Article
Multidisciplinary Sciences
Yuzhu Ma, Hongjin Zhang, Runfeng Lin, Yan Ai, Kun Lan, Linlin Duan, Wenyao Chen, Xuezhi Duan, Bing Ma, Changyao Wang, Xiaomin Li, Dongyuan Zhao
Summary: In this study, a nanodroplet remodeling strategy is proposed for the synthesis of hierarchical multi-chambered mesoporous silica nanoparticles with tunable architectures. The dual-chambered nanoparticles have a high surface area and two interconnected cavities, allowing for separate anchoring of multiple species without mutual interference. Additionally, the dual-chambered mesoporous nanoreactors prepared using this strategy exhibit efficient mass transfer, leading to improved selectivity of the target product.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Rashad Kariuki, Rowan Penman, Saffron J. Bryant, Rebecca Orrell-Trigg, Nastaran Meftahi, Russell J. Crawford, Chris F. McConville, Gary Bryant, Kislon Voitchovsky, Charlotte E. Conn, Andrew J. Christofferson, Aaron Elbourne
Summary: Nanomaterials have the potential to revolutionize biological and biomedical research, and this study provides detailed insights into how gold nanoparticles interact with phospholipid membranes. The study shows that the nanoparticles can be absorbed and internalized by fluid-phase membranes, and partially embed into gel-phase membranes, causing perturbations throughout the bilayers.
Article
Chemistry, Multidisciplinary
Paul Joyce, Silver Joemetsa, Simon Isaksson, Shakhawath Hossain, Per Larsson, Christel Bergstrom, Fredrik Hook
Summary: This study established a new method to monitor membrane permeation kinetics using mesoporous silica substrate and total internal reflection fluorescence microscopy. By contrasting the permeation behavior of pure felodipine with felodipine coupled to the permeability enhancer caprylate (C8), evidence for C8-facilitated transport across lipid membranes was provided, validating the potential of this approach to quantify carrier system-induced changes to cellular membrane permeation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biophysics
Surajit Ghosh, Zeinab Mohamed, Jung-Ho Shin, Samavi Farnush Bint E. Naser, Karan Bali, Tobias Dorr, Roisin M. Owens, Alberto Salleo, Susan Daniel
Summary: Antibiotic resistance is a global health concern due to the decreasing number of available antibiotics and the development of drug-resistant bacteria. Understanding the interactions between the bacterial membrane and antibiotics is crucial for designing novel antimicrobial drugs. By creating a surface-supported planar bacterial outer membrane model, researchers can study these interactions and gain insights into membrane properties for drug design.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Physical
Zhihong Zhang, Wendong Ma, Kejie He, Bing Yuan, Kai Yang
Summary: This study investigated the diffusion behaviors of ligand-decorated nanoparticles on a lipid bilayer membrane using molecular dynamics simulations. The results showed that PGLa-coated nanoparticles exhibited enhanced circling during hopping and confined circling during jiggling stages, while MAG2-coated nanoparticles demonstrated constant circling tendencies throughout the diffusion process. The differences in translational and rotational dynamics were attributed to the different ligand-lipid interactions of PGLa and MAG2.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Article
Materials Science, Multidisciplinary
Tun Naw Sut, Bo Kyeong Yoon, Won-Yong Jeon, Joshua A. Jackman, Nam-Joon Cho
Summary: Supported lipid bilayer (SLB) coatings, versatile cell-membrane-mimicking biointerfaces, have been expanded for medical and biotechnology applications, facilitating various studies and applications like biosensors, diagnostics, and antifouling surfaces.
APPLIED MATERIALS TODAY
(2021)
Article
Chemistry, Analytical
Karutha Pandian Divya, Shanmuganathan Keerthana, Chinnuswamy Viswanathan, Nagamony Ponpandian
Summary: This paper reports a biomimetic bilayer lipid membrane supported MXene based biosensor for electrochemical hybridization detection of the most prevalent and potential breast cancer biomarker BRCA1. A 2D MXene nanosheet-anchored gold nanoparticle-decorated biomimetic bilayer lipid membrane (AuNP@BLM) biosensor is used for the attachment of thiolated single-stranded DNA (HS-ssDNA) targeting hybridization detection. The synergistic combination of MXene and AuNP@BLM has proven to efficiently improve the detection signal to several folds.
