Review
Pharmacology & Pharmacy
Araceli Lerida-Viso, Alejandra Estepa-Fernandez, Alba Garcia-Fernandez, Vicente Marti-Centelles, Ramon Martinez-Manez
Summary: This review highlights the importance of mesoporous silica nanoparticles (MSNs) in biomedical applications and discusses their potential uses in nanomedicine. The biosafety properties of MSNs are analyzed, and the potential challenges related to the clinical application of silica materials are discussed.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Elisa Bindini, Maria de los Angeles Ramirez, Xabier Rios, Unai Cossio, Cristina Simo, Vanessa Gomez-Vallejo, Galo Soler-Illia, Jordi Llop, Sergio E. Moya
Summary: A novel method was reported to track the in vivo degradation of mesoporous silica nanoparticles, showing that these nanoparticles have fast degradation kinetics in vivo.
Article
Chemistry, Physical
Bassam Jameel, Tomasz Hornowski, Rafal Bielas, Arkadiusz Jozefczak
Summary: Ultrasound attenuation spectroscopy is widely used in studying colloidal dispersions, offering the advantage of applicability to high concentration systems without sample preparation. This study characterizes suspensions of magnetite and silica nanoparticles in high viscous media using ultrasound spectroscopy. The results show significant differences in ultrasound attenuation coefficients between the two types of nanoparticles, suggesting different particle sizes. The technique provides a method to estimate the real size of objects suspended in high viscous media.
Article
Pharmacology & Pharmacy
Leanne De Silva, Ju-Yen Fu, Thet Thet Htar, Wan Hamirul Bahrin Wan Kamal, Azahari Kasbollah, Saravanan Muniyandy, Lay-Hong Chuah
Summary: The study found that Technetium-99m-labeled niosomes had high radiolabeling efficiency and stability in vivo, with scintigraphic imaging showing radioactivity mainly accumulated in the liver, spleen, and kidneys, indicating higher specificity for the tumor area.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Acoustics
S. Lahiri, A. Mishra, D. Mandal, R. L. Bhardwaj, P. R. Gogate
Summary: This study focused on recovering adsorbed uranium from silica nanoparticles and its biohybrid using ultrasound, demonstrating a significant increase in dissolution efficiency compared to silent operation. The results showed that the sorbents could adsorb high percentages of uranium in the second cycle, but the adsorption capacity decreased after acid treatment. The recovery and reuse of both nuclear material and sorbent could be an effective nuclear remediation technique in line with the UN's Sustainable Development Goals.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Pranav Shah, Priya Dubey, Bhavin Vyas, Ankur Kaul, Anil Kumar Mishra, Dimple Chopra, Priya Patel
Summary: The study developed LTG-PNPs nanoparticles that displayed better brain targeting efficacy upon intranasal administration, potentially reducing dosing frequency and side effects. Further validation in higher animals and human volunteers is needed for confirmation.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Svetlana Fedorenko, Alexey Stepanov, Olga Bochkova, Kirill Kholin, Irek Nizameev, Alexandra Voloshina, Oksana Tyapkina, Dmitry Samigullin, Sofiya Kleshnina, Bulat Akhmadeev, Alexander Romashchenko, Evgenii Zavjalov, Rustem Amirov, Asiya Mustafina
Summary: The co-doped silica nanoparticles with paramagnetic and luminescent complexes were successfully synthesized. The specific distribution of the paramagnetic complex within the nanoparticles significantly enhanced the magnetic relaxivities compared to those in solutions. The leaching of paramagnetic complex from the shell was minimized by co-doping luminescent complex into the core of the nanoparticles. The co-doped nanoparticles exhibited colloid stability in aqueous solutions, including blood serum. The cytotoxicity, hemoagglutination, and hemolytic activities of the co-doped nanoparticles were suitable for in vivo studies.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Ruma Rani, Parth Malik, Sunena Dhania, Tapan Kumar Mukherjee
Summary: Breast cancer ranks second in cancer-related global female deaths. Late diagnosis and drug resistance limit the effectiveness of chemotherapeutic drugs, leading to relapse and metastasis. Core-shell mesoporous silica nanoparticles (MSNPs) have emerged as potential drug carriers for breast cancer treatment due to their high surface area, drug loading capacity, and stealth drug delivery capabilities. This article discusses the preparation methods, drug delivery mechanisms, and emerging utility of MSNPs in breast cancer treatment.
