Article
Engineering, Biomedical
Peiyan Wang, Xinyue Meng, Runze Wang, Wei Yang, Lanting Yang, Jianxun Wang, Dong-An Wang, Changjiang Fan
Summary: This study explores the use of chemically cross-linked gelatin microsphere aggregates (C-GMSs) scaffolds for vascularized bone reconstruction. The scaffolds enhance focal adhesion, proliferation, and function of functional cells by optimizing cell-material interfaces. In vitro and in vivo experiments confirm the efficacy of C-GMSs scaffolds in inducing angiogenesis and osteogenesis, as well as promoting integration with host bone.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Lu Liu, Jiancai Jiang, Xinyang Jin, Ran Li, Liqian Huang, Ni Wang, Narendra Reddy, Wanshuang Liu, Qiuran Jiang
Summary: This study successfully improved the zein ultrafine fibrous scaffold model using a two-step dry state treatment, resulting in better mechanical properties, longer degradation time, and improved cytocompatibility. This method holds promise for developing strong, wet stable, and cytocompatible ultrafine fibers for a wide range of applications in tissue engineering scaffolds, biosensors, and drug carriers.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Chemistry, Applied
Jue Hu, Zhuozhi Wang, Jacob M. Miszuk, Min Zhu, Thiranjeewa Lansakara, Alexei Tivanski, Jeffrey A. Banas, Hongli Sun
Summary: The study developed a novel chitosan-vanillin-bioglass (CVB) scaffold with good mechanical properties and porous structure, as well as antibacterial and osteoconductive characteristics. The results showed that CVB scaffolds hold great promise for bone tissue engineering applications.
CARBOHYDRATE POLYMERS
(2021)
Article
Pharmacology & Pharmacy
Martin Philipp Dieterle, Thorsten Steinberg, Pascal Tomakidi, Jiri Nohava, Kirstin Vach, Simon Daniel Schulz, Elmar Hellwig, Susanne Proksch
Summary: This study developed a new nonwoven scaffold for periodontal tissue engineering. Nonwovens of 16% gelatin/5% hydroxyapatite with additional porosity were produced by electrospinning and in situ cross-linking. The results showed that the scaffold efficiently supported the adhesion and survival of human mesenchymal stem cells (hMSCs) and periodontal ligament fibroblasts (PDLFs), indicating its potential applications.
Article
Biotechnology & Applied Microbiology
Anne Metje van Genderen, Katja Jansen, Marleen Kristen, Joost van Duijn, Yang Li, Carl C. L. Schuurmans, Jos Malda, Tina Vermonden, Jitske Jansen, Rosalinde Masereeuw, Miguel Castilho
Summary: This study successfully fabricated small-diameter, highly organized tubular fibrous scaffolds using melt-electrowriting (MEW) technology, and seeded them with human umbilical vein endothelial cells and human conditionally immortalized proximal tubular epithelial cells, demonstrating improved cell functionality and potential for implantation as kidney tubules.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Baiyang Song, Li Fang, Xufeng Mao, Xianwang Ye, Zejun Yan, Qi Ma, Zewen Shi, Yiwei Hu, Yabin Zhu, Yue Cheng
Summary: This study investigates the use of gelatin-grafted tubular scaffolds for ureteral repair. The grafting of gelatin improves the adhesion and proliferation of urothelial cells, leading to enhanced ureteral regeneration. Animal experiments demonstrate good biocompatibility and urethra regeneration with the gelatin-grafted scaffold.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Navid Toosi Saidy, Alicia Fernandez-Colino, Behzad Shiroud Heidari, Ross Kent, Michael Vernon, Onur Bas, Shane Mulderrig, Andreas Lubig, Jose Carlos Rodriguez-Cabello, Barry Doyle, Dietmar W. Hutmacher, Elena M. De-Juan-Pardo, Petra Mela
Summary: Heart valve tissue engineering aims to provide autologous heart valve implants with regenerative capabilities and durability. This study demonstrates the additive manufacturing of bioinspired tubular scaffolds using melt electrowriting, which can meet the mechanical requirements of heart valves and enable cellular infiltration. The scaffolds are then embedded with a microporous hydrogel to enhance cell infiltration and ensure compatibility with blood flow.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Ayse Karakecili, Serdar Korpayev, Kaan Orhan
Summary: Bio-composite scaffolds that mimic the natural microenvironment of bone tissue have advantages in bone regeneration. The use of glyoxal cross-linked scaffolds containing equal amounts of chitosan and collagen mass and 1% (w/v) nanohydroxyapatite shows the best potential for osteoblast differentiation and matrix mineralization.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Review
Polymer Science
Josefa Alarcon Apablaza, Maria Florencia Lezcano, Alex Lopez Marquez, Karina Godoy Sanchez, Gonzalo H. Oporto, Fernando Jose Dias
Summary: The study summarizes the main morphological characteristics of nerve guide conduits (NGC) that influence nerve regeneration, including diameter, wall thickness, porosity, pore size, fiber alignment, and thickness.
