Article
Cell Biology
Qian Sun, Xiao Chen, Wei Liu, Shenpan Li, Yan Zhou, Xingfen Yang, Jianjun Liu
Summary: Long-term low-dose STX exposure can lead to cognitive deficiency and brain neuronal damage in mice, affecting spatial memory. Proteomics analysis identified the involvement of Ppp1c and Arsa in the neurotoxic effects of STX exposure.
Article
Microbiology
Davide Diena, Anna Allesina, Fabrizio Fop, Alberto Mella, Rossana Cavallo, Cristina Costa, Caterina Dolla, Ester Gallo, Francesco Giuseppe De Rosa, Antonio Lavacca, Roberta Giraudi, Filippo Mariano, Luigi Biancone
Summary: This study aims to explore the burden of Cytomegalovirus (CMV) on the long-term post-transplant course in kidney-transplanted patients (KTs) with extensive adoption of expanded-criteria donors (ECDs). A retrospective evaluation of 929 consecutive first KTs was performed, and CMV incidence was found to be 19.5%. Donor and recipient age, recipient pre-transplant hypertension, DR antigen compatibility, cold ischemia time, and post-transplant early complications were associated with CMV. The findings of this study have important implications for the long-term post-transplant outcomes and prognosis of kidney transplant recipients.
Article
Obstetrics & Gynecology
Maryam Pirani, Marefat Ghaffari Novin, Mohammad-Amin Abdollahifar, Abbas Piryaei, Zahra Kuroshli, Zahra Shams Mofarahe
Summary: In a mouse model of long-term scrotal hyperthermia, Fisetin has both preventive and curative effects, significantly improving testicular volume, density of germ cells, and sperm parameters among others.
REPRODUCTIVE SCIENCES
(2021)
Article
Neurosciences
Martyna Rakowska, Mahmoud E. A. Abdellahi, Paulina Bagrowska, Miguel Navarrete, Penelope A. Lewis
Summary: The effects of TMR on task performance can last for at least 10 days post-encoding, with time spent in stage 2 of NREM sleep predicting cueing benefit. In addition, there is a significant increase in spindle density and SO-spindle coupling during the cue period, highlighting their importance in procedural memory consolidation.
Article
Neurosciences
Maria Gomis-Gonzalez, Lorena Galera-Lopez, Marc Ten-Blanco, Arnau Busquets-Garcia, Thomas Cox, Rafael Maldonado, Andres Ozaita
Summary: The study revealed that PKC-gamma knockout mice exhibit severe impairment in hippocampal-dependent short-term memory performance while long-term memory tasks remain unaffected. This indicates that PKC-gamma plays a crucial role in memory processes, particularly in the formation of short-term memory and the differential involvement in short-term and long-term memory processes.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zhaojia Wang, Ziheng Jia, Zandong Zhou, Xiaotong Zhao, Feng Wang, Xu Zhang, Gary Tse, Guangping Li, Yang Liu, Tong Liu
Summary: Abdominal irradiation causes long-term damage to the non-irradiated heart, characterized by electrical and structural remodeling, mechanical dysfunction, and abnormal amino acid biosynthesis and metabolism.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Izabelle Dias Benfato, Ana Carolina Silvares Quintanilha, Jessica Salles Henrique, Melyssa Alves Souza, Barbara dos Anjos Rosario, Jose Ivo Araujo Beserra Filho, Robson Luiz Oliveira Santos, Alessandra Mussi Ribeiro, Luciana Le Sueur Maluf, Camila Aparecida Machado de Oliveira
Summary: The study found that long-term social isolation can have effects on metabolism, behavior, and the central nervous system in middle-aged mice. The isolated group showed impaired memory, altered food intake, increased physical activity, and evidence of anxiety-like behavior. Short-term memory deficit was associated with lower levels of hippocampal AFosB and BDNF in middle age.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Review
Clinical Neurology
Ines Tran, Anne-Kathrin Gellner
Summary: Translational mouse models are commonly used in studying neuropsychiatric disorders, but most studies focus on the short-term effects of chronic stress, overlooking the long-term consequences.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Plant Sciences
Yalin Wang, Wenyan Zhu, Fei Ren, Na Zhao, Shixiao Xu, Ping Sun
Summary: The study revealed that grazing intensity has significant effects on key pathways and related genes in Taraxacum mongolicum, including plant hormone and signal transduction pathways, carbohydrate and secondary metabolism, and photosynthesis. Heavy grazing resulted in a stronger transcriptomic response compared with light grazing by increasing the expression of secondary metabolism- and photosynthesis-related genes. These findings shed light on the molecular mechanisms of plant response to grazing.
Article
Behavioral Sciences
Guy Escoffier, Martine Migliorati, Melinda Rahrah, Charles S. M. Roman, Michel Khrestchatisky, Francois S. Roman
Summary: The Helico Maze was used to assess long-term memory in BALB, C57, and DBA mice, revealing that BALB mice outperformed the other two strains in the task.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Behavioral Sciences
Toshiro Sakamoto, Joi Yashima
Summary: The prefrontal cortex is crucial for long-term social recognition memory in mice, while its role in short-term memory is unclear. It also plays a significant role in social motivation but has no impact on anxiety-related behavior or general activity.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Paola Colucci, Alessia Santori, Luca Romanelli, Clemens Zwergel, Antonello Mai, Sergio Scaccianoce, Patrizia Campolongo
Summary: The study found that amphetamine enhances memory consolidation in rats under mild stress conditions, but impairs long-term memory performance in rats exposed to strong stress, depending on the stress-induced activation of the peripheral adrenergic response.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Engineering, Environmental
Xiangsheng Hong, Rui Chen, Le Zhang, Liang Yan, Jiajing Xin, Jiasu Li, Jinmiao Zha
Summary: This study investigated the long-term neurotoxic effects of residual antidepressant citalopram on zebrafish. The results showed that continuous exposure to citalopram led to decreased motor function, learning, and memory in both larval and adult zebrafish. However, the effects were reversible in larval zebrafish after transferring to a clean medium. The study provides insights into the neurotoxic mechanisms of citalopram and its potential environmental and health risks.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Neurosciences
Baiwei Liu, Xinyu Li, Jan Theeuwes, Benchi Wang
Summary: It has been traditionally believed that information retrieved from long-term memory (LTM) needs to be brought back into working memory (WM). However, this study demonstrates that retrieval from LTM is possible even when WM capacity is fully occupied. EEG results indicate that retrieving items from LTM while WM is fully engaged enhances the suppression of alpha oscillations, suggesting alternative mechanisms for accessing LTM when WM is fully occupied.
Article
Neurosciences
Gaifen Li, Yuying Guan, Yakun Gu, Mengyuan Guo, Wei Ma, Qianqian Shao, Jia Liu, Xunming Ji
Summary: This study investigated the mechanism and treatment strategy for hypoxia-induced nerve injury. The researchers found that short-term hypoxia promotes neurogenesis, while long-term hypoxia inhibits neurogenesis. Intermittent hypoxic conditioning showed a neuroprotective effect by promoting neural stem cell generation and suppressing inflammation induced by long-term hypoxia stress. This study provides a new concept for the treatment of hypoxia-related brain injury.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)