Article
Engineering, Environmental
Siyi Lin, Hongna Zhang, Chen Wang, Xiu-Li Su, Yuanyuan Song, Pengfei Wu, Zhu Yang, Ming-Hung Wong, Zongwei Cai, Chunmiao Zheng
Summary: Plastic debris in the global biosphere is a growing concern, with the toxicity of nanoplastic (NPs) in humans not yet fully understood. This study investigates the impact of 80 nm NPs on mitochondrial functions and metabolic pathways in human liver and lung cells. The results show that NPs can enter the cells and cause mitochondrial damage, leading to altered mitochondrial functions and metabolic toxicity. Liver cells are more vulnerable to NP exposure compared to lung cells. This study provides insights into the potential adverse effects of NP-induced mitochondrial dysfunction on human health.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Biomedical
Sabine Rosenfeldt, Frank Mickoleit, Cornelia Joerke, Joachim H. Clement, Simon Markert, Valerie Jerome, Stephan Schwarzinger, Ruth Freitag, Dirk Schueler, Rene Uebe, Anna S. Schenk
Summary: This study characterizes a multi-step purification protocol for bacterial magnetosomes (MS) in terms of purity, iron content, size, and polydispersity. The potential cytotoxic effects of isolated MS when incubated with mammalian cells are also addressed. The study helps establish prerequisites for real-world applications of magnetosomes in biotechnology and biomedicine by providing a detailed overview of the process-structure relationship during the isolation of MS.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Environmental
Mislav Mustapic, Zvonko Glumac, Marija Heffer, Milorad Zjalic, Ivan Proloscic, Mostafa Masud, Senka Blazetic, Ana Vukovic, Motasim Billah, Aslam Khan, Suzana Segota, Md Shahriar Al Hossain
Summary: The research developed a drug delivery system based on combined AC/DC magnetic fields, using a magnetic syringe device to stimulate drug release and reduce cell viability, with the removal of drug carriers to prevent potential side effects in the patient's body.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Milos Ognjanovic, Zeljko Jacimovic, Milica Kosovic-Perutovic, Irina Besu Zizak, Tatjana Stanojkovic, Zeljko Zizak, Biljana Dojcinovic, Dalibor M. Stankovic, Bratislav Antic
Summary: Partial cation substitution can change the physical properties of compounds, and in this study, yttrium-substituted iron oxide nanoconstructs (YIONs) were prepared. The Y3+ substitution in maghemite (γ-Fe2O3) crystal structures was limited to 1.5%. The YIONs showed excellent heating efficiency and low toxicity, making them suitable for potential medical and technological applications such as magnetic hyperthermia cancer treatment and catalysis.
Article
Pharmacology & Pharmacy
Xuan-Hai Do, Tu Dac Nguyen, Thi Thu Huong Le, Thuy Thanh To, Thi Van Khanh Bui, Nam Hong Pham, Khanh Lam, Thi My Nhung Hoang, Phuong Thu Ha
Summary: This study evaluated the biological activity of nanoconjugates composed of superparamagnetic Fe3O4 nanoparticles coated with alginate and curcumin (Fe3O4/Cur@ALG) in cancer cells. The results showed that Fe3O4 nanoparticles had high biocompatibility and low toxicity in mice. Fe3O4/Cur@ALG enhanced the magnetic resonance imaging contrast and inhibited the growth of sarcoma 180 tumors through magnetic heating and the anticancer effects of curcumin.
Article
Biochemistry & Molecular Biology
Ane Elexpe, Laura Sanchez-Sanchez, Tarson Tolentino-Cortez, Egoitz Astigarraga, Maria Torrecilla, Gabriel Barreda-Gomez
Summary: Drug side effects are a major reason for treatment withdrawal in clinical trials. This study evaluated the formation of reactive oxygen species (ROS) in cell membranes of various drugs and compounds with different properties. The findings suggest that some drugs directly affect mitochondrial complex I and that ROS formation may anticipate adverse effects.
