Article
Chemistry, Multidisciplinary
Paolo Emidio Costantini, Matteo Di Giosia, Luca Ulfo, Annapaola Petrosino, Roberto Saporetti, Carmela Fimognari, Pier Paolo Pompa, Alberto Danielli, Eleonora Turrini, Luca Boselli, Matteo Calvaresi
Summary: This study introduces the use of branched gold nanoparticles as a treatment for photothermal eradication of colon cancer cells. The experiment demonstrates that BGNPs have high light-to-heat conversion efficiency under laser irradiation, leading to rapid clearing of colon cancer cells, while also exhibiting good biocompatibility with cells.
Article
Biochemistry & Molecular Biology
Pamela Maher
Summary: High glucose favors NO production, but pro-inflammatory cytokine production is highest in the presence of carbon sources that drive OXPHOS. Glutamine is a very potent inducer of IL6 production among carbon sources that drive OXPHOS, and this effect is dampened in the presence of glucose. These findings may offer new prospects for the therapeutic manipulation of neuroinflammation in the context of diabetes and AD.
Article
Plant Sciences
Dusadee Ospondpant, Yingjie Xia, Queenie Wing Sze Lai, Gary Ka-Wing Yuen, Meixia Yang, Kanlayakorn Chanthanam, Tina Tingxia Dong, Karl Wah Keung Tsim
Summary: This study evaluated the anti-neuroinflammatory activities of D. cochinchinensis stemwood extract in activated microglia. The results showed that the extract suppressed neuroinflammatory response, increased the expression of anti-inflammatory biomarker Arg1, and modulated excessive phagocytosis. These findings suggested that D. cochinchinensis extract could be a promising natural product for the treatment of neuroinflammatory and neurodegenerative diseases, like AD.
Article
Biology
Corinne Benakis, Alba Simats, Sophie Tritschler, Steffanie Heindl, Simon Besson-Girard, Gemma Llovera, Kelsey Pinkham, Anna Kolz, Alessio Ricci, Fabian J. Theis, Stefan Bittner, Oezguen Goekce, Anneli Peters, Arthur Liesz
Summary: Neuroinflammation after stroke is characterized by the activation of microglia and leukocytes in the brain. Although the number of infiltrating lymphocytes is small, they have been shown to play a significant role in secondary inflammatory brain injury. However, the exact mechanism by which these lymphocytes affect stroke outcomes is still unclear. Using a mouse model, researchers found that different T cell subpopulations regulate the early activation of microglia in response to stroke. Acute treatment with IL-10-overexpressing T cells resulted in a switch of microglial gene expression associated with pro-regenerative functions. While the polarization of microglia by T cell subsets did not affect the development of infarct volume, targeting T cell-microglia interactions may have translational relevance for immune-targeted therapies for stroke and other neuroinflammatory conditions.
Article
Biochemistry & Molecular Biology
Keren Zohar, Elyad Lezmi, Fanny Reichert, Tsiona Eliyahu, Shlomo Rotshenker, Marta Weinstock, Michal Linial
Summary: This study found that the combination of bzATP and LPS can induce a sustained and robust inflammatory response in neonatal microglial cells, characterized by the release of pro-inflammatory cytokines and the induction of long noncoding RNAs. Analyzing the transcriptional profile and related signaling pathways, the researchers suggest that neonatal glial cells exhibit a distinctive expression program in which inflammatory-related genes are significantly upregulated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sho Yamazaki, Keisuke Yamaguchi, Akimasa Someya, Isao Nagaoka, Masakazu Hayashida
Summary: Dexmedetomidine may alleviate delirium by exhibiting anti-inflammatory action on microglial cells. The study found that Dexmedetomidine suppressed the production of inflammatory cytokines and inhibited the activation of related signaling pathways in both stimulated and unstimulated microglial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Joel Gruchot, Ferdinand Lein, Isabel Lewen, Laura Reiche, Vivien Weyers, Patrick Petzsch, Peter Goettle, Karl Koehrer, Hans-Peter Hartung, Patrick Kuery, David Kremer
Summary: Siponimod, a modulator of S1PR, can selectively modulate the reaction of microglia in the central nervous system. It has the potential to be a treatment option for multiple sclerosis, as it can promote neurorepair while inhibiting autoimmune inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ying Chen, Andrea Schlotterer, Luke Kurowski, Lin Li, Marcus Dannehl, Hans-Peter Hammes, Jihong Lin
Summary: miR-124 plays a protective role in diabetic retinopathy by reducing vasoregression, glial activation, and inflammatory responses, and improving neuroretinal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Anna A. Pimenova, Manon Herbinet, Ishaan Gupta, Saima I. Machlovi, Kathryn R. Bowles, Edoardo Marcora, Alison M. Goate
Summary: The study demonstrates that PU.1 expression levels in microglia modulate various microglial responses, with increased expression associated with heightened pro-inflammatory response related to increased cell viability under cytotoxic conditions. On the other hand, low expression of PU.1 leads to increased cell death under cytotoxic conditions and reduced pro-inflammatory signaling, highlighting the protective effect of SPI1 genotype in Alzheimer's disease.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Yingjie Xia, Qiyun Wu, Shinghung Mak, Etta Y. L. Liu, Brody Z. Y. Zheng, Tina T. X. Dong, Rongbiao Pi, Karl W. K. Tsim
Summary: This study explores the role of AChE in neuroinflammation and finds that AChE expression is upregulated during inflammation, while ACh or α7 nAChR agonists can suppress the production of pro-inflammatory cytokines and the phagocytosis of microglia.
