Article
Chemistry, Applied
Peuli Ghosh, Ake Rasmuson, Sarah P. Hudson
Summary: This study investigated the impact of single or combinations of additives on the generation and drying process of nanosuspensions of two poorly water-soluble pharmaceutical ingredients. It was found that using combinations of additives could stabilize the particle size distribution and improve the purity of the dried powder. However, the addition of additives did not significantly affect the dissolution profiles of the powders after freeze-drying.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2023)
Article
Chemistry, Physical
Fanwen Meng, Pengcheng Jia, Xiaomeng Li, Yang Tang, Bo Song, Junhan Guo, Liang Qin, Yufeng Hu, Feng Teng, Zhidong Lou, Yanbing Hou
Summary: In this study, the performance of PTAA as a hole-transport layer in inverted perovskite solar cells was improved by modifying the PTAA film with CuI. CuI modification not only improved the wettability but also promoted the crystallization of the perovskite film, effectively inhibiting the formation of defects and enhancing carrier transport efficiency.
ACS APPLIED ENERGY MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Shengzhe Jia, Peng Yang, Zhenguo Gao, Zhonghua Li, Chen Fang, Junbo Gong
Summary: This paper introduces and summarizes the applications and process intensification pathways of antisolvent crystallization in pharmaceutical crystal engineering. It presents methods and technologies for optimizing product properties and pharmaceutical process design.
Article
Chemistry, Multidisciplinary
Yohwan Park, Kwangjin Song, Hee Cheul Choi
Summary: Emulsion particles are found when ethanol is mixed into immiscible or miscible liquids, providing a space for crystallization. The size change of emulsion particles, influenced by the amount of ethanol, can explain the change in crystallization environment until a supersaturation state is reached. This is believed to be a key indicator of the ASC mechanism prior to nucleation.
Article
Chemistry, Multidisciplinary
Noor Titan Putri Hartono, Mansoor Ani Najeeb, Zhi Li, Philip W. Nega, Clare A. Fleming, Xiaohe Sun, Emory M. Chan, Antonio Abate, Alexander J. Norquist, Joshua Schrier, Tonio Buonassisi
Summary: This study presents a systematic exploration of nine bipyridine-and terpyridine-based additives for the crystallization of lead-halide perovskite. A previously unreported additive, 6,6'-dimethyl-2,2'-dipyridyl, is found to significantly improve the crystallization of methylammonium lead iodide. The machine-learning-guided high-throughput experimentation strategy used in this study can be applied to other crystal growth problems.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Huaxin Gong, Diego Uruchurtu Patino, Jan Ilavsky, Ivan Kuzmenko, Amnahir Estefania Pena-Alcantara, Chenhui Zhu, Aidan H. Coffey, Lukas Michalek, Ahmed Elabd, Xin Gao, Shucheng Chen, Chengyi Xu, Hongping Yan, Yuanwen Jiang, Weichen Wang, Yucan Peng, Yitian Zeng, Hao Lyu, Hanul Moon, Zhenan Bao
Summary: A versatile method for synthesizing nanostructured carbon materials based on flower-like PAN chemistry is reported. The resulting PAN superstructures can be easily converted to carbon superstructures. Surface modification of the nanostructured films resulted in high surface roughness and a contact angle of approximately 180 degrees. This study offers a strategy for the synthesis of nanostructured carbon materials for various applications.
Review
Chemistry, Multidisciplinary
Jose Roberto Bautista-Quijano, Oscar Telschow, Fabian Paulus, Yana Vaynzof
Summary: The solvent-engineering method is commonly used for fabricating metal halide perovskite films. This method involves the application of an antisolvent to trigger crystallisation during spin-coating of a perovskite precursor solution. This review focuses on the understanding of the processes involved in perovskite layer crystallisation by solvent engineering, with emphasis on the role of antisolvent properties and solvent-antisolvent interactions. Guidelines for selecting the appropriate antisolvent are proposed based on the impact of Hansen solubility parameters, and future research directions and open questions in the fabrication of perovskite films using this method are outlined.