Article
Biochemistry & Molecular Biology
Mariana Garces, Natalia D. Magnani, Alessandra Pecorelli, Valeria Calabro, Timoteo Marchini, Lourdes Caceres, Erika Pambianchi, Juan Galdoporpora, Tamara Vico, Jimena Salgueiro, Marcela Zubillaga, Marcela A. Moretton, Martin F. Desimone, Silvia Alvarez, Giuseppe Valacchi, Pablo Evelson
Summary: The study found that exposure to AgNP may lead to lung harm, manifested as alterations in oxygen metabolism and oxidative damage, ultimately resulting in impaired lung function.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mohammad Mehdi Ommati, Hossein Niknahad, Omid Farshad, Negar Azarpira, Reza Heidari
Summary: The study reveals that lithium-induced renal injury is characterized by a significant increase in urine and serum biomarkers of renal impairment, along with oxidative stress in kidney tissue and changes in mitochondrial function. The mechanisms behind this renal injury may involve oxidative stress, mitochondrial dysfunction, and cellular energy crisis.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Engineering, Environmental
Chenyang He, Yu Guo, Bikash Karmakar, Attalla El -kott, Ahmed Ezzat Ahmed, Ahmed Khames
Summary: Nanotechnology involves utilizing atomic and molecular features to create modern systems, tools, and materials, with potential applications in various fields such as medical diagnostics, food, medicine, and biotechnology. Recent studies have shown promising cytotoxic effects on breast carcinoma cell lines using novel Ag NPs supported chitosan-starch composite functionalized Fe3O4 nanoparticles.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Pharmacology & Pharmacy
Gabriel Principe, Virginia Lezcano, Silvina Tiburzi, Alicia B. Miravalles, Paula S. Rivero, Maria G. Montiel Schneider, Veronica Lassalle, Veronica Gonzalez-Pardo
Summary: Magnetic nanosystems show potential as alternatives for diagnosing and treating various pathologies. This study proposes a series of biological tests to validate a magnetic nanoplatform for Kaposi's sarcoma treatment. The selected nanosystems, polyethylene glycol-coated iron oxide nanoparticles (MAG.PEG), were characterized and evaluated for in vivo administration. Biological assays demonstrated that MAG.PEG at moderate concentrations could be a suitable drug carrier for Kaposi's sarcoma treatment. The results provide a foundation for further development and improvement of this theranostic platform.
Article
Chemistry, Multidisciplinary
Adriana Zelenakova, Jaroslava Szucsova, Lubos Nagy, Vladimir Girman, Vladimir Zelenak, Veronika Huntosova
Summary: In this study, a drug delivery composite (DDC) consisting of ordered mesoporous silica, iron oxide magnetic nanoparticles (Fe2O3), and the drug naproxen (Napro) was prepared. The results reveal the suppression of the Brownian relaxation process and indicate the potential application of the composite as a drug nanocarrier for magnetic-targeted drug delivery.
Article
Chemistry, Multidisciplinary
Rui Xu, Linzhuo Huang, Jiayu Liu, Yuxuan Zhang, Ya Xu, Rong Li, Shicheng Su, Xiaoding Xu
Summary: A mitochondria-targeted RNAi nanoparticle platform for effective regulation of mitochondrial metabolism and breast cancer therapy is developed. This platform can specifically deliver siRNA into the mitochondria and efficiently down-regulate mtDNA-encoded ATP6 expression, leading to combinatorial inhibition of tumor growth by suppressing the energy supply for tumor cells and repolarizing tumor-associated macrophages into tumor-inhibiting M1-like macrophages.
Review
Polymer Science
V. Vinodhini, C. Krishnamoorthi
Summary: Magnetic nanoparticles are commonly functionalized with dispersants in biomedical applications to enhance stability and reduce toxicity, with polyethylene glycol polymer being a preferable option due to its high colloidal stability and low cytotoxicity.
