Article
Oncology
Fumihiro Fujiki, Akihiro Tsuboi, Soyoko Morimoto, Naoya Hashimoto, Miki Inatome, Hiroko Nakajima, Jun Nakata, Sumiyuki Nishida, Kana Hasegawa, Naoki Hosen, Yoshihiro Oka, Yusuke Oji, Shinji Sogo, Haruo Sugiyama
Summary: The study showed a stronger induction of WT1-specific CTLs in patients who received WT1 CTL + WT1 helper peptide vaccine compared to those who received WT1 CTL vaccine alone. Importantly, a clear correlation was demonstrated between WT1-specific CTL and WT1(332)-specific HTL responses.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Oncology
Hiroko Nakajima, Jun Nakata, Kanako Imafuku, Hiromu Hayashibara, Kazuki Isokawa, Keiko Udaka, Fumihiro Fujiki, Soyoko Morimoto, Kana Hasegawa, Naoki Hosen, Yoshiko Hashii, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Shinji Sogo, Haruo Sugiyama
Summary: This study identified three novel mouse Th epitope peptides that strongly induced and maintained WT1-specific CTLs, efficiently rejected WT1-expressing tumor cells, and showed that these CTLs played a central role in tumor rejection. The majority of WT1-specific CTLs induced by the co-immunization with WT1 CTL and the WT1-specific Th peptides were effector memory CD8(+) T cells, demonstrating their essential function in WT1-specific tumor immunity.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Immunology
Xuan Zhao, Zhen Zhang, Chunli Wen, Jianmin Huang, Shuangning Yang, Jinyan Liu, Huizhen Geng, Bing Peng, Zibo Li, Yi Zhang
Summary: This study demonstrates that multiple peptide-pulsed DCs combined with CTLs therapy has manageable safety and promising efficacy for cancer patients, which might provide a precise immunotherapeutic strategy for cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Tzu-Li Lu, Yuh-Pyng Sher, Hui-Chen Chen, Wei-Chung Cheng, Ling-Heng Hsu, Chen-Chen Lee
Summary: This study reveals that the B chain of articulatin can activate mouse bone marrow-derived dendritic cells, inducing antigen-specific T cell immune response. This finding has potential implications for the development of vaccines against pathogens and tumors.
Review
Immunology
Vanaja Konduri, Damilola Oyewole-Said, Jonathan Vazquez-Perez, Scott A. Weldon, Matthew M. Halpert, Jonathan M. Levitt, William K. Decker
Summary: NK1.1 and its human homolog CD161 are expressed on various immune cells and play different roles in NK cells, T cells, and NKT cells. CD161-expressing CD8(+) T cells, initially studied in viral infections, have potential implications in tumor immunology, although their exact role is not well understood.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Fengyin Li, Xin Zhao, Yali Zhang, Peng Shao, Xiaoke Ma, William J. Paradee, Chengyu Liu, Jianmin Wang, Hai-Hui Xue
Summary: Precise regulation of coinhibitory receptors is crucial for maintaining immune tolerance and protective immunity. In protein immunization, T-FH cells lacking Tcf1 and Lef1 show abnormal upregulation of CTLA4 and LAG3, impacting B-cell help. Targeting CTLA4 and LAG3 can rectify T-FH cell defects and balance immune responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Yue Liu, Joanna Pagacz, Donald J. Wolfgeher, Kenneth D. Bromerg, Jacob Gorman, Stephen J. Kron
Summary: Antigen presentation may be the limiting factor in the low immune response to radiation therapy, and combining immune checkpoint blockade does not restore cytotoxic T lymphocytes function. Therapeutic vaccines based on senescent tumor cells or SnC-activated dendritic cells have the potential to enhance immune therapies and limit recurrence or metastasis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Immunology
Andrea Sabatini, Gisella Guerrera, Marta Corsetti, Gabriella Ruocco, Marco De Bardi, Sonia Renzi, Duccio Cavalieri, Luca Battistini, Daniela Francesca Angelini, Elisabetta Volpe
Summary: Saccharomyces cerevisiae is a commensal yeast colonizer of mucosal surfaces and can become an opportunistic pathogen in the mucosa and bloodstream. It has been found that human dendritic cells (DCs) can sense S. cerevisiae and produce inflammatory cytokines and interferon-alpha in response. This finding highlights the role of DCs in regulating the host microbiota-immune system balance and the anti-fungal immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hae-Bin Park, So-Jung Kim, Dhananjay Yadav, Eun-Koung An, Wei Zhang, Hee-Yun Eom, Minseok Kwak, Tatsuya Oda, Peter Chang-Whan Lee, Jun-O Jin
Summary: This study found that porphyran derived from Pyropia yezoensis has an inhibitory effect on dextran sodium sulfate (DSS)-induced colitis in mice. Oral or intraperitoneal administration of porphyran can inhibit the progression of colitis and prevent immune cell infiltration in the colon. Porphyran inhibits T cell activation by suppressing dendritic cells and macrophages and attenuates chronic colitis caused by long-term DSS administration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Environmental Sciences
Jinlong Li, Yuanyuan Guo, Xiaoxu Duan, Bing Li
Summary: Inorganic arsenic induces immune tolerance in murine dendritic cells by down-regulating the expression of phenotypic molecules, pro-inflammatory factors, and T-lymphocyte cytokines. The immunosuppressive property of arsenic may be partially mediated by the HO-1 pathway, contributing to the development of infections and malignant diseases.
