Article
Dentistry, Oral Surgery & Medicine
X. Gao, Z. Wang, H. Yang, C. Huang
Summary: A prebonding rapid intrafibrillar mineralization strategy was developed to optimize dentin bonding durability. Polyacrylic acid-stabilized amorphous calcium fluoride (PAA-ACF) was used to induce rapid intrafibrillar mineralization of collagen, strengthen dentin mechanical properties, inhibit degradation and bacterial erosion, and demonstrate high-quality integration of the hybrid layer and dentin.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Chemistry, Applied
Haiyan Wu, Changyu Shao, Jue Shi, Zihe Hu, Yanyan Zhou, Zhuo Chen, Ruikang Tang, Zhijian Xie, Wenjing Jin
Summary: Non-collagenous proteins (NCPs) embedded in hyaluronic acid (HA) play a crucial role in regulating collagen fibril mineralization in bone and dentin extracellular matrix (ECM). Through reducing the electronegativity of collagen surface and providing additional nucleation sites, HA promotes intrafibrillar collagen mineralization and accelerates the crystallization process. The effects of HA on collagen mineralization are observed in collagen hydrogel and in vitro dentin remineralization, demonstrating its potential as a biomaterial for repairing collagen mineralized tissues.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Physical
Qi Zhang, Jiaxin Guo, Zihua Huang, Sui Mai
Summary: This study found that carboxymethyl chitosan (CMC) can promote mineralization and remineralization of carious dentin, improving bond performance and durability. These findings have important potential implications for treating deep caries.
Article
Engineering, Chemical
Priscila Raquel Schiroky, Isadora Martini Garcia, Fernanda Coradini Noal, Vicente Castelo Branco Leitune, Fernando Borba de Araujo, Fabricio Mezzomo Collares
Summary: The study evaluated the influence of alpha-TCP on the physical-chemical properties of an experimental adhesive resin and the immediate and long-term properties of caries-affected dentin. The addition of alpha-TCP increased the initial Knoop hardness of the adhesive resin and the hardness of caries-affected dentin. There was no significant difference in other properties such as softening in solvent, polymerization rate, degree of conversion, microtensile bond strength, and mineral deposition.
INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES
(2021)
Article
Engineering, Biomedical
Mustafa Gungormus, Fatih Tulumbaci
Summary: Bonding with dentin involves a complex process of physical and chemical adhesion, requiring the adhesive to penetrate and envelop collagen fibers. Acid etching clears debris from dentin but also exposes susceptible mineral-free collagen fibers. Researchers have developed a rapid remineralization approach to restore the mineral content of etched dentin, improving mechanical properties and stability. Future studies will further validate the benefits of this method for clinical applications.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Dentistry, Oral Surgery & Medicine
T. Shan, L. Huang, F. R. Tay, L. Gu
Summary: The concept of extrafibrillar demineralization involves selectively removing apatite crystallites from the spaces between mineralized dentin fibers without affecting the minerals within the collagen fibers. Quaternized carboxymethyl chitosan (QCMC)-based demineralization is effective in improving resin-dentin bond durability by retaining intrafibrillar minerals, preserving the elastic modulus of collagen fibers, reducing proteolytic activity, and inhibiting bacteria biofilms.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Engineering, Biomedical
Umer Daood, Amr Fawzy
Summary: The aim of this study is to evaluate the development of an experimental multi-mode/Universal resin-based dentin adhesive modified with synthetic Mg2+ doped hydroxyapatite crystals (HAp) that have self-remineralization and antibiofilm properties. The experimental adhesive was tested for degree of conversion, X-ray diffraction, bond strength, electron microscopy imaging, nanoleakage, nanoindentation, confocal analysis, and Raman analysis. The effects of the modified adhesive on S. mutans, nucleating abilities, alkaline phosphatase, Runx2, Ocn transcripts, and level of mineralization were investigated. The experimental dentin adhesive with 0.5% Hap/Mg2+ demonstrated improved interaction with dentin and showed preservation of a uniform intact hybrid layer with the absence of nanoleakage, indicating dentin bond integrity.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
SoeKayThwe ThanNaing, Ahmed Abdou, Mahmoud Sayed, Yasunori Sumi, Junji Tagami, Noriko Hiraishi
Summary: The study found that resin cement containing S-PRG fillers can reduce mineral loss, promote remineralization, and has the potential to preserve dentin integrity and resist acidic attack.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Chemistry, Physical
Hyun-Jung Kim, Ji-Hyun Jang, Sang Uk Woo, Kyoung-Kyu Choi, Sun-Young Kim, Jack L. Ferracane, Jung-Hwan Lee, Dongseok Choi, Samjin Choi, Soogeun Kim, Ayoung Bang, Duck-Su Kim
Summary: The study found that the novel BAG-containing dentin adhesive has the potential to reduce the permeability of demineralized dentin and promote dentin remineralization.
