Review
Cell Biology
Sajad Dehnavi, Mahvash Sadeghi, Jalil Tavakol Afshari, Mojgan Mohammadi
Summary: This review introduces the potential of mesenchymal stromal/stem cells (MSCs) in treating rheumatoid arthritis (RA), including their immunomodulatory and inhibitory effects. It summarizes the therapeutic effects of MSCs on animal models of arthritis and RA patients, and categorizes their effects on different immune cells. The limitations and future considerations for the use of MSCs as a therapeutic approach in RA patients are also discussed.
CELLULAR IMMUNOLOGY
(2023)
Article
Cell & Tissue Engineering
Lindsay C. Davies, Suzanna Queckborner, Cecilia E. Jylha, Anton Tornqvist Andren, Tacha Zi Plym Forshell, Katarina Le Blanc
Summary: This study shows that most MSCs are rapidly lysed upon contact with blood, whereas the surviving MSCs demonstrate a shift in their phenotype, including a reduction in the secretion of monocyte recruitment factors and an enhanced ability to skew the phenotype of monocytes. The addition of MSCs to whole blood leads to significant shifts in the innate immune repertoire towards an immunosuppressive profile, even after the infused MSCs have been cleared.
Review
Biochemistry & Molecular Biology
Gregorie Lebeau, Franck Ah-Pine, Matthieu Daniel, Yosra Bedoui, Damien Vagner, Etienne Frumence, Philippe Gasque
Summary: Mesenchymal stem cells (MSCs) play a critical role in response to infection and can remove cell debris, regulate immune activities, control pathogens, and contribute to tissue remodeling. However, chronic infection and inflammation can affect the functions and immune regulatory activities of MSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Matthieu Daniel, Yosra Bedoui, Damien Vagner, Loic Raffray, Franck Ah-Pine, Berenice Doray, Philippe Gasque
Summary: The treatment of sepsis and septic shock remains a major public health issue. Mesenchymal stem cells (MSCs) are emerging as a potential approach for cell therapy in sepsis, but the mechanisms underlying their beneficial effects are still unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Luise Mueller, Antje Tunger, Manja Wobus, Malte von Bonin, Russell Towers, Martin Bornhaeuser, Francesco Dazzi, Rebekka Wehner, Marc Schmitz
Summary: Mesenchymal stromal cells (MSCs) have the ability to regulate and inhibit the function of immune cells, playing a crucial role in the pathogenesis of inflammatory disorders and showing promise in the treatment of conditions such as acute graft-versus-host disease, graft rejection, and autoimmune diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Dragan Primorac, Martin Cemerin, Vid Matisic, Vilim Molnar, Marko Strbad, Lenart Girandon, Lucija Zenic, Miomir Knezevic, Stephen Minger, Denis Polancec
Summary: The COVID-19 pandemic has had a significant impact globally and the overaggressive immune reaction in response to the virus can lead to ARDS. Mesenchymal stromal cell therapy presents a potential treatment option for severe patients.
Review
Immunology
Ayman F. Refaie, Batoul L. Elbassiouny, Malgorzata Kloc, Omaima M. Sabek, Sherry M. Khater, Amani M. Ismail, Rania H. Mohamed, Mohamed A. Ghoneim
Summary: MSC-based therapy for T1DM shows promise, but there are conflicting views on their immunological profile. Research focuses on understanding the mechanisms of their immunomodulatory functions and exploring ways to enhance their effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Joo Dong Park, Kwang-Soo Kim, Seung Hee Choi, Gae Hoon Jo, Jin-Ho Choi, Si-Won Park, Eun-Su Ko, Minwook Lee, Dae-Keum Lee, Hye Jung Jang, Sohyun Hwang, Hae-Yun Jung, Kyung-Soon Park
Summary: This study found that the ELK3-Mid51 axis is directly associated with mitochondrial dynamics and NK cell immune response in TNBC, providing new strategies to improve the efficacy of NK cell-based immunotherapy of TNBC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Likun Zheng, Lei Zhang, Yixuan Guo, Xintong Xu, Zhaoyun Liu, Zhenyu Yan, Rong Fu
