Article
Plant Sciences
Yi Wang, Yanxiang Zhao, Shanshan Wang, Junfeng Liu, Xiqing Wang, Yanlai Han, Fang Liu
Summary: Overexpressing endogenous NADPH-dependent 2-alkenal reductase (ZmAER) in maize enhanced tolerance to low nitrogen stress, reduced oxidative stress, and improved nutrient use efficiency. Up-regulated ZmAER expression increased biomass, nitrogen accumulation, NUE, and leaf photosynthesis in transgenic plants compared to wild-type plants under low nitrogen conditions.
PLANT CELL AND ENVIRONMENT
(2021)
Article
Cell Biology
Yasukazu Saitoh, Yuuki Yamaguchi, Yuhei Okada
Summary: H-2 exhibits protective effects against oxidative stress, lipid peroxidation, and carbonyl stress-induced cellular injuries in human keratinocytes by suppressing intracellular oxidative stress and peroxide generation, making it a promising component in future cosmetic formulations.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Nurbubu T. Moldogazieva, Sergey P. Zavadskiy, Dmitry V. Astakhov, Alexander A. Terentiev
Summary: This study reviews the advancements in understanding the generation of reactive carbonyl species (RCS), the formation of protein/DNA adducts, and their identification and quantification in biological samples. It reveals that at certain concentrations, RCS can activate specific signaling pathways through the modification of susceptible residues, but at toxic concentrations, irreversible modification of Cys residues occurs, leading to the development of diseases.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Serafina Perrone, Carmelo Romeo, Lucia Marseglia, Sara Manti, Cristina Rizzo, Silvia Carloni, Maria Cristina Albertini, Walter Balduini, Giuseppe Buonocore, Michael D. Weiss, Eloisa Gitto
Summary: This pilot study found that oral melatonin supplementation effectively reduces perioperative oxidative stress in newborn infants undergoing surgery. The group receiving melatonin had significantly lower levels of non-protein-bound iron, advanced oxidation protein products, and F2-isoprostanes, indicating a potential role of melatonin in protecting babies from oxidative stress.
Article
Environmental Sciences
Ahmed Abdelraouf Salem, Kira Trares, Matthias Kohl, Eugene Jansen, Hermann Brenner, Ben Schottker
Summary: The study found a significant association between current smoking and increased levels of oxidative stress biomarker D-ROM, while there was no association with TTP levels. There is a dose-response relationship between smoking amount and D-ROM concentrations, indicating long-term effects of smoking on redox balance.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Aimin Wu, Bin Feng, Jie Yu, Lijun Yan, Lianqiang Che, Yong Zhuo, Yuheng Luo, Bing Yu, De Wu, Daiwen Chen
Summary: Iron overload-induced ferroptosis in hepatocytes is promoted by excessive HO-1 expression, while FGF21 protein can protect against this process by inhibiting ferroptosis and preventing liver damage. These findings suggest that activating FGF21 could be an effective strategy for potential treatment of iron overload-induced ferroptosis-related diseases like hereditary haemochromatosis.
Article
Biochemistry & Molecular Biology
Marta Martin-Fernandez, Victor Arroyo, Carmen Carnicero, Rebeca Siguenza, Reyes Busta, Natalia Mora, Beatriz Antolin, Eduardo Tamayo, Patricia Aspichueta, Irene Carnicero-Frutos, Hugo Gonzalo-Benito, Rocio Aller
Summary: This study found that elevated levels of lipid peroxidation (LPO) are significantly associated with a NASH score of >= 4 in NAFLD patients. LPO levels above 315.39 μM were identified as an independent risk factor. The model showed good discrimination ability in distinguishing NASH patients. Therefore, understanding the molecular mechanisms of basal inflammation may help identify biomarkers and therapeutic targets for NASH.
Review
Biochemistry & Molecular Biology
Heshu Chen, Chenyu Wang, Zemin Liu, Xinmiao He, Wenjie Tang, Liuqin He, Yanzhong Feng, Di Liu, Yulong Yin, Tiejun Li
Summary: Ferroptosis is a novel type of non-apoptotic cell death that can be triggered by specific modulators. It has potential implications in preventing inflammatory storms and cancer development. Ferroptosis may mediate biological processes such as oxidative stress and iron overload to treat cancer.