Article
Dentistry, Oral Surgery & Medicine
Tainah Oliveira Rifane, Karen Evellin Moura Cordeiro, Francisbenia Alves Silvestre, Marina Trevelin Souza, Edgar Dutra Zanotto, Vitaliano Gomes Araujo-Neto, Marcelo Giannini, Salvatore Sauro, Diego Martins de Paula, Victor Pinheiro Feitosa
Summary: The objective of this study is to analyze the effects of simplified adhesives containing pure or silanized bioglass 45S5 or Sr-45S5 fillers on dentin. The results showed that the incorporation of silanized 45S5 bioglass into the adhesive improved dentin remineralization, bonding performance, and adhesive polymerization. However, the silanized Sr-45S5 compromised the bond strength, interface nanoleakage, and had a negative impact on HYP outcomes.
Article
Polymer Science
Ting He, Die Hu, Qian Ren, Zhongcheng Li, Sili Han, Longjiang Ding, Ziqian Lu, Linglin Zhang
Summary: Biomimetic mineralization is a promising strategy for dentin repair. However, the degradation of collagen fibrils and the lack of sustained supply of calcium and phosphorus ions are two main limitations. In this study, a novel nanoscale platform called PA-ACP/NPs was proposed to address these limitations. PA-ACP/NPs effectively protected collagen and induced complete intrafibrillar mineralization, facilitating remineralization of demineralized dentin. The nanoscale delivery of PA-ACP/NPs exhibited excellent effects in stabilizing collagen and providing long-term mineral ions supply.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Stephanie R. Lopes, Amanda G. N. Matuda, Raquel P. Campos, Ana Paula V. P. Mafetano, Ana Helena M. Barnabe, Gabriela S. Chagas, Daphne C. Barcellos, Li-Na Niu, Franklin R. Tay, Cesar R. Pucci
Summary: This study evaluated the antibacterial activity of a nisin-doped adhesive against Streptococcus mutans and its impact on the degree of conversion and microtensile bond strength. The results showed that the nisin-doped adhesives significantly inhibited the growth of Streptococcus mutans, but the incorporation of higher concentrations of nisin reduced the degree of conversion of the adhesive. However, the microtensile bond strength was not significantly affected after incorporating 1% nisin.
Article
Polymer Science
Madalena Belmar da Costa, Antonio H. S. Delgado, Tomas Amorim Afonso, Luis Proenca, Ana Sofia Ramos, Ana Mano Azul
Summary: Comparing the adhesive interface of eroded dentin, the study found that Clearfil SE Protect exhibited similar mechanical and adhesive performance to Clearfil SE Bond 2, with promising long-term results in eroded dentin due to increased enzymatic activity and the need for remineralization.
Article
Nanoscience & Nanotechnology
Beibei Wang, Fei Han, Ran You, Chen Chen, Haifeng Xie
Summary: The objective of this study was to investigate the effects of proanthocyanidins (PA), myricetin, resveratrol, and kaempferol on dentin collagen modification and MMP activity inhibition, as well as their contributions to biomimetic remineralization and resin-dentin bonding performance. The results showed that these four polyphenols can modify dentin collagen, inhibit MMP activity, promote biomimetic remineralization, and improve resin-dentin bond durability.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
R. A. T. Noschang, D. Seebold, R. Walter, A. Rivera-Concepcion, I. A. Alraheam, M. Cardoso, P. A. Miguez
Summary: The study showed that SLRP proteins have positive effects on dentrin bonding and remineralization, with full proteoglycans containing GAGs significantly improving bonding over time.
