Review
Immunology
Nishelle D'souza, Milena Weber, Eszter Sarzsinszky, Susanne Vrtala, Mirela Curin, Mirjam Schaar, Victoria Garib, Margarete Focke-Tejkl, Yanqiu Li, Richard Jones, Hao Chen, Rudolf Valenta, Baoqing Sun
Summary: Approximately 30% of the global population suffers from IgE-mediated allergy, with China having the largest population and over 400 million allergic patients. Allergy prevention and treatment strategies include allergen avoidance, vaccination, and tolerance induction, requiring a detailed understanding of relevant allergen molecules affecting specific populations.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Ana Rostaher, Nina Maria Fischer, Alessio Vigani, Barbara Steblaj, Franco Martini, Salina Brem, Claude Favrot, Mitja Kosnik
Summary: This study aimed to demonstrate that venom immunotherapy (VIT) is not only safe, but also effective in treating dogs allergic to bee or wasp stings. Out of the 10 dogs treated with VIT, all of them tolerated the therapy and were able to tolerate subsequent stings.
Article
Immunology
Ewa Czerwinska, Marita Nittner-Marszalska, Robert Pawlowicz, Leszek Szenborn
Summary: Simultaneous administration of allergen immunotherapy and seasonal influenza vaccines is safe and well-tolerated, with no increase in adverse reactions. This procedure is feasible in patients with a history of systemic allergic reactions after Hymenoptera stings, and does not lead to an increase in adverse reactions.
Review
Food Science & Technology
Ziye Zhang, Xiu-Min Li, Hao Wang, Hong Lin, Hang Xiao, Zhenxing Li
Summary: This paper provides an overview of seafood allergens, IgE-binding epitopes, and allergen immunotherapy for seafood allergies, highlighting the importance of identifying and characterizing allergens for allergy diagnosis and treatment.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Annemiek Dickhout, Dawid M. Kaczor, Alexandra C. A. Heinzmann, Sanne L. N. Brouns, Johan W. M. Heemskerk, Marc A. M. J. van Zandvoort, Rory R. Koenen
Summary: After deposition on endothelial cells, CCL5 and CXCL4 are rapidly and actively internalized by the cells, primarily depending on dynamin, clathrin, and G protein-coupled receptors. The chemokines seem to be directed towards the nucleus, with internalization process not impacting leukocyte arrest.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Allergy
Debra de Silva, Pablo Rodriguez del Rio, Nicolette W. de Jong, Ekaterina Khaleva, Chris Singh, Anna Nowak-Wegrzyn, Antonella Muraro, Philippe Begin, Giovanni Pajno, Alessandro Fiocchi, Angel Sanchez, Carla Jones, Caroline Nilsson, Carsten Bindslev-Jensen, Gary Wong, Hugh Sampson, Kirsten Beyer, Mary-Jane Marchisotto, Montserrat Fernandez Rivas, Rosan Meyer, Susanne Lau, Ulugbek Nurmatov, Graham Roberts
Summary: Oral immunotherapy improves tolerance in patients with peanut, cow's milk, and hen's egg allergy during therapy and is likely safe. The effects of other allergies and administration routes are inconclusive and require further research.
Article
Immunology
Yasmeen S. El Ansari, Cynthia Kanagaratham, Oliver T. Burton, Jenna V. Santos, Brianna-Marie A. Hollister, Owen L. Lewis, Harald Renz, Hans C. Oettgen
Summary: Mast cells and basophils play important roles in IgE-mediated hypersensitivity reactions. IgG and IgA antibodies can regulate the activation of these cells by activating or inhibiting receptors. This study found that IgA antibodies can bind to mast cells and basophils, and inhibit their activation to maintain immune homeostasis at mucosal sites.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Johannes Grosch, Antoine Lesur, Stephanie Kler, Francois Bernardin, Gunnar Dittmar, Elisabetta Francescato, Simon J. Hewings, Constanze A. Jakwerth, Ulrich M. Zissler, Matthew D. Heath, Markus Ollert, Matthias F. Kramer, Christiane Hilger, Maria Beatrice Bilo, Carsten B. Schmidt-Weber, Simon Blank
Summary: Allergy to Polistes dominula venom is a significant issue in Southern Europe and may become a threat in other regions. Venom immunotherapy (VIT) is an effective treatment for this allergy. This study compared five different VIT preparations for P. dominula venom allergy in Spain and found that the majority of samples contained comparable levels of major allergens.
