Article
Chemistry, Physical
Florian Kraushofer, Matthias Meier, Zdenek Jakub, Johanna Huetner, Jan Balajka, Jan Hulva, Michael Schmid, Cesare Franchini, Ulrike Diebold, Gareth S. Parkinson
Summary: This study investigates the (111) facet of magnetite (Fe3O4) and reveals three new surface structures that are more favorable under reducing conditions. The new structures change the coordination of iron atoms to a tetrahedral configuration. Atomically-resolved microscopy confirms the presence of tetrahedral iron atoms capped by 3-fold coordinated oxygen atoms. This discovery explains the inert nature of the reduced patches.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Oncology
Yao Wang, Xiaoyue Xu, Jacqueline E. Marshall, Muxue Gong, Yang Zhao, Kamal Dua, Philip M. Hansbro, Jincheng Xu, Gang Liu
Summary: HAPLN1 is downregulated in CRC patients, and it controls collagen deposition through the TGF-beta signaling pathway to regulate tumor growth. Therefore, increasing HAPLN1 levels may be a novel therapeutic option for CRC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Jingjing Zhang, Jinxin Qiu, Wenyong Zhou, Jianping Cao, Xuefei Hu, Wenli Mi, Bing Su, Bin He, Ju Qiu, Lei Shen
Summary: This study identifies neuropilin-1 (Nrp1) as a tissue-specific marker of lung-resident ILC2s, which enhances their function and type 2 immune response by upregulating IL-33 receptor ST2 expression. Inhibition of Nrp1 suppresses IL-5 and IL-13 production by ILC2s and protects mice from the development of pulmonary fibrosis.
Article
Chemistry, Medicinal
Eleonora Binatti, Gianni Zoccatelli, Francesca Zanoni, Giulia Dona, Federica Mainente, Roberto Chignola
Summary: The study demonstrates that astaxanthin-loaded microparticles are radiation-resistant, well-tolerated by J774A.1 macrophages, significantly reduce intracellular reactive oxygen species, and inhibit the release of active TGF beta. This indicates that micro-encapsulation of bioactive molecules is a promising strategy to specifically target phagocytic cells and modulate their functions.
Article
Cell Biology
Shan Song, Chonglin Shi, Yawei Bian, Zhaohua Yang, Lin Mu, Haijiang Wu, Huijun Duan, Yonghong Shi
Summary: The study found that Sestrin2 is low-expressed in diabetic kidney disease and can alleviate podocyte injury by modulating the activity of TSP-1/TGF-beta 1/Smad3 pathway.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Xiaoshuang Wang, Mei Feng, Tengfei Xiao, Baosen Guo, Danyang Liu, Chenglong Liu, Jinpeng Pei, Qiaofeng Liu, Yi Xiao, Rina Rosin-Arbesfeld, Ying Shi, Yang Zhou, Mengxuan Yang, Yu-Xiong Feng, Yizhou Jiang, Zhimin Shao, Ker Yu, Di Zhu
Summary: The expression of BCL9 and BCL9L is correlated with malignancy in TNBC patient tumors, and they promote tumor cell growth, migration, and metastasis. Inhibition of BCL9/BCL9L and TGF-beta suppresses Treg activity, while TGF-beta signaling increases tumor infiltration of cytotoxic CD8 (+) T cells. Inhibiting BCL9/BCL9L synergizes with PD-1/L1 antibodies to inhibit tumor growth.
Review
Pharmacology & Pharmacy
Yonghui Zou, Yi Xu, Xiaofeng Chen, Yaoqi Wu, Longsheng Fu, Yanni Lv
Summary: LRG1 is an important protein involved in normal physiological activities of the nervous system and has been found to affect the development of various diseases. However, research on its role in disease is still in its early stages, and further studies are needed to uncover its potential therapeutic value.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Justin Joseph, Capucine R. Magaut, Simon Storevik, Luiz H. Geraldo, Thomas Mathivet, Md Abdul Latif, Justine Rudewicz, Joris Guyon, Matteo Gambaretti, Frida Haukas, Amalie Trones, Lars A. Romo Ystaas, Jubayer A. Hossain, Sandra Ninzima, Sylvain Cuvellier, Wenjing Zhou, Tushar Tomar, Barbara Klink, Lalit Rane, Bronwyn K. Irving, Joanne Marrison, Peter O'Toole, Heiko Wurdak, Jian Wang, Zhang Di, Even Birkeland, Frode S. Berven, Frank Winkler, Frank A. E. Kruyt, Andreas Bikfalvi, Rolf Bjerkvig, Thomas Daubon, Hrvoje Miletic
Summary: Analysis of TCGA data revealed a high activation of the TGF-beta pathway in GBMs compared to oligodendroglial tumors. Stimulation of GBM cell lines with TGF-beta 1 enhanced MT formation and communication via calcium signaling, while inhibition of the TGF-beta pathway significantly reduced MT formation and invasion. Downstream of TGF-beta, thrombospondin 1 (TSP1) was identified as a potential mediator of MT formation in GBM, which was upregulated upon TGF-beta stimulation and inhibited MT formation when knocked down in vitro and in vivo.