Article
Dentistry, Oral Surgery & Medicine
Anas Aaqel Salim Salim Al-Ani, Ikram Aqel Salim, Roda Seseogullari-Dirihan, Murat Mutluay, Leo Tjaderhane, Arzu Tezvergil-Mutluay
Summary: This study evaluated the cytotoxicity of methacrylate-based resins containing dimethyl sulfoxide (DMSO). The results showed that incorporating DMSO into hydrophilic self-etching resins may increase cytotoxicity, while it does not affect the biocompatibility of hydrophobic resins.
EUROPEAN JOURNAL OF ORAL SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Diletta Forgione, Mohannad Nassar, Roda Seseogullari-Dirihan, Suppason Thitthaweerat, Arzu Tezvergil-Mutluay
Summary: The study found that phytic acid has a significant inhibitory effect on dentin degradation, particularly at a concentration of 3%. Furthermore, the phytic acid treatment group showed significantly lower levels of degradation, MMP activity, and collagen degradation compared to the phosphoric acid treatment group.
EUROPEAN JOURNAL OF ORAL SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Thiago Henrique Scarabello Stape, Mustafa Murat Mutluay, Leo Tjaderhane, Emilia Uurasjarvi, Arto Koistinen, Arzu Tezvergil-Mutluay
Summary: The study found that DMSO-containing pretreatments have significant effects on long-term bond strength, hybrid layer quality, monomer conversion, and collagen structure, suggesting that they could improve the longevity of resin-dentin bonds.
Article
Dentistry, Oral Surgery & Medicine
Thiago Henrique Scarabello Stape, Merve Uctasli, Hatice Sumeyye Cibelik, Leo Tjaderhane, Arzu Tezvergil-Mutluay
Summary: The study suggests that dry bonding with DMSO can effectively reduce the influence of dentin moisture on bonding performance, improving bond strength and collagen wettability.
Article
Dentistry, Oral Surgery & Medicine
Thiago Henrique Scarabello Stape, Tapio Viita-aho, Ana Sezinando, Patrik Wik, Murat Mutluay, Arzu Tezvergil-Mutluay
Summary: This study aimed to investigate the bonding performance and fatigue strength of resin-dentin interfaces created by a universal adhesive under different H3PO4 application times. The results showed that application modes significantly affected etching patterns, fatigue strength, endurance limits, and hybrid layer morphology. Reductions in fatigue strength of self-etched bonded interfaces raised concerns about the true ability of universal adhesives to properly bond to dentin.
Article
Dentistry, Oral Surgery & Medicine
Thiago Henrique Scarabello Stape, Oskari Tulkki, Ikram Aqel Salim, Kaveh Nik Jamal, Mustafa Murat Mutluay, Arzu Tezvergil-Mutluay
Summary: The objective of this study was to investigate whether the composition of universal adhesives and the use of silane coupling agents could affect the fatigue strength of composite repair. Results showed that the composition of universal adhesives affected the repair potential, and the highest endurance limits were achieved with the separate application of silane coupling agents. These findings indicate that the additional use of silane coupling agents remains an important procedure in composite repairs.
Article
Dentistry, Oral Surgery & Medicine
Ozlem Kara, Roda Seseogullari Dirihan, Gulsum Sayin Ozel, Arzu Tezvergil Mutluay, Aslihan Usumez
Summary: This study found that using antimicrobial photodynamic therapy can reduce endogenous protease activity and improve dentin bond strength. Therefore, aPDT may be considered as a treatment method to reduce protease-mediated dentin degradation.
Article
Dentistry, Oral Surgery & Medicine
Meltem Tekbas Atay, Roda Seseogullari-Dirihan, Mustafa Murat Mutluay, Arzu Tezvergil-Mutluay
Summary: The study demonstrated that treatment with curcuminoids can improve the microtensile bond strength of dentin, especially after 12 months of storage. Curcuminoids may serve as potential protease inhibitors to effectively protect collagen fibrils in the hybrid layer.
EUROPEAN JOURNAL OF ORAL SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ikram Salim, Roda Seseogullari-Dirihan, Satoshi Imazato, Arzu Tezvergil-Mutluay
Summary: This study examines the impact of ions released from S-PRG fillers on enzymatic degradation of dentin collagen matrices. The results indicate that the released ions have the potential to inhibit MMP-mediated enzymatic activity.