Review
Pharmacology & Pharmacy
Juan L. Paris, Lalitkumar K. Vora, Maria Jose Torres, Cristobalina Mayorga, Ryan F. Donnelly
Summary: The incidence of allergies has been increasing recently. Allergen-specific immunotherapy (AIT) is the only approach that can induce long-term immune tolerance towards allergens. However, its clinical success is limited by efficacy and safety concerns related to the administration route. Microneedles have been proposed to improve therapeutic delivery into the skin, but the stratum corneum poses a challenge. This review discusses recent developments in the use of microneedles for AIT and suggests future research directions.
DRUG DISCOVERY TODAY
(2023)
Article
Biochemistry & Molecular Biology
Reni Ajoy, Yu-Chun Lo, Man-Hau Ho, You-Yin Chen, Yun Wang, Yuan-Hao Chen, Chiu Jing-Yuan, Chun Austin Changou, Yuan-Chin Hsiung, Hui-Min Chen, Tzu-Hao Chang, Cheng-Yang Lee, Yung-Hsiao Chiang, Wen-Chang Chang, Barry Hoffer, Szu-Yi Chou
Summary: In addition to its neuroinflammatory functions, chemokine CCL5 also exhibits strong neurotrophic properties. CCL5 plays a critical role in promoting hippocampal glucoregulatory efficiency, which in turn enhances synaptic plasticity and memory and cognition functions. CCL5's actions on glucose aerobic metabolism are essential for mitochondrial function, contributing to hippocampal spine and synapse formation, ultimately improving learning and memory.
MOLECULAR PSYCHIATRY
(2021)
Article
Allergy
Charles F. Schuler, Sofija Volertas, Dilawar Khokhar, Huseyin Yuce, Lu Chen, Onur Baser, Jenny M. Montejo, Cem Akin
Summary: Using an insurance claims database and a retrospective study at the University of Michigan, it was found that the prevalence of HVA in the US is lower than previously reported, while the prevalence of mastocytosis in patients with HVA is higher but still lower than previously reported. There was no correlation between tryptase level and reaction severity in patients undergoing VIT.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
I-Hui Lin, Ming-Chin Tsai, Jun-Peng Chen, Lin-Shien Fu
Summary: The study found that for two thirds of atopic children, a specific allergen could be identified during follow-up tests. Specific allergens could be identified through MAST tests and further assist in treatment options.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Biochemistry & Molecular Biology
Kavita Reginald, Fook Tim Chew
Summary: This review evaluates the current modes of allergen-specific immunotherapy for cockroach allergens in terms of clinical outcomes and explores future trends in research and development for a more targeted approach to cockroach immunotherapy with better efficacy and fewer adverse effects.
MOLECULAR IMMUNOLOGY
(2023)
Review
Allergy
Mohamed H. Shamji, Rudolf Valenta, Theodore Jardetzky, Valerie Verhasselt, Stephen R. Durham, Peter A. Wurtzen, R. J. Joost van Neerven
Summary: IgE-mediated allergy is a common hypersensitivity disease impacting over 30% of the population. Allergen-specific IgE triggers release of inflammatory mediators, while inducing IgG and IgA antibodies can compete with IgE for allergen binding to prevent allergic responses. Anti-IgE treatment can also prevent IgE from binding to receptors on mast cells and basophils to inhibit allergic reactions.
Review
Medicine, General & Internal
Riccardo Castagnoli, Mattia Giovannini, Francesca Mori, Simona Barni, Luca Pecoraro, Stefania Arasi, Francesca Saretta, Carla Mastrorilli, Lucia Liotti, Lucia Caminiti, Gunter Johannes Sturm, Gian Luigi Marseglia, Elio Novembre
Summary: Hymenoptera stings typically result in local reactions, with potential for immediate, delayed, or unusual hypersensitivity responses. While uncommon, it is important for clinicians to be aware of the possible clinical manifestations of unusual reactions to Hymenoptera stings. Further research is needed to improve diagnostic and therapeutic approaches for these conditions.
