Review
Biochemistry & Molecular Biology
Marco Fiorentino, Francesca Bagagli, Annamaria Deleonardis, Alessandra Stasi, Rossana Franzin, Francesca Conserva, Barbara Infante, Giovanni Stallone, Paola Pontrelli, Loreto Gesualdo
Summary: Kidney transplantation is the preferred treatment for end-stage renal disease (ESRD). Kidney transplant recipients (KTRs) are at a higher risk of ICU admission, mainly in the late post-transplant period. Urosepsis and bloodstream infections are the main reasons for ICU admissions, and side effects of immunosuppressive treatment should also be accounted for. AKI incidence is common in KTRs during ICU stay, and in-hospital mortality can be high. The present review aims to explore the impact of AKI on outcomes in KTRs and provide insights into its diagnosis, management, and immunosuppression modulation.
Article
Critical Care Medicine
Wen-Kuang Yu, J. Brennan McNeil, Nancy E. Wickersham, Ciara M. Shaver, Julie A. Bastarache, Lorraine B. Ware
Summary: Endothelial dysfunction and injury biomarkers were found to be associated with severe acute kidney injury (AKI) in sepsis patients, with Angiopoietin-2 being the most robust biomarker independently associated with development of severe AKI and other organ dysfunctions, non-pulmonary sepsis, and death. These findings highlight the importance of early endothelial dysfunction and injury in the pathogenesis of sepsis-induced AKI.
Article
Multidisciplinary Sciences
Son Ngoc Do, Chinh Quoc Luong, Dung Thi Pham, My Ha Nguyen, Nga Thi Nguyen, Dai Quang Huynh, Quoc Trong Ai Hoang, Co Xuan Dao, Trung Minh Le, Ha Nhat Bui, Hung Tan Nguyen, Hai Bui Hoang, Thuy Thi Phuong Le, Lien Thi Bao Nguyen, Phuoc Thien Duong, Tuan Dang Nguyen, Yen Hai Vu, Giang Thi Tra Pham, Tam Van Bui, Thao Thi Ngoc Pham, Hanh Trong Hoang, Cuong Van Bui, Nguyen Minh Nguyen, Giang Thi Huong Bui, Thang Dinh Vu, Nhan Duc Le, Trang Huyen Tran, Thang Quang Nguyen, Vuong Hung Le, Chi Van Nguyen, Bryan Francis McNally, Jason Phua, Anh Dat Nguyen
Summary: Sepsis is a common cause of in-hospital deaths in LMICs, especially in low-income and lower-middle-income countries. A study in Vietnam found that ICUs with accredited training programs and completion of the sepsis bundle were associated with decreased hospital mortality, while factors like intensivist-to-patient ratio, mechanical ventilation, and renal replacement therapy were associated with increased ICU mortality. Improvements in sepsis management in Vietnam are needed to enhance patient outcomes and reduce mortality rates.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Yunlin Feng, Qiang Li, Simon Finfer, John Myburgh, Rinaldo Bellomo, Vlado Perkovic, Meg Jardine, Amanda Y. Wang, Martin Gallagher
Summary: This study developed a predictive model for identifying ICU patients at high risk of severe AKI using readily available clinical variables. The model showed good discrimination and calibration, and demonstrated net benefit in the prediction of severe AKI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Critical Care Medicine
Kyle C. White, Ary Serpa-Neto, Rod Hurford, Pierre Clement, Kevin B. Laupland, Emily See, James McCullough, Hayden White, Kiran Shekar, Alexis Tabah, Mahesh Ramanan, Peter Garrett, Antony G. Attokaran, Stephen Luke, Siva Senthuran, Philippa McIlroy, Rinaldo Bellomo
Summary: This study aims to describe the epidemiology of sepsis-associated acute kidney injury (SA-AKI). The incidence of SA-AKI reached 18% in 2021, with patients typically being admitted from home via the emergency department (ED) and diagnosed with SA-AKI within 1 day of ICU admission. Compared to other diagnostic criteria, SA-AKI patients diagnosed by low urinary output (UO) only had a lower need for renal replacement therapy and a lower mortality risk.