Article
Materials Science, Multidisciplinary
Ala Manohar, V. Vijayakanth, S. V. Prabhakar Vattikuti, Ki Hyeon Kim
Summary: The particle size of spinel ferrite nanoparticles plays a crucial role in determining their properties and behavior in biomedical applications. This review focuses on the role of nanoparticle size in various biomedical applications, including induction heating, photocatalysis, and cytotoxicity. The review also discusses the biocompatibility properties and potential applications of spinel ferrite nanoparticles in medicine and the environment.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Chemistry, Organic
Lucie Wohlrabova, Jana Okorocenkova, Eduardo Palao, Erika Kuzmova, Karel Chalupsky, Petr Klan, Tomas Slanina
Summary: In this study, it was discovered that sulfonothioated BODIPY can cleave a sulfonylthio group from the meso-methyl position with a 10-fold higher quantum yield than previously studied leaving groups. The photocleavage was observed in both solution and cells, and it led to the controlled release of H2Sn. Therefore, sulfonothioated BODIPY has potential applications in cell signaling, redox homeostasis, and metabolic regulation studies.
Article
Nanoscience & Nanotechnology
Hak-Sung Jung, Kyung-Jin Cho, Seung-Jin Ryu, Yasuharu Takagi, Paul A. Roche, Keir C. Neuman
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Biochemistry & Molecular Biology
Seokgyu Han, Sein Kim, Zhenzhong Chen, Hwa Kyoung Shin, Seo-Yeon Lee, Hyo Eun Moon, Sun Ha Paek, Sungsu Park
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemical Research Methods
Jinseung Bae, Seogkyu Han, Sungsu Park
Article
Biotechnology & Applied Microbiology
Tae Hwan Shin, Abdurazak Aman Ketebo, Da Yeon Lee, Seungah Lee, Seong Ho Kang, Shaherin Basith, Balachandran Manavalan, Do Hyeon Kwon, Sungsu Park, Gwang Lee
Summary: Overdose of MNPs@SiO2(RITC) induced lipid peroxidation and decreased membrane fluidity in HEK293 cells. The aspect ratio of cells decreased, traction force increased, and cell movement velocity decreased. Metabotranscriptomics network analysis revealed interplay among lipid peroxidation, focal adhesion, and cell movement.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Hak-Sung Jung, Keir C. Neuman
Summary: Fluorescent nanodiamonds (FNDs) are a new class of carbon nanomaterials that show great potential for biological applications such as cell labeling, imaging, and sensing due to their exceptional optical properties and biocompatibility. Various surface functionalization methods for nanodiamonds are overviewed, including homogeneous surface termination approaches, as well as covalent and non-covalent surface modification with different functional moieties. The review also covers the coupling of biomolecules onto functionalized nanodiamonds and discusses biomedical applications of nanodiamonds in the context of functionalization.
Article
Engineering, Environmental
Jinyeop Lee, Cheolwoo Bong, Wanyoung Lim, Pan Kee Bae, Abdurhaman Teyib Abafogi, Seung Ho Baek, Yong-Beom Shin, Moon Soo Bak, Sungsu Park
Summary: During the COVID-19 pandemic, researchers found that ozone gas produced by a dielectric barrier discharge plasma generator can rapidly disinfect contaminated face masks while maintaining filtration efficiency. The study demonstrates that this method is effective for at least five uses, protecting the cleanliness and safety of the masks.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2021)
Article
Chemistry, Inorganic & Nuclear
Anjong Florence Tikum, Wanyoung Lim, Maxine Mambo Fortibui, Sohyun Lee, Sungsu Park, Jinheung Kim
Summary: A new palladium complex probe has been developed for detecting carbon monoxide with fast response and high selectivity and stability. The probe is capable of detecting CO in aqueous buffer as well as in living cells, providing a potential real-time indicator for studying CO-involved reactions in biological systems.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jaewon Kim, Atsushi Tamura, Sachiko Tsukita, Sungsu Park
Summary: Immature cell monolayers are susceptible to tensile strain, leading to dynamic changes in cell morphology that can be explained by an increase in di-phosphorylated myosin light chain (pp-MLC). The study suggests that a miniaturized stretching device can be used to investigate the morphological response of epithelial cell monolayers to tensile strain.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Abdurazak Aman Ketebo, Chanyong Park, Jaewon Kim, Myeongjun Jun, Sungsu Park
Summary: The study found that Filamin A (FLNa) plays an important role in cell polarization, migration speed, and invasiveness in U87 glioma cells.