Article
Biotechnology & Applied Microbiology
Rita M. Pinto, Saleh Yazdani, Catarina Leal Seabra, Martine De Jonge, Mukaddes Izci, Rebeca Cruz, Susana Casal, Stefaan J. Soenen, Salette Reis, Claudia Nunes, Patrick Van Dijck
Summary: Staphylococcus aureus is a high priority pathogen due to its prevalence and ability to form biofilms. Current treatments do not target the matrix that contributes to antimicrobial tolerance. This study proposes the use of lipid nanoparticles encapsulating caspofungin to disrupt the matrix, and combining them with moxifloxacin-loaded nanoparticles to reduce biofilms. In vitro and in vivo studies showed promising results, with reduced biofilm formation and no bacterial dissemination into vital organs.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Article
Nanoscience & Nanotechnology
Julia Nowak-Jary, Beata Machnicka
Summary: Magnetic iron oxide nanoparticles have broad potential applications in medical and biological sciences. They can be used in targeted drug delivery, internal radiotherapy, magnetic resonance imaging, hyperthermia, and radiolabelling. The appropriate design of nanoparticles allows them to be delivered to desired tissues and organs, with an external magnetic field increasing their biodistribution. Factors such as size, shape, surface charge, coating molecules, and route of administration affect their biodistribution. Modern techniques can determine nanoparticle accumulation sites and concentration in isolated tissues or the body in vivo.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Joanna Sobska, Magdalena Waszkielewicz, Anna Podlesny-Drabiniok, Joanna Olesiak-Banska, Wojciech Krezel, Katarzyna Matczyszyn
Summary: Gold nanoparticles hold great promise for clinical and preclinical applications, but toxicity and accumulation issues are major barriers. Research on Au18 gold nanoclusters with low toxicity and good biodistribution profile may contribute to future biomedical studies.
Article
Chemistry, Multidisciplinary
Guangze Yang, Yun Liu, Yue Hui, Tengjisi, Dong Chen, David A. Weitz, Chun-Xia Zhao
Summary: This study compared two types of dye-labeled nanoparticles and found that nanoparticles with dye molecules in a solid state undergo dye quenching, while those in a soluble state do not. To standardize the comparative study, the proposed solutions include using lower dye loading or utilizing medium analysis for quantifying cell uptake of nanoparticles. Valuable insights into selecting valid quantification methods for bio-nano studies are provided.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Cell & Tissue Engineering
Charlotte Beerts, Carlien Brondeel, Glenn Pauwelyn, Eva Depuydt, Liesa Tack, Luc Duchateau, Yangfeng Xu, Jimmy H. Saunders, Kathelijne Peremans, Jan H. Spaas
Summary: This study investigated the biodistribution pattern of equine peripheral blood-derived mesenchymal stem cells in healthy dogs, showing a distinct difference compared to free (99m)Technetium in terms of accumulation sites and patterns after different injection routes. The results suggest that these stem cells have a specific pharmacokinetic pattern after systemic administration and differ from experiments using different sources of mesenchymal stem cells.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Chae Moon Hong, Prakash Gangadaran, Ji Min Oh, Ramya Lakshmi Rajendran, Arunnehru Gopal, Liya Zhu, Byeong-Cheol Ahn
Summary: This study developed a nuclear imaging method for tracking EVs derived from cell lines, showing that radioiodine-labeled EVs had good biodistribution. The radioiodine labeling did not significantly affect the morphology and properties of EVs.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Sinan Sabuncu, Ruth Javier Ramirez, Jared M. Fischer, Fehmi Civitci, Adem Yildirim
Summary: Localization-based ultrasound imaging methods using microbubbles or nanodroplets provide high-resolution images with reduced background signal, but suffer from long acquisition times. A new ultrafast localization method using blinking ultrasound-responsive nanoparticles (BNPs) is introduced, enabling background-free ultrasound images with acquisition times as low as 11 ms. In vivo background-free ultrasound imaging in mice is also demonstrated with the use of BNPs, suggesting its potential for more sensitive detection of cancer and other diseases.