Review
Biochemistry & Molecular Biology
Ashley K. Putman, G. Andres Contreras, Lorraine M. Sordillo
Summary: Oxidative stress is associated with the generation of oxidized products such as IsoP, which are highly specific biomarkers of lipid peroxidation. Despite advancements in their detection and use, there is still limited knowledge about the biological activity and potential roles of IsoP in oxidative stress pathology, especially in veterinary medicine.
Article
Environmental Sciences
Malachy N. O. Ajima, Kundan Kumar, Nalini Poojary, Pramod K. Pandey
Summary: This study found that long-term exposure to diclofenac can induce oxidative imbalance, neurotoxicity, and alterations in gene expression related to stress in Nile tilapia. These biomarkers could potentially be used to monitor the adverse effects of pharmaceuticals on organisms in aquatic ecosystems.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Linas Cerniauskas, Asta Mazeikiene, Egle Mazgelyte, Egle Petrylaite, Ausra Linkeviciute-Dumce, Neringa Burokiene, Dovile Karciauskaite
Summary: Cardiovascular diseases are the leading cause of mortality worldwide. This study aimed to evaluate oxidative lipid degradation biomarkers and antioxidant defense system components in healthy women and their relationships with age, anthropometric measures, and lipid metabolism biomarkers. The findings suggest that these indices could be useful biomarkers in the research of aging, obesity, and atherosclerosis pathogenesis.
Article
Biochemistry & Molecular Biology
Marlena Rademacher, Hartmut Kuhn, Astrid Borchert
Summary: GPX4, as the only enzyme capable of reducing complex lipid peroxides to the corresponding alcohols, plays a role in erythroid differentiation of mouse erythroleukemia cells, but heterozygous expression of a catalytically inactive Gpx4 is not sufficient to compromise erythropoiesis in vivo and ex vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Vesna Sredoja Tisma, Stela Bulimbasic, Danica Galesic Ljubanovic, Kresimir Galesic, Jadranka Morovic-Vergles, Josko Mitrovic, Koji Uchida, Franz Tatzber, Neven Zarkovic, Morana Jaganjac
Summary: This study investigated the implication of oxidative stress in small-vessel vasculitis, focusing on acrolein immunohistochemistry in affected skin vessels and systemic stress response. It was found that systemic redox homeostasis and iron metabolism are altered in SVV patients, with possible biomarkers identified for evaluating oxidative status, disease activity, and prevalence. Furthermore, a strong correlation between the accumulation of acrolein-protein adducts in the skin and disease progression was revealed.
Article
Biochemistry & Molecular Biology
Po-Keng Cheng, Hsin-Chang Chen, Pao-Lin Kuo, Jung-Wei Chang, Wan-Ting Chang, Po-Chin Huang
Summary: This study investigated the association between oxidative and nitrosative stress and thyroid hormones, finding that an imbalance of oxidative and nitrosative stress may alter thyroid hormone homeostasis during pregnancy, which could affect embryonic and fetal development.
Article
Biochemistry & Molecular Biology
Yingya Zhao, Marina S. Nogueira, Ginger L. Milne, Xingyi Guo, Hui Cai, Qing Lan, Nathaniel Rothman, Qiuyin Cai, Yu-Tang Gao, Qingxia Chen, Xiao-Ou Shu, Gong Yang
Summary: The study found that miRNAs associated with F2-IsoP-M are enriched for various lipid peroxidation-related processes, and some miRNAs exhibited functional interactions with mRNAs involved in the regulation of beta-oxidation.