CHEMICAL COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Tingxuan Yan, Haili Wang, Xingfang Song, Tingyuan Yan, Yuwen Ding, Kang Luo, Juan Zhen, Gui He, Libin Nian, Shuangshou Wang, Zhixiang Wang
Summary: Flavonoids have positive pharmacological properties, but their low solubility and dissolution rate limit their use. Microparticles and nanoparticles of apigenin were prepared using antisolvent precipitation technologies, resulting in enhanced dissolution rate and bioactivity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Physical
Jinhyeok Choi, Seok Joo Yang, Se Gyo Han, Woong Sung, Dongho Yoo, Kilwon Cho
Summary: A multifunctional molecular additive, fulleropyrrolidine, is used for the first time to passivate the surfaces and grain boundaries in Sn-based perovskite solar cells (Sn-PSCs). This passivation suppresses nonradiative recombination, inhibits the formation of Sn4+ and I3-, and improves the stability of Sn-PSCs.
CHEMISTRY OF MATERIALS
(2023)
Review
Instruments & Instrumentation
Rahul Kumar, Amit K. Thakur, Nilanjana Banerjee, Ashutosh Kumar, Gajendra Kumar Gaurav, Raj Kumar Arya
Summary: The present work reviews the application of liquid antisolvent crystallization (LASC) in preparing pharmaceutical compounds as nanoparticles, aiming to improve their solubility, dissolution rate, and bioavailability. Various techniques, such as ultrasound and additives, are discussed to achieve narrow size distribution of the particles. Additionally, the use of ionic liquid as an alternative solvent is also presented. The paper highlights the less-explored applications of LASC in pharmaceutical research, and discusses the potential of combining LASC with traditional techniques for nanoparticle preparation.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Crystallography
Corin Mack, Johannes Hoffmann, Jan Sefcik, Joop H. ter Horst
Summary: This study presents an efficient methodology for constructing the phase diagram of a ternary system consisting of compound, solvent, and antisolvent in the antisolvent crystallization process. The methodology is exemplified with four model compounds and includes clear point temperature measurements to obtain solubilities of single solvent and mixed solvent-antisolvent systems. The results show non-linear solubility dependencies and more complex solubility behavior as a function of antisolvent fraction. A semi-empirical model equation is used to describe the phase diagram as a function of temperature and antisolvent fraction, allowing for the identification of optimal conditions in continuous antisolvent crystallization processes.
Review
Chemistry, Physical
Qiuju Liang, Wangchang Li, Haodong Lu, Zhenhao Yu, Xinyi Zhang, Qingjie Dong, Chunpeng Song, Zongcheng Miao, Jiangang Liu
Summary: BHJ organic photovoltaics are highly promising for green energy technology, but optimizing the morphology of the active layer is crucial. The addition of solid additives has become a popular strategy, but the relationship between additive properties and active layer morphology is still unclear.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Environmental Sciences
Seung Yeop Lee, Hyo Jin Seo, Ha-Rim An, Jang-Soon Kwon
Summary: An innovative method was discovered to effectively remove highly mobile radioiodide and reduce waste volume through a spontaneous phase transformation. Under anaerobic conditions, metallic copper (II) combined with bicarbonate to form CuI crystal, which transformed into marshite crystal with low solubility in water. The selective absorption of I- by marshite crystal was promoted by the presence of anionic competitors, leading to a promising way to remove I- in practical environments.
Article
Biochemistry & Molecular Biology
Sara Chergaoui, Damien P. Debecker, Tom Leyssens, Patricia Luis
Summary: This study investigates the impact of solution velocity, antisolvent composition, temperature, and gravity on crystallization using polypropylene flat sheet membranes and a glycine-water-ethanol model system. The results demonstrate that membrane antisolvent crystallization provides a narrower crystal size distribution and more consistent crystal morphology compared to batch and drop-by-drop crystallization. The crystal size does not show a clear correlation with solution velocities or antisolvent composition, but increases with higher temperature or gravity resistance. Furthermore, the monoclinic form of alpha-glycine is perfectly maintained under all conditions.
Article
Chemistry, Multidisciplinary
Ming-Chung Wu, Ching-Mei Ho, Kai-Chi Hsiao, Shih-Hsuan Chen, Yin-Hsuan Chang, Meng-Huan Jao
Summary: This study improves the morphology, crystallinity, and element distribution of lead-free perovskite films through anti-solvent engineering and deionized water treatment, resulting in a 3.2 times enhancement of photovoltaic performance.
