Article
Biochemistry & Molecular Biology
Kyung-Jong Won, Rami Lee, Sun-Hye Choi, Ji-Hun Kim, Sung-Hee Hwang, Seung-Yeol Nah
Summary: This study aimed to elucidate the involvement of EGFRs in gintonin-induced wound repair in HaCaT keratinocytes. Results showed that gintonin increased EGF receptor activation, as well as promoted proliferation and migration in HaCaT cells. Additionally, gintonin stimulated the expression and release of HB-EGF. These findings suggest a close relationship between gintonin's wound-healing effects and the collaboration of EGF receptor activation and HB-EGF release.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sun-Hye Choi, Kyung-Jong Won, Rami Lee, Han-Sung Cho, Sung-Hee Hwang, Seung-Yeol Nah
Summary: This study demonstrates that gintonin promotes wound healing by enhancing migration and proliferation of skin cells, as well as increasing vascular endothelial growth factor release, possibly through activation of LPA receptors and downstream signaling pathways involving VEGF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Xixi Chen, Gaozan Tong, Junfu Fan, Yingjie Shen, Nan Wang, Wenjie Gong, Zijing Hu, Kunxuan Zhu, Xiaokun Li, Litai Jin, Weitao Cong, Jian Xiao, Zhongxin Zhu
Summary: FGF21 plays a crucial role in promoting migration and differentiation of epidermal cells during wound healing, potentially through activation of fibroblasts and regulation of autophagy-related pathways. It may serve as a novel therapeutic target for accelerating wound healing processes.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Entomology
Yu-Lan Piao, Chun-Yang Zhang, Yue Zhang, Kun Qian, Ying Zhou, Jun-Yan Liu, Young-Cheol Chang, Hoon Cho, Dubok Choi
Summary: In this study, the wound-healing effect of Antheraea pernyi epidermal growth factor (ApEGF) was evaluated through sequence analysis, cloning, and prokaryotic expression. The results showed that ApEGF promoted cell growth and healing, making it a potential therapy for wound healing.
Review
Chemistry, Medicinal
Shasha Jia, Xueya Wang, Guowei Wang, Xiaojing Wang
Summary: Soft tissue damage stimulates the release of catecholamine hormones which bind to beta-adrenergic receptors on the cell membrane surface, impairing soft tissue wound healing. Beta-blockers inhibit this activation and accelerate wound healing by reducing inflammation, promoting cell migration, and inhibiting bacterial effects. They are being studied for their efficacy in various soft tissue wound repair applications, but further investigation into their mechanisms of action is necessary.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Saebin Lim, Ji An Kim, Yoon Hong Chun, Hyun Jong Lee
Summary: This study developed a light-responsive hydrogel-based drug delivery system for controlled release of EGF in wound healing. The results indicate that this system enables precise temporal release of EGF, enhancing its therapeutic potential. This highlights the importance of incorporating stimulus-responsive functionalities into hydrogel-based drug delivery systems for optimizing the clinical applications of protein drugs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Ly Thi Huong Nguyen, Sang-Hyun Ahn, Min-Jin Choi, In-Jun Yang, Heung-Mook Shin
Summary: Puerarin has been shown to promote wound healing by accelerating wound closure rate, increasing keratinocyte proliferation and migration, and enhancing capillary density and collagen fiber levels at the wound sites. Additionally, it activates the ERK and Akt signaling pathways to facilitate keratinocyte function. These findings suggest that puerarin could be a potential treatment for delayed and impaired wound healing caused by dexamethasone.