DENTAL MATERIALS JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Diletta Forgione, Mohannad Nassar, Roda Seseogullari-Dirihan, Ahmed Jamleh, Arzu Tezvergil-Mutluay
Summary: The study investigated the effect of phytic acid (IP6) on collagen solubilization, its binding potential to demineralized (DD) and mineralized dentin (MD), and the effect of different media on debinding of IP6. The results showed that IP6 bound to DD and MD in a concentration-dependent manner. Ethanol was found to be the most effective in debinding IP6 from DD, while urea caused the most displacement in MD. These findings contribute to the potential use of IP6 as an alternative to phosphoric acid for dentin etching, improving the long-term stability of resin-dentin adhesion.
JOURNAL OF DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Piia Huopainen, Sirke Virkkunen, Johanna Snall, Arzu Tezvergil-Mutluay, Jaana Hagstrom, Satu Apajalahti
Summary: This study aimed to compare the detectability of periapical foreign materials in dentoalveolar imaging and histopathology. The results showed that histopathology was more accurate in diagnosing periapical foreign bodies or foreign body reactions. Clinicians should be aware of the limitations of imaging when diagnosing and planning treatment.
ACTA ODONTOLOGICA SCANDINAVICA
(2023)
Article
Dentistry, Oral Surgery & Medicine
Michel Wendlinger, Andres Felipe Millan Cardenas, Fabiana Suelen Figueredo de Siqueira, Pedro Henrique de Aguiar Moreira, Milena Maria Andrade Trova Trovao, Thiago Henrique Scarabello Stape, Arzu Tezvergil-Mutluay, Alessandro D. Loguercio
Summary: This study evaluated the effect of DMSO on the bonding strength and nanoleakage of universal adhesives on eroded dentine. The results showed that there was no significant decrease in mu TBS and NL values after four years of water storage when DMSO was applied.
Article
Engineering, Chemical
Merve Uctasli, Thiago Henrique Scarabello Stape, Mustafa Murat Mutluay, Arzu Tezvergil-Mutluay
Summary: This study aimed to evaluate the effect of SDF-based treatments on the resin-dentin bonding efficiency of a universal adhesive under different application modes. The results showed that SDF-based treatments had an impact on dentin bonding depending on the application mode and surface treatment approaches. However, the negative effect of SDF on etch-and-rinse bonding could be avoided by incorporating water-rinsing before hybridization. Delayed bonding also reduced dentin permeability and improved mineral deposition.
INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Xin Yan, Qi Zhang, Xinyue Ma, Yewen Zhong, Hengni Tang, Sui Mai
Summary: Biomineralization is a regulated process involving intracellular processes and extracellular deposition of calcium phosphate particles. Recent studies have made progress in understanding the dynamic formation of amorphous calcium phosphate precursors and their relationship with physicochemical structure development. However, the precise mechanisms and integration with extracellular mineralization remain unclear.
JAPANESE DENTAL SCIENCE REVIEW
(2023)
Article
Dentistry, Oral Surgery & Medicine
Sherry Shiqian Gao, Gwendolyn Amarquaye, Peter Arrow, Kalpana Bansal, Raman Bedi, Guglielmo Campus, Kitty Jieyi Chen, Ana Claudia Rodrigues Chibinski, Tselmuun Chinzorig, Yasmi O. Crystal, Duangporn Duangthip, Maria Laura Ferri, Morenike Oluwatoyin Folayan, Ariuntuul Garidkhuu, Hamdi H. Hamama, Varangkanar Jirarattanasopha, Arthur Kemoli, Soraya C. Leal, Pattarawadee Leelataweewud, Vijay Prakash Mathur, Tshepiso Mfolo, Yasuko Momoi, Nicoline Potgieter, Arzu Tezvergil-Mutluay, Edward Chin Man Lo, Chun Hung Chu
Summary: Silver diamine fluoride (SDF) is a widely used method for managing dental caries globally, with various manufacturers producing SDF at different concentrations. Despite its effectiveness, SDF is not allowed for use in mainland China, and guidelines for its clinical use have been developed by different government organizations and dental associations in other countries. Undergraduate and postgraduate dental curriculums in almost all countries include training for using SDF, but research on the actual utilization of SDF by dentists, especially in the private sector, is limited.
FRONTIERS IN ORAL HEALTH
(2021)
