期刊
ACS NANO
卷 8, 期 5, 页码 4650-4661出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn5004088
关键词
tubular polymersomes; polymersomes; nanotubes; drug delivery; endocytosis
类别
资金
- MRC
- BBSRC
- Biocompatibles Ltd.
- Parkinson's UK [G1202]
- MRC Senior Clinical Fellowship
- ERC-STG Award (MEVIC)
- Engineering and Physical Sciences Research Council [EP/G062137/1] Funding Source: researchfish
- Medical Research Council [990236, G108/595, 1010961, MR/K006312/1, G0701932] Funding Source: researchfish
- Parkinson's UK [G-1202] Funding Source: researchfish
- EPSRC [EP/G062137/1] Funding Source: UKRI
- MRC [G108/595, MR/K006312/1, G0701932] Funding Source: UKRI
Optimizing the shape of a nanovector influences its interaction with a cell and determines the internalization kinetics. Block copolymer amphiphiles self-assemble into monodisperse structures in aqueous solutions and have been explored extensively as drug delivery vectors. However, the structure of self-assembled block copolymers has mainly been limited to spherical vesicles or spherical and worm-like micelles. Here we show the controlled formation and purification of tubular polymersomes, long cylindrical vesicles. Tubular polymersomes are purified from other structures, and their formation is manipulated by incorporating the biocompatible membrane components cholesterol and phospholipids. Finally we show that these tubular polymersomes have different cellular internalization kinetics compared with spherical polymersomes and can successfully encapsulate and deliver fluorescent bovine serum albumin protein intracellularly.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据