Article
Materials Science, Multidisciplinary
Yashar Rezaeipour, Parvin Alizadeh, Mozhgan Keshavarz
Summary: This study synthesized a bioactive glass and prepared composite scaffolds with different collagen concentrations. CSBG5 showed the best cell viability and adhesion, indicating its potential as a scaffold for uterine regeneration.
APPLIED MATERIALS TODAY
(2023)
Article
Engineering, Multidisciplinary
M. Elhadary, A. Hamdy, W. Shaker
Summary: The study investigated the extrinsic non-autonomic self-healing of composite material in two cases of crack, with and without bridging phenomena. It was found that bridging significantly increased the efficiency of crack healing, demonstrating the importance of bridging in enhancing self-healing capabilities.
ALEXANDRIA ENGINEERING JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Yannan Li, Juan Ge, Meng Luo, Wen Niu, Xiangwei Ling, Ke Xu, Cai Lin, Bo Lei, Xingxing Zhang
Summary: The study introduces a bioactive elastomeric self-healing antibacterial nanocomposite hydrogel scaffold for enhancing the skull defect reconstruction. The scaffold efficiently matches the skull defect morphology, enhances osteogenic differentiation, and regenerates bone tissues, showing significant potential in treating trauma-induced skull defects.
APPLIED MATERIALS TODAY
(2022)
Article
Pharmacology & Pharmacy
Mohamed S. El-Okaily, Amany A. Mostafa, Judyta Dulnik, Piotr Denis, Pawel Sajkiewicz, Azza A. Mahmoud, Reham Dawood, Amr Maged
Summary: Nanofiber membranes made of polycaprolactone and bioactive glass nanoparticles were prepared using electrospinning. The incorporation of bioactive glass increased the crystallinity of polycaprolactone, and nanofibers containing 5% bioactive glass showed the best mechanical properties. Atorvastatin-loaded nanofibers with a 10% coating polymer exhibited gradual drug release and promoted wound closure in human skin fibroblast cells.
Article
Biochemistry & Molecular Biology
Yue-Hua Chen, Zhou-Feng Rao, Yu-Jie Liu, Xiang-Sheng Liu, Yu-Fei Liu, Lan-Ju Xu, Ze-Qi Wang, Jing-Yue Guo, Lin Zhang, Yun-Sheng Dong, Chun-Xiao Qi, Chao Yang, Shu-Fang Wang
Summary: The development of a multifunctional injectable composite hydrogel containing cerium-containing bioactive glass (Ce-BG) and Gelatin methacryloyl (GelMA) has shown great potential in promoting diabetic foot wound healing by improving angiogenesis and antibacterial properties. In vitro studies demonstrated good cytocompatibility and promotion of endothelial cells migration and tube formation. Additionally, in vivo studies showed accelerated wound healing in diabetic rats through improved granulation tissue formation, collagen deposition, and angiogenesis.
Article
Chemistry, Multidisciplinary
Shicheng Huo, Shu Liu, Qianqian Liu, En Xie, Licai Miao, Xiangyu Meng, Zihao Xu, Chun Zhou, Xuesong Liu, Guohua Xu
Summary: A new sequential immunomodulatory approach using a novel hybrid hydrogel dressing based on the immune characteristics of bacteria-associated wounds is proposed to promote effective and rapid wound healing. The hybrid hydrogel demonstrates controlled release of Cu2+ and Zn2+ ions and sequential regulation of macrophage phenotypic transition, leading to enhanced antibacterial activity and wound healing.