FRONTIERS IN MEDICINE
(2021)
Article
Allergy
Olga Branicka, Edyta Jura-Szoltys, Barbara Rogala, Joanna Gluck
Summary: The study evaluated the changes in serum levels of sCD48 in patients with intermittent allergic rhinitis during and out of the pollen season, finding that sCD48, FeNO nasal and bronchial fractions, and TNSS were significantly higher during the pollen season. However, there were no correlations found between sCD48 and eosinophil-related parameters.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Article
Immunology
Olga Branicka, Edyta Jura-Szoltys, Barbara Rogala, Joanna Gluck
Summary: This study found significantly higher sCD48 levels in NAR patients compared to PAR and healthy controls, with a significant correlation between sCD48 levels and eosinophils. ECP and eotaxin-1/CCL11 levels were also significantly higher in the NAR group.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2021)
Article
Allergy
Andrzej Bozek, Beata Galuszka, Radoslaw Gawlik, Maciej Misiolek, Wojciech Scierski, Alicja Grzanka, Giorgio Walter Canonica
Summary: For adult patients with local allergic rhinitis and asthma, a 12-month course of sublingual immunotherapy for house dust mite allergies can improve nasal and bronchial symptoms and reduce symptomatic treatment.
Article
Allergy
Joanna Glueck, Marek Glueck, Barbara Rogala, Jerzy Piecuch
Summary: The purpose of this study was to assess cytokines activating ILCs2 in the serum of patients with obesity and the effect of bariatric surgery on these parameters.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2022)
Article
Allergy
Emilia Vassilopoulou, Isabel Skypala, Gavriela Feketea, Radoslaw Gawlik, Audrey Dunn Galvin, Rosan Meyer, Constantinos Pitsios, Raluca Maria Pop, Dermot Ryan, Maria Said, Sophie Schiere, Berber Vlieg-Boerstra, Inger Kull
Summary: Nurses, allied healthcare professionals, and general practitioners, through collaborative work in multidisciplinary teams, can enhance patients' understanding, treatment adherence, and self-care abilities, ultimately improving the quality of life for patients with allergic diseases.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Allergy
Dermot Ryan, Bertine M. J. Flokstra-de Blok, Evangeline Clark, Clara Gaudin, Myriam Mamodaly, Janwillem Kocks, Jantina Lucia van der Velde, Liz Angier, Kerstin Romberg, Radek Gawlik, Pascal Demoly, Luciana Kase Tanno
Summary: To address the lack of accessible and pragmatic guidance, flow diagrams for common allergic conditions were designed. These diagrams provide tools to aid diagnosis and management of allergies, but further validation is needed in primary care settings.
Article
Primary Health Care
Janwillem W. H. Kocks, Hans Wouters, Sinthia Bosnic-Anticevich, Joyce van Cooten, Jaime Correia de Sousa, Biljana Cvetkovski, Richard Dekhuijzen, Lars Dijk, Evgeni Dvortsin, Marina Garcia Pardo, Asparuh Gardev, Iris van Geer-Postmus, Iris van der Ham, Marten Harbers, Alberto de la Hoz, Ymke Janse, Marjan Kerkhof, Federico Lavorini, Tiago Maricoto, Jiska Meijer, Boyd Metz, David Price, Miguel Roman-Rodriguez, Kirsten Schuttel, Nilouq Stoker, Ioanna Tsiligianni, Omar Usmani, Marika T. Leving
Summary: This study aimed to determine the associations between Peak Inspiratory Flow (PIF), inhalation technique, adherence, and health status in COPD patients using DPI maintenance therapy. The results showed that suboptimal PIF was significantly associated with poorer health status, highlighting the importance of PIF assessment in DPI inhalation therapy. Inhalation technique and adherence did not have a significant impact on health status. Overall, these findings provide insights into the factors influencing health status in COPD patients using DPI maintenance therapy.
NPJ PRIMARY CARE RESPIRATORY MEDICINE
(2022)
Article
Respiratory System
Marika T. Leving, Job F. M. van Boven, Sinthia Z. Bosnic-Anticevich, Joyce van Cooten, Jaime Correia de Sousa, Biljana Cvetkovski, Richard Dekhuijzen, Lars Dijk, Marina Garcia Pardo, Asparuh Gardev, Radoslaw Gawlik, Iris van der Ham, Elisabeth Sophia Hartgers-Gubbels, Ymke Janse, Federico Lavorini, Tiago Maricoto, Jiska Meijer, Boyd Metz, David B. Price, Miguel Roman-Rodriguez, Kirsten Schuttel, Nilouq Stoker, Ioanna Tsiligianni, Omar S. Usmani, Janwillem H. Kocks
Summary: This study found that suboptimal Peak Inspiratory Flow (sPIF) and inhalation technique errors are associated with increased healthcare resource utilization and costs in Chronic Obstructive Pulmonary Disease (COPD) patients receiving maintenance therapy via a Dry Powder Inhaler (DPI).