Summary: Myelodysplastic syndrome (MDS) is a common hematological malignant disease characterized by abnormal proliferation of malignant hematopoietic stem cells in the bone marrow. The dysfunction of mesenchymal stromal cells (MSCs) in the bone marrow microenvironment plays a critical role in MDS progression through modulation of immune cell function, enabling evasion of immune surveillance by MDS-associated malignant cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Alasdair G. Kay, James M. Fox, James P. Hewitson, Andrew P. Stone, Sophie Robertson, Sally James, Xiao-nong Wang, Elizabeth Kapasa, Xuebin B. Yang, Paul G. Genever
Summary: The heterogeneity of bone marrow mesenchymal stromal cells (MSCs) poses challenges for their clinical development. A subtype of MSCs characterized by CD317 expression has been identified, and they show a constitutive interferon signature linked to human disease. CD317(pos) MSCs induce tissue damage in a skin inflammation model, while CD317(neg) MSCs have no effect. CD317(neg) MSCs can suppress the proliferation of activated human T cells, while CD317(pos) MSCs increase the polarization towards pro-inflammatory Th1 cells. CD317(neg) and CD317(pos) MSCs can suppress leukocyte recruitment, but only CD317(neg) MSCs suppress macrophage numbers.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Kellen J. Cavagnero, Richard L. Gallo
Summary: Fibroblasts are stromal cells that produce extracellular matrix and play a role in tissue structure and scar formation. Recent studies have found that they are highly heterogeneous and actively participate in both innate and adaptive immune defense. Detailed analysis of barrier tissues such as skin, gut, and lung shows that some fibroblasts directly sense pathogens and other danger signals, contributing to host defense functions such as antimicrobial activity, white blood cell recruitment, and production of cytokines relevant to inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell & Tissue Engineering
Yuko Nitahara-Kasahara, Soya Nakayama, Koichi Kimura, Sho Yamaguchi, Yuko Kakiuchi, Chikako Nito, Masahiro Hayashi, Tomoyuki Nakaishi, Yasuyoshi Ueda, Takashi Okada
Summary: This study demonstrates the immunomodulatory effects of amnion-derived mesenchymal stromal cells (hAMSCs) on macrophage polarization and their therapeutic potential in dystrophin-deficient muscular dystrophy (DMD) mice. Systemic administration of hAMSCs ameliorated the progressive phenotypes of DMD mice, including pathological inflammation and motor dysfunction, resulting in long-term improvement of skeletal and cardiac muscle function.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Sayan Chakraborty, Sayantani Sinha, Amitava Sengupta
Summary: The integration of epigenetic regulation with transcriptional and cell signaling machinery plays a crucial role in determining tissue resident adult pluripotent mesenchymal stem/stromal cell (MSC) activity, lineage commitment, and immunomodulation. Histone modifying enzymes and chromatin remodeling complexes are central features influencing gene regulation and tissue identity establishment in MSCs. Modulation of transcription factor expression gradient and flexibility of chromatin architecture are exciting approaches to regulate MSC activity.
Article
Biology
Xiao Su, Xiaolei Li, Shiqing Wang, Xiaotong Xue, Rui Liu, Xiaojing Bai, Pixia Gong, Chao Feng, Lijuan Cao, Tingting Wang, Yayun Ding, Junjie Jiang, Yongjing Chen, Yufang Shi, Changshun Shao
Summary: This study found that Nestin-positive mesenchymal stromal cells (T-MSCs) mainly distribute in the medulla and cortical-medulla junction of the thymus, and possess immunosuppressive ability. Additionally, T-MSCs exhibit remarkable therapeutic efficacy in acute liver injury and inflammatory bowel disease (IBD).
Article
Dentistry, Oral Surgery & Medicine
Alice Blufstein, Christian Behm, Barbara Kubin, Johannes Gahn, Andreas Moritz, Xiaohui Rausch-Fan, Oleh Andrukhov
Summary: This study reveals the immunomodulatory properties of GMSCs towards PMNs, with IL-1 beta enhancing their anti-apoptotic effects. However, GMSCs did not affect the ROS production of PMNs.