Article
Biochemistry & Molecular Biology
Emanuela Efodili, Ashlynn Knight, Maryem Mirza, Cedric Briones, Il-Hyung Lee
Summary: This study demonstrates the spontaneous transfer of small membrane-bound peptides between a supported lipid bilayer and giant unilamellar vesicles in vitro. The transfer occurs through the formation of hemi-fusion stalks and is limited to small peptides due to the highly curved structure of the stalk. This system provides a synthetic platform for studying peptide trafficking between synthetic membranes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Pharmacology & Pharmacy
Sara Kheirkhah, Mehdi Abedi, Fateme Zare, Mohsen Salmanpour, Samira Sadat Abolmaali, Ali Mohammad Tamaddon
Summary: In this study, mesoporous silica nanoparticles (MSNs) were used as a delivery strategy for dexamethasone (DEX) to overcome its unfavorable pharmacokinetics and side effects. The MSNs were modified to improve drug loading and then combined with lipid bilayers to sustain drug release. The optimized MSNs showed high-capacity DEX loading, long-term release, and hemocompatibility, indicating their potential application in chronic inflammatory diseases.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kathleen W. Swana, Terri A. Camesano, Ramanathan Nagarajan
Summary: Supported lipid bilayers (SLBs) on quartz crystals are versatile model systems for studying cell membrane behavior. This study successfully formed entirely anionic SLBs by treating the quartz crystal, which provides valuable model systems for studying interactions with Gram-positive bacterial membranes.
Article
Chemistry, Multidisciplinary
Zaiwang Zhao, Linlin Duan, Yujuan Zhao, Lipeng Wang, Junye Zhang, Fanxing Bu, Zhihao Sun, Tengsheng Zhang, Mengli Liu, Hanxing Chen, Yi Yang, Kun Lan, Zirui Lv, Lianhai Zu, Pengfei Zhang, Renchao Che, Yun Tang, Dongliang Chao, Wei Li, Dongyuan Zhao
Summary: In this study, a method for fabricating three-dimensional mesoporous N-doped carbon superstructures with controllable morphology and adjustable pore structure was reported. The superstructures possess a large hollow, spherical mesopores, and interconnected porous structure, exhibiting high accessible surface area and good underwater aerophilicity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Nanoscience & Nanotechnology
Nicolo Paracini, Philipp Gutfreund, Rebecca Welbourn, Juan Francisco Gonzalez-Martinez, Kexin Zhu, Yansong Miao, Nageshwar Yepuri, Tamim A. . Darwish, Christopher Garvey, Sarah Waldie, Johan Larsson, Max Wolff, Marite Cardenas
Summary: Arrays of nanoparticle-supported lipid bilayers (nanoSLB) are lipid-coated nanopatterned interfaces that provide a platform to study curved model biological membranes using surface-sensitive techniques. We investigated the structure of lipid bilayers formed on nanoparticle arrays through vesicle fusion using scattering techniques and direct imaging. The presence of both flat and curved supported lipid bilayers on the same substrate, combined with the accuracy of grazing incidence neutron scattering, offers a promising approach to studying curvature-dependent membrane phenomena.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Applied
Vignesh Krishnan, Joy Sebastian Prakash, Venkatesan Manigandan, G. Devanand Venkatasubbu, Arivalagan Pugazhendhi, Kathirvel Brindhadevi, T. Kalaivani
Summary: This study synthesized mesoporous silicon dioxide nanoparticles with different pore volumes and evaluated their toxicity effects on zebrafish. The results showed that the nanoparticles had excellent drug loading capacity and the survival rate of zebrafish was above 85%.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Electrochemistry
ZhangFei Su, Barbara Goodall, J. Jay Leitch, Jacek Lipkowski
Summary: The ion channel properties of gramicidin A in a model floating bilayer lipid membrane were studied, showing that the transport of Na+ across the membrane is independent of the transport of the counterion and the conductivity of the gA sodium channel depends on the transmembrane potential, with more gA molecules inserting into the bilayer as the transmembrane potential decreases.