Article
Biotechnology & Applied Microbiology
Hongtao Xu, Yanlun Zhu, Jiankun Xu, Wenxue Tong, Shiwen Hu, Yi-Fan Chen, Shuai Deng, Hao Yao, Jie Li, Chien-Wei Lee, Hon Fai Chan
Summary: This study investigated the use of a bioactive glass and sodium alginate hydrogel to enhance tendon healing. The results showed that the hydrogel could accelerate tenogenesis, increase angiogenesis, and induce a phenotypic switch in macrophages. Additionally, the hydrogel was able to partially reverse pathological changes in the tendon and improve its mechanical properties.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Engineering, Environmental
Ruiguo Chen, Qian Li, Qi Zhang, Shuai Xu, Jian Han, Peiyan Huang, Zhiwu Yu, Daping Jia, Juanjuan Liu, Huiling Jia, Ming Shen, Bingwen Hu, Howard Wang, Hongbing Zhan, Teng Zhang, Kun Ma, Junfeng Wang
Summary: A novel approach was proposed to produce nano-HCA@BG for soft tissue repair, which improved biocompatibility through a porous structure and surface-coated amorphous HCA layer. The HCA-coated nanoporous architecture significantly promoted cell growth and proliferation, benefiting wound healing in rodent skin defects.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Biomedical
Laura Ramos Rivera, Andrea Cochis, Sarah Biser, Elena Canciani, Sara Ferraris, Lia Rimondini, Aldo R. Boccaccini
Summary: In this study, a novel surface coating composed of zein, bioactive glass, and copper-containing bioactive glass was developed by electrophoretic deposition (EPD) to improve the bioactivity and antibacterial properties of stainless steel implants for bone replacement. The coatings exhibited excellent cytocompatibility, maintained pro-osteogenic properties towards progenitor cells, and demonstrated antibacterial activity against common joint pathogens. Additionally, the ability of copper to recruit blood vessels and inhibit bacterial infection was confirmed in vivo, enhancing the therapeutic potential of the coatings for orthopedic applications.
BIOACTIVE MATERIALS
(2021)
Article
Materials Science, Biomaterials
Sarika Tomar, Rakesh Pandey, Priyanka Surya, Ranjan Verma, Rashi Mathur, Gurudutta Gangenahalli, Sweta Singh
Summary: Effective wound management is challenging due to complexity of wound microenvironment, bacterial infections, impaired angiogenesis, aggravated inflammation, and enduring pain. A multifunctional composite hydrogel was developed to address these challenges, comprised of gelatin, chitosan, polydopamine-coated bioactive glass (BG), and curcumin-capped silver nanoparticles (Cur-AgNPs). The PDA-coated BG provides adhesive, angiogenic, and pain-relieving properties, while Cur-AgNPs offer bactericidal and anti-inflammatory benefits. The composite hydrogel showed excellent wound healing potential by alleviating pain, eliminating microbes, reducing inflammation, promoting angiogenesis, and achieving effective skin regeneration.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Xuyan Lu, Zirui Liu, Qirui Jia, Qiusheng Wang, Qi Zhang, Xiaoran Li, Jianyong Yu, Bin Ding
Summary: Self-expanding cryogels with unique properties have potential for treating uncontrollable hemorrhages. In this study, a superelastic cellular-structured bioactive glass nanofibrous cryogel (BGNC) was developed, showing high absorption capacity, fast self-expanding ability, injectability, and good tissue adhesion. The BGNCs demonstrated superior hemostatic capacity in animal models and promoted wound healing. These findings offer a promising strategy for the development of multifunctional hemostatic and wound repair materials.
Article
Engineering, Biomedical
Fengling Tang, Junliang Li, Weihan Xie, Yunfei Mo, Lu Ouyang, Fujian Zhao, Xiaoling Fu, Xiaofeng Chen
Summary: The study demonstrates that bioactive glass extracts can enhance the barrier function of keratinocytes by promoting cell differentiation and tight junction formation, leading to accelerated re-epithelialization in chronic wounds.
BIOACTIVE MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Mahshid Monavari, Shahin Homaeigohar, Rucha Medhekar, Qaisar Nawaz, Mehran Monavari, Kai Zheng, Aldo R. Boccaccini
Summary: In this study, a wound dressing composed of an alginate dialdehyde-gelatin (ADA-GEL) hydrogel incorporated by astaxanthin (ASX) and 70B borate bioactive glass (BBG) microparticles was developed through 3D printing. The composite hydrogel construct, stiffened by ASX and BBG particles, showed prolonged degradation and steady release of ASX, promoting cell adhesion, proliferation, and migration for faster wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Polymer Science
Ozgur Basal, Ozlem Ozmen, Aylin M. Deliormanli
Summary: In this study, graphene-coated bioactive glass scaffolds were found to enhance bone formation in rat femur defects. The highest amount of bone formation was observed in the group containing 10 wt% graphene.
