期刊
ACTA BIOMATERIALIA
卷 6, 期 2, 页码 577-585出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2009.08.021
关键词
Apatites; Resorbable bioceramics; Spark plasma sintering; Low-temperature sintering
资金
- ANR Agence Nationale de la Recherche [ANR-07-BLAN-0373]
- Agence Nationale de la Recherche (ANR) [ANR-07-BLAN-0373] Funding Source: Agence Nationale de la Recherche (ANR)
Nanocrystalline apatites analogous to bone mineral are very promising materials for the preparation of highly bioactive ceramics due to their unique intrinsic physico-chemical characteristics. Their surface reactivity is indeed linked to the presence of a metastable hydrated layer on the surface of the nanocrystals. Yet the sintering of such apatites by conventional techniques, at high temperature, strongly alters their physico-chemical characteristics and biological properties, which points out the need for softer sintering processes limiting such alterations. In the present work a non-conventional technique, spark plasma sintering, was used to consolidate such nanocrystalline apatites at non-conventional, very low temperatures (T < 300 degrees C) so as to preserve the surface hydrated layer present on the nanocrystals. The bioceramics obtained were then thoroughly characterized by way of complementary techniques. In particular, microstructural, nanostructural and other major physico-chemical features were investigated and commented on. This work adds to the current international concern aiming at improving the capacities of present bioceramics, in view of elaborating a new generation of resorbable and highly bioactive ceramics for bone tissue engineering. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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