ELECTROCHIMICA ACTA
(2021)
Article
Biochemistry & Molecular Biology
Frederic Lirussi, Kyrylo Pyrshev, Semen Yesylevskyy, Timothee Rivel, Tatiana Lopez, Eleonore Coppens, Simona Mura, Patrick Couvreur, Christophe Ramseyer
Summary: Despite differences in lipid composition between benign and malignant cells, lipid bilayers have rarely been considered as targets in cancer therapy. However, this study demonstrates that the lipid bilayer of the plasma membrane can be targeted for selective delivery of amphiphilic gemcitabine-squalene nanomedicines to cancer cells. Data from various assays and simulations provide evidence of the selective accumulation of gemcitabine-squalene in disrupted plasma membranes and its preferential uptake by malignant cells, resulting in pronounced cytotoxicity on cancer cells compared to benign counterparts.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Chemistry, Multidisciplinary
Varvara Apostolopoulou-Kalkavoura, Pierre Munier, Lennart Bergstrom
Summary: Thermally insulating materials based on renewable nanomaterials like nanocellulose have the potential to reduce energy consumption and environmental impact in the building sector. Recent advances in superinsulating cellulose nanomaterial-based aerogels and foams have shown significantly better heat transport properties than traditional materials, leading to increased research activity in this area.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Tom Willhammar, Kazuho Daicho, Duncan N. Johnstone, Kayoko Kobayashi, Yingxin Liu, Paul A. Midgley, Lennart Bergstrom, Tsuguyuki Saito
Summary: This study used scanning electron diffraction and atomic force microscopy to directly measure the local ordering of polysaccharide chains and twisting structures in cellulose nanofibers, shedding new light on the properties of single-cellulose fibrils. This understanding has important implications for optimizing cellulose extraction and separation processes in dense assemblies.
Article
Chemistry, Multidisciplinary
Adrian Moreno, Jinrong Liu, Robin Gueret, Seyed Ehsan Hadi, Lennart Bergstrom, Adam Slabon, Mika H. Sipponen
Summary: The study demonstrates that controlling the degree of esterification can significantly improve the stability of lignin oleate nanoparticles under acidic and basic conditions. The high stability is attributed to the alkyl chains accumulated in the shell of the particle, delaying protonation/deprotonation of carboxylic acid and phenolic hydroxyl groups. Through enhanced stability, acid- and base-catalyzed functionalization of the nanoparticles were successfully performed at pH 2.0 and pH 12.0.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Materials Science, Paper & Wood
Mohit Garg, Varvara Apostolopoulou-Kalkavoura, Mathieu Linares, Tahani Kaldeus, Eva Malmstrom, Lennart Bergstrom, Igor Zozoulenko
Summary: Foams made from cellulose nanomaterials have high porosity and excellent mechanical and thermal insulation properties. Moisture uptake in these materials increases with relative humidity and decreases with temperature, with amorphous cellulose films showing higher water uptake due to the formation of water-filled pores.
Article
Multidisciplinary Sciences
Varvara Apostolopoulou-Kalkavoura, Pierre Munier, Lukasz Dlugozima, Veit-Lorenz Heuthe, Lennart Bergstrom
Summary: Anisotropic cellulose nanocrystal (CNC) foams with densities between 25 and 130 kg m(-3) were prepared by directional ice-templating of aqueous dispersions. The thermal conductivity of the foams is influenced by solid and gas conduction, with interfacial phonon scattering contributing to the small increase in radial thermal conductivity with increasing foam density. The foam wall nanoporosity, particle orientation, and alignment of macropores also impact the insulation performance of the foams.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Physical
Pierre Munier, Seyed Ehsan Hadi, Mo Segad, Lennart Bergstrom
Summary: The development of robust production processes is crucial for advanced materials based on renewable and Earth-abundant resources. Combining cellulose nanomaterials with other nanoparticles can generate multifunctional films and foams, with shear affecting particle orientation in the dispersions.
Article
Biochemistry & Molecular Biology
Tamara L. Church, Konstantin Kriechbaum, Carina Schiele, Varvara Apostolopoulou-Kalkavoura, Seyed Ehsan Hadi, Lennart Bergstrom
Summary: By combining the techniques of foam formation and directional freezing, we have created a low-density, anisotropic foam material with low thermal conductivity.
Article
Biochemistry & Molecular Biology
Delphine Menard, Leonard Blaschek, Konstantin Kriechbaum, Cheng Choo Lee, Henrik Serk, Chuantao Zhu, Alexander Lyubartsev, Nuoendagula, Zoltan Bacsik, Lennart Bergstrom, Aji Mathew, Shinya Kajita, Edouard Pesquet
Summary: Different vascular cell types control their lignin biochemistry to adjust their biomechanics and hydraulic properties to face developmental and environmental constraints.
