期刊
ACTA BIOMATERIALIA
卷 7, 期 8, 页码 3150-3157出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2011.04.022
关键词
Cyanoacrylates; Tissue adhesives; Surgical glue; Biocompatibility; Mechanical properties
资金
- MIT-DuPont Alliance
Cyanoacrylate glues are easily applied to wounds with good cosmetic results. However, they tend to be brittle and can induce local tissue toxicity. A series of cyanoacrylate monomers with a flexible ether linkage and varying side-chain lengths was synthesized and characterized for potential use as tissue adhesives. The effect of side-chain length on synthesis yield, physical and mechanical properties, formaldehyde generation, cytotoxicity in vitro and biocompatibility in vivo were examined. The incorporation of etheric oxygen allowed the production of flexible monomers with good adhesive strength. Monomers with longer side-chains were found to have less toxicity both in vitro and in vivo. Polymerized hexoxyethyl cyanoacrylate was more elastic than its commercially available and widely used alkyl analog 2-octyl cyanoacrylate, without compromising biocompatibility. Published by Elsevier Ltd. on behalf of Acta Materialia Inc.
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