Article
Optics
Holger Beh, Daniel Hiller, Jan Salava, Frantisek Trojanek, Margit Zacharias, Petr Maly, Jan Valenta
JOURNAL OF LUMINESCENCE
(2018)
Article
Materials Science, Multidisciplinary
Holger Beh, Daniel Hiller, Margit Zacharias
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
(2018)
Article
Materials Science, Multidisciplinary
Max O. Williams, Ada L. H. Jervell, Daniel Hiller, Margit Zacharias
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
(2018)
Article
Nanoscience & Nanotechnology
Daniel Hiller, Julian Lopez-Vidrier, Keita Nomoto, Michael Wahl, Wolfgang Bock, Tomas Chlouba, Frantisek Trojanek, Sebastian Gutsch, Margit Zacharias, Dirk Konig, Petr Maly, Michael Kopnarski
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
(2018)
Article
Computer Science, Interdisciplinary Applications
Irving Cruz-Matias, Dolors Ayala, Daniel Hiller, Sebastian Gutsch, Margit Zacharias, Sonia Estrade, Francesca Peiro
JOURNAL OF COMPUTATIONAL SCIENCE
(2019)
Article
Materials Science, Multidisciplinary
Krishna Kanth Neelisetty, Xiaoke Mu, Sebastian Gutsch, Alexander Vahl, Alan Molinari, Falk von Seggern, Mirko Hansen, Torsten Scherer, Margit Zacharias, Lorenz Kienle, V. S. Kiran Chakravadhanula, Christian Kuebell
MICROSCOPY AND MICROANALYSIS
(2019)
Article
Polymer Science
Dennis Graf, Sven Burchard, Julian Crespo, Christof Megnin, Sebastian Gutsch, Margit Zacharias, Thomas Hanemann
Article
Physics, Applied
J. L. Frieiro, J. Lopez-Vidrier, O. Blazquez, D. Yazicioglu, S. Gutsch, J. Valenta, S. Hernandez, M. Zacharias, B. Garrido
JOURNAL OF APPLIED PHYSICS
(2019)
Article
Physics, Applied
T. Chlouba, F. Trojanek, V. Kopecky, J. Lopez-Vidrier, S. Hernandez, D. Hiller, S. Gutsch, M. Zacharias, P. Maly
JOURNAL OF APPLIED PHYSICS
(2019)
Article
Multidisciplinary Sciences
J. Valenta, M. Greben, S. A. Dyakov, N. A. Gippius, D. Hiller, S. Gutsch, M. Zacharias
SCIENTIFIC REPORTS
(2019)
Article
Nanoscience & Nanotechnology
Deniz Yazicioglu, Sebastian Gutsch, Margit Zacharias
Article
Materials Science, Coatings & Films
Maximilian Kolhep, Cheng Sun, Juergen Blaesing, Bjoern Christian, Margit Zacharias
Summary: Highly textured ZnO thin films were successfully grown on Si(111) using an epitaxial AlN buffer layer at deposition temperatures between 100 and 300 degrees C. X-ray diffraction analysis confirmed epitaxial relationships and showed improved crystalline quality with increasing deposition temperatures. Additionally, a thermal postannealing step at 800 degrees C further enhanced the crystal structure.
JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A
(2021)
Article
Nanoscience & Nanotechnology
Jasmin-Clara Buerger, Serin Lee, Jan Buettner, Sebastian Gutsch, Maximilian Kolhep, Anna Fischer, Frances M. M. Ross, Margit Zacharias
Summary: The SnO2/ZnO core/shell nanowires, as anode materials in LIBs, were studied using electrochemical analysis and electron microscopy to understand the relationship between structural changes and battery performance. The combination of SnO2 and ZnO showed higher storage capacities, but cycling caused significant structural changes and loss of mechanical integrity. This study provides insights into the stability limitations of SnO2/ZnO heterostructure LIB anodes and offers guidance for the design of next-generation anode materials.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Jasmin-Clara Burger, Sebastian Gutsch, Vanessa Wollersen, Di Wang, Bjorn Christian, Zhe Fu, Oliver Ambacher, Christian Kubel, Margit Zacharias
Summary: SnO2 nanowires were grown on r-plane sapphire substrates and characterized by scanning electron microscopy and atomic force microscopy, which revealed their highly oriented growth towards the substrate edges. High-resolution transmission electron microscopy and strain mapping were used to analyze the crystallographic alignment and defect distribution within the nanowire cross section. The findings were compared to freestanding SnO2 nanowires and SnO2 thin films on sapphire substrates.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Materials Science, Multidisciplinary
Max Owen Williams, Maximilian Kolhep, Margit Zacharias
ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY
(2019)