期刊
ACS NANO
卷 6, 期 3, 页码 2542-2549出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn204990n
关键词
harmonic nanoparticles; nonlinear microscopy; cell labeling
类别
资金
- European FP7 Research Project [NMP4-LA-2010-246479]
Nonlinear optical nanocrystals have been recently introduced as a promising alternative to fluorescent probes for multiphoton microscopy. We present for the first time a complete survey of the properties of five nanomaterials (KNbO3, LiNbO3, BaTiO3, KIP, and ZnO), describing their preparation and stabilization and providing quantitative estimations of their nonlinear optical response. In the light of their prospective use as biological and clinical markers, we assess their biocompatibility on human healthy and cancerous cell lines. Finally, we demonstrate the great potential for cell imaging of these inherently nonlinear probes in terms of optical contrast, wavelength flexibility, and signal photostability.
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