Article
Environmental Sciences
Muhammad Furqan Akhtar, Muhammad Omer Mehal, Ammara Saleem, Ahmad El Askary, Mohamed M. Abdel-Daim, Fareeha Anwar, Muhammad Ayaz, Alam Zeb
Summary: The study demonstrated that treatment with Prosopis cineraria ethanolic extract (PCDE) effectively prevented paraquat-induced toxicity in prepubertal mice by reducing oxidative stress levels and improving neurotransmitter levels in the brain. The high amount of quercetin, kaempferol, and ellagic acid derivatives in PCDE contributed to its beneficial effects on muscle and neural functions in mice exposed to paraquat.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Environmental Sciences
Chenmala Karthika, Anoop Pattanoor Appu, Rokeya Akter, Md. Habibur Rahman, Priti Tagde, Ghulam Md. Ashraf, Mohamed M. Abdel-Daim, Syed Shams ul Hassan, Areha Abid, Simona Bungau
Summary: Alzheimer's disorder is difficult to manage and treat due to the complexity of the brain and the blood-brain barrier. A combined strategy using a nano-based formulation containing vitamin E, quercetin, and basil oil, administered nasally, shows promise in treating and alleviating Alzheimer's disease. Intranasal drug administration is a non-invasive approach that enhances bioavailability and bypasses the blood-brain barrier, reducing systemic side effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Inorganic & Nuclear
Yanli Yang, Hongmei Sun, Nasser S. Awwad, Hala A. Ibrahium, Fatimah A. Alhomaid, Attalla F. El-kott, Mohamed M. Abdel-Daim
Summary: This study demonstrates the preparation and characterization of kaolin supported Au nanoparticles using Mentha extract as a green reluctant and capping agent. The study also evaluates the cytotoxicity and anti-cervical carcinoma properties of the prepared nanocomposite on different cervical carcinoma cell lines. The results show that the Au nanoparticles are homogeneously dispersed on the modified kaolin surface, and the nanocomposite exhibits dose-dependent reduction in the viability of malignant cervical cell lines.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Xiancheng Ou, Bikash Karmakar, Nasser S. Awwad, Hala A. Ibrahium, Hosam-Eldin Hussein Osman, Attalla F. El-Kott, Mohamed M. Abdel-Daim
Summary: This study describes a green protocol for the synthesis of Au nanoparticles (NPs) supported on chitosan-encapsulated magnetic Fe3O4 NPs. The morphological and physicochemical features of the material were determined using advanced techniques. The synthesized nanocomposite showed promising antioxidant properties and anticancer activity.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Sehrish Asad, Natasha Anwar, Mohib Shah, Zeeshan Anwar, Muhammad Arif, Mamoona Rauf, Kazim Ali, Muddaser Shah, Waheed Murad, Ghadeer M. Albadrani, Ahmed E. Altyar, Mohamed M. Abdel-Daim
Summary: This study synthesized silver nanoparticles from Amaryllis vittata leaf and bulb extracts and found that these nanoparticles exhibited insecticidal and phytotoxic activity, as well as potential antibacterial and antifungal properties. Furthermore, the nanoparticles were shown to induce biomass and antioxidants in an in vitro culture of Solanum tuberosum plants.
Article
Environmental Sciences
Zahid Ullah, Yifan Xu, Xian-Chun Zeng, Abdur Rashid, Asmat Ali, Javed Iqbal, Mikhlid H. Almutairi, Lotfi Aleya, Mohamed M. Abdel-Daim, Muddaser Shah
Summary: Fluoride contamination in drinking groundwater is a significant health risk in Pakistan. This study evaluated the health risk and suitability of elevated fluoride in groundwater for drinking purposes. The results showed that fluoride levels exceeded the WHO recommended limit, posing the greatest health risk to children. Additionally, the groundwater sources were found to be contaminated due to geological and anthropogenic actions.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Partha Biswas, Shabana Bibi, Qudsia Yousafi, Asim Mehmood, Shahzad Saleem, Awais Ihsan, Dipta Dey, M. D. Nazmul Hasan Zilani, M. D. Nazmul Hasan, Rasha Saleem, Aeshah A. Awaji, Usama A. Fahmy, Mohamed M. Abdel-Daim
Summary: An onco-informatics-based evaluation was conducted to assess the expression and predictive significance of the MDM2 gene in brain lower-grade glioma (LGG) cancer. The study analyzed the differential expression of MDM2 and searched for mutations and copy number variations. Several transcriptome servers and bioinformatics tools were used to determine the survival rate and protein interactions related to the MDM2 gene in LGG cancer patients.
