期刊
ACS NANO
卷 6, 期 6, 页码 5291-5296出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn301082g
关键词
plasmonics; STED microscopy; super-resolution; nanoshells; photobleaching; triplets
类别
资金
- Royal Society
- European Science Foundation
- Leverhulme Trust
- EOARD [FA8659-09-1-3080]
We show that metal nanoparticles can be used to improve the performance of super-resolution fluorescence nanoscopes based on stimulated-emission-depletion (STED). Compared with a standard STED nanoscope, we show theoretically a resolution improvement by more than an order of magnitude, or equivalently, depletion intensity reductions by more than 2 orders of magnitude and an even stronger photostabilization. Our scheme may allow improvement of existing STED nanoscopes and assist in the development of low-power, low-cost nanoscopes. This has the potential to increase the availability of STED nanoscopes and lead to a significant expansion of our understanding of biological and biochemical phenomena occurring on the nanoscale.
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