APPLIED SCIENCES-BASEL
(2021)
Article
Materials Science, Multidisciplinary
Proma Bhattacharya, Moumita Kundu, Subhayan Das, Yash Verma, Mahitosh Mandal, Sudarsan Neogi
Summary: This study developed a nanocomposite hydrogel for wound healing by incorporating magnesium oxide nanoparticles, which significantly improved the properties of the hydrogel and demonstrated good biocompatibility and stimulated cell growth.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Kazharskaia Mariia, Muhammad Arif, Jie Shi, Fulai Song, Zhe Chi, Chenguang Liu
Summary: A novel polysaccharide composite hydrogel has been developed in this study through a freeze-dried process, showing improved microstructure and excellent drug release performance. The experimental results suggest that the hydrogel has the potential to enhance wound healing efficiency.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Wang Xiaojie, Joshua Banda, Hui Qi, Alan K. Chang, Canol Bwalya, Lu Chao, Xiaokun Li
Summary: The process of wound healing involves the interaction of growth factors and cytokines, including inflammation, proliferation, and remodeling. Abnormal regulation of these events can lead to excessive scarring or non-healing wounds. Early events in wound healing play a crucial role in the outcome, and high levels of inflammation can result in scarring. Inhibiting TGF-β3 and administering KGFs have shown positive results in wound closure and reduced scarring, hinting at the potential for scarless wound healing.
CYTOKINE & GROWTH FACTOR REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Maria Pia Polito, Grazia Marini, Michele Palamenghi, Elena Enzo
Summary: The epidermis is a protective tissue in the human body, consisting of proliferative basal cells and differentiating suprabasal layers. Understanding the molecular mechanisms and pathways involved in keratinocytes' organization and regeneration is crucial for therapeutic approaches. Single-cell techniques have identified disease-specific drivers and therapeutic targets, advancing personalized therapies. This review summarizes the latest findings on transcriptomic and epigenetic profiling of human epidermal cells under different skin conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Chen-Liang Tsai, Chih-Ying Changchien, Ying Chen, Hsin-Han Chang, Wen-Chiuan Tsai, Yi-Wen Wang, Kai-Chieh Chou, Ming-Hsien Chiang, Yu-Ling Tsai, Hao-Chung Tsai, Chieh-Yung Wang, Ming-Sheng Shen, Li-Ting Cheng, Hung-Yi Lin, Tse-Bin Yang, Chih-Feng Chian
Summary: This study found that heart failure- and lung cancer-associated pleural fluid promoted HaCaT cell proliferation, migration, and MMP2 upregulation. Furthermore, using LCPF as a dressing material significantly accelerated wound closure and re-epithelialization by increasing neo-epidermis thickness and dermis collagen synthesis to promote wound healing.
Review
Biochemistry & Molecular Biology
Thayaalini Subramaniam, Mh Busra Fauzi, Yogeswaran Lokanathan, Jia Xian Law
Summary: Skin injury healing involves complex processes with various cells, extracellular matrix, and mediators. Cell differentiation, migration, and proliferation are crucial for tissue integrity restoration. Although calcium shows promise in wound healing, challenges need to be addressed before clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Jing-Si Jiang, Jie Zang, Yi Ru, Ying Luo, Jian-Kun Song, Yue Luo, Xiao-Ya Fei, Zhan Zhang, Ying Zhang, Dan Yang, Mi Zhou, Qi-Long Chen, Yun Bai, Yong -Yong Li, Le Kuai, Bin Li
Summary: This study discovered a low level of CCN1 in individuals with diabetic ulcers (DUs). By developing a nanoformulation of CCN1, the researchers were able to protect CCN1 from degradation and enhance its intracellular delivery efficiency. The nanoformulation exhibited anti-inflammatory effects and promoted cell proliferation and migration. Topical application of the nanoformulation showed significant curative effects on delayed wound healing in diabetic patients.
Article
Biochemical Research Methods
Vindya Ramanayake-Mudiyanselage, D. Maheeka Embogama, Mary Kay H. Pflum
Summary: Cell signaling involves a complex network of protein interactions and post-translational modifications. The K-BMAPS method, utilizing ATP-biotin to label substrates, is a powerful tool for mapping dynamic phosphorylation in cell signaling pathways. This method has been used successfully to study the EGFR pathway and identify key phosphoproteins associated with late and continuous signaling events.
JOURNAL OF PROTEOME RESEARCH
(2021)