期刊
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
卷 46, 期 7, 页码 590-596出版社
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gmu036
关键词
miR-27; 3T3-L1 cells; TNF-alpha; adipogenesis
资金
- Henan Profit Research Project [09yy0066]
- National Basic Research Program [2014CB94 3601]
miR-27 plays a negative role in the regulation of adipogenesis. However, the molecular mechanism still remains to be clarified. In the present study, we found that miR-27 inhibits adipogenesis partially by repressing the early adipogenic transcription factor cAMP response element-binding protein by directly targeting its 3' untranslated region. In addition, we demonstrated that tumor necrosis factor-alpha (TNF-alpha) treatment up-regulates miR-27 through the NF-kappa B pathway. Furthermore, anti-miR-27 reduces the TNF-alpha-induced inhibition of adipogenesis. Simultaneously, the levels of miR-27 expression were decreased in mature adipocytes of obese mice when compared with lean mice. Our data revealed a novel mechanism of miR-27 in the regulation of adipogenesis.
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