Article
Biochemistry & Molecular Biology
Yan Chen, Hengrui Zhang, Yu Zhao, Ye Zhang, Saige Yin, Yan Hu, Guolan Ma, Di Lu, Jun Sun
Summary: Understanding microglia development is crucial for understanding the central nervous system and neurological diseases. This study investigated the changes in morphology, inflammatory response, and expression of immune-related proteins in microglia during development. The results showed that the expression levels of CD11b and CX3CR1 in microglia changed dynamically with age, and the inflammatory response was highest during the perinatal period. Neonatal microglia exhibited more vigorous inflammatory response and distinct morphology and function compared to adult microglia. These findings highlight the importance of microglial integrin, chemokine receptors, and inflammatory responses in age-related neurological diseases.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Juan M. Espinosa, Jose M. Castellano, Silvia Garcia-Rodriguez, Angelica Quintero-Florez, Natalia Carrasquilla, Javier S. Perona
Summary: Microglial cells contribute to Alzheimer's disease by triggering an inflammatory response that leads to neuronal death. The presence of amyloid-beta in the brain is associated with alterations in the blood-brain barrier and permeation of triglyceride-rich lipoproteins (TRL). In this study, lab-made TRL were used as carriers of lipophilic bioactive compounds to modulate the inflammatory response of microglial cells. The inclusion of oleanolic acid, alpha-tocopherol, and beta-sitosterol in TRL reduced the release of proinflammatory cytokines, such as IL-1 beta, IL-6, and TNF-alpha, as well as NO and iNOS generation. These findings suggest the potential therapeutic application of these lipophilic bioactive compounds in the treatment of Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Sangderk Lee, Nicholas A. Devanney, Lesley R. Golden, Cathryn T. Smith, James L. Schwartz, Adeline E. Walsh, Harrison A. Clarke, Danielle S. Goulding, Elizabeth J. Allenger, Gabriella Morillo-Segovia, Cassi M. Friday, Amy A. Gorman, Tara R. Hawkinson, Steven M. MacLean, Holden C. Williams, Ramon C. Sun, Josh M. Morganti, Lance A. Johnson
Summary: This study investigates the role of APOE in different age, neuroinflammatory, and AD pathological processes by combining bulk, single-cell, and spatial transcriptomics with cell-specific and spatially resolved metabolic analyses. The findings suggest that APOE4 microglia exhibit immunometabolic changes and altered lipid metabolism, potentially contributing to the association with metabolic dysfunction and heightened pro-inflammatory response.
Article
Neurosciences
Mohamed H. Yousef, Mohamed Salama, Hassan A. N. El-Fawal, Anwar Abdelnaser
Summary: This study aims to explore the therapeutic utility of GSK3 inhibition in multimodal disease modification and emphasizes the difference in therapeutic value between selective isoform inhibition. The results reveal that GSK3 beta-selective inhibition has superior anti-inflammatory and anti-oxidative efficacy compared to GSK3 alpha-selective and non-selective pan-inhibition.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hiroshi Nakanishi, Junjun Ni, Saori Nonaka, Yoshinori Hayashi
Summary: Microglia in the cortex exhibit different shapes and functions during wakefulness and sleep, with their molecular circadian clock playing a key role in regulating these processes. Disruption of the microglial clock system could lead to sleep disturbances, impaired social interaction, and cognitive impairment, potentially contributing to the pathogenesis of neurodegenerative disorders such as Alzheimer's disease. Understanding and targeting the microglial circadian molecular clock may offer insights for developing novel pharmacological interventions for neuropsychiatric and neurodegenerative disorders.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Biotechnology & Applied Microbiology
Taeyun Ku, Justin Swaney, Jeong-Yoon Park, Alexandre Albanese, Evan Murray, Jae Hun Cho, Young-Gyun Park, Vamsi Mangena, Jiapei Chen, Kwanghun Chung
NATURE BIOTECHNOLOGY
(2016)
Editorial Material
Biology
Alexandre Albanese, Kwanghun Chung
Article
Optics
Norman Lippok, Martin Villiger, Alexandre Albanese, Eelco F. J. Meijer, Kwanghun Chung, Timothy P. Padera, Sangeeta N. Bhatia, Brett E. Bouma
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Chemistry, Multidisciplinary
Alexandre Albanese, Warren C. W. Chan
Article
Chemistry, Multidisciplinary
Alexandre Albanese, Carl D. Walkey, Jonathan B. Olsen, Hongbo Guo, Andrew Emili, Warren C. W. Chan
Review
Engineering, Biomedical
Alexandre Albanese, Peter S. Tang, Warren C. W. Chan
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 14
(2012)
Article
Immunology
Evridiki Sgouroudis, Alexandre Albanese, Ciriaco A. Piccirillo
JOURNAL OF IMMUNOLOGY
(2008)
News Item
Optics
Edward A. Sykes, Alexandre Albanese, Warren C. W. Chan
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Multidisciplinary Sciences
Alexandre Albanese, Alan K. Lam, Edward A. Sykes, Jonathan V. Rocheleau, Warren C. W. Chan
NATURE COMMUNICATIONS
(2013)
Article
Neurosciences
Tomoyuki Mano, Alexandre Albanese, Hans-Ulrich Dodt, Ali Erturk, Viviana Gradinaru, Jennifer B. Treweek, Atsushi Miyawaki, Kwanghun Chung, Hiroki R. Ueda
JOURNAL OF NEUROSCIENCE
(2018)
Article
Biochemical Research Methods
Taeyun Ku, Webster Guan, Nicholas B. Evans, Chang Ho Sohn, Alexandre Albanese, Joon-Goon Kim, Matthew P. Frosch, Kwanghun Chung
Article
Biochemical Research Methods
Alexandre Albanese, Kim M. Tsoi, Warren C. W. Chan
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Endocrinology & Metabolism
Michael Tritt, Evridiki Sgouroudis, Eva d'Hennezel, Alexandre Albanese, Ciriaco A. Piccirillo