Article
Engineering, Biomedical
Lior Debbi, Barak Zohar, Margarita Shuhmaher, Yulia Shandalov, Idit Goldfracht, Shulamit Levenberg
Summary: By combining living cells, biological hydrogel, and biodegradable synthetic polymer, a multi-scale vascular network within thick, implantable engineered tissues was successfully fabricated in this study. The functionality and patency of the multi-scale vascular network were demonstrated by dextran passage and physiological flow conditions, leading to significant improvements in blood perfusion compared to control micro-scale-vascularized grafts. This innovative approach of designing and fabricating multi-scale vascular architectures within 3D engineered tissues shows promise for both in vitro models and therapeutic translation research.
Article
Engineering, Biomedical
Patrycja Domalik-Pyzik, Anna Morawska-Chochol
Summary: This study aims to develop double-layered tubular scaffolds with enhanced anticoagulant properties for tissue engineering of small blood vessels. The scaffolds are made of polycaprolactone and polylactide, and fabricated through thermally induced phase separation and electrospinning. The results show that the scaffolds release heparin and have anticoagulant activity. Furthermore, the scaffolds promote early vascular formation in endothelial cell culture. Therefore, the proposed scaffold design and composition have great potential for wide application in tissue engineering of small blood vessels.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Hamidreza Tolabi, Negar Bakhtiary, Shaghayegh Sayadi, Maryam Tamaddon, Farnaz Ghorbani, Aldo R. Boccaccini, Chaozong Liu
Summary: This review summarizes the recent discoveries and applications of polydopamine as a surface coating material for tackling musculoskeletal disorders. Polydopamine, with its adhesive properties to various substrates, has shown potential in creating pro-healing interfaces and personalized scaffolds. The review also highlights the potential applications of polydopamine in bioengineering, such as carriers and nanoparticles.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Engineering, Biomedical
Tejas M. Koushik, Catherine M. Miller, Elsa Antunes
Summary: Bone tissue engineering has become a well-known field of study in the past decade, with advancements in materials, processing techniques, and understanding of bone healing pathways. Synthetic scaffolds face the challenge of providing load-bearing capability and interaction with the local extracellular matrix for promoting bone healing. This article discusses the usage and processing of multi-materials and hierarchical structures to mimic the structure of natural bone tissues for bioactive and load-bearing synthetic scaffolds.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Febe Carolina Vazquez-Vazquez, Daniel Chavarria-Bolanos, Marine Ortiz-Magdaleno, Vincenzo Guarino, Marco Antonio Alvarez-Perez
Summary: The fabrication of instructive materials for bone substitute scaffolds using additive manufacturing techniques is an important challenge in tissue engineering. This study proposes a combined approach of 3D printing and air-jet spinning techniques to optimize the fabrication of PLA tubes with nanostructured fibrous coatings for long bone defects. The results show that the 3D-printed scaffolds with nanofiber coatings have highly reproducible mechanical and thermal properties and improved cell adhesion and growth response.