INTENSIVE CARE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Xiao Chen, Xiaofeng Zhu, Huichang Zhuo, Jiandong Lin, Xian Lin
Summary: This study reveals that the absence of basophils in ICU patients is strongly associated with poor prognosis and mortality. The findings suggest that basophil-mediated immunity may serve as a potential predictor for ICU patients' prognosis, and help identify patients who would benefit from intensified treatment and immunoenhancement therapy.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Dan Liao, Yonghua Deng, Xinchun Li, Ju Huang, Jiayue Li, Ming Pu, Fenglian Zhang, Lijun Wang
Summary: This study found that elevated GNRI in critically ill patients is strongly correlated with a lower risk of unfavorable outcomes.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Haoquan Huang, Xiaohui Bai, Fengtao Ji, Hui Xu, Yanni Fu, Minghui Cao
Summary: This study found a non-linear relationship between early-phase UO6-12h and progression of AKI, with 1.1 ml/kg/h identified as the inflection point above which progression risk leveled off significantly. Patients with UO6-12h >= 1.1 ml/kg/h had shorter ICU and hospital stays, and lower 30-day mortality. The robustness of the findings was confirmed by sensitivity and subgroup analyses.
FRONTIERS IN MEDICINE
(2021)
Article
Pharmacology & Pharmacy
N. Dereli, M. Babayigit, O. Mentes, F. Koc, O. Ari, E. Dogan, E. Onhan
Summary: COVID-19-related acute kidney injury occurs in a considerable number of hospitalized and ICU patients, leading to prolonged hospital stays, increased treatment requirements, and higher mortality rates.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yuan Hong Du, Cheng Jing Guan, Lin Yu Li, Ping Gan
Summary: This study is the first meta-analysis investigating the predictive value of machine learning in assessing the risk of AKI among ICU patients. The results demonstrate that machine learning-based methods have excellent predictive value for identifying AKI risk in ICU patients and could potentially be used for early detection.
Article
Geriatrics & Gerontology
Q. Li, P. Hu, H. Kang, Feihu Zhou
Summary: This study revealed that 44.9% of hospitalized COVID-19 patients developed AKI, while 45.8% of AKI cases were not recognized. The findings suggest that AKI has a significant impact on patient outcomes and the protection of kidney function is crucial.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Critical Care Medicine
Stephani K. Zakutansky, Harlan McCaffery, Elizabeth M. Viglianti, Erin F. Carlton
Summary: There are differences in mortality rates for young adults with severe sepsis treated in pediatric intensive care units (PICUs) versus medical/surgical ICUs (MICUs/SICUs). However, there is no difference in length of stay. This variation in mortality is likely due to significant differences in the patient populations, including comorbidity status.
JOURNAL OF INTENSIVE CARE MEDICINE
(2023)
Article
Surgery
Bo You, Zichen Yang, Yulong Zhang, Yu Chen, Yali Gong, Yajie Chen, Jing Chen, Lili Yuan, Gaoxing Luo, Yizhi Peng, Zhiqiang Yuan
Summary: This retrospective study analyzed data from severely burned patients and found that AKI is prevalent in these patients and is associated with higher mortality. Late-onset acute kidney injury is more severe and has a worse prognosis compared to early-onset acute kidney injury.
FRONTIERS IN SURGERY
(2022)
Review
Biochemistry & Molecular Biology
Yu-Ming Chang, Yu-Ting Chou, Wei-Chih Kan, Chih-Chung Shiao
Summary: This review discusses the bidirectional interplay and pathophysiological mechanisms between sepsis and acute kidney injury (AKI), as well as preventive strategies for these conditions. The primary pathophysiology of sepsis-associated AKI involves inflammation, vascular dysfunction, cell cycle arrest, and apoptosis. On the other hand, the pathophysiology of sepsis following AKI includes fluid overload, hyperinflammation, immunosuppression, and infection associated with kidney replacement therapy and catheter cannulation. Several limitations persistently prevent a full understanding of the bidirectional pathophysiologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Bruce M. Biccard, Malcolm Miller, William L. Michell, David Thomson, Adesoji Ademuyiwa, Ernest Aniteye, Greg Calligaro, Maman Sani Chaibou, Hailu Tamiru Dhufera, Mohamed Elfagieh, Mahmoud Elfiky, Muhammed Elhadi, Maher Fawzy, David Fredericks, Meseret Gebre, Abebe Genetu Bayih, Anneli Hardy, Ivan Joubert, Fitsum Kifle, Hyla-Louise Kluyts, Kieran D. M. Macleod, Zelalem Mekonnen, Mervyn Mer, Atilio Morais, Vanessa Msosa, Wakisa Mulwafu, Andrew Ndonga, Zipporah Ngumi, Akinyinka Omigbodun, Christian Owoo, Fathima Paruk, Jenna L. Piercy, Juan Scribante, Yakob Seman, Elliott H. Taylor, Dawid E. A. van Straaten, P. Dean Gopalan
Summary: The ACCCOS study aimed to determine factors associated with mortality in critically ill African COVID-19 patients. The study found that mortality was higher in African countries compared to other regions, with factors such as age, comorbidities, organ dysfunction, and resource availability playing a role in patient outcomes.