Review
Pharmacology & Pharmacy
Yicheng Wei, Jialuo Cai, Ruiqiu Zhu, Ke Xu, Hongchang Li, Jianxin Li
Summary: This review focuses on the role of TRPA1 channel in fibroblasts, exploring its interactions with inflammatory factors and its different functions in the fibrosis process in different organs. The aim of this review is to describe the function of TRP channels in controlling fibrosis through fibroblasts in various inflammatory and immune-mediated diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Joshua M. Moreau, Maria Velegraki, Chelsea Bolyard, Michael D. Rosenblum, Zihai Li
Summary: TGF-beta 1 plays a crucial role in the development and function of T-reg, although its pleiotropic and context-dependent activity makes it complicated.
SCIENCE IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Giulia Siciliano, Maria Serena Chiriaco, Francesco Ferrara, Antonio Turco, Luciano Velardi, Maria Assunta Signore, Marco Esposito, Giuseppe Gigli, Elisabetta Primiceri
Summary: Oral cancer, a common type of cancer in Europe, necessitates the development of low-cost and reliable portable platforms for its diagnosis. In this study, a molecularly imprinted polymer (MIP)-based electrochemical sensor for TGF-β1 detection was developed and characterized. The optimized biosensor shows potential for early screening of oral cancer. The MIP sensor demonstrates a linear response, high selectivity, and sensitivity in buffer solution and saliva samples, making it suitable for large-scale fast screening in oral cancer diagnosis.
Article
Multidisciplinary Sciences
Radoslaw Pluta, Eric Aragon, Nicholas A. Prescott, Lidia Ruiz, Rebeca A. Mees, Blazej Baginski, Julia R. Flood, Pau Martin-Malpartida, Joan Massague, Yael David, Maria J. Macias
Summary: FoxH1 is an essential maternal pioneer factor during embryonic development, and this study reveals the molecular basis for its binding specificity and pioneer factor activity through high-resolution structures of FoxH1 proteins and DNAs.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Marta Maruszewska-Cheruiyot, Michael James Stear, Maja Machcinska, Katarzyna Donskow-Lysoniewska
Summary: There has been little interaction between parasitologists and oncologists historically, although some helminth infections may predispose to tumor development. Recent research suggests that both tumors and parasites suppress the immune response to increase their chances of survival. They both exploit the TGF beta signaling pathway to modulate the immune response for their own benefit.
Article
Medicine, General & Internal
Margherita Sisto, Domenico Ribatti, Giuseppe Ingravallo, Sabrina Lisi
Summary: FSTL1 plays a crucial role in the pathological response of SS and modulates the activation of the EMT program through the SMAD2/3-dependent signaling pathway.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Immunology
Chaoyu Ma, Nu Zhang
Summary: This study summarizes recent findings on Tcf-1(+) T cells, focusing on their migratory and resident behavior, as well as the mechanisms underlying their differentiation and maintenance during persistent antigen stimulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Materials Science, Biomaterials
Juan Zhou, Mingyu Wang, Huiyan Ying, Dandan Su, Huijie Zhang, Guozhong Lu, Jinghua Chen
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Chemistry, Applied
Giuseppina Sandri, Silvia Rossi, Maria Cristina Bonferoni, Dalila Miele, Angela Faccendini, Elena Del Favero, Emanuela Di Cola, Antonia Icaro Cornaglia, Cinzia Boselli, Thomas Luxbacher, Lorenzo Malavasi, Laura Cantu', Franca Ferrari
CARBOHYDRATE POLYMERS
(2019)
Article
Chemistry, Applied
Roi Peretz, Elizaveta Sterenzon, Yoram Gerchman, Vinod Kumar Vadivel, Thomas Luxbacher, Hadas Mamane
CARBOHYDRATE POLYMERS
(2019)
Article
Chemistry, Physical
Natalia V. Smirnova, Konstantin A. Kolbe, Elena N. Dresvyanina, Sergey F. Grebennikov, Irina P. Dobrovolskaya, Vladimir E. Yudin, Thomas Luxbacher, Pierfrancesco Morganti
Article
Biochemistry & Molecular Biology
Lidija Fras Zemljic, Olivija Plohl, Alenka Vesel, Thomas Luxbacher, Sanja Potrc
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Physical
Lukasz Kaniuk, Sara Ferraris, Silvia Spriano, Thomas Luxbacher, Zuzanna Krysiak, Krzysztof Berniak, Angelika Zaszczynska, Mateusz M. Marzec, Andrzej Bernasik, Pawel Sajkiewicz, Urszula Stachewicz
Summary: The study demonstrated clear advantages of PHBV films and fibrous meshes in cell-material interactions, with the fibrous meshes providing excellent support for cell stretching and the flat films contributing to increased cell proliferation.