Article
Medicine, General & Internal
Jaehyung Jeon, Chanyong Park, Dinesh Veeran Ponnuvelu, Sungsu Park
Summary: This study introduces a novel method for fabricating 3D-muPADs with enclosed channels, which show enhanced sensitivity compared to traditional hemi channel designs. The stoppage of evaporation in the enclosed channels significantly improves detection performance, with glucose detection as low as 0.3 mM achieved.
Article
Chemistry, Analytical
Hak-Sung Jung, Junsang Cho, Keir C. Neuman
Summary: Latent fingerprints are crucial evidence in crime scenes, and an efficient method for detecting them is important in forensic science. This study introduces a new method using stable CsPbBr3 perovskite nanocrystals to develop latent fingerprints on diverse surfaces, providing high resolution images with unique friction ridge arrangements.
ANALYTICA CHIMICA ACTA
(2021)
Article
Biochemistry & Molecular Biology
Ganesh Shenoy, Jessica Ettedgui, Chandrasekhar Mushti, Jennifer Hong, Kelly Lane, Burchelle Blackman, Hak-Sung Jung, Yasuharu Takagi, Yeonee Seol, Martin Brechbiel, Rolf E. Swenson, Keir C. Neuman
Summary: This article presents a method to enrich the carboxylic acid content on the surface of fluorescent nanodiamonds (FNDs). The method involves reducing oxygen-containing surface groups to alcohols and then converting them to carboxylic acids through a catalyzed reaction. This enrichment process improves the uniformity and functionalization efficiency of the nanodiamonds.
Article
Nanoscience & Nanotechnology
Hak-Sung Jung, Kyung-Jin Cho, Sihwa Joo, Mina Lee, Myeong Yun Kim, Ik Hwan Kwon, Nam Woong Song, Jeong Hyun Shim, Keir C. Neuman
Summary: In this study, mesoporous polydopamine (mPDA) encapsulation of fluorescent nanodiamonds (FNDs) was demonstrated for efficient functionalization. The mPDA shell could be easily modified with different functional groups such as thiol-terminated methoxy polyethylene glycol (mPEG-SH), hyperbranched polyglycerol (HPG), and d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS). The modified PEGylated FND@mPDA particles showed efficient cellular uptake and served as a fluorescent imaging probe for HeLa cells. Moreover, HPG-functionalized FND@mPDA was used for microRNA detection via hybridization, while the increased surface area of the mPDA shell allowed efficient loading of doxorubicin hydrochloride and its enhanced delivery with TPGS modification, resulting in high toxicity to cancer cells.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Hak-Sung Jung, Hyejin Choe, Jiwoo Park, Yejin Kim, Sang Jae Oh, Seung-Jin Ryu, Hee-Kyung Na, Seong-Joo Lee, Keir C. Neuman, Junsang Cho, Jeong Hyun Shim
Summary: This study demonstrates a highly efficient, sensitive, and background-free dual-color emission latent fingerprint detection method. By using manganese-doped perovskite nanocrystals, it allows for the visualization of fingerprint structures and enhances the resolution and sensitivity of the detection.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biophysics
Anita Devi, Krishna Neupane, Haksung Jung, Keir C. Neuman, Michael T. Woodside
Summary: This study characterized the trapping of nanoscale beads made of diamond and titanium dioxide in a single-beam gradient trap and found that the trapping stiffness was significantly higher for TiO2 beads due to notable enhancement from nonlinear optical effects. The results suggest that diamond and TiO2 nanobeads can be used to improve time resolution in optical tweezers measurements.
BIOPHYSICAL JOURNAL
(2023)
