期刊
ACS NANO
卷 6, 期 1, 页码 747-759出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn204231g
关键词
polyelectrolytes; DNA compaction; magnetoplexes; cellular uptake; cytotoxicity
类别
资金
- Ministerio de Ciencia e Innovacion, Spain
- Spanish Ministerio de Ciencia e Innovacion
- Xunta de Galicia [MAT2008-06126, CTQ2009-10002, 10PXIB312260PR, 2010/78]
- InBioMed
Magnetic silica nanoparticles show great promise for drug delivery. The major advantages correspond to their magnetic nature and ease of biofunctionalization, which favors their ability to interact with cells and tissues. We have prepared magnetic silica nanoparticles with DNA fragments attached on their previously polyelectrolyte-primed surface. The remarkable feature of these materials is the compromise between the positive charges of the polyelectrolytes and the negative charges of the DNA. This dual-agent formulation dramatically changes the overall cytotoxicity and chemical degradation of the nanoparticles, revealing the key role that surface functionalization plays in regulating the mechanisms Involved.
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