APPLIED SURFACE SCIENCE
(2021)
Article
Polymer Science
Klementina Pusnik Cresnar, Marko Bek, Thomas Luxbacher, Mihael Bruncko, Lidija Fras Zemljic
Summary: The surface properties of wood fiber filled polymer composites depend on filler loading, distribution, and orientation in the polymer matrix. Furthermore, the addition of wood fibers affects the surface structure, modulus, and hardness of the composites. Additionally, increasing amounts of wood fibers result in higher hydrophilicity of the composite surface.
Article
Engineering, Chemical
Navpreet Singh, Paras H. Gopani, Hemanta K. Sarma, Padmaja Mattey, Digambar S. Negi, Vivek R. Srivastava, Thomas Luxbacher
Summary: The study aims to indirectly estimate the zeta potential for high salinity brine using measurements for low salinity brine and develop an understanding of electrostatic shielding as predicted by the electric double layer (EDL) model.
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
(2022)
Article
Chemistry, Physical
Matea Ban, Thomas Luxbacher, Johannes Lutzenkirchen, Alberto Viani, Sabrina Bianchi, Klaudia Hradil, Andreas Rohatsch, Valter Castelvetro
Summary: This study analyzes the transformation pathways of porous limestone and dense marble surfaces using a combination of techniques and reveals the influence of factors such as surface roughness, thermal treatment, and chemical reactions. It found that pore conductivity may lead to a significant underestimation of zeta potential.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Physical
Urban Ajdnik, Thomas Luxbacher, Alenka Vesel, Alja Stern, Bojana Zegura, Janja Trcek, Lidija Fras Zemljic
Summary: A study focused on the formation of a polysaccharide-based bilayer coating on PDMS films for enhanced protein repulsion and antimicrobial activity. The results from various experiments showed the improved antifouling properties of the bilayer coatings compared to a reference or single layer, indicating potential for medical device applications.
Article
Chemistry, Multidisciplinary
Elizaveta Sterenzon, Vinod Kumar Vadivel, Yoram Gerchman, Thomas Luxbacher, Ramsundram Narayanan, Hadas Mamane
Summary: The study demonstrates that pine tree-derived biochar is effective in removing AV dye, and monitoring the effluent ratio can enhance colorant removal efficiency. The Langmuir isotherm model best fits the adsorption of AV onto biochar.
Article
Chemistry, Medicinal
Natalie Deiringer, Daniel Ruediger, Thomas Luxbacher, Stefan Zahler, Wolfgang Friess
Summary: Interfacial adsorption and particle formation during the processing of biopharmaceutics were studied in this research. The driving forces and rate of adsorption of a monoclonal antibody to the silicone rubber surface, as well as the influence of formulation parameters on particle concentration and size distribution, were investigated. It was found that formulation parameters, pH, and ionic strength, had an effect on the total amount of adsorbed protein and the formation of particles larger than 25 mm.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Engineering, Environmental
Dan Zhao, Maria Louise Leth, Maher Abou Hachem, Iram Aziz, Natalija Jancic, Thomas Luxbacher, Claus Helix-Nielsen, Wenjing Zhang
Summary: Biocatalytic nanofibrous membranes have efficient catalytic performance and operational catalytic stability in wastewater treatment. The fabrication of flexible SiO2 biocatalytic nanofiber membranes and their application in emerging pollutant bioremediation have been reported. The membranes showed high enzyme immobilization yield and maintained residual activity after multiple cycles.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Agnieszka Stroz, Thomas Luxbacher, Karolina Dudek, Bartosz Chmiela, Patrycja Osak, Bozena Losiewicz
Summary: Surface charge and in vitro corrosion resistance are important parameters for biomaterials in the interaction with the biological environment. This study analyzed the in vitro bioelectrochemical behavior of second-generation oxide nanotubes (ONTs) on a Ti-13Zr-13Nb alloy. The ONTs were produced by anodization and their properties were characterized using microscopy and spectroscopy techniques. The results showed that electrolyte type and strength influenced the bioelectrochemical properties of the ONTs layers.
Article
Chemistry, Multidisciplinary
Olivija Plohl, Lidija Fras Zemljic, Sanja Potrc, Thomas Luxbacher
