cartilage phenotype.
ACTA BIOMATERIALIA
(2021)
Review
Chemistry, Multidisciplinary
Pedro Lavrador, Marco R. Esteves, Vitor M. Gaspar, Joao F. Mano
Summary: Recent advances in the design of stimuli-responsive nanocomposite hydrogels have expanded their potential for operating as advanced systems in various biomedical applications, benefitting from tailored single or multi-responsiveness. The combination of hydrogels and nanoparticles showcases an intrinsic ability to react to external or internal/physiological stimuli, developing intelligent systems with application-oriented features.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Polymer Science
Qijun Wu, Chao Ma, Lian Chen, Ye Sun, Xianshuo Wei, Chunxin Ma, Hongliang Zhao, Xiuling Yang, Xiaofan Ma, Chunmei Zhang, Gaigai Duan
Summary: In this study, a light-responsive composite actuator was developed by combining inkjet-printed tissue paper with PNIPAM hydrogel. The mechanical property of the composite actuator was highly enhanced due to the high strength of tissue paper and the strong interaction within the interface of the bilayer structure. Furthermore, remote manipulation of light-responsive actuation was achieved using a stamping graphite electrode with high efficiency of photothermal conversion. Biomimetic actuating devices based on the near-infrared (NIR) light response of the composite actuator were also remotely controlled. This work provides a simple strategy for the construction of biomimetic anisotropic actuators and inspires the exploration of new intelligent materials.
Article
Biochemistry & Molecular Biology
Yifeng Yu, Xiaofeng Yu, Danlei Tian, Aixi Yu, Ying Wan
Summary: Amino-functionalized mesoporous silica nanoparticles were optimally synthesized and used in combination with silk fibroin and chitosan to create a thermoresponsive, elastic, and injectable composite hydrogel. The composite gels supported cell growth, matrix deposition, and exhibited osteogenic capacity, showing promising potential in bone repair and regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
