☆ 4.8 Article

Hyaluronate-Gold Nanoparticle/Tocilizumab Complex for the Treatment of Rheumatoid Arthritis

ACS NANO (2014)

期刊

ACS NANO

卷 8, 期 5, 页码 4790-4798

出版社

AMER CHEMICAL SOC

DOI: 10.1021/nn500685h

关键词

gold nanoparticle; tocilizumab; hyaluronic acid; drug delivery; rheumatoid arthritis

类别

Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary

资金

Converging Research Center Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2009-0081871]
Midcareer Researcher Program through NRF - MEST [2012R1A2A2A06045773]
National Research Foundation of Korea [2009-0081871] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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摘要

Rheumatoid arthritis (RA) is a chronic inflammatory immune disease causing the inflammation of synovial membrane and the articular cartilage destruction. In this work, hyaluronate gold nanoparticle/Tocilizumab (HA-AuNP/TCZ) complex was prepared for the treatment of RA. AuNP was used as a drug carrier with antiangiogenic effect. in is a humanized monoclonal antibody against the interleukin-6 (IL-6) receptor and used as an immunosuppressive drug by Interfering IL-6 in the pathogenesis of RA. HA is known to have cartilage-protective and lubricant effects. HA was modified with cystamine via reductive amination, which was reduced with dithiothreitol (DTT) to prepare end-group thiolated HA (HA-SH). AuNP was chemically modified with HA-SH and physically modified with T. The formation of HA-AuNP/TCZ complex was corroborated by UV-vis spectroscopy, dynamic light scattering (DLS), and transmission electron microscopy (TEM). The therapeutic effect of HA-AuNP/TCZ complex on RA was confirmed In collagen-induced arthritis (CIA) model mice by ELISA, histological, and Western blot analyses.

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Hyaluronic acid engineered gallic acid embedded chitosan nanoparticle as an effective delivery system for treatment of psoriasis

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