BIOENGINEERING-BASEL
(2022)
Article
Materials Science, Multidisciplinary
B. Kaczmarek-Szczepanska, O. Milek, M. Michalska-Sionkowska, A. M. Osyczka
Summary: The study investigated the safety and compatibility of chitosan/tannic acid cross-linked scaffolds for medical applications through bio-studies. The results indicated that glyoxal is a safe cross-linker for chitosan/tannic acid mixtures, with nonhemolytic properties and high metabolic activity observed in cells cultured on the scaffolds. These findings suggest potential use of the proposed materials as wound dressings in medical applications.
Article
Engineering, Biomedical
W. J. E. M. Habraken, H. B. Liao, Z. Zhang, J. G. C. Wolke, D. W. Grijpma, A. G. Mikos, J. Feijen, J. A. Jansen
ACTA BIOMATERIALIA
(2010)
Article
Engineering, Biomedical
Hongbing Liao, X. Frank Walboomers, Wouter J. E. M. Habraken, Zheng Zhang, Yubao Li, Dirk W. Grijpma, Antonios G. Mikos, Joop G. C. Wolke, John A. Jansen
ACTA BIOMATERIALIA
(2011)
Article
Biochemistry & Molecular Biology
Erhan Bat, Josee A. Plantinga, Martin C. Harmsen, Marja J. A. van Luyn, Zheng Zhang, Dirk W. Grijpma, Jan Feijen
Article
Biochemistry & Molecular Biology
Sven D. Sommerfeld, Zheng Zhang, Marius C. Costache, Sebastian L. Vega, Joachim Kohn
Article
Engineering, Biomedical
Wouter J. E. M. Habraken, Zheng Zhang, Joop G. C. Wolke, Dirk W. Grijpma, Antonios G. Mikos, Jan Feijen, John A. Jansen
Article
Dentistry, Oral Surgery & Medicine
Takanori Iwata, Masayuki Yamato, Zheng Zhang, Shigeki Mukobata, Kaoru Washio, Tomohiro Ando, Jan Feijen, Teruo Okano, Isao Ishikawa
JOURNAL OF CLINICAL PERIODONTOLOGY
(2010)
Meeting Abstract
Chemistry, Multidisciplinary
Y. Song, F. Yang, J. A. Jansen, M. M. J. Kamphuis, Z. Zhang, A. A. Poot, I. Vermes, D. W. Grijpma, J. Feijen
JOURNAL OF CONTROLLED RELEASE
(2008)
Meeting Abstract
Chemistry, Multidisciplinary
Z. Zhang, S. J. Buwalda, P. J. Dijkstra, D. W. Grijpma, A. A. Poot, W. Steenbergen, J. Feijen
JOURNAL OF CONTROLLED RELEASE
(2008)
Article
Chemistry, Multidisciplinary
Brian E. Kilfoyle, Larisa Sheihet, Zheng Zhang, Marissa Laohoo, Joachim Kohn, Bozena B. Michniak-Kohn
JOURNAL OF CONTROLLED RELEASE
(2012)
Article
Chemistry, Multidisciplinary
Jared Bushman, Asa Vaughan, Larisa Sheihet, Zheng Zhang, Marius Costache, Joachim Kohn
JOURNAL OF CONTROLLED RELEASE
(2013)
Review
Cell & Tissue Engineering
Erhan Bat, Zheng Zhang, Jan Feijen, Dirk W. Grijpma, Andre A. Poot
REGENERATIVE MEDICINE
(2014)
Review
Nanoscience & Nanotechnology
Zheng Zhang, Pei-Chin Tsai, Tannaz Ramezanli, Bozena B. Michniak-Kohn
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2013)
Meeting Abstract
Cell & Tissue Engineering
Y. Song, M. Kamphuis, Z. Zhang, I. Vermes, A. A. Poot, D. W. Grijpma, J. Feijen
TISSUE ENGINEERING PART A
(2008)
Meeting Abstract
Cell & Tissue Engineering
Y. Song, H. H. Weekamp, M. Kamphuis, Z. Zhang, I. Vermes, A. A. Poot, D. W. Grijpma, J. Feijen
TISSUE ENGINEERING
(2007)