Article
Medicine, Research & Experimental
Srinivasa Rao Nagubothu, Rachael V. Sugars, Nikolce Tudzarovski, Anton Tornqvist Andren, Matteo Bottai, Lindsay C. Davies, Stellan Hertegard, Katarina Le Blanc
Article
Cell & Tissue Engineering
Stellan Hertegard, Srinivasa Rao Nagubothu, Emma Malmstrom, Cecilia E. Strom, Anna Tolf, Lindsay C. Davies, Katarina Le Blanc
STEM CELLS AND DEVELOPMENT
(2019)
Letter
Hematology
Erik Boberg, Nadir Kadri, Jeanette Winterling, Lindsay C. Davies, Andreas Bjorklund, Mussie Msghina, Ellen Iacobaeus, Katarina Le Blanc
Article
Cell & Tissue Engineering
Caroline Gavin, Erik Boberg, Lena Von Bahr, Matteo Bottai, Anton Toernqvist Andren, Annika Wernerson, Lindsay C. Davies, Rachael V. Sugars, Katarina Le Blanc
STEM CELL RESEARCH & THERAPY
(2019)
Article
Cell & Tissue Engineering
Suzanna Queckborner, Elisabeth Syk Lundberg, Kristina Gemzell-Danielsson, Lindsay C. Davies
STEM CELL RESEARCH & THERAPY
(2020)
Article
Health Care Sciences & Services
Suzanna Queckborner, Carolina von Grothusen, Nageswara Rao Boggavarapu, Roy Mathew Francis, Lindsay C. Davies, Kristina Gemzell-Danielsson
Summary: By utilizing single-cell RNA sequencing, researchers identified multiple stromal populations in the endometrium with potential roles in controlling inflammation and extracellular matrix composition. These findings contribute to a better understanding of healthy regeneration mechanisms and may lead to the identification of novel therapy targets for gynecological disorders affecting endometrial regeneration and proliferation.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Cell & Tissue Engineering
Zi Y. Kok, Nadia Y. A. Alaidaroos, Amr Alraies, John S. Colombo, Lindsay C. Davies, Rachel J. Waddington, Alastair J. Sloan, Ryan Moseley
Summary: This article reviews the biology and heterogeneity of human dental pulp stem/stromal cells (hDPSCs). There are still unanswered questions regarding the developmental origins, hierarchical organization, and stem cell niche locations of hDPSC subpopulations. The identification and characterization of specific cell features can distinguish hDPSC subpopulations with different characteristics. Such knowledge advancements will contribute to the development of novel strategies for regenerative medicine applications.
STEM CELLS INTERNATIONAL
(2022)
Article
Cell & Tissue Engineering
Samuel A. Molina, Stephanie J. Davies, Dalip Sethi, Steve Oh, Nisha Durand, Michael Scott, Lindsay C. Davies, Klaus Wormuth, Dominic Clarke
Article
Endocrinology & Metabolism
Per-Ola Carlsson, Daniel Espes, Sofia Sisay, Lindsay C. Davies, C. I. Edvard Smith, Mathias G. Svahn
Summary: This study aimed to investigate the safety and efficacy of treatment with allogeneic Wharton's jelly-derived mesenchymal stromal cells (MSCs) in recent-onset type 1 diabetes. Results showed that treatment with ProTrans resulted in smaller decline in C-peptide levels and no change in insulin requirements, suggesting the potential to preserve beta cell function.
Article
Multidisciplinary Sciences
Shruthi Kalgudde Gopal, Ruoxuan Dai, Ania Maria Stefanska, Meshal Ansari, Jiakuan Zhao, Pushkar Ramesh, Johannes W. Bagnoli, Donovan Correa-Gallegos, Yue Lin, Simon Christ, Ilias Angelidis, Valerio Lupperger, Carsten Marr, Lindsay C. Davies, Wolfgang Enard, Hans-Guenther Machens, Herbert B. Schiller, Dongsheng Jiang, Yuval Rinkevich
Summary: The study shows that injury induces temporary migration of adipocytes, but they do not convert into myofibroblasts like fibroblasts. Adipocytes do not contribute to fibrotic scar formation and remain non-fibrogenic both in vitro and in vivo.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Cell & Tissue Engineering
P. Carlsson, D. Espes, L. Davies, M. Svahn
Meeting Abstract
Cell Biology
S. Queckborner, K. Gemzell-Danielsson, L. Davies
WOUND REPAIR AND REGENERATION
(2020)
Meeting Abstract
Cell Biology
L. Davies, E. Board-Davies, B. Shamlou, G. Tour, A. Sloan, P. Stephens, K. Le Blanc
WOUND REPAIR AND REGENERATION
(2020)
Meeting Abstract
Cell Biology
C. Gavin, T. Plym Forshell, C. Strom, A. Tornqvist-Andren, K. Le Blanc, L. Davies
WOUND REPAIR AND REGENERATION
(2020)
Meeting Abstract
Cell Biology
S. Rao Nagubothu, S. Hertegard, T. Plym Forshell, C. Strom, E. Malmstrom, A. Tolf, L. Davies, K. Le Blanc
WOUND REPAIR AND REGENERATION
(2020)