Article
Engineering, Biomedical
Zhi Wei Loh, Mohd Hafiz Mohd Zaid, Khamirul Amin Matori, Mohd Mustafa Awang Kechik, Yap Wing Fen, Mohd Zul Hilmi Mayzan, Shahira Liza, Wei Mun Cheong
Summary: This study investigates the effect of sintering temperature on bioactive glass-ceramics derived from a new composition of CaO-P2O5-Na2O-B2O3-SiO2 glass system. The sintering behavior of the samples' physical, structural, and mechanical properties is examined. The results showed that sintering improved the crystallization and hardness of the final product. The bioactive glass-ceramics sintered at 700 degrees C exhibited the highest densification and optimal mechanical properties, making them a potential candidate for dental applications.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Orthopedics
Erik Aro, Jessica J. Alm, Niko Moritz, Kimmo Mattila, Hannu T. Aro
Article
Orthopedics
Sami Finnila, Niko Moritz, Niko Strandberg, Jessica J. Alm, Hannu T. Aro
JOURNAL OF ORTHOPAEDIC RESEARCH
(2019)
Article
Engineering, Biomedical
Carsten Rendenbach, Claudius Steffen, Kay Sellenschloh, Mark Heyland, Michael M. Morlock, Joonas Toivonen, Niko Moritz, Ralf Smeets, Max Heiland, Pekka K. Vallittu, Gerd Huber
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2019)
Article
Engineering, Biomedical
Oliver Liesmaki, Artem Plyusnin, Julia Kulkova, Lippo V. J. Lassila, Pekka K. Vallittu, Niko Moritz
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2019)
Article
Veterinary Sciences
Artem Plyusnin, Julia Kulkova, Gareth Arthurs, Niki Jalava, Peter Uppstu, Niko Moritz
RESEARCH IN VETERINARY SCIENCE
(2020)
Letter
Orthopedics
Hannu T. Aro, Sanaz Nazari-Farsani
Article
Orthopedics
Sanaz Nazari-Farsani, Mia E. Vuopio, Hannu T. Aro
JOURNAL OF ARTHROPLASTY
(2020)
Letter
Endocrinology & Metabolism
Hannu T. Aro, Sanaz Nazari-Farsani, Eliisa Loyttyniemi
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Biophysics
Sanaz Nazari-Farsani, Mia Vuopio, Eliisa Loyttyniemi, Hannu T. Aro
Summary: Cementless total hip arthroplasty relies on initial press-fit fixation of femoral stems against cortical bone for osseointegration, posing challenges in stability, especially in postmenopausal women with decreased bone mineral density. Postoperative hip BMD and walking activity are significantly associated with femoral stem rotation, with height acting as a potential confounding factor. The study highlights the need for high-resolution imaging techniques to explore reasons for stem subsidence even in women with normal hip BMD.
JOURNAL OF BIOMECHANICS
(2021)
Article
Orthopedics
Hannu T. Aro, Klaus Engelke, Kimmo Mattila, Eliisa Loyttyniemi
Summary: In postmenopausal women undergoing cementless total hip arthroplasty, initial femoral stem migration, as measured by RSA, is clinically significant. Patients with less than 2mm of initial stem subsidence showed faster recovery and better patient-reported outcome measures, while those with greater subsidence had slower recovery and less satisfactory outcomes.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2021)
Editorial Material
Orthopedics
Hannu T. Aro
Article
Orthopedics
Hannu T. Aro, Ville-Valtteri Valimaki, Niko Strandberg, Petteri Lankinen, Eliisa Loyttyniemi, Virva Saunavaara, Marko Seppanen
Summary: This study investigated the clinical efficacy of bioactive glass (BG) granules in filling defects following surgery for benign bone tumors. The results showed that BG granules had similar rates of treatment success compared to standard bone grafts. Additionally, BG granules had advantages in certain aspects, such as shorter operative time and less postoperative pain.
Article
Endocrinology & Metabolism
Sami Finnila, Eliisa Loyttyniemi, Hannu T. Aro
Summary: In a trial involving 65 postmenopausal women, denosumab failed to reduce initial migration of a cementless femoral stem despite preventing periprosthetic bone loss. Women with normal bone mineral density had significantly less stem subsidence compared to those with osteopenia and osteoporosis. Understanding 3D implant migration events can provide valuable insights for future large-scale trials.
Article
Endocrinology & Metabolism
Hannu T. Aro, Sanaz Nazari-Farsani, Mia Vuopio, Eliisa Loyttyniemi, Kimmo Mattila