Editorial Material
Anesthesiology
S. T. Vaara, M. Reinikainen, J. Bouchard
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2018)
Article
Critical Care Medicine
Rahul Raj, Stepani Bendel, Matti Reinikainen, Sanna Hoppu, Teemu Luoto, Tero Ala-Kokko, Sami Tetri, Ruut Laitio, Timo Koivisto, Jaakko Rinne, Riku Kivisaari, Jari Siironen, Alisa Higgins, Markus B. Skrifvars
CRITICAL CARE MEDICINE
(2018)
Letter
Critical Care Medicine
Pekka Jakkula, Markus B. Skrifvars, Ville Pettila, Johanna Hastbacka, Matti Reinikainen
INTENSIVE CARE MEDICINE
(2019)
Review
Behavioral Sciences
Reetta Kalviainen, Matti Reinikainen
EPILEPSY & BEHAVIOR
(2019)
Article
Anesthesiology
Anders Aneman, Johanna Laurikalla, Paul Pham, Erika Wilkman, Pekka Jakkula, Matti Reinikainen, Jussi Toppila, Markus B. Skrifvars
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2019)
Article
Clinical Neurology
Era D. Mikkonen, Markus B. Skrifvars, Matti Reinikainen, Stepani Bendel, Ruut Laitio, Sanna Hoppu, Tero Ala-Kokko, Atte Karppinen, Rahul Raj
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2019)
Article
Critical Care Medicine
Lauri Wihersaari, Marjaana Tiainen, Markus B. Skrifvars, Stepani Bendel, Kirsi-Maija Kaukonen, Jukka Vaahersalo, Jarkko Romppanen, Ville Pettila, Matti Reinikainen
Article
Clinical Neurology
Marika Fallenius, Markus B. Skrifvars, Matti Reinikainen, Stepani Bendel, Sami Curtze, Gerli Sibolt, Nicolas Martinez-Majander, Rahul Raj
Article
Biochemistry & Molecular Biology
Henna Jaurila, Vesa Koivukangas, Marjo Koskela, Fiia Gaddnas, Sami Myllymaa, Arja Kullaa, Tuula Salo, Tero Ala-Kokko
Article
Critical Care Medicine
Sanna Tornblom, Sara Nisulal, Liisa Petaja, Suvi T. Vaara, Mikko Haapio, Eero Pesonen, Ville Pettila
ANNALS OF INTENSIVE CARE
(2020)
Article
Medicine, General & Internal
Jaana Humaloja, Maximo Vento, Julia Kuligowski, Sture Andersson, Jose David Pineiro-Ramos, Angel Sanchez-Illana, Erik Litonius, Pekka Jakkula, Johanna Hastbacka, Stepani Bendel, Marjaana Tiainen, Matti Reinikainen, Markus B. Skrifvars
Summary: The levels of lipid peroxidation biomarkers peaked at 24 hours after cardiac arrest, suggesting ongoing oxidative stress. However, the clinical relevance of this remains unresolved. No association was found between the biomarkers and oxygen exposure either before or after randomization in the study.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Eric A. Hoste, Suvi T. Vaara, Jorien De Loor, Mikko Haapio, Lieve Nuytinck, Kristel Demeyere, Ville Pettila, Evelyne Meyer
Article
Critical Care Medicine
Pekka Jakkula, Johanna Haestbacka, Matti Reinikainen, Ville Pettilae, Pekka Loisa, Marjaana Tiainen, Erika Wilkman, Stepani Bendel, Thomas Birkelund, Anni Pulkkinen, Minna Baecklund, Sirkku Heino, Sari Karlsson, Hiski Kopponen, Markus B. Skrifvars
Article
Critical Care Medicine
Pirkka T. Pekkarinen, Minna Backlund, Ilmar Efendijev, Rahul Raj, Daniel Folger, Erik Litonius, Ruut Laitio, Stepani Bendel, Sanna Hoppu, Tero Ala-Kokko, Matti Reinikainen, Markus B. Skrifvars
Article
Clinical Neurology
Monica Ferlisi, Sara Hocker, Eugen Trinka, Simon Shorvon