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Materials Science, Multidisciplinary
Edyta Jura-Szoltys, Lesia Rozlucka, Radoslaw Gawlik, Joanna Gluck
Summary: According to the analysis, the use of paraformaldehyde as a dental material can cause delayed hypersensitivity reactions, which can be life-threatening. Approximately 50% of patients treated with paraformaldehyde had positive specific IgE levels. Compared to the control group, the level of certainty of anaphylactic reaction after paraformaldehyde application was significantly higher in the PF-positive group according to the Brighton criteria.
Article
Primary Health Care
Marika T. Leving, Sinthia Bosnic-Anticevich, Joyce van Cooten, Jaime Correia de Sousa, Biljana Cvetkovski, Richard Dekhuijzen, Lars Dijk, Marina Garcia Pardo, Asparuh Gardev, Radoslaw Gawlik, Iris van Der Ham, Ymke Janse, Federico Lavorini, Tiago Maricoto, Jiska Meijer, Boyd Metz, David Price, Miguel Roman-Rodriguez, Kirsten Schuttel, Nilouq Stoker, Ioanna Tsiligianni, Omar Usmani, Rachel Emerson-Stadler, Janwillem W. H. Kocks
Summary: A study on patients using dry powder inhalers (DPIs) for COPD maintenance therapies found that measuring peak inspiratory flow (PIF) is important for ensuring proper inhalation technique. Some patients may benefit from inhalation training or switching to a more suitable DPI. Observing inhalation technique is valuable, but may miss suboptimal PIF. Assessing adherence is also important, as deliberate non-adherence could indicate a mismatch between patient and inhaler.
NPJ PRIMARY CARE RESPIRATORY MEDICINE
(2022)
Editorial Material
Allergy
Oliver J. Price, Stefano Del Giacco, Radoslaw Gawlik, Christer Janson, Mikaela Odemyr, Nikolaos G. Papadopoulos, Matteo Bonini
Review
Allergy
Magdalena Kokoszka, Grazyna Stryjewska-Makuch, Ada Kantczak, Dorota Gorny, Joanna Gluck
Summary: Allergic fungal rhinosinusitis (AFRS) is a Th2-mediated, chronic rhinosinusitis, mainly occurring in subtropical and tropical regions with high temperatures and humidity, which promote fungal growth. Specific IgE antibodies against fungal allergens play a diagnostic role in distinguishing AFRS from eosinophilic fungal rhinosinusitis. Treatment options for AFRS vary and relapses are common, with sinus surgery being the preferred method. Steroid therapy is important, while the effectiveness of antifungal treatment and immunotherapy remains unclear. This study aims to investigate the prevalence and environmental factors of AFRS in Europe, as well as the importance of diagnostic criteria and treatment methods, providing an overview of the literature and sharing two case studies.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Grazyna Stryjewska-Makuch, Joanna Gluck, Olga Branicka, Grazyna Lisowska
Summary: The aim of this study was to investigate the incidence of a specific chronic rhinosinusitis (CRS) phenotype with age and compare the values of neutrophils, lymphocytes, and neutrophil-to-lymphocyte ratio in the peripheral blood between patients below and above 65 years of age with different CRS phenotypes. The study found that bilateral CRSwNP occurred significantly more often in patients aged 65 and above compared to those below 65, and the absolute neutrophil count was higher in older patients with bilateral CRSsNP.
MEDICINA-LITHUANIA
(2023)
Article
Allergy
Edyta Jura-Szoltys, Radoslaw Gawlik, Olga Branicka, Grazyna Stryjewska-Makuch, Joanna Gluck
Summary: Allergen immunotherapy is effective in treating intermittent allergic rhinitis, with a high percentage of eosinophils in nasal cytology before subcutaneous immunotherapy predicting clinical efficacy, especially in grass pollen allergy.
POSTEPY DERMATOLOGII I ALERGOLOGII
(2022)