Article
Nanoscience & Nanotechnology
Natalie Mendez, Alexander Liberman, Jacqueline Corbeil, Christopher Barback, Robert Viveros, James Wang, Jessica Wang-Rodriguez, Sarah L. Blair, Robert Mattrey, David Vera, William Trogler, Andrew C. Kummel
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2017)
Article
Materials Science, Biomaterials
Jian Yang, Erin Ward, Tsai W. Sung, James Wang, Christopher Barback, Natalie Mendez, Sarah Blair, William C. Trogler, Andrew C. Kummel
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2017)
Article
Materials Science, Biomaterials
Jian Yang, Erin Ward, Tsai W. Sung, James Wang, Christopher Barback, Natalie Mendez, Sarah Blair, William C. Trogler, Andrew C. Kummel
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2017)
Article
Computer Science, Interdisciplinary Applications
James Wang, Christopher V. Barback, Casey N. Ta, Joi Weeks, Natalie Gude, Robert F. Mattrey, Sarah L. Blair, William C. Trogler, Hotaik Lee, Andrew C. Kummel
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2018)
Article
Surgery
Erin P. Ward, Jian Yang, Jonathan C. Delong, Tsai-Wen Sung, James Wang, Chris Barback, Natalie Mendez, Santiago Horgan, William Trogler, Andrew C. Kummel, Sarah L. Blair
Article
Radiology, Nuclear Medicine & Medical Imaging
Gregory J. Anthony, Kenneth B. Bader, James Wang, Marta Zamora, Allison Ostdiek, Tatjana Antic, Sascha Krueger, Steffen Weiss, William C. Trogler, Sarah L. Blair, Andrew C. Kummel, Steffen Sammet
Article
Nanoscience & Nanotechnology
Ching-Hsin Huang, Natalie Mendez, Oscar Hernandez Echeagaray, Joi Weeks, James Wang, Charles N. Vallez, Natalie Gude, William C. Trogler, Dennis A. Carson, Tomoko Hayashi, Andrew C. Kummel
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Chemistry, Multidisciplinary
Ching-Hsin Huang, James Wang, Jian Yang, Juan Pablo Oviedo, Seungjin M. Na, William C. Trogler, Sarah L. Blair, Moon J. Kim, Andrew C. Kummel
ADVANCED FUNCTIONAL MATERIALS
(2019)
Article
Chemistry, Physical
Adrian Garcia Badaracco, Erin Ward, Christopher Barback, Jian Yang, James Wang, Ching-Hsin Huang, Moon Kim, Qingxiao Wang, Seungjin Nam, Jonathan Delong, Sarah Blair, William C. Trogler, Andrew Kummel
APPLIED SURFACE SCIENCE
(2020)
Article
Chemistry, Multidisciplinary
Yuanli Liu, Chuanbai Yu, Zhixin Cao, Daniel Shvarts, William C. Trogler
CHEMISTRY-A EUROPEAN JOURNAL
(2017)
Meeting Abstract
Chemistry, Multidisciplinary
Ching-Hsin Huang, Jian Yang, James Wang, Juan Oviedo, William Trogler, Andrew Kummel, Moon Kim
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Meeting Abstract
Chemistry, Multidisciplinary
Jian Yang, Erin Ward, Tsai Sung, James Wang, Christopher Barback, Natalie Mendez, Jonathan Delong, Sarah Blair, William Trogler, Andrew Kummel
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Meeting Abstract
Chemistry, Multidisciplinary
James Wang, Jian Yang, Gregory Anthony, Steffan Sammet, William Trogler, Andrew Kummel
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Meeting Abstract
Chemistry, Multidisciplinary
Tsai Wen Sung, Jian Yang, James Wang, Erin Ward, Natalie Mendez, Christopher Barback, Sarah Blair, Andrew Kummel, William Trogler
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Nanoscience & Nanotechnology
Jian Yang, James Wang, Casey N. Ta, Erin Ward, Christopher V. Barback, Tsai-Wen Sung, Natalie Mendez, Sarah L. Blair, Andrew C. Kummel, William C. Trogler
ACS APPLIED MATERIALS & INTERFACES
(2017)