Article
Biochemistry & Molecular Biology
Muhammad Zahid Khan, Abul Kalam Azad, Saleem Jan, Muhammad Safdar, Shabana Bibi, Amin Malik Shah Abdul Majid, Ghadeer M. Albadrani, Nehal Ahmed Talaat Nouh, Jawaher A. Abdulhakim, Mohamed M. Abdel-Daim
Summary: The essential oil of Urtica dioica L. whole plant was evaluated for its antioxidant, phytotoxic, and antibacterial activities using GC-MS technique. The analysis identified various constituents and demonstrated potential antioxidant effects and antibacterial activity against selected pathogens. Protein-ligand docking study further correlated docking results with experimental analysis and provided insight for further investigation.
Article
Environmental Sciences
Ali B. Jebur, Raghda A. El-Sayed, Mohamed M. Abdel-Daim, Fatma M. El-Demerdash
Summary: The study aimed to investigate the protective effects of pomegranate peel extract (PGPE) against testicular toxicity and oxidative stress induced by fenpropathrin (FNP). The results showed that PGPE exerted significant protective effects against oxidative stress and toxicity in the testes of rats, indicating its potential antioxidant activity.
Review
Multidisciplinary Sciences
Hesham R. El-Seedi, Noha S. Said, Nermeen Yosri, Hamada B. Hawash, Dina M. El-Sherif, Mohamed Abouzid, Mohamed M. Abdel-Daim, Mohammed Yaseen, Hany Omar, Qiyang Shou, Nour F. Attia, Xiaobo Zou, Zhiming Guo, Shaden A. M. Khalifa
Summary: The use of gelatin and gelatin-blend polymers for the synthesis of electrospun nanofibers has brought about a revolution in the biomedical field. Gelatin, despite variations in processing technology, is a versatile biopolymer. Electrospinning is an efficient and cost-effective technique for manufacturing gelatin electrospun nanofibers (GNFs), which have high porosity, large surface area, and biocompatibility. However, some limitations, such as rapid degradation and poor mechanical strength, can be overcome through cross-linking, leading to improved biological properties and various biomedical applications of GNFs.
Article
Anatomy & Morphology
Sameh M. Farouk, Walaa A. A. Basha, Mahmoud A. Emam, Elsayed Metwally
Summary: This study reveals the spatiotemporal distribution of key proteins, including alpha-SMA, CD34, Osteopontin, and E-cadherin, which play a crucial role in metanephrogenesis in camel fetuses. The expression patterns of these proteins vary in different stages and different renal tissues.
ANATOMIA HISTOLOGIA EMBRYOLOGIA
(2023)
Editorial Material
Multidisciplinary Sciences
Nikita Maruti Gaikwad, Pravin Digambar Chaudhari, Karimunnisa Sameer Shaikh, Somdatta Yashwant Chaudhari, Rasha Mohammed Saleem, Mohammad Algahtani, Ahmed E. Altyar, Ghadeer M. Albadrani, Mohamed Kamel, Mohamed M. Abdel-Daim
Summary: Drug repurposing is the process of discovering new activity for existing drugs. This study investigates the interaction of Albendazole, a well-known antihelmintic drug, with the tyrosine kinase protein receptor VEGFR-2. The findings suggest that Albendazole has potential as a potent angiogenesis inhibitor and could aid in the development of anticancer therapies.
Correction
Biology
Yasmina K. Mahmoud, Ahmed A. Ali, Heba M. A. Abdelrazek, Tahany Saleh Aldayel, Mohamed M. Abdel-Daim, Menna Allah I. El-Menyawy
Article
Multidisciplinary Sciences
Ahmed E. Altyar, Osama A. Kensara, Amany A. Sayed, Lotfi Aleya, Mikhlid H. Almutairi, Mohamed Sayed Zaazouee, Alaa Ahmed Elshanbary, Fatma M. El-Demerdash, Mohamed M. Abdel-Daim
Summary: The study evaluated the potential protective effects of morin against acute AFB1-induced hepatic and cardiac toxicity. The results showed that morin significantly decreased the levels of certain serum markers and exerted protective effects on hepatic and cardiac parameters.
Correction
Environmental Sciences
Eman A. Alwaleed, Mostafa El-Sheekh, Mohamed M. Abdel-Daim, Hani Saber
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