Article
Virology
Mona Sadat Larijani, Amitis Ramezani, Maryam Mashhadi Abolghasem Shirazi, Azam Bolhassani, Mohammad Hassan Pouriayevali, Sepideh Shahbazi, Seyed Mehdi Sadat
Summary: Various approaches have been explored to combat HIV-1 since 1981, but no effective vaccine has been found. In this study, antigens derived from p24 and nef genes were evaluated in full and truncated forms for their immunogenicity. Results showed that the truncated form of p24 and nef induced strong cellular immune responses, demonstrating potential as a dendritic cell therapeutic vaccine candidate against HIV-1.
Article
Pharmacology & Pharmacy
Dominik Damm, Ehsan Suleiman, Jannik T. Wagner, Stephan Klessing, Felix Pfister, Hassan Elsayed, Bernd Walkenfort, Jule Stobrawe, Julia Mayer, Elisabeth Lehner, Sandra M. Mueller-Schmucker, Mike Hasenberg, Richard T. Wyatt, Karola Vorauer-Uhl, Vladimir Temchura, Klaus Ueberla
Summary: The encapsulation of HIV-unrelated T helper peptides into liposomal vaccines presenting trimers of the HIV-1 envelope glycoprotein on the surface, known as T helper liposomes, can modulate the HIV-specific immune response. In this study, cationic T helper liposomes were used to induce strong activation of Env-specific B cells and CD4+ T cells, and target Env-specific B cells in secondary lymphoid organs. Mouse immunization experiments revealed modulation of the antibody response and enhancement of antibody longevity. Clinical evaluation of this intrastructural help concept is warranted.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Jae Wook Jung, Ae Rin Lee, Jaesung Kim, Young Rim Kim, Jassy Mary S. Lazarte, Jung Suk Lee, Kim D. Thompson, Hyeongsu Kim, Tae Sung Jung
Summary: The study successfully generated monoclonal antibodies against CD8 T lymphocytes in olive flounder and confirmed their specificity. The populations of CD4 and CD8 T lymphocytes significantly increased in fish infected or immunized, with up-regulation of Th1-related genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Ippei Date, Terutsugu Koya, Takuya Sakamoto, Misa Togi, Haruhiko Kawaguchi, Asuka Watanabe, Tomohisa Kato, Shigetaka Shimodaira
Summary: This study demonstrates that human platelet lysate (HPL) can enhance the viability, yield, and purity of interferon-alpha-induced dendritic cells (IFN-DCs), leading to increased antigen-specific cytotoxic T lymphocytes (CTLs) production. Additionally, HPL-induced IFN-DCs show elevated cytokine production and improved endocytic and proteolytic activities, suggesting a novel approach for dendritic cell-based immunotherapies.
Article
Microbiology
Sean Turner, Brent Raisley, Kimberly Roach, Sandra Bajana, Melissa E. Munroe, Judith A. James, K. Mark Coggeshall, Susan Kovats
Summary: Gram-positive bacterial infections can cause organ failure and death in sepsis. Bacillus anthracis PGN, a component shed during bacterial replication, can promote sepsis-like pathology. This study found that purified Bacillus anthracis PGN can activate human dendritic cells (DCs), promote the production of proinflammatory cytokines, and induce the differentiation of T(H)17 cells.