期刊
ACS NANO
卷 8, 期 5, 页码 4815-4826出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn500702g
关键词
polymeric carriers; confined water; near-infrared radiation; photothermal effect; triggered release
类别
资金
- King Abdulaziz City for Science and Technology (KACST-UC San Diego Center of Excellence in Nanomedicine)
- NIH [1 DP2 OD006499-01, R01AG032132]
- NSF
Near-infrared (NIR) light-triggered release from polymeric capsules could make a major impact on biological research by enabling remote and spatiotemporal control over the release of encapsulated cargo. The few existing mechanisms for NIR-triggered release have not been widely applied because they require custom synthesis of designer polymers, high-powered lasers to drive inefficient two-photon processes, and/or coencapsulation of bulky inorganic particles. In search of a simpler mechanism, we found that exposure to laser light resonant with the vibrational absorption of water (980 nm) in the NIR region can induce release of payloads encapsulated in particles made from inherently non-photo-responsive polymers. We hypothesize that confined water pockets present in hydrated polymer particles absorb electromagnetic energy and transfer it to the polymer matrix, Inducing a thermal phase change. In this study, we show that this simple and highly universal strategy enables instantaneous and controlled release of payloads in aqueous environments as well as in living cells using both pulsed and continuous wavelength lasers without significant heating of the surrounding aqueous solution.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据