Article
Chemistry, Multidisciplinary
Andi Di, Jipeng Xu, Thomas Zinn, Michael Sztucki, Wentao Deng, Anumol Ashok, Cheng Lian, Lennart Bergstrom
Summary: This study presents a time-resolved small-angle X-ray scattering investigation on the co-assembly process of amphiphilic organo-functionalized Wells-Dawson-type polyoxometalate (POM) metal-oxygen clusters with Pluronic block copolymer in aqueous solutions. The study revealed the formation of large vesicles, a lamellar phase, a mixture of two cubic phases, and eventually a hexagonal phase at concentrations above 110 mM.
Article
Chemistry, Multidisciplinary
Andi Di, Carina Schiele, Seyed Ehsan Hadi, Lennart Bergstrom
Summary: Low-density foams and aerogels based on upcycled and bio-based nanofibers and additives are potential alternatives to fossil-based thermal insulation materials. This study focuses on the preparation of super-insulating foams using upcycled acid-treated aramid nanofibers (upANFA) and tempo-oxidized cellulose nanofibers (CNF), and highlights the importance of the very small diameter of upANFA for phonon scattering. The foams exhibit high thermal stability, low thermal conductivity, and are moisture-resilient. The use of significant amounts of upcycled textile nanofibers can reduce carbon footprint and energy demand in thermal management applications.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Seyed Ehsan Hadi, H. Aygul Yeprem, Agnes ahl, Mohammad Morsali, Martin Kapuscinski, Konstantin Kriechbaum, Mika H. Sipponen, Lennart Bergstrom
Summary: Lightweight iron oxide nanoparticle (IONP)/TEMPO-oxidized cellulose nanofibril (TOCNF) hybrid foams with an anisotropic structure and high IONP content were produced using magnetic field-enhanced unidirectional ice-templating. Coating the IONP with tannic acid (TA) improved the processability, mechanical performance, and thermal stability of the hybrid foams. These highly magnetic hybrid foams are of potential interest for environmental remediation, energy storage, and electromagnetic interference shielding.
Article
Automation & Control Systems
Frederic Heraly, Miao Zhang, Agnes Ahl, Wei Cao, Lennart Bergstrom, Jiayin Yuan
Summary: The study presents a nanomaterial-based organic-inorganic humidity-sensitive bilayer actuator characterized by large humidity-driven locomotion and fast unbending. Cationic exchange and control of layer thickness can be used to adjust and dictate the actuator's response to humidity variations.
ADVANCED INTELLIGENT SYSTEMS
(2022)
Article
Chemistry, Physical
Pierre Munier, Andi Di, Seyed Ehsan Hadi, Martin Kapuscinski, Mo Segad, Lennart Bergstrom
Summary: Time-resolved small-angle X-ray scattering was utilized to investigate the assembly of cellulose nanocrystals (CNC) and montmorillonite (MNT) in aqueous levitating droplets. Results showed that MNT promotes gelation and assembly of CNC, and liquid crystal assembly competes with gelation in CNC dispersions up to 35% volume fractions.
Article
Materials Science, Multidisciplinary
Varvara Apostolopoulou-Kalkavoura, Shiqian Hu, Nathalie Lavoine, Mohit Garg, Mathieu Linares, Pierre Munier, Igor Zozoulenko, Junichiro Shiomi, Lennart Bergstrom
Summary: This study highlights that in super-insulating nanocellulose foams, thinner fibrils result in lower thermal conductivity, which strongly depends on relative humidity. Controlling heat transport of hygroscopic super-insulating nanofibrillar foams through moisture uptake and release could have potential applications in packaging and building.
Article
Materials Science, Multidisciplinary
B. Gross, S. Philipp, E. Josten, J. Leliaert, E. Wetterskog, L. Bergstrom, M. Poggio
Summary: Researchers have utilized sensitive dynamic cantilever magnetometry to study the magnetic properties of individual micrometer-sized gamma-Fe2O3 mesocrystals, revealing a clear cubic anisotropy. By combining the self-assembly of highly ordered mesocrystals with the ability to resolve their individual magnetism, the signatures of anisotropy and its origins have come to light. This combination holds promise for future studies of magnetic anisotropy in nanoparticles that are too small to investigate individually.
